Bruce Reed

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi Cognitive activities during adulthood are more important than education in building reserve
    Bruce R Reed
    Department of Neurology, School of Medicine, University of California, Davis, CA, USA
    J Int Neuropsychol Soc 17:615-24. 2011
  2. ncbi Coronary risk correlates with cerebral amyloid deposition
    Bruce R Reed
    Department of Neurology, School of Medicine, University of California, Davis, CA, USA
    Neurobiol Aging 33:1979-87. 2012
  3. ncbi Impaired acquisition and rapid forgetting of patterned visual stimuli in Alzheimer's disease
    B R Reed
    Department of Neurology, University of California at Davis, USA
    J Clin Exp Neuropsychol 20:738-49. 1998
  4. ncbi Measuring cognitive reserve based on the decomposition of episodic memory variance
    Bruce R Reed
    Department of Neurology, School of Medicine, University of California, Davis, CA, USA
    Brain 133:2196-209. 2010
  5. ncbi Clinical and neuropsychological features in autopsy-defined vascular dementia
    Bruce R Reed
    Alzheimer s Disease Center, University of California, Davis 94553, USA
    Clin Neuropsychol 18:63-74. 2004
  6. ncbi Profiles of neuropsychological impairment in autopsy-defined Alzheimer's disease and cerebrovascular disease
    Bruce R Reed
    University of California, Davis, CA, USA
    Brain 130:731-9. 2007
  7. ncbi Effects of white matter lesions and lacunes on cortical function
    Bruce R Reed
    University of California Davis Alzheimer s Disease Center, Martinez, CA 94553, USA
    Arch Neurol 61:1545-50. 2004
  8. ncbi Frontal lobe hypometabolism predicts cognitive decline in patients with lacunar infarcts
    B R Reed
    Department of Neurology, University of California, Davis, CA, USA
    Arch Neurol 58:493-7. 2001
  9. ncbi Vascular dementia
    Bruce R Reed
    Alzheimer's Disease Center, University of California, Davi, 94553, USA
    Arch Neurol 61:433-5. 2004
  10. ncbi Heterogeneity of cognitive trajectories in diverse older persons
    Dan Mungas
    Department of Neurology, School of Medicine, University of California, Sacramento, CA 95817, USA
    Psychol Aging 25:606-19. 2010

Research Grants

  1. Brain pathologies, reserve and cognition in aging and dementia
    Bruce Reed; Fiscal Year: 2009
  2. Brain pathologies, reserve and cognition in aging and dementia
    Bruce Reed; Fiscal Year: 2010
  3. Brain pathologies, reserve and cognition in aging and dementia
    Bruce Reed; Fiscal Year: 2009
  4. Brain pathologies, reserve and cognition in aging and dementia
    Bruce Reed; Fiscal Year: 2010

Detail Information

Publications49

  1. ncbi Cognitive activities during adulthood are more important than education in building reserve
    Bruce R Reed
    Department of Neurology, School of Medicine, University of California, Davis, CA, USA
    J Int Neuropsychol Soc 17:615-24. 2011
    ..Results suggest that leisure cognitive activities throughout adulthood are more important than education in determining reserve. Discrepancies between cognitive activity and education may be informative in estimating late life reserve...
  2. ncbi Coronary risk correlates with cerebral amyloid deposition
    Bruce R Reed
    Department of Neurology, School of Medicine, University of California, Davis, CA, USA
    Neurobiol Aging 33:1979-87. 2012
    ..Although this is a correlational observation it may represent a causal relationship as there are multiple, plausible, amyloidogenic mechanisms of vascular risk factors...
  3. ncbi Impaired acquisition and rapid forgetting of patterned visual stimuli in Alzheimer's disease
    B R Reed
    Department of Neurology, University of California at Davis, USA
    J Clin Exp Neuropsychol 20:738-49. 1998
    ..DRR was also lower in an analysis of subgroups closely matched on initial performance. The findings suggest that forgetting is accelerated in AD because multiple aspects of memory processing, including storage, are impaired...
  4. ncbi Measuring cognitive reserve based on the decomposition of episodic memory variance
    Bruce R Reed
    Department of Neurology, School of Medicine, University of California, Davis, CA, USA
    Brain 133:2196-209. 2010
    ..Decomposing the variance in cognitive function scores offers a promising new approach to the measure and study of cognitive reserve...
  5. ncbi Clinical and neuropsychological features in autopsy-defined vascular dementia
    Bruce R Reed
    Alzheimer s Disease Center, University of California, Davis 94553, USA
    Clin Neuropsychol 18:63-74. 2004
    ..A illustrative case example is included. We conclude that the profile of cognitive impairment in IVD is highly variable, but that in clinical settings neuropsychological readings may contribute to the differential diagnosis of dementia...
  6. ncbi Profiles of neuropsychological impairment in autopsy-defined Alzheimer's disease and cerebrovascular disease
    Bruce R Reed
    University of California, Davis, CA, USA
    Brain 130:731-9. 2007
    ....
  7. ncbi Effects of white matter lesions and lacunes on cortical function
    Bruce R Reed
    University of California Davis Alzheimer s Disease Center, Martinez, CA 94553, USA
    Arch Neurol 61:1545-50. 2004
    ..Whether small-vessel disease in fact predominantly affects the frontal lobes is not well documented...
  8. ncbi Frontal lobe hypometabolism predicts cognitive decline in patients with lacunar infarcts
    B R Reed
    Department of Neurology, University of California, Davis, CA, USA
    Arch Neurol 58:493-7. 2001
    ..Studies of Alzheimer disease have shown that imaging measures of temporal and parietal metabolism and blood flow predict disease course...
  9. ncbi Vascular dementia
    Bruce R Reed
    Alzheimer's Disease Center, University of California, Davi, 94553, USA
    Arch Neurol 61:433-5. 2004
  10. ncbi Heterogeneity of cognitive trajectories in diverse older persons
    Dan Mungas
    Department of Neurology, School of Medicine, University of California, Sacramento, CA 95817, USA
    Psychol Aging 25:606-19. 2010
    ....
  11. ncbi Cognitive and anatomic contributions of metabolic decline in Alzheimer disease and cerebrovascular disease
    Beth Kuczynski
    Helen Wills Neuroscience Institute and the Lawrence Berkeley National Laboratory, University of California, Berkeley, CA 94720, USA
    Arch Neurol 65:650-5. 2008
    ..Understanding how each disease contributes to dementia is essential from both a pathophysiologic and diagnostic perspective...
  12. ncbi Neuropathological basis of magnetic resonance images in aging and dementia
    William J Jagust
    School of Public Health and Helen Wills Neuroscience Institute, University of California, Berkeley, CA 94720 3190, USA
    Ann Neurol 63:72-80. 2008
    ..Magnetic resonance (MR) imaging is used widely for assessment of patients with cognitive impairment, but the pathological correlates are unclear, especially when multiple pathologies are present...
  13. ncbi MRI predictors of cognitive change in a diverse and carefully characterized elderly population
    Owen Carmichael
    Department of Neurology, School of Medicine, University of California, Davis, USA
    Neurobiol Aging 33:83-95. 2012
    ..Trajectories of cognitive decline among elderly individuals are heterogeneous, and markers that have high reliability for predicting cognitive trajectories across a broad spectrum of the elderly population have yet to be identified...
  14. ncbi Coevolution of white matter hyperintensities and cognition in the elderly
    Pauline Maillard
    Imaging of Dementia and Aging Laboratory, University of California, Davis, Davis, CA, USA
    Neurology 79:442-8. 2012
    ..To investigate the effects of baseline white matter hyperintensity (WMH) and rates of WMH extension and emergence on rate of change in cognition (episodic memory and executive function)...
  15. ncbi Idea density measured in late life predicts subsequent cognitive trajectories: implications for the measurement of cognitive reserve
    Sarah Tomaszewski Farias
    Department of Neurology, University of California, Davis, CA 95817, USA
    J Gerontol B Psychol Sci Soc Sci 67:677-86. 2012
    ..The present study examined whether ID measured in late life continues to predict the trajectory of cognitive change...
  16. ncbi Maximal brain size remains an important predictor of cognition in old age, independent of current brain pathology
    Sarah Tomaszewski Farias
    Department of Neurology, University of California, Davis, Sacramento, CA 95817, USA
    Neurobiol Aging 33:1758-68. 2012
    ..Results suggest maximal brain development and measures of brain injury/atrophy jointly contribute to cognitive function in older people...
  17. ncbi Coronary artery disease is associated with cognitive decline independent of changes on magnetic resonance imaging in cognitively normal elderly adults
    Ling Zheng
    Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    J Am Geriatr Soc 60:499-504. 2012
    ..To examine in cognitively normal elderly adults whether vascular factors predict cognitive decline and whether these associations are mediated by magnetic resonance imaging (MRI) measures of subclinical vascular brain injury...
  18. ncbi Differences in brain volume, hippocampal volume, cerebrovascular risk factors, and apolipoprotein E4 among mild cognitive impairment subtypes
    Jing He
    Department of Neurology, and the Imaging of Dementia and Aging Laboratory, Center for Neuroscience Preventive Medicine, University of California at Davis, Sacramento, CA 95817, USA
    Arch Neurol 66:1393-9. 2009
    ..To evaluate demographics, magnetic resonance imaging (MRI) measures, and vascular risk among mild cognitive impairment (MCI) subtypes...
  19. ncbi Memory in the aging brain: doubly dissociating the contribution of the hippocampus and entorhinal cortex
    Andrew P Yonelinas
    Department of Psychology, University of California, Davis, California 95616, USA
    Hippocampus 17:1134-40. 2007
    ....
  20. ncbi Cognitive impact of subcortical vascular and Alzheimer's disease pathology
    Helena C Chui
    Department of Neurology, University of Southern California, Los Angeles, USA
    Ann Neurol 60:677-87. 2006
    ..To assess the interactions among three types of pathology (ie, cerebrovascular disease, hippocampal sclerosis [HS], and Alzheimer's disease [AD]), cognitive status, and apolipoprotein E genotype...
  21. ncbi Diagnosing depression in Alzheimer disease with the national institute of mental health provisional criteria
    Edmond Teng
    Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90073, USA
    Am J Geriatr Psychiatry 16:469-77. 2008
    ....
  22. ncbi Longitudinal MRI and cognitive change in healthy elderly
    Joel H Kramer
    Department of Neurology, San Francisco Medical Center, University of California, San Francisco, CA 94143, USA
    Neuropsychology 21:412-8. 2007
    ..The association between WMSH and EXEC further highlights the cognitive sequealae associated with cerebrovascular disease in normal elderly...
  23. ncbi Computerized analysis of error patterns in digit span recall
    David L Woods
    Human Cognitive Neurophysiology Laboratory, Veterans Affairs Northern California Health Care System, Martinez, CA, USA
    J Clin Exp Neuropsychol 33:721-34. 2011
    ..Overall, 32% of the TBI patients showed DS abnormalities and 11% showed abnormal DSMIs. Computerized error-pattern analysis improves the sensitivity of DS assessment and can assist in the detection of malingering...
  24. ncbi Association of depressed mood and mortality in older adults with and without cognitive impairment in a prospective naturalistic study
    Helen Lavretsky
    Department of Psychiatry, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    Am J Psychiatry 167:589-97. 2010
    ....
  25. ncbi Subcortical lacunes are associated with executive dysfunction in cognitively normal elderly
    Catherine L Carey
    Department of Psychiatry, University of California, San Diego, 150 W Washington, 2nd Floor San Diego, CA 92103, USA
    Stroke 39:397-402. 2008
    ..We therefore hypothesized that MRI markers of SIVD would be selectively associated with worse executive functioning...
  26. ncbi White matter hyperintensity penumbra
    Pauline Maillard
    Department of Neurology and Center for Neuroscience, School of Medicine, University of California, Davis, Davis, CA, USA
    Stroke 42:1917-22. 2011
    ..Diffusion tensor imaging provides more sensitive indications of subtle white matter disruption and can therefore clarify whether WMHs represent foci of generalized white matter damage that extends over a broader neighborhood...
  27. ncbi Influence of functional connectivity and structural MRI measures on episodic memory
    Jing He
    Imaging of Dementia and Aging IDeA Laboratory, Department of Neurology, University of California, Davis, Davis, CA 95618, USA
    Neurobiol Aging 33:2612-20. 2012
    ..In addition, the relationship between resting state functional connectivity and memory performance, particularly amongst those individuals with more brain atrophy, strongly suggests compensation against the effects of neuronal injury...
  28. ncbi Everyday functioning in relation to cognitive functioning and neuroimaging in community-dwelling Hispanic and non-Hispanic older adults
    Sarah Tomaszewski Farias
    Department of Neurology, School of Medicine, University of California, Davis, USA
    J Int Neuropsychol Soc 10:342-54. 2004
    ..The relationships between cognitive variables and functional status, as well as between the imaging variables and the IQCODE, did not differ across language-ethnic groups...
  29. ncbi Cognitive and neuroimaging predictors of instrumental activities of daily living
    Deborah A Cahn-Weiner
    Department of Neurology, University of California, San Francisco, California 94143 0138, USA
    J Int Neuropsychol Soc 13:747-57. 2007
    ..Perhaps executive function is particularly important with respect to maintaining IADLs. Alternatively, executive dysfunction may be a sentinel event indicating widespread cortical involvement and poor prognosis...
  30. ncbi Forgetting in dementia with and without subcortical lacunes
    Joel H Kramer
    San Francisco Medical Center, University of California, CA 94143, USA
    Clin Neuropsychol 18:32-40. 2004
    ..Three SIVD patients with rapid forgetting followed to autopsy all had AD pathology, further supporting the link between memory patterns and AD...
  31. ncbi Associations among vascular risk factors, carotid atherosclerosis, and cortical volume and thickness in older adults
    Valerie A Cardenas
    University of California, San Francisco, Department of Veterans Affairs Medical Center, 4150 Clement Street 114M, San Francisco, CA 94121
    Stroke 43:2865-70. 2012
    ..The purpose of this study was to investigate whether the Framingham Cardiovascular Risk Profile and carotid artery intima-media thickness are associated with cortical volume and thickness...
  32. ncbi Sub-Regional Hippocampal Injury is Associated with Fornix Degeneration in Alzheimer's Disease
    Dong Young Lee
    Imaging of Dementia and Aging Laboratory, Department of Neurology, Center for Neuroscience, University of California at Davis Davis, CA, USA
    Front Aging Neurosci 4:1. 2012
    ..The region-specific association between fornix integrity and hippocampal neuronal death may provide in vivo evidence for degenerative white matter injury in AD: axonal pathology that is closely linked to neuronal injury...
  33. ncbi Psychometrically matched measures of global cognition, memory, and executive function for assessment of cognitive decline in older persons
    Dan Mungas
    Department of Neurology, School of Medicine, University of California, Davis, Sacramento 95817, USA
    Neuropsychology 17:380-92. 2003
    ..Association of measures with quantitative structural magnetic resonance imaging variables followed expected patterns. This approach to scale development may have applications for other neuropsychological assessment problems...
  34. ncbi Spanish and English Neuropsychological Assessment Scales (SENAS): further development and psychometric characteristics
    Dan Mungas
    Department of Neurology, University of California, Davis, 4860 Y Street, Suite 3700, Sacramento, CA 95817, USA
    Psychol Assess 16:347-59. 2004
    ..Effects of DIF on scale-level ability scores were limited. Results demonstrate an empirically guided psychometric approach to test construction for multiethnic and multilingual test applications...
  35. ncbi Measurement invariance of neuropsychological tests in diverse older persons
    Dan Mungas
    Department of Neurology, School of Medicine, University of California, Davis, 4860 Y Street, Suite 3700, Sacramento, CA 95817, USA
    Neuropsychology 25:260-9. 2011
    ..We examined the dimensional structure of a neuropsychological test battery in linguistically and demographically diverse older adults...
  36. ncbi MCI is associated with deficits in everyday functioning
    Sarah T Farias
    Department of Neurology, University of California, Davis, CA, USA
    Alzheimer Dis Assoc Disord 20:217-23. 2006
    ..The current findings suggest that individuals with MCI demonstrate deficits in a wide range of everyday functions but that the magnitude of these changes is greatest for those functional abilities that rely heavily on memory...
  37. ncbi Criterion-referenced validity of a neuropsychological test battery: equivalent performance in elderly Hispanics and non-Hispanic Whites
    Dan Mungas
    Department of Neurology, School of Medicine, University of California, Davis, Sacramento, California 95817, USA
    J Int Neuropsychol Soc 11:620-30. 2005
    ..Object naming improved discrimination of CIND from demented beyond that of verbal memory alone. These results provide evidence of equivalent validity across Hispanics and Whites...
  38. ncbi Spanish and English neuropsychological assessment scales: relationship to demographics, language, cognition, and independent function
    Dan Mungas
    Department of Neurology, School of Medicine, University of California, Davis, Sacramento, CA 95817, USA
    Neuropsychology 19:466-75. 2005
    ....
  39. ncbi The measurement of everyday cognition (ECog): scale development and psychometric properties
    Sarah Tomaszewski Farias
    Department of Neurology, University of California, CA 95817, USA
    Neuropsychology 22:531-44. 2008
    ..Different subtypes of MCI also showed different patterns. Results suggest the ECog shows promise as a useful tool for the measurement of general and domain-specific everyday functions in the elderly...
  40. ncbi Longitudinal changes in memory and executive functioning are associated with longitudinal change in instrumental activities of daily living in older adults
    Sarah Tomaszewski Farias
    Department of Neurology, School of Medicine, University of California, Davis, CA, USA
    Clin Neuropsychol 23:446-61. 2009
    ..Findings indicate that declines in MEM and EXEC over time make unique and independent contributions to declines in older adults' ability to function in daily life...
  41. ncbi Brain behavior relationships among African Americans, whites, and Hispanics
    Charles DeCarli
    Department of Neurology, University of California at Davis, Sacramento, CA 95817, USA
    Alzheimer Dis Assoc Disord 22:382-91. 2008
    ..Moreover, interesting and potentially biologically relevant differences were found that might stimulate further research related to the understanding of dementia etiology within an increasingly racially and ethnically diverse population...
  42. ncbi Age and education effects on relationships of cognitive test scores with brain structure in demographically diverse older persons
    Dan Mungas
    Department of Neurology, School of Medicine, University of California, Davis, Sacremento, CA 95817, USA
    Psychol Aging 24:116-28. 2009
    ....
  43. ncbi Progression of mild cognitive impairment to dementia in clinic- vs community-based cohorts
    Sarah Tomaszewski Farias
    Department of Neurology, University of California, Davis, 4860 Y St, Ste 3700, Sacramento, CA 95817, USA
    Arch Neurol 66:1151-7. 2009
    ..Annual conversion rates, however, vary across different studies with clinic samples showing higher rates of conversion than community-based samples...
  44. ncbi Different mechanisms of episodic memory failure in mild cognitive impairment
    Christine Wu Nordahl
    Center for Neuroscience, University of California at Davis, Davis, CA, USA
    Neuropsychologia 43:1688-97. 2005
    ..Although both syndromes are associated with episodic memory deficits, CVD is additionally associated with working memory and executive control deficits...
  45. ncbi Mild cognitive impairment: baseline and longitudinal structural MR imaging measures improve predictive prognosis
    Linda K McEvoy
    Department of Radiology, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093, USA
    Radiology 259:834-43. 2011
    ..To assess whether single-time-point and longitudinal volumetric magnetic resonance (MR) imaging measures provide predictive prognostic information in patients with amnestic mild cognitive impairment (MCI)...
  46. ncbi Hippocampal volume and retention in Alzheimer's disease
    Joel H Kramer
    Department of Neurology, University of California at San Francisco, 94143, USA
    J Int Neuropsychol Soc 10:639-43. 2004
    ..Results suggest that the role of the hippocampus is relatively specific to the consolidation of new memories...
  47. ncbi Imaging Interactions between Alzheimer's disease and cerebrovascular disease
    Christine C Wu
    Department of Neurology, University of California-Davis, 4860 Y Street, Sacramento, CA 95616, USA
    Ann N Y Acad Sci 977:403-10. 2002
    ..In this article, we review two recent studies from our laboratory that use MRI and PET to begin to reveal the nature and mechanisms of the relationship between AD, CVD, and dementia...
  48. ncbi White matter lesions are associated with cortical atrophy more than entorhinal and hippocampal atrophy
    An-Tao Du
    Magnetic Resonance Unit (114M, Department of Veterans Affairs Medical Center, 4150, Clement Street, San Francisco, CA 94121, USA
    Neurobiol Aging 26:553-9. 2005
    ..Further, AD pathology and subcortical vascular disease may independently affect cortical atrophy...
  49. ncbi Age effects on atrophy rates of entorhinal cortex and hippocampus
    An-Tao Du
    Magnetic Resonance Unit (114M, Department of Veterans Affairs Medical Center, 4150, Clement Street, San Francisco, CA 94121, USA
    Neurobiol Aging 27:733-40. 2006
    ..In conclusion, age and presence of lacunes should be taken into consideration in imaging studies of CN subjects and AD patients to predict AD progression and assess the response to treatment trials...

Research Grants4

  1. Brain pathologies, reserve and cognition in aging and dementia
    Bruce Reed; Fiscal Year: 2009
    ....
  2. Brain pathologies, reserve and cognition in aging and dementia
    Bruce Reed; Fiscal Year: 2010
    ....
  3. Brain pathologies, reserve and cognition in aging and dementia
    Bruce Reed; Fiscal Year: 2009
    ....
  4. Brain pathologies, reserve and cognition in aging and dementia
    Bruce Reed; Fiscal Year: 2010
    ....