Research Topics
| T Brett ReeceSummaryAffiliation: University of Virginia Country: USA Publications
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Publications
Functional and cytoarchitectural spinal cord protection by ATL-146e after ischemia/reperfusion is mediated by adenosine receptor agonismT Brett Reece
Department of Surgery, University of Virginia, Charlottesville, VA 22908, USA
J Vasc Surg 44:392-7. 2006....- Comparison of systemic and retrograde delivery of adenosine A2A agonist for attenuation of spinal cord injury after thoracic aortic cross-clampingT Brett Reece
Department of Surgery, University of Virginia, Charlottesville, Virginia, USA
Ann Thorac Surg 81:902-9. 2006..We hypothesized that despite retrograde spinal perfusion of an adenosine A2A agonist (ATL-146e), systemic therapy produces superior spinal cord protection with reduced inflammation... - Adenosine A2A receptor activation reduces inflammation and preserves pulmonary function in an in vivo model of lung transplantationT Brett Reece
Department of Surgery, University of Virginia Health System, PO Box 801359, Charlottesville, VA 22908, USA
J Thorac Cardiovasc Surg 129:1137-43. 2005..We hypothesized that adenosine A 2A receptor activation by ATL-146e during the initial reperfusion period preserves pulmonary function and attenuates inflammation in a porcine model of lung transplantation... - Adenosine A2A receptor agonist improves cardiac dysfunction from pulmonary ischemia-reperfusion injuryT Brett Reece
Department of Surgery, University of Virginia Health System, Charlottesville, Virginia, USA
Ann Thorac Surg 79:1189-95. 2005..We hypothesized that pulmonary ischemia-reperfusion causes secondary heart dysfunction and ATL-146e will improve this dysfunction... - The evolution of ischemic spinal cord injury in function, cytoarchitecture, and inflammation and the effects of adenosine A2A receptor activationT Brett Reece
Department of Surgery, University of Virginia Health System, PO Box 801359, Charlottesville, VA 22908, USA
J Thorac Cardiovasc Surg 128:925-32. 2004..This study defines injury progression in terms of function, cytoarchitecture, and inflammation and assesses whether adenosine A 2A receptor activation by ATL-146e limits injury progression... - Adenosine A2A analogue reduces long-term neurologic injury after blunt spinal traumaT Brett Reece
Department of Surgery, University of Virginia, Charlottesville, VA 22908, USA
J Surg Res 121:130-4. 2004..In the current study, we extended the treatment paradigm and tested neurobehavioral functioning out to 1 week after injury to assess if early neurological improvement is sustained long term by an adenosine analogue... - Mitral repair is superior to replacement when associated with coronary artery diseaseT Brett Reece
Department of Surgery, Division of Thoracic and Cardiovascular Surgery, University of Virginia Health Sciences Center, MR Building, Room 3116, Charlottesville, VA 22908, USA
Ann Surg 239:671-5; discussion 675-7. 2004..To compare the outcomes of mitral repair and replacement in revascularized patients with ischemic mitral regurgitation... - Central cannulation is safe in acute aortic dissection repairT Brett Reece
University of Virginia, Department of Surgery, Division of Thoracic and Cardiovascular Surgery, Charlottesville, VA, USA
J Thorac Cardiovasc Surg 133:428-34. 2007..We hypothesized that cannulation of the dissected aorta could be done safely with acceptable complication and mortality rates in this high-risk population... - A comparison of adenosine A2A agonism and methylprednisolone in attenuating neuronal damage and improving functional outcome after experimental traumatic spinal cord injury in rabbitsDavid O Okonkwo
Department of Neurological Surgery, University of Virginia Health System, Charlottesville 22908 0212, USA
J Neurosurg Spine 4:64-70. 2006..The authors of this study evaluated ATL-146e and methylprednisolone for their ability to preserve neuronal viability and motor function in experimental SCI... - Adenosine A2A activation attenuates nontransplantation lung reperfusion injuryPeter I Ellman
Department of Surgery, University of Virginia, Charlottesville, Virginia 22908, USA
J Surg Res 149:3-8. 2008..There has been little work, however, examining its effects in the setting of nontransplant ischemia reperfusion. Our hypothesis was that an A(2A) agonist would attenuate lung reperfusion injury in a warm ischemia hilar clamping model... - Early adenosine receptor activation ameliorates spinal cord reperfusion injuryT Brett Reece
Department of Surgery, University of Virginia, Charlottesville, Virginia, USA
J Cardiovasc Med (Hagerstown) 9:363-7. 2008..We hypothesized that adenosine receptor activation with ATL-146e would produce similar protection from ischemic spinal cord injury, whether given at reperfusion or in a delayed fashion... - A change in perspective: results for ischemic mitral valve repair are similar to mitral valve repair for degenerative diseaseLeo M Gazoni
Department of Surgery, University of Virginia, Charlottesville, Virginia 22908, USA
Ann Thorac Surg 84:750-7; discussion 758. 2007..We hypothesized that mitral valve repair for ischemic MR results in outcomes similar to those for mitral valve repair for degenerative MR... - Replacement of the proximal aorta adds no further risk to aortic valve proceduresT Brett Reece
Department of Surgery, Division of Thoracic and Cardiovascular Surgery, University of Virginia, Charlottesville, Virginia, USA
Ann Thorac Surg 84:473-8; discussion 478. 2007..We hypothesized that the addition of proximal aortic intervention adds no further risk to aortic valve surgery, which may avoid subsequent proximal aortic procedures or catastrophes... - Attenuation of lung reperfusion injury by modified ventilation and reperfusion techniquesR Ramesh Singh
University of Virginia Health System, Department of Surgery, Charlottesville 22908, USA
J Heart Lung Transplant 25:1467-73. 2006..CONCLUSIONS: This protective approach of ventilation and perfusion after ischemia may improve lung function after transplantation, a simple method that could easily be applied clinically... - Sleep deprivation does not affect operative results in cardiac surgeryPeter I Ellman
Department of Cardiovascular Surgery, University of Virginia, Charlottesville, Virginia, USA
Ann Thorac Surg 78:906-11; discussion 906-11. 2004..CONCLUSIONS: Sleep deprivation does not affect operative morbidity or mortality in cardiac surgical operations. These data do not support a need for work hour restrictions on surgeons... - Acute sleep deprivation in the thoracic surgical resident does not affect operative outcomesPeter I Ellman
Department of Cardiovascular Surgery, University of Virginia, Charlottesville, Virginia, USA
Ann Thorac Surg 80:60-4; discussion 64-5. 2005..CONCLUSIONS: Acute sleep deprivation in thoracic surgical residents does not affect operative efficiency, morbidity, or mortality in cardiac surgical operations... - Reevaluating the need for left subclavian artery revascularization with thoracic endovascular aortic repairT Brett Reece
Department of Thoracic and Cardiovascular Surgery, University of Virginia, Charlottesville, Virginia, USA
Ann Thorac Surg 84:1201-5; discussion 1205. 2007..We hypothesize that for patients undergoing TEVAR requiring coverage of the LSA, the need for LSA revascularization is higher than reported in the literature... - Cytokine expression profile in human lungs undergoing normothermic ex-vivo lung perfusionMiral R Sadaria
Department of Surgery, Division of Cardiothoracic Surgery, University of Colorado at Denver and Health Sciences Center, Aurora, Colorado 80045, USA
Ann Thorac Surg 92:478-84. 2011..We sought to establish representative cytokine expression in human donor lungs meeting acceptable lung transplant criteria after prolonged normothermic EVLP... - Elective hypothermic circulatory arrest to address aortic pathology is safe for the elderlyT Brett Reece
Thoracic and Cardiovascular Surgery, University of Virginia, Charlottesville, Virginia, USA
J Card Surg 24:240-4. 2009..We hypothesized that the use of HCA would not increase mortality or complications in elderly patients compared to younger counterparts... - Hyperoxic ventilation exacerbates lung reperfusion injuryPeter I Ellman
Department of Cardiovascular Surgery, University of Virginia, Charlottesville, VA, USA
J Thorac Cardiovasc Surg 130:1440. 2005..Thus the patient should be ventilated with as low a fraction of inspired oxygen as possible to achieve adequate oxygen saturations during this critical reperfusion period... - The beating heart approach is not necessary for the Dor procedureThomas S Maxey
Division of Thoracic and Cardiovascular Surgery, University of Virginia Health Science Center, Charlottesville, Virginia, USA
Ann Thorac Surg 76:1571-4; discussion 1574-5. 2003.... - Coronary artery bypass with ventricular restoration is superior to coronary artery bypass alone in patients with ischemic cardiomyopathyThomas S Maxey
Department of Thoracic Surgery, University of Virginia, Charlottesville 22908, USA
J Thorac Cardiovasc Surg 127:428-34. 2004..Most importantly, left ventricular restoration reduces late morbidity and mortality compared with coronary artery bypass alone in patients with large ventricles... - Statin therapy attenuates growth and malignant potential of human esophageal adenocarcinoma cellsMiral R Sadaria
Division of Cardiothoracic Surgery, Department of Surgery, University of Colorado at Denver and Health Sciences Center, Aurora, Colo 80045, USA
J Thorac Cardiovasc Surg 142:1152-60. 2011..We hypothesize that statin therapy may attenuate growth and malignant potential via ICAM-1 expression and nuclear factor-kappa beta activation in human esophageal adenocarcinoma cells... - Safety and efficacy of the supraclavicular approach to thoracic outlet decompressionThomas S Maxey
Division of Thoracic and Cardiovascular Surgery, University of Virginia Health Science Center, Charlottesville, Virginia 22908, USA
Ann Thorac Surg 76:396-9; discussion 399-400. 2003..5%) had no resolution. There were no deaths and morbidity was minimal with 6 complications (8.3%). CONCLUSIONS: The supraclavicular approach is a safe and effective technique in managing all forms of thoracic outlet compression... - The evolution of chemokine release supports a bimodal mechanism of spinal cord ischemia and reperfusion injuryPhillip D Smith
Department of Surgery, Division of Cardiothoracic Surgery, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA
Circulation 126:S110-7. 2012..This study sought to characterize the inflammatory response in the spinal cord after IR and hypothesized that this would support a bimodal mechanism of injury... - A simplified approach to degenerative disease: triangular resections of the mitral valveLeo M Gazoni
Department of Surgery, University of Virginia, Charlottesville, Virginia 22908, USA
Ann Thorac Surg 83:1658-64; discussion 1664-5. 2007..These techniques have been perceived to be difficult and have possibly reduced the incidence of MV repair. We present our experience with a simplified approach to MV repair utilizing a triangular resection and larger rings... - The role of pharmacology in spinal cord protection during thoracic aortic reconstructionT Brett Reece
Department of Surgery, Division of Thoracic and Cardiovascular Surgery, University of Virginia, Charlottesville, VA 22908, USA
Semin Thorac Cardiovasc Surg 15:365-77. 2003..This article reviews the pathophysiology of ischemic spinal cord injury and summarizes the investigational pharmacology that may prevent these serious complications... - Is off-pump coronary artery bypass grafting superior to conventional bypass in octogenarians?Damien J LaPar
Department of Surgery, Division of Thoracic and Cardiovascular Surgery, University of Virginia Health System, Charlottesville, VA, USA
J Thorac Cardiovasc Surg 141:81-90. 2011..We hypothesized that off-pump coronary bypass offers a greater operative benefit to elderly patients when compared with conventional coronary artery bypass... - Coarctation of a right aortic archThomas S Maxey
Department of Surgery, College of Medicine, University of South Florida, Tampa, Florida, USA
J Card Surg 21:261-3. 2006..The frequency with which other anomalies exist in either of the above conditions requires thorough cardiac evaluation and detailed imaging. Surgical repair of this anomaly can safely be undertaken through a right thoracotomy... - Transverse arch hypoplasia may predispose patients to aneurysm formation after patch repair of aortic coarctationThomas S Maxey
Department of Surgery, Division of Thoracic and Cardiovascular Surgery, University of Virginia Health System, Charlottesville, Virginia 22908, USA
Ann Thorac Surg 76:1090-3. 2003..CONCLUSIONS: Aneurysm formation after patch repair of aortic coarctation develops into a subgroup of patients. Aortic arch hypoplasia associated with coarctation independently predicts future aneurysm formation... - Early repair of complete atrioventricular septal defect is safe and effectiveR Ramesh Singh
Department of Surgery, University of Virginia, Charlottesville, Virginia 22908, USA
Ann Thorac Surg 82:1598-601; discussion 1602. 2006..5% versus 10.3% respectively, p = 0.68). CONCLUSIONS: These results suggest that repair of CAVSD defects in children 3 months of age or younger had similar outcomes compared with those who underwent surgical repair after 3 months of age... - General surgery morning report: a competency-based conference that enhances patient care and resident educationBrendon M Stiles
Department of Surgery, University of Virginia Health System, Charlottesville, Virginia 22908, USA
Curr Surg 63:385-90. 2006..Although initially oriented toward transfer of patient information, MR is also hypothesized to serve as a competency-based resident education tool... - Endothelial nitric oxide synthase is essential for postpneumonectomy compensatory vasodilationThomas S Maxey
Department of Surgery, University of South Florida, Tampa, Florida, USA
Ann Thorac Surg 81:1234-8. 2006..The eNOS-/- mice failed to display compensatory vasodilation yet could be rescued with iNO. These results suggest that eNOS is essential for postpneumonectomy compensatory vasodilation... - Toll-like receptor 4 mediates oxidized LDL-induced macrophage differentiation to foam cellsKenneth W Howell
Department of Surgery, Division of Cardiothoracic Surgery, University of Colorado Anschutz Medical Center, Aurora, Colorado 80045, USA
J Surg Res 171:e27-31. 2011..Further, oxidized low density lipoprotein (oxLDL) enhances TLR4 expression in macrophages. We hypothesized that TLR4 mediates macrophage differentiation to foam cells... - Survival after biventricular assist device implantation: an analysis of the Interagency Registry for Mechanically Assisted Circulatory Support databaseJoseph C Cleveland
Department of Surgery, Division of Cardiothoracic Surgery, University of Colorado Anschutz Medical Center, Aurora, Colorado 80045, USA
J Heart Lung Transplant 30:862-9. 2011.... - Secretory phospholipase A2 inhibition attenuates intercellular adhesion molecule-1 expression in human esophageal adenocarcinoma cellsMiral R Sadaria
Department of Surgery, Division of Cardiothoracic Surgery, University of Colorado at Denver and Health Sciences Center, Aurora, Colorado 80045, USA
Ann Thorac Surg 91:1539-45. 2011.... - Open thoracic aortic repair for dysphagia in patients with Kommerell's diverticulum and right-sided aortic arch with aberrant left subclavian arteryT Brett Reece
Division of Cardiovascular Surgery, Department of Surgery, The University of Pennsylvania Medical Center, Philadelphia, Pennsylvania, USA
J Card Surg 25:62-4. 2010..Both cases were successfully repaired with a staged open approach rather than an endovascular approach, which would not have addressed the presenting symptom of dysphagia... - Native lung volume reduction surgery relieves functional graft compression after single-lung transplantation for chronic obstructive pulmonary diseaseT Brett Reece
Division of Cardiothoracic Surgery, University of Colorado Health Sciences Center, Denver, Colo, USA
J Thorac Cardiovasc Surg 135:931-7. 2008..We hypothesized that patients with functional compromise from native lung hyperinflation would benefit from native lung volume reduction surgery...