Hari A Reddi

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Bone morphogenetic proteins and skeletal development: the kidney-bone connection
    A H Reddi
    Center for Tissue Regeneration and Repair, Department of Orthopaedic Surgery, University of California, Davis, School of Medicine, Sacramento 95817, USA
    Pediatr Nephrol 14:598-601. 2000
  2. ncbi request reprint Prevention of atrophic nonunion development by recombinant human bone morphogenetic protein-7
    Takeshi Makino
    Department of Orthopaedic Surgery and Center for Tissue Regeneration and Repair, University of California, Davis Sacramento, 95817, USA
    J Orthop Res 23:632-8. 2005
  3. ncbi request reprint Diverse biological effect and Smad signaling of bone morphogenetic protein 7 in prostate tumor cells
    Shangxin Yang
    Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Cancer Res 65:5769-77. 2005
  4. pmc Induction of superficial zone protein (SZP)/lubricin/PRG 4 in muscle-derived mesenchymal stem/progenitor cells by transforming growth factor-β1 and bone morphogenetic protein-7
    Jose A Andrades
    Department of Cell Biology, Genetic and Physiology, Faculty of Sciences, Networking Biomedical Research Center in Bioengineering, Biomaterials and Nanomedicine CIBER BBN, University of Malaga, 29071 Malaga, Spain
    Arthritis Res Ther 14:R72. 2012
  5. pmc Interplay between bone morphogenetic proteins and cognate binding proteins in bone and cartilage development: noggin, chordin and DAN
    A H Reddi
    Center for Tissue Regeneration and Repair, Department of Orthopaedic Surgery, University of California Davis, School of Medicine, Sacramento, California 95817, USA
    Arthritis Res 3:1-5. 2001
  6. pmc Cartilage morphogenetic proteins: role in joint development, homoeostasis, and regeneration
    A H Reddi
    Centre for Tissue Regeneration and Repair, Department of Orthopaedic Surgery, University of California, Davis School of Medicine, Sacramento, California 95817, USA
    Ann Rheum Dis 62:ii73-8. 2003
  7. ncbi request reprint Marshall R. Urist: a renaissance scientist and orthopaedic surgeon
    A Hari Reddi
    Center for Tissue Regeneration and Repair, Department of Orthopaedic Surgery, School of Medicine, University of California, Davis, Sacramento 95817, USA
    J Bone Joint Surg Am 85:3-7. 2003
  8. ncbi request reprint Mechanisms of tumor metastasis to the bone: challenges and opportunities
    A Hari Reddi
    Center for Tissue Regeneration and Repair, University of California, School of Medicine, Sacramento, California 95817, USA
    J Bone Miner Res 18:190-4. 2003
  9. doi request reprint Stimulation of the side population fraction of ATDC5 chondroprogenitors by hypoxia
    Koshi N Kishimoto
    Center for Tissue Regeneration and Repair, Department of Orthopaedic Surgery, School of Medicine, University of California at Davis, Sacramento, CA 95817, USA
    Cell Biol Int 33:1222-9. 2009
  10. pmc Aging, osteoarthritis and transforming growth factor-beta signaling in cartilage
    A Hari Reddi
    Lawrence J Ellison Center for Tissue Regeneration, University of California, Davis, School of Medicine, Sacramento, CA 95817, USA
    Arthritis Res Ther 8:101. 2006

Research Grants

  1. Chondroleukin and Articular Cartilage
    A Reddi; Fiscal Year: 2005

Collaborators

Detail Information

Publications65

  1. ncbi request reprint Bone morphogenetic proteins and skeletal development: the kidney-bone connection
    A H Reddi
    Center for Tissue Regeneration and Repair, Department of Orthopaedic Surgery, University of California, Davis, School of Medicine, Sacramento 95817, USA
    Pediatr Nephrol 14:598-601. 2000
    ..In conclusion, we are beginning to unravel the mysteries of kidney-bone connection with special reference to pediatric nephrology...
  2. ncbi request reprint Prevention of atrophic nonunion development by recombinant human bone morphogenetic protein-7
    Takeshi Makino
    Department of Orthopaedic Surgery and Center for Tissue Regeneration and Repair, University of California, Davis Sacramento, 95817, USA
    J Orthop Res 23:632-8. 2005
    ..In conclusion, we have demonstrated that the immediate application of BMP-7 may rescue the fracture healing process and prevent the development of nonunion following severe periosteal disruption...
  3. ncbi request reprint Diverse biological effect and Smad signaling of bone morphogenetic protein 7 in prostate tumor cells
    Shangxin Yang
    Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Cancer Res 65:5769-77. 2005
    ....
  4. pmc Induction of superficial zone protein (SZP)/lubricin/PRG 4 in muscle-derived mesenchymal stem/progenitor cells by transforming growth factor-β1 and bone morphogenetic protein-7
    Jose A Andrades
    Department of Cell Biology, Genetic and Physiology, Faculty of Sciences, Networking Biomedical Research Center in Bioengineering, Biomaterials and Nanomedicine CIBER BBN, University of Malaga, 29071 Malaga, Spain
    Arthritis Res Ther 14:R72. 2012
    ....
  5. pmc Interplay between bone morphogenetic proteins and cognate binding proteins in bone and cartilage development: noggin, chordin and DAN
    A H Reddi
    Center for Tissue Regeneration and Repair, Department of Orthopaedic Surgery, University of California Davis, School of Medicine, Sacramento, California 95817, USA
    Arthritis Res 3:1-5. 2001
    ..In addition, BMP actions may be potentiated by twisted gastrulation. BMPs and their binding proteins may play a critical role in regeneration of cartilage in osteoarthritis...
  6. pmc Cartilage morphogenetic proteins: role in joint development, homoeostasis, and regeneration
    A H Reddi
    Centre for Tissue Regeneration and Repair, Department of Orthopaedic Surgery, University of California, Davis School of Medicine, Sacramento, California 95817, USA
    Ann Rheum Dis 62:ii73-8. 2003
    ..Bone has the highest potential for regeneration. On the other hand, articular cartilage is recalcitrant to repair...
  7. ncbi request reprint Marshall R. Urist: a renaissance scientist and orthopaedic surgeon
    A Hari Reddi
    Center for Tissue Regeneration and Repair, Department of Orthopaedic Surgery, School of Medicine, University of California, Davis, Sacramento 95817, USA
    J Bone Joint Surg Am 85:3-7. 2003
  8. ncbi request reprint Mechanisms of tumor metastasis to the bone: challenges and opportunities
    A Hari Reddi
    Center for Tissue Regeneration and Repair, University of California, School of Medicine, Sacramento, California 95817, USA
    J Bone Miner Res 18:190-4. 2003
    ..Thus, the prostate/breast cancer bone interface and continuum has continuously presented challenges and opportunities and were discussed at a recent workshop...
  9. doi request reprint Stimulation of the side population fraction of ATDC5 chondroprogenitors by hypoxia
    Koshi N Kishimoto
    Center for Tissue Regeneration and Repair, Department of Orthopaedic Surgery, School of Medicine, University of California at Davis, Sacramento, CA 95817, USA
    Cell Biol Int 33:1222-9. 2009
    ..The results demonstrate that the SP fraction was stimulated by hypoxia and chondrogenic properties of SP and non-SP fraction of ATDC5 cells were similar...
  10. pmc Aging, osteoarthritis and transforming growth factor-beta signaling in cartilage
    A Hari Reddi
    Lawrence J Ellison Center for Tissue Regeneration, University of California, Davis, School of Medicine, Sacramento, CA 95817, USA
    Arthritis Res Ther 8:101. 2006
    ..This commentary places this discovery in the context of anabolic and catabolic signals and articular cartilage homeostasis in the joint...
  11. doi request reprint Nanomaterials and hydrogel scaffolds for articular cartilage regeneration
    A Hari Reddi
    Department of Orthopaedic Surgery, The Lawrence J Ellison Center for Tissue Regeneration and Repair, School of Medicine, University of California, Davis, Sacramento, California 95817, USA
    Tissue Eng Part B Rev 17:301-5. 2011
    ..This brief review focuses on the scaffold, with special emphasis on hydrogels and nanomaterials for the assembly of tissue-engineered cartilage, and ultimately leading to the total regeneration of articular cartilage in the joints...
  12. ncbi request reprint Initiation and promotion of endochrondral bone formation by bone morphogenetic proteins: potential implications for avian tibial dyschondroplasia
    A H Reddi
    Center for Tissue Regeneration and Repair, Department of Orthopaedic Surgery University of California, Davis, Sacramento 95817, USA
    Poult Sci 79:978-81. 2000
    ..Because there is a persistent defect in endochondral bone formation in the epiphysed growth plate in tibial dyschondroplasia in poultry, it is likely that BMP signaling mechanisms may be impaired...
  13. ncbi request reprint Morphogenesis and tissue engineering of bone and cartilage: inductive signals, stem cells, and biomimetic biomaterials
    A H Reddi
    Center for Tissue Regeneration and Repair and Department of Orthopaedic Surgery, University of California, Davis, Medical Center, Sacramento, California, USA
    Tissue Eng 6:351-9. 2000
    ..Thus, the rules of architecture for tissue engineering are an imitation of the laws of developmental biology and morphogenesis, and thus may be universal for all tissues, including bones and joints...
  14. ncbi request reprint Morphogenetic messages are in the extracellular matrix: biotechnology from bench to bedside
    A H Reddi
    Center for Tissue Regeneration and Repair and Department of Orthopaedic Surgery, University of California, Davis, Medical Center, Sacramento, CA 95817, USA
    Biochem Soc Trans 28:345-9. 2000
    ..Soluble morphogens are kept in the solid state by extracellular matrix. In this sense Nature used the principles of affinity matrices long before humans patented the principle of affinity chromatography...
  15. ncbi request reprint Role of morphogenetic proteins in skeletal tissue engineering and regeneration
    A H Reddi
    Center for Tissue Regeneration and Repair, University of California Davis, Medical Center, Sacramento 95817, USA
    Nat Biotechnol 16:247-52. 1998
    ..Rules of tissue architecture elucidated in bone morphogenesis may provide insights into tissue engineering and be universally applicable for all organs/tissues, including bones and joints...
  16. doi request reprint Dependence of nanoscale friction and adhesion properties of articular cartilage on contact load
    S M T Chan
    Center for Tissue Regeneration and Repair, University of California, Davis, Medical Center, Sacramento, CA 95817, USA
    J Biomech 44:1340-5. 2011
    ....
  17. ncbi request reprint Microfracture and bone morphogenetic protein 7 (BMP-7) synergistically stimulate articular cartilage repair
    A C Kuo
    The Center for Tissue Regeneration and Repair, Department of Orthopaedic Surgery, University of California, Davis, 4635 Second Avenue, Room 2000, Sacramento, CA 95817, USA
    Osteoarthritis Cartilage 14:1126-35. 2006
    ..We determined the effects of these two treatments alone and in combination on the quality and quantity of repair tissue formed in a model of full-thickness articular cartilage injury in adolescent rabbits...
  18. doi request reprint The role of lubricant entrapment at biological interfaces: reduction of friction and adhesion in articular cartilage
    S M T Chan
    Center for Tissue Regeneration and Repair, University of California, Davis, Medical Center, Sacramento, CA 95817, USA
    J Biomech 44:2015-20. 2011
    ..The results of this study reveal significant differences in the friction and adhesion properties between high- and low-load-bearing joint regions and elucidate the role of trapped lubricants in cartilage tribology...
  19. pmc Identification of superficial zone articular chondrocyte stem/progenitor cells
    Shintaro Hattori
    Center for Tissue Regeneration and Repair, University of California at Davis, School of Medicine, Research Building I, Room 2000, 4635 Second Avenue, Sacramento, CA 95817, USA
    Biochem Biophys Res Commun 358:99-103. 2007
    ..Our results demonstrate the presence of stem/progenitor cells in the SP fraction isolated from the surface zone of bovine cartilage and have the ability to specifically differentiate towards the superficial zone articular chondrocyte...
  20. ncbi request reprint Cartilage morphogenesis: role of bone and cartilage morphogenetic proteins, homeobox genes and extracellular matrix
    A H Reddi
    Department of Orthopaedic Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Matrix Biol 14:599-606. 1995
    ..An avalanche of recent advances from seemingly disparate areas bodes well for the complete elucidation of the molecular basis of morphogenesis of cartilage, the architectural blue-print for the skeleton...
  21. doi request reprint Induction of chondrogenesis and expression of superficial zone protein (SZP)/lubricin by mesenchymal progenitors in the infrapatellar fat pad of the knee joint treated with TGF-beta1 and BMP-7
    Sang Yang Lee
    Center for Tissue Regeneration and Repair, Department of Orthopaedic Surgery, University of California 4635 Second Avenue, Room 2000, Sacramento, CA 95817, USA
    Biochem Biophys Res Commun 376:148-53. 2008
    ....
  22. doi request reprint Regulation of the friction coefficient of articular cartilage by TGF-beta1 and IL-1beta
    Grayson DuRaine
    Center for Tissue Regeneration and Repair, Department of Orthopaedic Surgery, University of California, Davis, Medical Center, Sacramento, CA 95817, USA
    J Orthop Res 27:249-56. 2009
    ..These findings demonstrate that the low friction of articular cartilage can be modified by TGF-beta1 and IL-1beta treatment and that the friction coefficient depends on multiple factors, including SZP localization and surface roughness...
  23. pmc Mechanical compression of articular cartilage induces chondrocyte proliferation and inhibits proteoglycan synthesis by activation of the ERK pathway: implications for tissue engineering and regenerative medicine
    James A Ryan
    Center for Tissue Regeneration and Repair, Lawrence Ellison Musculoskeletal Research Center, Department of Orthopedic Surgery, University of California at Davis, Sacramento, CA 95817, USA
    J Tissue Eng Regen Med 3:107-16. 2009
    ..In conclusion, the ERK 1/2 pathway is involved in the proliferative and biosynthetic response of chondrocytes following acute static mechanical compression...
  24. ncbi request reprint Thermoreversible hydrogel scaffolds for articular cartilage engineering
    John P Fisher
    Department of Orthopaedic Surgery, Center for Tissue Regeneration and Repair, School of Medicine, University of California Davis, Research Building I, Room 2000, 4635 Second Avenue, Sacramento, CA 95817, USA
    J Biomed Mater Res A 71:268-74. 2004
    ..These results indicate that the temperature-responsive P(PF-co-EG) hydrogels are suitable for chondrocyte delivery for articular cartilage repair...
  25. ncbi request reprint Differential regulation of lubricin/superficial zone protein by transforming growth factor beta/bone morphogenetic protein superfamily members in articular chondrocytes and synoviocytes
    Takahiro Niikura
    University of California, Davis School of Medicine, Sacramento, CA 95817, USA
    Arthritis Rheum 56:2312-21. 2007
    ..To investigate the role of transforming growth factor beta (TGFbeta)/bone morphogenetic protein (BMP) superfamily members on accumulation of superficial zone protein (SZP) in articular chondrocytes and synoviocytes...
  26. pmc Immunolocalization of IL-17A, IL-17B, and their receptors in chondrocytes during fracture healing
    Takeshi Kokubu
    Center for Tissue Regeneration and Repair, Department of Orthopedics, University of California, School of Medicine, 4635 Second Avenue, Sacramento, CA 95817, USA
    J Histochem Cytochem 56:89-95. 2008
    ..Moreover, we found significant parallels to the localization of these cytokines and their receptors in chondrocytes during an endochondral differentiation program in the epiphyseal growth plate...
  27. ncbi request reprint Bone morphogenetic protein signaling in articular chondrocyte differentiation
    Ayako Nishihara
    Center for Tissue Regeneration and Repair and Department of Orthopedic Surgery, University of California Davis, Medical Center, Sacramento, CA 95817, USA
    Biochem Biophys Res Commun 301:617-22. 2003
    ..These results together strongly suggest that induction of chondrocyte differentiation by BMP-7 is regulated by Smad pathways...
  28. doi request reprint Profiling microRNA expression in bovine articular cartilage and implications for mechanotransduction
    Walter Dunn
    Lawrence Ellison Center for Tissue Regeneration and Repair, Department of Orthopaedic Surgery, University of California, Davis, Sacramento, CA 95817, USA
    Arthritis Rheum 60:2333-9. 2009
    ..The purpose of this study was to test our hypothesis that miRNA expression profiles in the different articular cartilage zones as well as between regions subjected to different levels of weight-bearing stresses are unique...
  29. doi request reprint Atomic force microscope investigation of the boundary-lubricant layer in articular cartilage
    S M T Chan
    Center for Tissue Regeneration and Repair, Department of Orthopaedic Surgery, University of California, Davis, Sacramento, CA 95817, USA
    Osteoarthritis Cartilage 18:956-63. 2010
    ....
  30. ncbi request reprint Growth/differentiation factor-10: a new member of the transforming growth factor-beta superfamily related to bone morphogenetic protein-3
    N S Cunningham
    Department of Orthopaedic Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Growth Factors 12:99-109. 1995
    ..Gdf10 was mapped to the proximal region of mouse chromosome 14 close to a region known to contain a spontaneous recessive mutation that is associated with a craniofacial defect...
  31. ncbi request reprint Bone morphogenetic protein-7 selectively enhances mechanically induced bone formation
    A J Cheline
    Orthopaedic Research Laboratory, Center for Tissue Regeneration and Repair, University of California at Davis Medical Center, Sacramento 95817, USA
    Bone 31:570-4. 2002
    ..The higher BMP-7 dose more than doubled the load-induced increase in endosteal lamellar bone formation rate, primarily by increasing the amount of bone forming surface...
  32. ncbi request reprint Interleukin-17 family and IL-17 receptors
    T A Moseley
    Department of Orthopaedic Surgery, Center for Tissue Regeneration and Repair, School of Medicine, University of California, Davis, Sacramento, CA 95817, USA
    Cytokine Growth Factor Rev 14:155-74. 2003
    ..This survey reviews the biological actions of IL-17 signaling in cancers, musculoskeletal tissues, the immune system and other tissues...
  33. ncbi request reprint Induction of chondrogenesis and superficial zone protein accumulation in synovial side population cells by BMP-7 and TGF-beta1
    Shintaro Yamane
    Lawrence Ellison Center for Tissue Regeneration and Repair, Department of Orthopaedic Surgery, School of Medicine, University of California, Davis, 4635 Second Avenue, Room 2000, Sacramento, California 95817, USA
    J Orthop Res 26:485-92. 2008
    ..These findings demonstrate that side population cells of synovium differentiate toward an articular chondrocyte phenotype of the surface layer and have direct implications for tissue engineering and regeneration of articular cartilage...
  34. ncbi request reprint Mechanotransduction of bovine articular cartilage superficial zone protein by transforming growth factor beta signaling
    COREY P NEU
    Center for Tissue Regeneration and Repair, University of California, Davis, Medical Center, Sacramento, CA 95817, USA
    Arthritis Rheum 56:3706-14. 2007
    ..This study was undertaken to investigate the mechanotransduction process of expression of superficial zone protein (SZP), a critical joint lubricant...
  35. doi request reprint Mesenchymal progenitor cells derived from synovium and infrapatellar fat pad as a source for superficial zone cartilage tissue engineering: analysis of superficial zone protein/lubricin expression
    Sang Yang Lee
    Department of Orthopaedic Surgery, Lawrence J Ellison Center for Tissue Regeneration and Repair, University of California Davis, Sacramento, California, USA
    Tissue Eng Part A 16:317-25. 2010
    ..In conclusion, both synovium and IFP are promising cell sources for tissue engineering of superficial zone cartilage...
  36. ncbi request reprint Expression of interleukin-17B in mouse embryonic limb buds and regulation by BMP-7 and bFGF
    Zongbing You
    Department of Orthopaedic Surgery, Center for Tissue Regeneration and Repair, School of Medicine, University of California, Davis, Sacramento, CA 95817, USA
    Biochem Biophys Res Commun 326:624-31. 2005
    ..This study provides the first evidence that IL-17B is expressed in the mouse embryonic limb buds and may play a role in chondrogenesis and osteogenesis...
  37. ncbi request reprint Increased accumulation of superficial zone protein (SZP) in articular cartilage in response to bone morphogenetic protein-7 and growth factors
    Afshin Khalafi
    Center for Tissue Regeneration and Repair, Department of Orthopaedic Surgery, University of California Davis, Sacramento, California 95817, USA
    J Orthop Res 25:293-303. 2007
    ..Furthermore, tissue engineering approaches to articular cartilage may depend on the optimal synthesis and assembly of SZP in the superficial zone to ensure functional tissue architecture...
  38. ncbi request reprint Global gene profiling reveals a downregulation of BMP gene expression in experimental atrophic nonunions compared to standard healing fractures
    Takahiro Niikura
    Center for Tissue Regeneration and Repair, Department of Orthopaedic Surgery, University of California, Davis, 4860 Y Street, Suite 3800, Sacramento, California 95817, USA
    J Orthop Res 24:1463-71. 2006
    ..Downregulation in expression of osteogenic BMPs may account for the nonunions of fracture. The balance between BMPs and their endogenous antagonists is critical for optimal fracture healing...
  39. ncbi request reprint Regulation of articular chondrocyte phenotype by bone morphogenetic protein 7, interleukin 1, and cellular context is dependent on the cytoskeleton
    Ruth L Vinall
    Center for Tissue Regeneration and Repair, University of California Davis, Sacramento, California 95817, USA
    Exp Cell Res 272:32-44. 2002
    ..Taken together these data demonstrate that cytoskeletal components play a critical role in the response to morphogens and cytokines in the regulation of chondrocyte phenotype. (c)2001 Elsevier Science...
  40. ncbi request reprint Recombinant human BMP-7 effectively prevents non-union in both young and old rats
    David J Hak
    Department of Orthopaedic Surgery and Center for Tissue Regeneration and Repair, University of California, Davis, Sacramento, California 95817, USA
    J Orthop Res 24:11-20. 2006
    ..In conclusion, rhBMP-7 can effectively stimulate fracture repair in both young (3-month-old) and old (18-month-old) rats. However, the effect of rhBMP-7 on the rate of fracture healing is greater in young rats compared to old rats...
  41. ncbi request reprint Interleukin-17 receptor-like gene is a novel antiapoptotic gene highly expressed in androgen-independent prostate cancer
    Zongbing You
    Center for Tissue Regeneration and Repair, Department of Orthopaedic Surgery, School of Medicine, University of California, Davis, Sacramento, California 95817, USA
    Cancer Res 66:175-83. 2006
    ..Thus, IL-17RL is a potential therapeutic target in the treatment of prostate cancer...
  42. doi request reprint Effects of TGF-β1 on alternative splicing of Superficial Zone Protein in articular cartilage cultures
    G D Duraine
    Lawrence Ellison Center for Tissue Regeneration and Repair, Department of Orthopaedic Surgery, University of California Davis, School of Medicine, Sacramento, CA, United States
    Osteoarthritis Cartilage 19:103-10. 2011
    ..The hypothesis of this study was that between load-bearing, and non-load-bearing locations, of the femoral medial condyle alternative splice isoforms of SZP are different, and regulated by TGF-β1...
  43. pmc The interface of functional biotribology and regenerative medicine in synovial joints
    COREY P NEU
    Department of Orthopaedic Surgery, Center for Tissue Regeneration and Repair, School of Medicine, University of California, Davis, Sacramento, California, USA
    Tissue Eng Part B Rev 14:235-47. 2008
    ..Surface engineering of replacement tissues exhibiting low friction and high wear resistance is examined using articular cartilage as an illustrative model system...
  44. doi request reprint Superficial zone protein (lubricin) in the different tissue compartments of the knee joint: modulation by transforming growth factor beta 1 and interleukin-1 beta
    Sang Yang Lee
    Department of Orthopaedic Surgery, University of California, Davis, Sacramento, CA 95817, USA
    Tissue Eng Part A 14:1799-808. 2008
    ....
  45. doi request reprint Induction of chondrogenesis from human embryonic stem cells without embryoid body formation by bone morphogenetic protein 7 and transforming growth factor beta1
    Toshiyuki Nakagawa
    University of California Davis, Sacramento, CA, USA
    Arthritis Rheum 60:3686-92. 2009
    ....
  46. ncbi request reprint Gene expression profiling of mouse articular and growth plate cartilage
    Shintaro Yamane
    Lawrence Ellison Center for Tissue Regeneration and Repair, Department of Orthopaedic Surgery, School of Medicine, University of California, Davis, Sacramento, California 95817, USA
    Tissue Eng 13:2163-73. 2007
    ..The results of this investigation will be of use in the evaluation of tissue engineered cartilage...
  47. ncbi request reprint Cartilage-derived morphogenetic proteins and cartilage morphogenesis
    A H Reddi
    Department of Orthopaedic Surgery, University of California Davis, School of Medicine, Sacramento 95817, USA
    Microsc Res Tech 43:131-6. 1998
    ..Morphogens bind to extracellular matrix components and assemble a morphogenetic scaffold. Recent advances in CDMPs may aid in articular cartilage repair and regeneration...
  48. ncbi request reprint The temporal sequence of spontaneous repair of osteochondral defects in the knees of rabbits is dependent on the geometry of the defect
    S A Lietman
    Department of Orthopaedic Surgery, The Johns Hopkins University, Baltimore, Maryland 21205, USA
    J Bone Joint Surg Br 84:600-6. 2002
    ..Specifically, the defects of 1 mm first peaked in terms of metachromasia at day 21, those of 2 mm at day 28, followed by defects of 3 mm and 4 mm. The healing of the subchondral bone was slowest in defects of 1 mm...
  49. ncbi request reprint Bone morphogenetic protein (BMP)-6 signaling and BMP antagonist noggin in prostate cancer
    Dominik R Haudenschild
    Center for Tissue Regeneration and Repair, Department of Orthopedic Surgery, School of Medicine, University of California, Davis, Sacramento, California 95817, USA
    Cancer Res 64:8276-84. 2004
    ....
  50. ncbi request reprint Development of an atrophic nonunion model and comparison to a closed healing fracture in rat femur
    Takeshi Kokubu
    Department of Orthopaedic Surgery and Center for Tissue Regeneration and Repair, University of California, Davis, 4860 Y Street, Suite 3800, Sacramento 95817, USA
    J Orthop Res 21:503-10. 2003
    ..In conclusion, we have developed a reproducible atrophic nonunion model in the rat femur that simulates the clinical condition in which there is periosteal disruption but no bone defect...
  51. ncbi request reprint Thyroxine downregulates Sox9 and promotes chondrocyte hypertrophy
    Yasunori Okubo
    Center for Tissue Regeneration and Repair, Department of Orthopaedic Surgery, School of Medicine, University of California, Davis, Sacramento, CA 95817, USA
    Biochem Biophys Res Commun 306:186-90. 2003
    ..Thus, T4 acts directly on chondrocytes. In conclusion, we demonstrated that T4 enhances the cellular and molecular events of terminal differentiation and hypertrophy of chondrocytes in the three-dimensional cultures...
  52. ncbi request reprint Soluble and transmembrane isoforms of novel interleukin-17 receptor-like protein by RNA splicing and expression in prostate cancer
    Dominik Haudenschild
    Center for Tissue Regeneration and Repair and Department of Orthopaedic Surgery, School of Medicine, University of California, Davis, Sacramento, California 95817, USA
    J Biol Chem 277:4309-16. 2002
    ..Using antibodies directed at the cytoplasmic and extracellular domains of this protein, we investigated its localization and found that it was expressed in a variety of normal human tissues including prostate and in prostate cancer...
  53. ncbi request reprint Efficacy of osteogenic protein-1 in a challenging multilevel fusion model
    Matthew J Mermer
    Department of Orthopaedic Surgery, University of California, Davis, Sacramento 95817, USA
    Spine (Phila Pa 1976) 29:249-56. 2004
    ..A therapeutic study compared the influence of osteogenic protein-1 to autograft and collagen carrier in multilevel sheep spine fusions...
  54. ncbi request reprint Generation of interleukin-17 receptor-like protein (IL-17RL) in prostate by alternative splicing of RNA
    Dominik R Haudenschild
    Center for Tissue Regeneration and Repair, Department of Orthopaedic Surgery, School of Medicine, University of California, Sacramento, California 95817, USA
    Prostate 66:1268-74. 2006
    ..Predominant IL-17RL splice isoform variants have not been identified, hindering functional studies...
  55. ncbi request reprint Estrogen-dependent actions of bone morphogenetic protein-7 on spine fusion in rats
    Payam Moazzaz
    Department of Orthopaedic Surgery, University of California, Davis, Sacramento, CA 95817, USA
    Spine (Phila Pa 1976) 30:1706-11. 2005
    ..Intertransverse process spinal fusion using recombinant human bone morphogenetic protein-7 (rhBMP-7) was performed in intact and ovariectomized female rats...
  56. doi request reprint Nonunions and the potential of stem cells in fracture-healing
    Susan S Tseng
    Center for Tissue Regeneration and Repair, Department of Orthopaedic Surgery, University of California, Davis, 4635 Second Avenue, Research Building 1, Room 2000, Sacramento, CA 95817, USA
    J Bone Joint Surg Am 90:92-8. 2008
    ..This review highlights the recent progress in the utilization of stem cells and cell-based gene therapy in promoting fracture-healing and its potential utility in the clinical setting...
  57. doi request reprint Cultivating liver cells on printed arrays of hepatocyte growth factor
    Caroline N Jones
    Department of Biomedical Engineering, University of California, Davis, 451 East Health Sciences Dr 2519, Davis, CA 95616, USA
    Biomaterials 30:3733-41. 2009
    ..In the future, the number of growth factors printed on ECM microarrays will be expanded to enable multiplexed and combinatorial screening of inducers of cellular differentiation or proliferation...
  58. ncbi request reprint Are recombinant human bone morphogenetic protein-7 and tobramycin compatible? An experiment in rats
    Alan T Kawaguchi
    Alpine Orthopaedic Medical Group Inc, 333 East Alpine Avenue, Stockton, CA 95204, USA
    J Orthop Trauma 18:225-32. 2004
    ..To evaluate the effects of local antibiotics on bone morphogenetic protein-induced new bone formation in vivo...
  59. ncbi request reprint Bone morphogenetic protein 7 protects prostate cancer cells from stress-induced apoptosis via both Smad and c-Jun NH2-terminal kinase pathways
    Shangxin Yang
    Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Cancer Res 66:4285-90. 2006
    ....
  60. ncbi request reprint Characterization of growth factor-binding structures in heparin/heparan sulfate using an octasaccharide library
    Satoko Ashikari-Hada
    Institute for Molecular Science of Medicine, Aichi Medical University, Nagakute, Aichi 480 1195, Japan
    J Biol Chem 279:12346-54. 2004
    ..Thus, the library may provide new reagents to specifically regulate bindings of the growth factors to HS...
  61. ncbi request reprint The application of bone morphogenetic proteins to dental tissue engineering
    Misako Nakashima
    Faculty of Dental Science, Kyushu University, Fukuoka 812 8582, Japan
    Nat Biotechnol 21:1025-32. 2003
    ..In the near term, these advances are likely to be applied to endodontics and periodontal surgery; ultimately, they may facilitate approaches to regenerating whole teeth for use in tooth replacement...
  62. ncbi request reprint Effects of selected growth factors on porcine meniscus in chemically defined medium
    Steven A Lietman
    Department of Orthopedic Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD 21205 0882, USA
    Orthopedics 26:799-803. 2003
    ..The current study provides data as to which growth factors might prove most useful in the maintenance and repair of menisci...
  63. ncbi request reprint Acceleration of regenerate ossification during distraction osteogenesis with recombinant human bone morphogenetic protein-7
    Yoshihiko Mizumoto
    J Bone Joint Surg Am 85:124-30. 2003
    ..In the present study, we examined the effect of a single dose of recombinant human bone morphogenetic protein-7 (rhBMP-7) on the rate of new-bone formation during distraction osteogenesis in the rat...
  64. doi request reprint A novel bone morphogenetic protein signaling in heterotypic cell interactions in prostate cancer
    Shangxin Yang
    Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Cancer Res 68:198-205. 2008
    ....
  65. ncbi request reprint Osteoinduction by a collagen mineral composite combined with isologous bone marrow in a subcutaneous rat model
    Mark Alvis
    NeuColl, Inc, Campbell, Calif 95008, USA
    Orthopedics 26:77-80. 2003
    ..38 units/mg) was significantly higher than any other group (P<.001 for all comparisons). This study demonstrates that Collagraft plus bone marrow is an osteoinductive matrix...

Research Grants4

  1. Chondroleukin and Articular Cartilage
    A Reddi; Fiscal Year: 2005
    ..Aim 2A. To identify the cognate receptors of lL-17B in articular chondrocytes. Aim 2B. To examine the hypothesis that the novel lL-17 receptor-like molecule (IL-1 7RL) is a functional receptor in articular cartilage. ..