R A Reenan

Summary

Affiliation: University of Connecticut Health Center
Country: USA

Publications

  1. ncbi The mle(napts) RNA helicase mutation in drosophila results in a splicing catastrophe of the para Na+ channel transcript in a region of RNA editing
    R A Reenan
    Department of Genetics and Developmental Biology, University of Connecticut Health Center, Farmington 06030, USA
    Neuron 25:139-49. 2000
  2. ncbi The RNA world meets behavior: A-->I pre-mRNA editing in animals
    R A Reenan
    Dept of Genetics and Developmental Biology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USA
    Trends Genet 17:53-6. 2001
  3. ncbi Molecular determinants and guided evolution of species-specific RNA editing
    Robert A Reenan
    Department of Genetics and Developmental Biology, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    Nature 434:409-13. 2005
  4. ncbi dADAR, a Drosophila double-stranded RNA-specific adenosine deaminase is highly developmentally regulated and is itself a target for RNA editing
    M J Palladino
    Department of Genetics and Developmental Biology, University of Connecticut Health Center, Farmington 06030, USA
    RNA 6:1004-18. 2000
  5. ncbi RNA editing of the Drosophila para Na(+) channel transcript. Evolutionary conservation and developmental regulation
    C J Hanrahan
    Department of Genetics and Developmental Biology, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    Genetics 155:1149-60. 2000
  6. ncbi A-to-I pre-mRNA editing in Drosophila is primarily involved in adult nervous system function and integrity
    M J Palladino
    Department of Genetics and Developmental Biology, University of Connecticut Health Center, Farmington 06030, USA
    Cell 102:437-49. 2000
  7. ncbi Extended life-span conferred by cotransporter gene mutations in Drosophila
    B Rogina
    Department of Genetics and Developmental Biology, School of Medicine, University of Connecticut Health Center, 263 Farmington Avenue, Farmington CT 06030, USA
    Science 290:2137-40. 2000
  8. ncbi RNA editing in regulating gene expression in the brain
    James E C Jepson
    Department of Molecular Biology, Cell Biology and Biochemistry, SFH Life Sciences Building, Brown University, 185 Meeting Street, Providence, RI 02912, USA
    Biochim Biophys Acta 1779:459-70. 2008
  9. ncbi Genetic approaches to studying adenosine-to-inosine RNA editing
    James E C Jepson
    Department of Molecular and Cellular Biology, Brown University, Providence, Rhode Island, USA
    Methods Enzymol 424:265-87. 2007
  10. ncbi Comparative genomic and bioinformatic approaches for the identification of new adenosine-to-inosine substrates
    Jaimie Sixsmith
    Department of Molecular and Cellular Biology, Brown University, Providence, Rhode Island, USA
    Methods Enzymol 424:245-64. 2007

Collaborators

Detail Information

Publications13

  1. ncbi The mle(napts) RNA helicase mutation in drosophila results in a splicing catastrophe of the para Na+ channel transcript in a region of RNA editing
    R A Reenan
    Department of Genetics and Developmental Biology, University of Connecticut Health Center, Farmington 06030, USA
    Neuron 25:139-49. 2000
    ..These results explain how mlen(napts) affects Na+ channel expression and provide new insights into the mechanism of RNA editing...
  2. ncbi The RNA world meets behavior: A-->I pre-mRNA editing in animals
    R A Reenan
    Dept of Genetics and Developmental Biology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USA
    Trends Genet 17:53-6. 2001
    ..Two recent reports of mutant mice and Drosophila deficient in ADAR activities provide further evidence that pre-mRNA editing has an ancient and primary role in the evolution of nervous system function and behavior...
  3. ncbi Molecular determinants and guided evolution of species-specific RNA editing
    Robert A Reenan
    Department of Genetics and Developmental Biology, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    Nature 434:409-13. 2005
    ..The results also provide models for the genesis of RNA editing sites through the stepwise addition of structural domains, or by short walks through sequence space from ancestral structures...
  4. ncbi dADAR, a Drosophila double-stranded RNA-specific adenosine deaminase is highly developmentally regulated and is itself a target for RNA editing
    M J Palladino
    Department of Genetics and Developmental Biology, University of Connecticut Health Center, Farmington 06030, USA
    RNA 6:1004-18. 2000
    ..Taken together, these findings show that both transcription and processing of dADAR transcripts are under strict developmental control and suggest that the process of RNA editing in Drosophila is dynamically regulated...
  5. ncbi RNA editing of the Drosophila para Na(+) channel transcript. Evolutionary conservation and developmental regulation
    C J Hanrahan
    Department of Genetics and Developmental Biology, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    Genetics 155:1149-60. 2000
    ..These results demonstrate that Na(+) channel diversity in Drosophila is increased by RNA editing via a mechanism analogous to that described for transcripts encoding mammalian GluRs...
  6. ncbi A-to-I pre-mRNA editing in Drosophila is primarily involved in adult nervous system function and integrity
    M J Palladino
    Department of Genetics and Developmental Biology, University of Connecticut Health Center, Farmington 06030, USA
    Cell 102:437-49. 2000
    ..Surprisingly, dADAR mutants are not short-lived. Thus, A-to-I editing of pre-mRNAs in Drosophila acts predominantly through nervous system targets to affect adult nervous system function, integrity, and behavior...
  7. ncbi Extended life-span conferred by cotransporter gene mutations in Drosophila
    B Rogina
    Department of Genetics and Developmental Biology, School of Medicine, University of Connecticut Health Center, 263 Farmington Avenue, Farmington CT 06030, USA
    Science 290:2137-40. 2000
    ..Excision of the P element resulted in a reversion to normal life-span. These mutations may create a metabolic state that mimics caloric restriction, which has been shown to extend life-span...
  8. ncbi RNA editing in regulating gene expression in the brain
    James E C Jepson
    Department of Molecular Biology, Cell Biology and Biochemistry, SFH Life Sciences Building, Brown University, 185 Meeting Street, Providence, RI 02912, USA
    Biochim Biophys Acta 1779:459-70. 2008
    ....
  9. ncbi Genetic approaches to studying adenosine-to-inosine RNA editing
    James E C Jepson
    Department of Molecular and Cellular Biology, Brown University, Providence, Rhode Island, USA
    Methods Enzymol 424:265-87. 2007
    ..A prerequisite for experiments in this field is the ability to quantify the levels of editing in a given mRNA. Therefore, several commonly used methods for the quantification of editing levels will also be described...
  10. ncbi Comparative genomic and bioinformatic approaches for the identification of new adenosine-to-inosine substrates
    Jaimie Sixsmith
    Department of Molecular and Cellular Biology, Brown University, Providence, Rhode Island, USA
    Methods Enzymol 424:245-64. 2007
    ..In this chapter, we discuss these approaches to identifying new editing sites...
  11. ncbi Tuning of RNA editing by ADAR is required in Drosophila
    Liam P Keegan
    MRC Human Genetics Unit, Western General Hospital, Edinburgh, UK
    EMBO J 24:2183-93. 2005
    ..Expression of this transcript in embryonic muscle is also lethal, with above-normal, adult-like levels of editing at sites in a transcript encoding a muscle voltage-gated calcium channel...
  12. ncbi Acquired temperature-sensitive paralysis as a biomarker of declining neuronal function in aging Drosophila
    Robert A Reenan
    Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI 02912, USA
    Aging Cell 7:179-86. 2008
    ..Thus, decreased neural transmission, a hallmark of which is ts paralysis, is a biomarker of aging...
  13. ncbi Identification of alternative splicing regulators by RNA interference in Drosophila
    Jung W Park
    Department of Genetics and Developmental Biology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030-3301, USA
    Proc Natl Acad Sci U S A 101:15974-9. 2004
    ..These results significantly expand the number of known splicing regulators and reveal an extraordinary richness in the mechanisms that regulate alternative splicing...