T Brett Reece

Summary

Affiliation: University of Virginia
Country: USA

Publications

  1. ncbi request reprint Central cannulation is safe in acute aortic dissection repair
    T Brett Reece
    University of Virginia, Department of Surgery, Division of Thoracic and Cardiovascular Surgery, Charlottesville, VA, USA
    J Thorac Cardiovasc Surg 133:428-34. 2007
  2. ncbi request reprint Functional and cytoarchitectural spinal cord protection by ATL-146e after ischemia/reperfusion is mediated by adenosine receptor agonism
    T Brett Reece
    Department of Surgery, University of Virginia, Charlottesville, VA 22908, USA
    J Vasc Surg 44:392-7. 2006
  3. ncbi request reprint Comparison of systemic and retrograde delivery of adenosine A2A agonist for attenuation of spinal cord injury after thoracic aortic cross-clamping
    T Brett Reece
    Department of Surgery, University of Virginia, Charlottesville, Virginia, USA
    Ann Thorac Surg 81:902-9. 2006
  4. ncbi request reprint Adenosine A2A receptor activation reduces inflammation and preserves pulmonary function in an in vivo model of lung transplantation
    T Brett Reece
    Department of Surgery, University of Virginia Health System, PO Box 801359, Charlottesville, VA 22908, USA
    J Thorac Cardiovasc Surg 129:1137-43. 2005
  5. ncbi request reprint Adenosine A2A receptor agonist improves cardiac dysfunction from pulmonary ischemia-reperfusion injury
    T Brett Reece
    Department of Surgery, University of Virginia Health System, Charlottesville, Virginia, USA
    Ann Thorac Surg 79:1189-95. 2005
  6. ncbi request reprint The evolution of ischemic spinal cord injury in function, cytoarchitecture, and inflammation and the effects of adenosine A2A receptor activation
    T Brett Reece
    Department of Surgery, University of Virginia Health System, PO Box 801359, Charlottesville, VA 22908, USA
    J Thorac Cardiovasc Surg 128:925-32. 2004
  7. ncbi request reprint Adenosine A2A analogue reduces long-term neurologic injury after blunt spinal trauma
    T Brett Reece
    Department of Surgery, University of Virginia, Charlottesville, VA 22908, USA
    J Surg Res 121:130-4. 2004
  8. pmc Mitral repair is superior to replacement when associated with coronary artery disease
    T Brett Reece
    Department of Surgery, Division of Thoracic and Cardiovascular Surgery, University of Virginia Health Sciences Center, MR Building, Room 3116, Charlottesville, VA 22908, USA
    Ann Surg 239:671-5; discussion 675-7. 2004
  9. ncbi request reprint A comparison of adenosine A2A agonism and methylprednisolone in attenuating neuronal damage and improving functional outcome after experimental traumatic spinal cord injury in rabbits
    David O Okonkwo
    Department of Neurological Surgery, University of Virginia Health System, Charlottesville 22908 0212, USA
    J Neurosurg Spine 4:64-70. 2006
  10. ncbi request reprint Adenosine A2A activation attenuates nontransplantation lung reperfusion injury
    Peter I Ellman
    Department of Surgery, University of Virginia, Charlottesville, Virginia 22908, USA
    J Surg Res 149:3-8. 2008

Detail Information

Publications40

  1. ncbi request reprint Central cannulation is safe in acute aortic dissection repair
    T Brett Reece
    University of Virginia, Department of Surgery, Division of Thoracic and Cardiovascular Surgery, Charlottesville, VA, USA
    J Thorac Cardiovasc Surg 133:428-34. 2007
    ..We hypothesized that cannulation of the dissected aorta could be done safely with acceptable complication and mortality rates in this high-risk population...
  2. ncbi request reprint Functional and cytoarchitectural spinal cord protection by ATL-146e after ischemia/reperfusion is mediated by adenosine receptor agonism
    T Brett Reece
    Department of Surgery, University of Virginia, Charlottesville, VA 22908, USA
    J Vasc Surg 44:392-7. 2006
    ....
  3. ncbi request reprint Comparison of systemic and retrograde delivery of adenosine A2A agonist for attenuation of spinal cord injury after thoracic aortic cross-clamping
    T Brett Reece
    Department of Surgery, University of Virginia, Charlottesville, Virginia, USA
    Ann Thorac Surg 81:902-9. 2006
    ..We hypothesized that despite retrograde spinal perfusion of an adenosine A2A agonist (ATL-146e), systemic therapy produces superior spinal cord protection with reduced inflammation...
  4. ncbi request reprint Adenosine A2A receptor activation reduces inflammation and preserves pulmonary function in an in vivo model of lung transplantation
    T Brett Reece
    Department of Surgery, University of Virginia Health System, PO Box 801359, Charlottesville, VA 22908, USA
    J Thorac Cardiovasc Surg 129:1137-43. 2005
    ..We hypothesized that adenosine A 2A receptor activation by ATL-146e during the initial reperfusion period preserves pulmonary function and attenuates inflammation in a porcine model of lung transplantation...
  5. ncbi request reprint Adenosine A2A receptor agonist improves cardiac dysfunction from pulmonary ischemia-reperfusion injury
    T Brett Reece
    Department of Surgery, University of Virginia Health System, Charlottesville, Virginia, USA
    Ann Thorac Surg 79:1189-95. 2005
    ..We hypothesized that pulmonary ischemia-reperfusion causes secondary heart dysfunction and ATL-146e will improve this dysfunction...
  6. ncbi request reprint The evolution of ischemic spinal cord injury in function, cytoarchitecture, and inflammation and the effects of adenosine A2A receptor activation
    T Brett Reece
    Department of Surgery, University of Virginia Health System, PO Box 801359, Charlottesville, VA 22908, USA
    J Thorac Cardiovasc Surg 128:925-32. 2004
    ..This study defines injury progression in terms of function, cytoarchitecture, and inflammation and assesses whether adenosine A 2A receptor activation by ATL-146e limits injury progression...
  7. ncbi request reprint Adenosine A2A analogue reduces long-term neurologic injury after blunt spinal trauma
    T Brett Reece
    Department of Surgery, University of Virginia, Charlottesville, VA 22908, USA
    J Surg Res 121:130-4. 2004
    ..In the current study, we extended the treatment paradigm and tested neurobehavioral functioning out to 1 week after injury to assess if early neurological improvement is sustained long term by an adenosine analogue...
  8. pmc Mitral repair is superior to replacement when associated with coronary artery disease
    T Brett Reece
    Department of Surgery, Division of Thoracic and Cardiovascular Surgery, University of Virginia Health Sciences Center, MR Building, Room 3116, Charlottesville, VA 22908, USA
    Ann Surg 239:671-5; discussion 675-7. 2004
    ..To compare the outcomes of mitral repair and replacement in revascularized patients with ischemic mitral regurgitation...
  9. ncbi request reprint A comparison of adenosine A2A agonism and methylprednisolone in attenuating neuronal damage and improving functional outcome after experimental traumatic spinal cord injury in rabbits
    David O Okonkwo
    Department of Neurological Surgery, University of Virginia Health System, Charlottesville 22908 0212, USA
    J Neurosurg Spine 4:64-70. 2006
    ..The authors of this study evaluated ATL-146e and methylprednisolone for their ability to preserve neuronal viability and motor function in experimental SCI...
  10. ncbi request reprint Adenosine A2A activation attenuates nontransplantation lung reperfusion injury
    Peter I Ellman
    Department of Surgery, University of Virginia, Charlottesville, Virginia 22908, USA
    J Surg Res 149:3-8. 2008
    ..There has been little work, however, examining its effects in the setting of nontransplant ischemia reperfusion. Our hypothesis was that an A(2A) agonist would attenuate lung reperfusion injury in a warm ischemia hilar clamping model...
  11. pmc Early adenosine receptor activation ameliorates spinal cord reperfusion injury
    T Brett Reece
    Department of Surgery, University of Virginia, Charlottesville, Virginia, USA
    J Cardiovasc Med (Hagerstown) 9:363-7. 2008
    ..We hypothesized that adenosine receptor activation with ATL-146e would produce similar protection from ischemic spinal cord injury, whether given at reperfusion or in a delayed fashion...
  12. ncbi request reprint Replacement of the proximal aorta adds no further risk to aortic valve procedures
    T Brett Reece
    Department of Surgery, Division of Thoracic and Cardiovascular Surgery, University of Virginia, Charlottesville, Virginia, USA
    Ann Thorac Surg 84:473-8; discussion 478. 2007
    ..We hypothesized that the addition of proximal aortic intervention adds no further risk to aortic valve surgery, which may avoid subsequent proximal aortic procedures or catastrophes...
  13. ncbi request reprint A change in perspective: results for ischemic mitral valve repair are similar to mitral valve repair for degenerative disease
    Leo M Gazoni
    Department of Surgery, University of Virginia, Charlottesville, Virginia 22908, USA
    Ann Thorac Surg 84:750-7; discussion 758. 2007
    ..We hypothesized that mitral valve repair for ischemic MR results in outcomes similar to those for mitral valve repair for degenerative MR...
  14. ncbi request reprint The evolution of chemokine release supports a bimodal mechanism of spinal cord ischemia and reperfusion injury
    Phillip D Smith
    Department of Surgery, Division of Cardiothoracic Surgery, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA
    Circulation 126:S110-7. 2012
    ..This study sought to characterize the inflammatory response in the spinal cord after IR and hypothesized that this would support a bimodal mechanism of injury...
  15. ncbi request reprint Sleep deprivation does not affect operative results in cardiac surgery
    Peter I Ellman
    Department of Cardiovascular Surgery, University of Virginia, Charlottesville, Virginia, USA
    Ann Thorac Surg 78:906-11; discussion 906-11. 2004
    ..We hypothesized that sleep deprivation would not be associated with increased morbidity or mortality in cardiac operations...
  16. ncbi request reprint Attenuation of lung reperfusion injury by modified ventilation and reperfusion techniques
    R Ramesh Singh
    University of Virginia Health System, Department of Surgery, Charlottesville 22908, USA
    J Heart Lung Transplant 25:1467-73. 2006
    ..We hypothesized that using combined protective approaches for ventilation and perfusion would be optimal for reducing injury and improving function after ischemia-reperfusion...
  17. ncbi request reprint Acute sleep deprivation in the thoracic surgical resident does not affect operative outcomes
    Peter I Ellman
    Department of Cardiovascular Surgery, University of Virginia, Charlottesville, Virginia, USA
    Ann Thorac Surg 80:60-4; discussion 64-5. 2005
    ..We have recently studied this in attending surgeons. The present study focused on thoracic surgical residents. Our hypothesis was that acute sleep deprivation would not lead to an increase in operative times or complications...
  18. ncbi request reprint Reevaluating the need for left subclavian artery revascularization with thoracic endovascular aortic repair
    T Brett Reece
    Department of Thoracic and Cardiovascular Surgery, University of Virginia, Charlottesville, Virginia, USA
    Ann Thorac Surg 84:1201-5; discussion 1205. 2007
    ..We hypothesize that for patients undergoing TEVAR requiring coverage of the LSA, the need for LSA revascularization is higher than reported in the literature...
  19. doi request reprint Preservation of motor function after spinal cord ischemia and reperfusion injury through microglial inhibition
    Phillip D Smith
    Department of Surgery, Division of Cardiothoracic Surgery, University of Colorado, Anschutz Medical Campus, Aurora, Colorado Electronic address
    Ann Thorac Surg 95:1647-53. 2013
    ..This study hypothesized that microglial inhibition by minocycline after SCIR will attenuate injury with preservation of motor function...
  20. doi request reprint Cytokine expression profile in human lungs undergoing normothermic ex-vivo lung perfusion
    Miral R Sadaria
    Department of Surgery, Division of Cardiothoracic Surgery, University of Colorado at Denver and Health Sciences Center, Aurora, Colorado 80045, USA
    Ann Thorac Surg 92:478-84. 2011
    ..We sought to establish representative cytokine expression in human donor lungs meeting acceptable lung transplant criteria after prolonged normothermic EVLP...
  21. ncbi request reprint Secretory Phospholipase A2 Mediates Human Esophageal Adenocarcinoma Cell Growth and Proliferation via ERK 1/2 Pathway
    Miral R Sadaria
    Assistant Professor of Surgery, University of Colorado Anschutz Medical Campus, Division of Cardiothoracic Surgery, Department of Surgery, Academic Office One, Room 6602, 12631 East 17th Avenue, C310, Aurora, CO 80045, U S A
    Anticancer Res 33:1337-42. 2013
    ..Phospholipase enzymes have been demonstrated to significantly influence these two growth regulating pathways in other tumor cells. We hypothesize sPLA2 to mediate HEAC growth control through ERK 1/2 and AKT...
  22. doi request reprint Elective hypothermic circulatory arrest to address aortic pathology is safe for the elderly
    T Brett Reece
    Thoracic and Cardiovascular Surgery, University of Virginia, Charlottesville, Virginia, USA
    J Card Surg 24:240-4. 2009
    ..We hypothesized that the use of HCA would not increase mortality or complications in elderly patients compared to younger counterparts...
  23. ncbi request reprint The beating heart approach is not necessary for the Dor procedure
    Thomas S Maxey
    Division of Thoracic and Cardiovascular Surgery, University of Virginia Health Science Center, Charlottesville, Virginia, USA
    Ann Thorac Surg 76:1571-4; discussion 1574-5. 2003
    ..It has been suggested that a beating heart approach improves ventricular function by allowing the surgeon to palpate that part of the ventricle to exclude...
  24. ncbi request reprint Hyperoxic ventilation exacerbates lung reperfusion injury
    Peter I Ellman
    Department of Cardiovascular Surgery, University of Virginia, Charlottesville, VA, USA
    J Thorac Cardiovasc Surg 130:1440. 2005
    ..We hypothesized that hyperoxic ventilation at the time of reperfusion could worsen the effects of lung reperfusion injury...
  25. ncbi request reprint Safety and efficacy of the supraclavicular approach to thoracic outlet decompression
    Thomas S Maxey
    Division of Thoracic and Cardiovascular Surgery, University of Virginia Health Science Center, Charlottesville, Virginia 22908, USA
    Ann Thorac Surg 76:396-9; discussion 399-400. 2003
    ..The traditional approach to thoracic outlet decompression has been transaxillary; however more centers are moving toward a more tailored approach through a supraclavicular incision...
  26. doi request reprint Statin therapy attenuates growth and malignant potential of human esophageal adenocarcinoma cells
    Miral R Sadaria
    Division of Cardiothoracic Surgery, Department of Surgery, University of Colorado at Denver and Health Sciences Center, Aurora, Colo 80045, USA
    J Thorac Cardiovasc Surg 142:1152-60. 2011
    ..We hypothesize that statin therapy may attenuate growth and malignant potential via ICAM-1 expression and nuclear factor-kappa beta activation in human esophageal adenocarcinoma cells...
  27. ncbi request reprint Coronary artery bypass with ventricular restoration is superior to coronary artery bypass alone in patients with ischemic cardiomyopathy
    Thomas S Maxey
    Department of Thoracic Surgery, University of Virginia, Charlottesville 22908, USA
    J Thorac Cardiovasc Surg 127:428-34. 2004
    ..Our hypothesis was that ventricular restoration plus coronary artery bypass provides improved outcome compared with coronary artery bypass alone in ischemic cardiomyopathy with ventricular enlargement...
  28. ncbi request reprint A simplified approach to degenerative disease: triangular resections of the mitral valve
    Leo M Gazoni
    Department of Surgery, University of Virginia, Charlottesville, Virginia 22908, USA
    Ann Thorac Surg 83:1658-64; discussion 1664-5. 2007
    ..These techniques have been perceived to be difficult and have possibly reduced the incidence of MV repair. We present our experience with a simplified approach to MV repair utilizing a triangular resection and larger rings...
  29. ncbi request reprint The role of pharmacology in spinal cord protection during thoracic aortic reconstruction
    T Brett Reece
    Department of Surgery, Division of Thoracic and Cardiovascular Surgery, University of Virginia, Charlottesville, VA 22908, USA
    Semin Thorac Cardiovasc Surg 15:365-77. 2003
    ..This article reviews the pathophysiology of ischemic spinal cord injury and summarizes the investigational pharmacology that may prevent these serious complications...
  30. ncbi request reprint Coarctation of a right aortic arch
    Thomas S Maxey
    Department of Surgery, College of Medicine, University of South Florida, Tampa, Florida, USA
    J Card Surg 21:261-3. 2006
    ..The frequency with which other anomalies exist in either of the above conditions requires thorough cardiac evaluation and detailed imaging. Surgical repair of this anomaly can safely be undertaken through a right thoracotomy...
  31. pmc Is off-pump coronary artery bypass grafting superior to conventional bypass in octogenarians?
    Damien J LaPar
    Department of Surgery, Division of Thoracic and Cardiovascular Surgery, University of Virginia Health System, Charlottesville, VA, USA
    J Thorac Cardiovasc Surg 141:81-90. 2011
    ..We hypothesized that off-pump coronary bypass offers a greater operative benefit to elderly patients when compared with conventional coronary artery bypass...
  32. ncbi request reprint Transverse arch hypoplasia may predispose patients to aneurysm formation after patch repair of aortic coarctation
    Thomas S Maxey
    Department of Surgery, Division of Thoracic and Cardiovascular Surgery, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    Ann Thorac Surg 76:1090-3. 2003
    ..Thoracic aortic aneurysm after patch repair of aortic coarctation is a potentially lethal complication. We hypothesized that transverse arch hypoplasia in association with patch repair of aortic coarctation predisposes aneurysm formation...
  33. ncbi request reprint Early repair of complete atrioventricular septal defect is safe and effective
    R Ramesh Singh
    Department of Surgery, University of Virginia, Charlottesville, Virginia 22908, USA
    Ann Thorac Surg 82:1598-601; discussion 1602. 2006
    ..Our hypothesis is that with modern techniques, the current risks of CAVSD repair in children aged younger than 3 months and in children older than 3 months are equal...
  34. doi request reprint Toll-like receptor 4 mediates oxidized LDL-induced macrophage differentiation to foam cells
    Kenneth W Howell
    Department of Surgery, Division of Cardiothoracic Surgery, University of Colorado Anschutz Medical Center, Aurora, Colorado 80045, USA
    J Surg Res 171:e27-31. 2011
    ..Further, oxidized low density lipoprotein (oxLDL) enhances TLR4 expression in macrophages. We hypothesized that TLR4 mediates macrophage differentiation to foam cells...
  35. ncbi request reprint General surgery morning report: a competency-based conference that enhances patient care and resident education
    Brendon M Stiles
    Department of Surgery, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    Curr Surg 63:385-90. 2006
    ..Although initially oriented toward transfer of patient information, MR is also hypothesized to serve as a competency-based resident education tool...
  36. ncbi request reprint Endothelial nitric oxide synthase is essential for postpneumonectomy compensatory vasodilation
    Thomas S Maxey
    Department of Surgery, University of South Florida, Tampa, Florida, USA
    Ann Thorac Surg 81:1234-8. 2006
    ..After pneumonectomy, the remaining lung vasculature must vasodilate to compensate for increased blood volume. We hypothesized that endothelial nitric oxide synthase (eNOS) is essential for compensatory vasodilation after pneumonectomy...
  37. doi request reprint Survival after biventricular assist device implantation: an analysis of the Interagency Registry for Mechanically Assisted Circulatory Support database
    Joseph C Cleveland
    Department of Surgery, Division of Cardiothoracic Surgery, University of Colorado Anschutz Medical Center, Aurora, Colorado 80045, USA
    J Heart Lung Transplant 30:862-9. 2011
    ....
  38. doi request reprint Secretory phospholipase A2 inhibition attenuates intercellular adhesion molecule-1 expression in human esophageal adenocarcinoma cells
    Miral R Sadaria
    Department of Surgery, Division of Cardiothoracic Surgery, University of Colorado at Denver and Health Sciences Center, Aurora, Colorado 80045, USA
    Ann Thorac Surg 91:1539-45. 2011
    ....
  39. doi request reprint Open thoracic aortic repair for dysphagia in patients with Kommerell's diverticulum and right-sided aortic arch with aberrant left subclavian artery
    T Brett Reece
    Division of Cardiovascular Surgery, Department of Surgery, The University of Pennsylvania Medical Center, Philadelphia, Pennsylvania, USA
    J Card Surg 25:62-4. 2010
    ..Both cases were successfully repaired with a staged open approach rather than an endovascular approach, which would not have addressed the presenting symptom of dysphagia...
  40. doi request reprint Native lung volume reduction surgery relieves functional graft compression after single-lung transplantation for chronic obstructive pulmonary disease
    T Brett Reece
    Division of Cardiothoracic Surgery, University of Colorado Health Sciences Center, Denver, Colo, USA
    J Thorac Cardiovasc Surg 135:931-7. 2008
    ..We hypothesized that patients with functional compromise from native lung hyperinflation would benefit from native lung volume reduction surgery...