Douglas S Reed

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. pmc Combined alphavirus replicon particle vaccine induces durable and cross-protective immune responses against equine encephalitis viruses
    Douglas S Reed
    Center for Aerobiological Sciences, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA
    J Virol 88:12077-86. 2014
  2. pmc Pathogenesis of aerosolized Eastern Equine Encephalitis virus infection in guinea pigs
    Chad J Roy
    Division of Microbiology, Tulane National Primate Research Center, Covington, Louisiana, USA
    Virol J 6:170. 2009
  3. pmc Pneumonic tularemia in rabbits resembles the human disease as illustrated by radiographic and hematological changes after infection
    Douglas S Reed
    Center for Vaccine Research, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 6:e24654. 2011
  4. pmc Live attenuated mutants of Francisella tularensis protect rabbits against aerosol challenge with a virulent type A strain
    Douglas S Reed
    Center for Vaccine Research, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Infect Immun 82:2098-105. 2014
  5. ncbi request reprint Aerosol exposure to western equine encephalitis virus causes fever and encephalitis in cynomolgus macaques
    Douglas S Reed
    Center for Aerobiological Sciences, US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland, USA
    J Infect Dis 192:1173-82. 2005
  6. ncbi request reprint Severe encephalitis in cynomolgus macaques exposed to aerosolized Eastern equine encephalitis virus
    Douglas S Reed
    Center for Aerobiological Sciences, US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702, USA
    J Infect Dis 196:441-50. 2007
  7. pmc Aerosolized rift valley fever virus causes fatal encephalitis in african green monkeys and common marmosets
    Amy L Hartman
    Center for Vaccine Research, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Virol 88:2235-45. 2014
  8. ncbi request reprint Gene expression profiling of nonhuman primates exposed to aerosolized Venezuelan equine encephalitis virus
    James Koterski
    United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702 9211, USA
    FEMS Immunol Med Microbiol 51:462-72. 2007
  9. pmc Broad spectrum antiviral activity of favipiravir (T-705): protection from highly lethal inhalational Rift Valley Fever
    Amy L Caroline
    Regional Biocontainment Laboratory, Center for Vaccine Research, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
    PLoS Negl Trop Dis 8:e2790. 2014
  10. doi request reprint Differences in aerosolization of Rift Valley fever virus resulting from choice of inhalation exposure chamber: implications for animal challenge studies
    Douglas S Reed
    Center for Vaccine Research, University of Pittsburgh, Pittsburgh, PA, USA Department of Immunology, University of Pittsburgh, Pittsburgh, PA, USA
    Pathog Dis 71:227-33. 2014

Collaborators

Detail Information

Publications21

  1. pmc Combined alphavirus replicon particle vaccine induces durable and cross-protective immune responses against equine encephalitis viruses
    Douglas S Reed
    Center for Aerobiological Sciences, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA
    J Virol 88:12077-86. 2014
    ....
  2. pmc Pathogenesis of aerosolized Eastern Equine Encephalitis virus infection in guinea pigs
    Chad J Roy
    Division of Microbiology, Tulane National Primate Research Center, Covington, Louisiana, USA
    Virol J 6:170. 2009
    ..These results indicate that guinea pigs experimentally infected by aerosolized EEEV recapitulate several key features of fatal human infection and thus should serve as a suitable animal model for aerosol exposure to EEEV...
  3. pmc Pneumonic tularemia in rabbits resembles the human disease as illustrated by radiographic and hematological changes after infection
    Douglas S Reed
    Center for Vaccine Research, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 6:e24654. 2011
    ..Animal models of pneumonic tularemia with a pathophysiology similar to the human disease are needed to evaluate the efficacy of these potential medical countermeasures...
  4. pmc Live attenuated mutants of Francisella tularensis protect rabbits against aerosol challenge with a virulent type A strain
    Douglas S Reed
    Center for Vaccine Research, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Infect Immun 82:2098-105. 2014
    ..The ΔguaBA and ΔaroD SCHU S4 derivatives warrant further evaluation and consideration as potential vaccines for tularemia and for identification of immunological correlates of protection. ..
  5. ncbi request reprint Aerosol exposure to western equine encephalitis virus causes fever and encephalitis in cynomolgus macaques
    Douglas S Reed
    Center for Aerobiological Sciences, US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland, USA
    J Infect Dis 192:1173-82. 2005
    ..Microscopic analysis also revealed a marked lymphocytic infiltrate in the CNS. Cynomolgus macaques will serve as a useful model of aerosol exposure to WEEV for the evaluation of potential vaccine candidates...
  6. ncbi request reprint Severe encephalitis in cynomolgus macaques exposed to aerosolized Eastern equine encephalitis virus
    Douglas S Reed
    Center for Aerobiological Sciences, US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702, USA
    J Infect Dis 196:441-50. 2007
    ..Increases in serum levels of blood urea nitrogen, sodium, and alkaline phosphatase were also seen. The rapid onset and severity of neurological signs mirror what has been reported for human cases of disease caused by EEE...
  7. pmc Aerosolized rift valley fever virus causes fatal encephalitis in african green monkeys and common marmosets
    Amy L Hartman
    Center for Vaccine Research, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Virol 88:2235-45. 2014
    ..Both AGM and marmosets would serve as useful models of aerosol infection with RVFV. ..
  8. ncbi request reprint Gene expression profiling of nonhuman primates exposed to aerosolized Venezuelan equine encephalitis virus
    James Koterski
    United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702 9211, USA
    FEMS Immunol Med Microbiol 51:462-72. 2007
    ..Altogether, this work provides novel information on common and tissue-specific host responses against VEEV in a nonhuman primate model of aerosol exposure...
  9. pmc Broad spectrum antiviral activity of favipiravir (T-705): protection from highly lethal inhalational Rift Valley Fever
    Amy L Caroline
    Regional Biocontainment Laboratory, Center for Vaccine Research, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
    PLoS Negl Trop Dis 8:e2790. 2014
    ..In the current study, the in vivo efficacy of T-705 was evaluated in Wistar-Furth rats infected with the virulent ZH501 strain of RVFV by the aerosol route...
  10. doi request reprint Differences in aerosolization of Rift Valley fever virus resulting from choice of inhalation exposure chamber: implications for animal challenge studies
    Douglas S Reed
    Center for Vaccine Research, University of Pittsburgh, Pittsburgh, PA, USA Department of Immunology, University of Pittsburgh, Pittsburgh, PA, USA
    Pathog Dis 71:227-33. 2014
    ..The implications of these findings for future pivotal efficacy studies are discussed. ..
  11. doi request reprint Aerosol exposure to Zaire ebolavirus in three nonhuman primate species: differences in disease course and clinical pathology
    Douglas S Reed
    U S Army Medical Research Institute of Infectious Diseases, Frederick, MD, USA
    Microbes Infect 13:930-6. 2011
    ..These data will be useful in selection of an animal model for efficacy studies...
  12. doi request reprint Nonhuman primate models of encephalitic alphavirus infection: historical review and future perspectives
    Lesley C Dupuy
    Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702 5011, USA
    Curr Opin Virol 2:363-7. 2012
    ..Recent advances have led to refinement and further characterization of these models toward the goal of utility in the licensure of next-generation alphavirus vaccines and therapeutics for use in humans by the Animal Rule...
  13. pmc Choice of inbred rat strain impacts lethality and disease course after respiratory infection with Rift Valley Fever Virus
    Jacquelyn M Bales
    Regional Biocontainment Laboratory, Center for Vaccine Research, University of Pittsburgh, Pittsburgh PA, USA
    Front Cell Infect Microbiol 2:105. 2012
    ....
  14. pmc Growth conditions and environmental factors impact aerosolization but not virulence of Francisella tularensis infection in mice
    Seth A Faith
    Regional Biocontainment Laboratory, Center for Vaccine Research, University of Pittsburgh Pittsburgh, PA, USA
    Front Cell Infect Microbiol 2:126. 2012
    ..Environmental factors and growth conditions should be evaluated when developing new animal models for aerosol infection, particularly for vegetative bacterial pathogens...
  15. pmc Identification of a surrogate marker for infection in the African green monkey model of inhalation anthrax
    Cynthia A Rossi
    Diagnostics Systems Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA
    Infect Immun 76:5790-801. 2008
    ..anthracis therapeutic development...
  16. doi request reprint Immunogenicity and protective efficacy of a DNA vaccine against Venezuelan equine encephalitis virus aerosol challenge in nonhuman primates
    Lesley C Dupuy
    Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702 5011, USA
    Vaccine 28:7345-50. 2010
    ..Therefore, although the sample size was small in this pilot study, these results indicate that a VEEV DNA vaccine administered by PMED can at least partially protect nonhuman primates against an aerosol VEEV challenge...
  17. ncbi request reprint Respiratory immunity is an important component of protection elicited by subunit vaccination against pneumonic plague
    Douglas S Reed
    Center for Aerobiological Sciences, US Army Medical Research Institute of Infectious Diseases USAMRIID, 1425 Porter Street, Fort Detrick, Frederick, MD 21702 5011, USA
    Vaccine 24:2283-9. 2006
    ..Immunity in the respiratory tract appears to be critical for protection against primary pneumonia caused by Y. pestis...
  18. doi request reprint Cellular immune response to Marburg virus infection in cynomolgus macaques
    Elizabeth A Fritz
    United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA
    Viral Immunol 21:355-63. 2008
    ..IL-6 production was detected late in the infection in CD14(+) spleen cells. These results suggest a robust innate immune response to MARV; however, this response was delayed relative to the infection...
  19. doi request reprint Development of novel mechanisms for housing, handling, and remote monitoring of common marmosets at animal biosafety level 3
    Diana S Powell
    Regional Biocontainment Laboratory, Center for Vaccine Research, University of Pittsburgh, Pittsburgh, PA, USA
    Pathog Dis 71:219-26. 2014
    ..This paper reviews the caging, handling, and safety-related adaptations and modifications that were required to humanely utilize marmosets as a model for high-hazard BSL-3 viral diseases. ..
  20. ncbi request reprint Status and challenges of filovirus vaccines
    Douglas S Reed
    Center for Aerobiological Sciences, U S Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, Frederick, MD 21702 5011, USA
    Vaccine 25:1923-34. 2007
    ..Nevertheless, nonhuman primate studies have shown that protection against Marburg and Ebola is possible and there is hope that one day a vaccine will be licensed for human use...
  21. ncbi request reprint Genetically engineered, live, attenuated vaccines protect nonhuman primates against aerosol challenge with a virulent IE strain of Venezuelan equine encephalitis virus
    Douglas S Reed
    Center for Aerobiological Sciences, U S Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, Frederick, MD 21702 5011, USA
    Vaccine 23:3139-47. 2005
    ..Genetically engineered, live attenuated vaccines for Venezuelan equine encephalitis: testing in animal models. Vaccine 2003;21(25-26):3854-62] and IE strains of VEE viruses...