MATTHEW REDINBO

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. ncbi request reprint Structural insights into drug processing by human carboxylesterase 1: tamoxifen, mevastatin, and inhibition by benzil
    Christopher D Fleming
    Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Mol Biol 352:165-77. 2005
  2. pmc The mechanism and control of DNA transfer by the conjugative relaxase of resistance plasmid pCU1
    Rebekah Potts Nash
    Department of Chemistry, University of North Carolina, Chapel Hill, CB 3290 and Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, CB 7260, Chapel Hill, NC 27599, USA
    Nucleic Acids Res 38:5929-43. 2010
  3. pmc Active nuclear receptors exhibit highly correlated AF-2 domain motions
    Denise G Teotico
    Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    PLoS Comput Biol 4:e1000111. 2008
  4. pmc Pseudomonas aeruginosa PilY1 binds integrin in an RGD- and calcium-dependent manner
    Michael D L Johnson
    Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
    PLoS ONE 6:e29629. 2011
  5. pmc Nerve agent hydrolysis activity designed into a human drug metabolism enzyme
    Andrew C Hemmert
    Department of Biochemistry Biophysics and Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
    PLoS ONE 6:e17441. 2011
  6. pmc Molecular insights into microbial β-glucuronidase inhibition to abrogate CPT-11 toxicity
    Adam B Roberts
    Departments of Biochemistry, Chemistry and Microbiology, University of North Carolina at Chapel Hill, NC, USA
    Mol Pharmacol 84:208-17. 2013
  7. pmc Structural basis of human pregnane X receptor activation by the hops constituent colupulone
    Denise G Teotico
    Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 3290, USA
    Mol Pharmacol 74:1512-20. 2008
  8. ncbi request reprint Human carboxylesterase 1: from drug metabolism to drug discovery
    M R Redinbo
    Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Biochem Soc Trans 31:620-4. 2003
  9. ncbi request reprint Mammalian carboxylesterases: from drug targets to protein therapeutics
    Matthew R Redinbo
    Department of Chemistry, Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC 27599 3290, USA
    Drug Discov Today 10:313-25. 2005
  10. ncbi request reprint Novel insights into catalytic mechanism from a crystal structure of human topoisomerase I in complex with DNA
    M R Redinbo
    Department of Biological Structure and Biomolecular Structure Center, Howard Hughes Medical Institute, University of Washington School of Medicine, Seattle, Washington 98195, USA
    Biochemistry 39:6832-40. 2000

Collaborators

Detail Information

Publications46

  1. ncbi request reprint Structural insights into drug processing by human carboxylesterase 1: tamoxifen, mevastatin, and inhibition by benzil
    Christopher D Fleming
    Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Mol Biol 352:165-77. 2005
    ..Our results provide detailed insights into the catalytic and non-catalytic processing of small molecules by hCE1, and suggest that the efficacy of clinical drugs may be modulated by targeted hCE1 inhibitors...
  2. pmc The mechanism and control of DNA transfer by the conjugative relaxase of resistance plasmid pCU1
    Rebekah Potts Nash
    Department of Chemistry, University of North Carolina, Chapel Hill, CB 3290 and Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, CB 7260, Chapel Hill, NC 27599, USA
    Nucleic Acids Res 38:5929-43. 2010
    ..In summary, our work outlines novel structural and functional aspects of the relaxase-mediated conjugative transfer of plasmid pCU1...
  3. pmc Active nuclear receptors exhibit highly correlated AF-2 domain motions
    Denise G Teotico
    Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    PLoS Comput Biol 4:e1000111. 2008
    ..Taken together, our findings indicate that long-range motions within the LBD scaffold are critical to nuclear receptor function by promoting a mobile AF-2 state ready to bind coactivators...
  4. pmc Pseudomonas aeruginosa PilY1 binds integrin in an RGD- and calcium-dependent manner
    Michael D L Johnson
    Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
    PLoS ONE 6:e29629. 2011
    ..Taken together, these data indicate that PilY1 binds to integrin in an RGD- and calcium-dependent manner in vitro. As such, P. aeruginosa may employ these interactions to mediate host epithelial cell binding in vivo...
  5. pmc Nerve agent hydrolysis activity designed into a human drug metabolism enzyme
    Andrew C Hemmert
    Department of Biochemistry Biophysics and Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
    PLoS ONE 6:e17441. 2011
    ..Such approaches may lead to novel countermeasures for nerve agent poisoning...
  6. pmc Molecular insights into microbial β-glucuronidase inhibition to abrogate CPT-11 toxicity
    Adam B Roberts
    Departments of Biochemistry, Chemistry and Microbiology, University of North Carolina at Chapel Hill, NC, USA
    Mol Pharmacol 84:208-17. 2013
    ..Taken together, these data advance our understanding of the chemical and structural basis of selective microbial β-glucuronidase inhibition, which may improve human drug efficacy and toxicity. ..
  7. pmc Structural basis of human pregnane X receptor activation by the hops constituent colupulone
    Denise G Teotico
    Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 3290, USA
    Mol Pharmacol 74:1512-20. 2008
    ..Taken together, these results reveal the structural basis for drug-drug interactions mediated by colupulone and related constituents of hops extracts...
  8. ncbi request reprint Human carboxylesterase 1: from drug metabolism to drug discovery
    M R Redinbo
    Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Biochem Soc Trans 31:620-4. 2003
    ..Selective hCE1 inhibitors targeted to several sites on the enzyme may also pave the way for novel clinical tools to manage cholesterol homoeostasis in humans...
  9. ncbi request reprint Mammalian carboxylesterases: from drug targets to protein therapeutics
    Matthew R Redinbo
    Department of Chemistry, Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC 27599 3290, USA
    Drug Discov Today 10:313-25. 2005
    ..Also included is an outline of how selective CE inhibitors could be used as co-drugs to improve the efficacy of clinically approved agents...
  10. ncbi request reprint Novel insights into catalytic mechanism from a crystal structure of human topoisomerase I in complex with DNA
    M R Redinbo
    Department of Biological Structure and Biomolecular Structure Center, Howard Hughes Medical Institute, University of Washington School of Medicine, Seattle, Washington 98195, USA
    Biochemistry 39:6832-40. 2000
    ..The implications of these structural features for the mechanism of the enzyme are discussed, including the potential requirement for a rotation of the scissile phosphate group during DNA strand cleavage and covalent attachment...
  11. ncbi request reprint Structural insights into CPT-11 activation by mammalian carboxylesterases
    Sompop Bencharit
    Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Nat Struct Biol 9:337-42. 2002
    ..These results may facilitate the design of improved anticancer drugs or enzymes for use in viral-directed cancer cotherapies...
  12. ncbi request reprint Structural basis of heroin and cocaine metabolism by a promiscuous human drug-processing enzyme
    Sompop Bencharit
    Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Nat Struct Biol 10:349-56. 2003
    ..The bioscavenger properties of hCE1 can likely be used to treat both narcotic overdose and chemical weapon exposure...
  13. pmc Multisite promiscuity in the processing of endogenous substrates by human carboxylesterase 1
    Sompop Bencharit
    Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Mol Biol 363:201-14. 2006
    ..These results expand our understanding of enzyme promiscuity and indicate that, in the case of hCE1, multiple non-specific sites are employed to perform distinct catalytic actions...
  14. ncbi request reprint 2.1 A crystal structure of human PXR in complex with the St. John's wort compound hyperforin
    Ryan E Watkins
    Department of Chemistry, The University of North Carolina at Chapel Hill, North Carolina 27599, USA
    Biochemistry 42:1430-8. 2003
    ....
  15. ncbi request reprint Crystal structure of human carboxylesterase 1 complexed with the Alzheimer's drug tacrine: from binding promiscuity to selective inhibition
    Sompop Bencharit
    Department of Chemistry, School of Dentistry, University of North Carolina, Chapel Hill, 27599, USA
    Chem Biol 10:341-9. 2003
    ..Further, we use our structure to identify tacrine derivatives that act as low-micromolar inhibitors of hCE1 and may provide new avenues for treating narcotic abuse and cholesterol-related diseases...
  16. ncbi request reprint Coactivator binding promotes the specific interaction between ligand and the pregnane X receptor
    Ryan E Watkins
    Departments of Chemistry and Biochemistry and Biophysics, and the Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Mol Biol 331:815-28. 2003
    ..They further reveal that specificity is required for PXR activation...
  17. pmc Crystal structure of the PXR-T1317 complex provides a scaffold to examine the potential for receptor antagonism
    Yu Xue
    Department of Chemistry, CB 3290, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 3290, USA
    Bioorg Med Chem 15:2156-66. 2007
    ..Based on these observations, we conclude that the generation of PXR antagonists targeted to the ligand binding pocket may be difficult due to the promiscuity and structural conformability of this xenobiotic sensor...
  18. pmc Disrupting antibiotic resistance propagation by inhibiting the conjugative DNA relaxase
    Scott A Lujan
    Department of Chemistry, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599 3290, USA
    Proc Natl Acad Sci U S A 104:12282-7. 2007
    ..Thus, the inhibition of conjugative relaxases is a potentially novel antimicrobial approach, one that selectively targets bacteria capable of transferring antibiotic resistance and generating multidrug resistant strains...
  19. pmc Crystal structure of the cofactor-binding domain of the human phase II drug-metabolism enzyme UDP-glucuronosyltransferase 2B7
    Michael J Miley
    Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 3290, USA
    J Mol Biol 369:498-511. 2007
    ..Point mutations at predicted catalytic residues in UGT2B7 abrogated activity, strongly suggesting human UGTs also utilize a serine hydrolase-like catalytic mechanism to facilitate glucuronic acid transfer...
  20. pmc Human carboxylesterase 1 stereoselectively binds the nerve agent cyclosarin and spontaneously hydrolyzes the nerve agent sarin
    Andrew C Hemmert
    Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 3290, USA
    Mol Pharmacol 77:508-16. 2010
    ..These results provide important insights toward the long-term goal of designing novel forms of hCE1 to act as protein-based therapeutics for nerve agent detoxification...
  21. ncbi request reprint Modulation of human nuclear receptor LRH-1 activity by phospholipids and SHP
    Eric A Ortlund
    Department of Chemistry, Lineberger Comprehensive Cancer Center, School of Medicine, University of North Carolina at Chapel Hill, 27599, USA
    Nat Struct Mol Biol 12:357-63. 2005
    ..Our results indicate that hLRH-1's control of gene expression is mediated by phospholipid binding, and establish hLRH-1 as a novel target for compounds designed to slow breast cancer development...
  22. ncbi request reprint Crystal structure of the pregnane X receptor-estradiol complex provides insights into endobiotic recognition
    Yu Xue
    Department of Chemistry, CB 3290, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 3290, USA
    Mol Endocrinol 21:1028-38. 2007
    ..The results provide detailed insights into the manner in which human PXR responds to a wide range of endobiotic compounds...
  23. ncbi request reprint Crystal structure of the human LRH-1 DBD-DNA complex reveals Ftz-F1 domain positioning is required for receptor activity
    Isaac H Solomon
    Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Mol Biol 354:1091-102. 2005
    ..Taken together, these results indicate that subtle structural changes in a nuclear receptor DBD can exert long-range functional effects on the LBD of a receptor, and significantly impact transcriptional regulation...
  24. pmc Alleviating cancer drug toxicity by inhibiting a bacterial enzyme
    Bret D Wallace
    Department of Chemistry, University of North Carolina, Chapel Hill, NC 27599, USA
    Science 330:831-5. 2010
    ..Finally, oral administration of an inhibitor protected mice from CPT-11-induced toxicity. Thus, drugs may be designed to inhibit undesirable enzyme activities in essential microbial symbiotes to enhance chemotherapeutic efficacy...
  25. pmc Triggered Mycobacterium tuberculosis heparin-binding hemagglutinin adhesin folding and dimerization
    Joseph V Lomino
    University of North Carolina Chapel Hill, Dept of Chemistry, Chapel Hill, NC 27599 3290, USA
    J Bacteriol 193:2089-96. 2011
    ..Thus, we show that HBHA dimerization and folding are linked and that the N-terminal region of this cell surface adhesin triggers the formation of an HBHA coiled-coil dimer...
  26. pmc Crystal structure of an ancient protein: evolution by conformational epistasis
    Eric A Ortlund
    Department of Chemistry, University of North Carolina, Chapel Hill, NC 27599, USA
    Science 317:1544-8. 2007
    ....
  27. doi request reprint Functional anatomy of phospholipid binding and regulation of phosphoinositide homeostasis by proteins of the sec14 superfamily
    Gabriel Schaaf
    Department of Cell and Developmental Biology, School of Medicine, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7090, USA
    Mol Cell 29:191-206. 2008
    ..Collectively, these findings outline functional mechanisms for the Sec14 superfamily and reveal additional layers of complexity for regulating phosphoinositide homeostasis in eukaryotes...
  28. pmc Crystal structure analysis reveals Pseudomonas PilY1 as an essential calcium-dependent regulator of bacterial surface motility
    Jillian Orans
    Department of Chemistry, University of North Carolina at Chapel Hill, CB 3290, Chapel Hill, NC 27599, USA
    Proc Natl Acad Sci U S A 107:1065-70. 2010
    ..Thus, PilY1 is an essential, calcium-dependent regulator of bacterial twitching motility...
  29. ncbi request reprint Structural insights into the promiscuity and function of the human pregnane X receptor
    Ryan E Watkins
    Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 3290, USA
    Curr Opin Drug Discov Devel 5:150-8. 2002
    ..The accumulating structural and functional data on PXR may facilitate the development of improved methods for in vitro, in vivo and in silico screening for PXR activation...
  30. pmc A novel fold in the TraI relaxase-helicase c-terminal domain is essential for conjugative DNA transfer
    Laura M Guogas
    Department of Chemistry, University of North Carolina at Chapel Hill, 27599 3290, USA
    J Mol Biol 386:554-68. 2009
    ..Taken together, these data establish the specific structural features of this noncatalytic domain that are essential to DNA conjugation...
  31. pmc Crystal structure of the HEAT domain from the Pre-mRNA processing factor Symplekin
    Sarah A Kennedy
    Department of Chemistry, University of North Carolina at Chapel Hill, 27599, USA
    J Mol Biol 392:115-28. 2009
    ..Together, these data support the conclusion that the Symplekin HEAT domain serves as a scaffold for protein-protein interactions essential to the mRNA maturation process...
  32. pmc Crystal structures of human carboxylesterase 1 in covalent complexes with the chemical warfare agents soman and tabun
    Christopher D Fleming
    Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Biochemistry 46:5063-71. 2007
    ..Taken together, these data provide important structural details toward the goal of engineering hCE1 into an organophosphate hydrolase and protein-based therapeutic for nerve agent exposure...
  33. ncbi request reprint The nuclear xenobiotic receptor pregnane X receptor: recent insights and new challenges
    Jillian Orans
    Department of Chemistry, CB 3290, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 3290, USA
    Mol Endocrinol 19:2891-900. 2005
    ..We also review the functional roles played by PXR in numerous biological pathways and outline emerging areas for the future examination of this key nuclear xenobiotic receptor...
  34. pmc 8-Oxoguanine rearranges the active site of human topoisomerase I
    Diem Thu Thieu Lesher
    Departments of Chemistry and Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC 27599, USA
    Proc Natl Acad Sci U S A 99:12102-7. 2002
    ..We propose that human topoisomerase I binds to DNA first in an inactive conformation and then rearranges its active site for catalysis. 8-OxoG appears to impact topoisomerase I by stabilizing the inactive, DNA-bound state...
  35. ncbi request reprint Structural disorder in the complex of human pregnane X receptor and the macrolide antibiotic rifampicin
    Jill E Chrencik
    Department of Chemistry, Campus Box 3290, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 3290, USA
    Mol Endocrinol 19:1125-34. 2005
    ..These observations highlight the key role that structural flexibility plays in PXR's promiscuous response to xenobiotics...
  36. pmc Human PXR forms a tryptophan zipper-mediated homodimer
    Schroeder M Noble
    Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Biochemistry 45:8579-89. 2006
    ..Taken together, these results suggest that the unique Trp-Zip-mediated PXR homodimer plays a role in the function of this nuclear xenobiotic receptor...
  37. ncbi request reprint Structural impact of the leukemia drug 1-beta-D-arabinofuranosylcytosine (Ara-C) on the covalent human topoisomerase I-DNA complex
    Jill E Chrencik
    Department of Chemistry, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Biol Chem 278:12461-6. 2003
    ..The subtle structural changes caused by the presence of Ara-C in the DNA duplex may contribute to the cytotoxicity of this leukemia drug by prolonging the lifetime of the covalent human topoisomerase I-DNA complex...
  38. ncbi request reprint Structure and function of the human nuclear xenobiotic receptor PXR
    Virginia E Carnahan
    Department of Biochemistry and Biophysics, and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 3290, USA
    Curr Drug Metab 6:357-67. 2005
    ..We also discuss the clinical implications of PXR's role in the drug-drug interactions, cancer, and cholestatic liver disease...
  39. ncbi request reprint Promiscuity: what protects us, perplexes us
    Matthew R Redinbo
    Drug Discov Today 9:431-2. 2004
  40. ncbi request reprint Orphan nuclear receptors adopted by crystallography
    Holly A Ingraham
    Department of Physiology, 1550 4 th Street, University of California, San Francisco, Box 2611, Mission Bay Campus, San Francisco, CA 94143 2611, USA
    Curr Opin Struct Biol 15:708-15. 2005
    ..Insights from these new structures illustrate how powerful a structural biology approach can be when integrated with molecular and cellular physiology...
  41. ncbi request reprint Molecular modeling of CPT-11 metabolism by carboxylesterases (CEs): use of pnb CE as a model
    Monika Wierdl
    Department of Molecular Pharmacology, St Jude Children s Research Hospital, 332 North Lauderdale, Memphis, Tennessee 38105, USA
    Biochemistry 43:1874-82. 2004
    ..As a result, COS-7 cells expressing this mutant were 3-fold less sensitive to CPT-11 than COS-7 cells expressing the wild-type protein...
  42. pmc Analysis of mammalian carboxylesterase inhibition by trifluoromethylketone-containing compounds
    Randy M Wadkins
    Department of Chemistry and Biochemistry, University of Mississippi, USA
    Mol Pharmacol 71:713-23. 2007
    ..These studies indicate that more potent, selective CE inhibitors, containing long alkyl or aromatic groups attached to the thioether chemotype in TFKs, can be developed for use in in vivo enzyme inhibition...
  43. ncbi request reprint Mechanisms of camptothecin resistance by human topoisomerase I mutations
    Jill E Chrencik
    Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Mol Biol 339:773-84. 2004
    ..These results advance our understanding of the mechanism of cell poisoning by camptothecin and suggest specific modifications to the drug that may improve efficacy...
  44. ncbi request reprint A minimal exonuclease domain of WRN forms a hexamer on DNA and possesses both 3'- 5' exonuclease and 5'-protruding strand endonuclease activities
    Yu Xue
    Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Biochemistry 41:2901-12. 2002
    ..Thus, the active form of this minimal exonuclease fragment of human WRN appears to be a hexamer. The implications these results have on our understanding of hWRN's roles in DNA replication and repair are discussed...
  45. ncbi request reprint Regulation of cyp3a gene transcription by the pregnane x receptor
    Bryan Goodwin
    Nuclear Receptor Systems Research, GlaxoSmithKline Research and Development, Research Triangle Park, NC 27709, USA
    Annu Rev Pharmacol Toxicol 42:1-23. 2002
    ..On the other hand, PXR agonists may prove useful in the treatment of diseases in which toxic metabolites accumulate, such as cholestatic liver disease...
  46. pmc Stereoselective hydrolysis of pyrethroid-like fluorescent substrates by human and other mammalian liver carboxylesterases
    Huazhang Huang
    Department of Entomology and Cancer Research Center, University of California, Davis, California 95616, USA
    Chem Res Toxicol 18:1371-7. 2005
    ..The implications these findings have on the design and use of effective pesticides are discussed...

Research Grants22

  1. Structure and Mechanism of Human Topoisomerase I
    MATTHEW REDINBO; Fiscal Year: 2001
    ....
  2. Structure and Function of the Human Pregnane X Receptor
    MATTHEW REDINBO; Fiscal Year: 2006
    ..5. Elucidate structures of hPXR in complexes with large drugs like rifampicin and taxol. 6. Examine structures of mouse and rabbit PXR to determine why different species respond to distinct xenobiotics. ..
  3. Improving CPT-11 Efficacy Using Structural Biology
    MATTHEW REDINBO; Fiscal Year: 2007
    ..2- 2 Description, ..
  4. Novel Protein-Based Therapeutics for Nerve Agent Detoxification
    MATTHEW REDINBO; Fiscal Year: 2007
    ..It is clear that effective catalytic countermeasures are urgently needed to safely protect military personnel and civilian first-responders from attacks involving chemical weapons. ..
  5. Structure and Inhibition of the Conjugative DNA Relaxase-Helicase
    MATTHEW REDINBO; Fiscal Year: 2009
    ..This project will extend our preliminary structural and chemical biology discoveries with the goal of understanding the molecular basis of DNA transfer and developing drugs that potently kill antibiotic resistant bacteria. ..
  6. Improving CPT-11 Efficacy Using Structural and Chemical Biology
    MATTHEW REDINBO; Fiscal Year: 2009
    ....
  7. Improving CPT-11 Efficacy Using Structural and Chemical Biology
    MATTHEW REDINBO; Fiscal Year: 2010
    ....
  8. Structure and Inhibition of the Conjugative DNA Relaxase-Helicase
    MATTHEW REDINBO; Fiscal Year: 2010
    ..This project will extend our preliminary structural and chemical biology discoveries with the goal of understanding the molecular basis of DNA transfer and developing drugs that potently kill antibiotic resistant bacteria. ..
  9. Improving CPT-11 Efficacy Using Structural Biology
    MATTHEW REDINBO; Fiscal Year: 2006
    ..5. Assess the efficacy of drug activation and the ability to sensitize cells expressing mutant forms of rCE, hCE1 and hiCE to CPT-11. ..
  10. Structure and Function of the Human Pregnane X Receptor
    MATTHEW REDINBO; Fiscal Year: 2005
    ..5. Elucidate structures of hPXR in complexes with large drugs like rifampicin and taxol. 6. Examine structures of mouse and rabbit PXR to determine why different species respond to distinct xenobiotics. ..
  11. Structure and Mechanism of Human Topoisomerase I
    MATTHEW REDINBO; Fiscal Year: 2002
    ....
  12. Structure and Function of the Human Pregnane X Receptor
    MATTHEW REDINBO; Fiscal Year: 2002
    ..5. Elucidate structures of hPXR in complexes with large drugs like rifampicin and taxol. 6. Examine structures of mouse and rabbit PXR to determine why different species respond to distinct xenobiotics. ..
  13. Improving CPT-11 Efficacy Using Structural Biology
    MATTHEW REDINBO; Fiscal Year: 2003
    ..5. Assess the efficacy of drug activation and the ability to sensitize cells expressing mutant forms of rCE, hCE1 and hiCE to CPT-11. ..
  14. Structure and Mechanism of Human Topoisomerase I
    MATTHEW REDINBO; Fiscal Year: 2003
    ....
  15. Structure and Function of the Human Pregnane X Receptor
    MATTHEW REDINBO; Fiscal Year: 2003
    ..5. Elucidate structures of hPXR in complexes with large drugs like rifampicin and taxol. 6. Examine structures of mouse and rabbit PXR to determine why different species respond to distinct xenobiotics. ..
  16. Structure and Mechanism of Human Topoisomerase I
    MATTHEW REDINBO; Fiscal Year: 2004
    ....
  17. Structure and Function of the Human Pregnane X Receptor
    MATTHEW REDINBO; Fiscal Year: 2004
    ..5. Elucidate structures of hPXR in complexes with large drugs like rifampicin and taxol. 6. Examine structures of mouse and rabbit PXR to determine why different species respond to distinct xenobiotics. ..
  18. Structure and Inhibition of the Conjugative DNA Relaxase-Helicase
    MATTHEW REDINBO; Fiscal Year: 2009
    ..This project will extend our preliminary structural and chemical biology discoveries with the goal of understanding the molecular basis of DNA transfer and developing drugs that potently kill antibiotic resistant bacteria. ..