JANE RECKELHOFF

Summary

Affiliation: University of Mississippi Medical Center
Country: USA

Publications

  1. ncbi request reprint Gender differences in hypertension in spontaneously hypertensive rats: role of androgens and androgen receptor
    J F Reckelhoff
    Department of Physiology and Biophysics, The Center for Excellence in Cardiovascular Renal Research, University of Mississippi Medical Center, Jackson, MS 39216 4505, USA
    Hypertension 34:920-3. 1999
  2. ncbi request reprint Testosterone supplementation in aging men and women: possible impact on cardiovascular-renal disease
    Jane F Reckelhoff
    Dept of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS 39216 4505, USA
    Am J Physiol Renal Physiol 289:F941-8. 2005
  3. ncbi request reprint Role of oxidative stress in the sex differences in blood pressure in spontaneously hypertensive rats
    Lourdes A Fortepiani
    Department of Physiology and Biophysics, The Center for Excellence in Cardiovascular Renal Research, University of Mississippi Medical Center, Jackson, Mississippi, USA
    J Hypertens 23:801-5. 2005
  4. doi request reprint Sex and sex steroids in cardiovascular-renal physiology and pathophysiology
    Jane F Reckelhoff
    Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi 39216 4505, USA
    Gend Med 5:S1-2. 2008
  5. ncbi request reprint Sex steroids, cardiovascular disease, and hypertension: unanswered questions and some speculations
    Jane F Reckelhoff
    Department of Physiology and Biophysics and The Center for Excellence in Cardiovascular and Renal Research, University of Mississippi Medical Center, 2500 N State St, Jackson, MS 39216, USA
    Hypertension 45:170-4. 2005
  6. ncbi request reprint Novel mechanisms responsible for postmenopausal hypertension
    Jane F Reckelhoff
    Department of Physiology and Biophysics, University of Mississippi Medical Center, 2500 N State Street, Jackson, MS 39216, USA
    Hypertension 43:918-23. 2004
  7. ncbi request reprint Gender differences in the regulation of blood pressure
    J F Reckelhoff
    Department of Physiology and Biophysics and The Center for Excellence in Cardiovascular Renal Research, University of Mississippi Medical Center, Jackson 39216 4505, USA
    Hypertension 37:1199-208. 2001
  8. ncbi request reprint Subpressor doses of angiotensin II increase plasma F(2)-isoprostanes in rats
    J F Reckelhoff
    Department of Physiology and Biophysics and The Center for Excellence for Cardiovascular Renal Research, University of Mississippi Medical Center, Jackson 39216 4505, USA
    Hypertension 35:476-9. 2000
  9. ncbi request reprint Gender differences in development of hypertension in spontaneously hypertensive rats: role of the renin-angiotensin system
    J F Reckelhoff
    Department of Physiology and Biophysics, The Center for Excellence in Cardiovascular Renal Research, University of Mississippi Medical Center, Jackson 39216 4505, USA
    Hypertension 35:480-3. 2000
  10. ncbi request reprint Characterization of an animal model of postmenopausal hypertension in spontaneously hypertensive rats
    Lourdes A Fortepiani
    Department of Physiology and Biophysics, University of Mississippi Medical Center, 2500 N State St, Jackson, MS 39216 4505, USA
    Hypertension 41:640-5. 2003

Collaborators

Detail Information

Publications42

  1. ncbi request reprint Gender differences in hypertension in spontaneously hypertensive rats: role of androgens and androgen receptor
    J F Reckelhoff
    Department of Physiology and Biophysics, The Center for Excellence in Cardiovascular Renal Research, University of Mississippi Medical Center, Jackson, MS 39216 4505, USA
    Hypertension 34:920-3. 1999
    ..There were no differences in glomerular filtration rate among the groups. These data indicate that hypertension in male SHR is mediated via the androgen receptor and does not require conversion of testosterone to dihydrotestosterone...
  2. ncbi request reprint Testosterone supplementation in aging men and women: possible impact on cardiovascular-renal disease
    Jane F Reckelhoff
    Dept of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS 39216 4505, USA
    Am J Physiol Renal Physiol 289:F941-8. 2005
    ..This review presents an overview of the data from human and animal studies in which the role of androgens in promoting renal and cardiovascular diseases has been investigated...
  3. ncbi request reprint Role of oxidative stress in the sex differences in blood pressure in spontaneously hypertensive rats
    Lourdes A Fortepiani
    Department of Physiology and Biophysics, The Center for Excellence in Cardiovascular Renal Research, University of Mississippi Medical Center, Jackson, Mississippi, USA
    J Hypertens 23:801-5. 2005
    ..The hypothesis was tested that differences in oxidative stress play a role in the sex differences in the development and maintenance of hypertension in spontaneously hypertensive rats (SHR)...
  4. doi request reprint Sex and sex steroids in cardiovascular-renal physiology and pathophysiology
    Jane F Reckelhoff
    Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi 39216 4505, USA
    Gend Med 5:S1-2. 2008
  5. ncbi request reprint Sex steroids, cardiovascular disease, and hypertension: unanswered questions and some speculations
    Jane F Reckelhoff
    Department of Physiology and Biophysics and The Center for Excellence in Cardiovascular and Renal Research, University of Mississippi Medical Center, 2500 N State St, Jackson, MS 39216, USA
    Hypertension 45:170-4. 2005
  6. ncbi request reprint Novel mechanisms responsible for postmenopausal hypertension
    Jane F Reckelhoff
    Department of Physiology and Biophysics, University of Mississippi Medical Center, 2500 N State Street, Jackson, MS 39216, USA
    Hypertension 43:918-23. 2004
    ..In this review, some of the possible mechanisms that could play a role in postmenopausal hypertension are discussed, as well as the characteristics of the aged female SHR as a model to study...
  7. ncbi request reprint Gender differences in the regulation of blood pressure
    J F Reckelhoff
    Department of Physiology and Biophysics and The Center for Excellence in Cardiovascular Renal Research, University of Mississippi Medical Center, Jackson 39216 4505, USA
    Hypertension 37:1199-208. 2001
    ....
  8. ncbi request reprint Subpressor doses of angiotensin II increase plasma F(2)-isoprostanes in rats
    J F Reckelhoff
    Department of Physiology and Biophysics and The Center for Excellence for Cardiovascular Renal Research, University of Mississippi Medical Center, Jackson 39216 4505, USA
    Hypertension 35:476-9. 2000
    ..Whether oxidative stress plays a causative role in Ang II-mediated slow-response hypertension or is secondary to the hypertension is not clear from these data and will require further study...
  9. ncbi request reprint Gender differences in development of hypertension in spontaneously hypertensive rats: role of the renin-angiotensin system
    J F Reckelhoff
    Department of Physiology and Biophysics, The Center for Excellence in Cardiovascular Renal Research, University of Mississippi Medical Center, Jackson 39216 4505, USA
    Hypertension 35:480-3. 2000
    ..However, the data further suggest that androgens promote the exacerbation of hypertension in male SHR via a mechanism involving the renin-angiotensin system...
  10. ncbi request reprint Characterization of an animal model of postmenopausal hypertension in spontaneously hypertensive rats
    Lourdes A Fortepiani
    Department of Physiology and Biophysics, University of Mississippi Medical Center, 2500 N State St, Jackson, MS 39216 4505, USA
    Hypertension 41:640-5. 2003
    ..These data suggest that the PMR rats, but not ovx rats, may be a suitable model for the study of postmenopausal hypertension, and that oxidative stress plays a role in the increased BP...
  11. ncbi request reprint Sex differences in oxidative stress and the impact on blood pressure control and cardiovascular disease
    Julio C Sartori-Valinotti
    Department of Physiology and Biophysics and The Center of Excellence in Cardiovascular Renal Research, University of Mississippi Medical Center, Jackson, Mississippi 39216 4504, USA
    Clin Exp Pharmacol Physiol 34:938-45. 2007
    ..Furthermore, anti-oxidant therapy in humans often does not ameliorate, or even attenuate, the negative cardiovascular consequences of increased oxidative stress. Our studies in SHR shed light on why these outcomes occur...
  12. doi request reprint Sex differences in the pressor response to angiotensin II when the endogenous renin-angiotensin system is blocked
    Julio C Sartori-Valinotti
    Department of Physiology and Biophysics, The Center for Excellence in Cardiovascular Renal Research, University of Mississippi Medical Center, Jackson, MS 39216 4505, USA
    Hypertension 51:1170-6. 2008
    ..With ACEI, MAP in females on normal salt is more responsive to Ang II but is independent of oxidative stress or renal injury. MAP in males is salt-sensitive with Ang II, which may be mediated by oxidative stress and renal injury...
  13. pmc Sex differences in control of blood pressure: role of oxidative stress in hypertension in females
    Arnaldo Lopez-Ruiz
    Dept of Physiology and Biophysics, Univ of Mississippi Medical Center, 2500 North State St, Jackson, MS 39216 4505, USA
    Am J Physiol Heart Circ Physiol 295:H466-74. 2008
    ..As such, future clinical trials should be designed and powered to evaluate the effects of oxidative stress on blood pressure separately in men and women...
  14. pmc Refractory blood pressure in female SHR to increased oxidative stress is not mediated by NO or by upregulation of renal antioxidant enzymes
    Arnaldo F Lopez-Ruiz
    Dept of Physiology and Biophysics, Univ of Mississippi Medical Center, 2500 North State St, Jackson, MS 39216 4505, USA
    Am J Physiol Regul Integr Comp Physiol 298:R266-71. 2010
    ....
  15. ncbi request reprint Systemic arterial pressure response to two weeks of Tempol therapy in SHR: involvement of NO, the RAS, and oxidative stress
    Licy Yanes
    Department of Physiology and Biophysics, Univ of Mississippi Medical Center, 2500 N State St, Jackson, MS 39216 4505, USA
    Am J Physiol Regul Integr Comp Physiol 288:R903-8. 2005
    ..These data suggest that, in hypertensive individuals with endothelial damage and chronic NO deficiency, antioxidants may be able to reduce oxidative stress but not blood pressure...
  16. ncbi request reprint Sexual dimorphism in the renin-angiotensin system in aging spontaneously hypertensive rats
    Licy L Yanes
    Department of Physiology and Biophysics, University of Mississippi Medical Center, 2500 N State St, Jackson, MS 39216 4505, USA
    Am J Physiol Regul Integr Comp Physiol 291:R383-90. 2006
    ....
  17. ncbi request reprint Role of androgens in mediating renal injury in aging SHR
    Lourdes A Fortepiani
    Department of Physiology and Biophysics, University of Mississippi Medical Center, 2500 North State St, Jackson, MS 39216 4505, USA
    Hypertension 42:952-5. 2003
    ..The data support the hypothesis that despite a reduction in testosterone with age, androgens play an important role in age-related renal injury and dysfunction in SHR...
  18. pmc Postmenopausal hypertension: role of the Renin-Angiotensin system
    Licy L Yanes
    Department of Physiology and Biophysics, University of Mississippi Medical Center, 2500 N State Street, Jackson, MS 39216 4505, USA
    Hypertension 56:359-63. 2010
    ..The data suggest that other mechanisms besides activation of the RAS are likely involved in postmenopausal hypertension...
  19. ncbi request reprint Increasing oxidative stress with molsidomine increases blood pressure in genetically hypertensive rats but not normotensive controls
    Lourdes A Fortepiani
    Dept of Physiology and Biophysics, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216 4505, USA
    Am J Physiol Regul Integr Comp Physiol 289:R763-70. 2005
    ..Increasing oxidative stress elevated blood pressure further in SHR but not WKY. WKY are likely protected because of higher bioavailable levels of NO and the ability to upregulate catalase and GPx...
  20. ncbi request reprint Impact of androgen-induced oxidative stress on hypertension in male SHR
    Radu Iliescu
    Department of Physiology and Biophysics, The Center for Excellence in Cardiovascular Renal Research, University of Mississippi Medical Center, 2500 N State St, Jackson, MS 39216 4505, USA
    Am J Physiol Regul Integr Comp Physiol 292:R731-5. 2007
    ..These data support the hypothesis that androgens cause oxidative stress and thereby increase blood pressure in male SHR via an NADPH oxidase-dependent mechanism...
  21. ncbi request reprint Role of oxidative stress in angiotensin-induced hypertension
    Jane F Reckelhoff
    Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA
    Am J Physiol Regul Integr Comp Physiol 284:R893-912. 2003
    ....
  22. ncbi request reprint Role of reactive oxygen species in endothelin-induced hypertension
    Mona H Sedeek
    Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Miss 39216 4505, USA
    Hypertension 42:806-10. 2003
    ..These data indicate that formation of reactive oxygen species may play an important role in mediating hypertension induced by chronic elevations in endothelin...
  23. doi request reprint Hypertension and cardiovascular disease in women
    John E Hall
    Department of Physiology, University of Mississippi Medical Center, Jackson, MS 39216 4505, USA
    Hypertension 51:951. 2008
  24. pmc Testosterone-dependent hypertension and upregulation of intrarenal angiotensinogen in Dahl salt-sensitive rats
    Licy L Yanes
    Univ of Mississippi Medical Center, Dept of Physiology and Biophysics, 2500 N State St, Jackson, MS 39216 4505, USA
    Am J Physiol Renal Physiol 296:F771-9. 2009
    ..Testosterone contributes to the development of hypertension and renal injury in male DS rats on HS diet possibly through upregulation of the intrarenal renin-angiotensin system...
  25. pmc Rosiglitazone decreases blood pressure and renal injury in a female mouse model of systemic lupus erythematosus
    Marcia Venegas-Pont
    Assistant Professor, Univ of Mississippi Medical Center, Dept of Physiology and Biophysics, 2500 North State St, Jackson, MS 39216 4505
    Am J Physiol Regul Integr Comp Physiol 296:R1282-9. 2009
    ..These data suggest that Rosi may be an important therapeutic option for the treatment of SLE hypertension and renal injury...
  26. ncbi request reprint Role of endothelin in mediating postmenopausal hypertension in a rat model
    Licy L Yanes
    Department of Physiology and Biophysics, University of Mississippi Medical Center, 2500 N State St, Jackson, MS 39216 4505, USA
    Am J Physiol Regul Integr Comp Physiol 288:R229-33. 2005
    ..ET(A)R antagonist reduced BP in PMR by 20% to the level found in control YF. ET(A)R antagonist had no effect on BP in YF. These data support the hypothesis that the increase in BP in PMR is mediated in part by endothelin and the ET(A)R...
  27. ncbi request reprint Disabled-2 is expressed in adrenal zona glomerulosa and is involved in aldosterone secretion
    Damian G Romero
    Division of Endocrinology, Department of Medicine, Montgomery VA Medical Center and The University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USA
    Endocrinology 148:2644-52. 2007
    ..Dab2 may therefore be a modulator of aldosterone secretion and be involved in mineralocorticoid secretion abnormalities...
  28. ncbi request reprint Treatment with tetrahydrobiopterin reduces blood pressure in male SHR by reducing testosterone synthesis
    Lourdes A Fortepiani
    Department of Physiology and Biophysics, University of Mississippi Medical Center, 2500 N State Street, Jackson, MI 39216 4505, USA
    Am J Physiol Regul Integr Comp Physiol 288:R733-6. 2005
    ..The mechanism(s) by which BH(4) reduces serum testosterone levels are not clear, but the data do not support a role for NO as a mediator...
  29. ncbi request reprint Increased expression of vascular endothelial growth factor and capillary density in hearts of spontaneously hypertensive rats
    Jian Wei Gu
    Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi 39216 4505, USA
    Microcirculation 11:689-97. 2004
    ....
  30. pmc Sexual dimorphism in the blood pressure response to angiotensin II in mice after angiotensin-converting enzyme blockade
    Marcia Venegas-Pont
    Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi, USA
    Am J Hypertens 23:92-6. 2010
    ..We tested whether female mice exhibit a greater MAP response to chronic Ang II during ACE inhibition...
  31. ncbi request reprint Age-related reduction in estrogen receptor-mediated mechanisms of vascular relaxation in female spontaneously hypertensive rats
    Fanisha L Wynne
    Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, USA
    Hypertension 43:405-12. 2004
    ..The age-related decrease in ER-mediated vascular relaxation may explain the increased vascular contraction and arterial pressure associated with aging in females...
  32. ncbi request reprint Role of the renal nerves in blood pressure in male and female SHR
    Radu Iliescu
    Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS 39216 4505, USA
    Am J Physiol Regul Integr Comp Physiol 290:R341-4. 2006
    ..These data indicate that renal nerves play a role in the control of blood pressure in SHR independent of sex, but do not play a role in mediating the sex differences in blood pressure...
  33. ncbi request reprint Gender difference in response to thromboxane A2/prostaglandin H2 receptor antagonism in spontaneously hypertensive rats
    Maria Carolina Acosta Cazal
    Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi 39216 4505, USA
    Gend Med 1:100-5. 2004
    ..As in humans, BP is higher in male spontaneously hypertensive rats (SHRs) than in female SHRs. The mechanism(s) responsible for the higher BP in men and male rats has not been elucidated...
  34. doi request reprint Sex steroids and renal disease: lessons from animal studies
    Licy L Yanes
    Department of Physiology and Biophysics, The Center for Excellence in Cardiovascular Renal Research, University of Mississippi Medical Center, Jackson, MS 39216 4505, USA
    Hypertension 51:976-81. 2008
  35. ncbi request reprint HO-1 induction lowers blood pressure and superoxide production in the renal medulla of angiotensin II hypertensive mice
    Trinity Vera
    Department of Physiology and Biophysics, University of Mississippi Medical Center, 2500 North State St, Jackson, MS 39216 4505, USA
    Am J Physiol Regul Integr Comp Physiol 292:R1472-8. 2007
    ..These results suggest that reduction in superoxide and possibly hydrogen peroxide production in the renal medulla may be a potential mechanism by which induction of HO-1 with CoPP lowers blood pressure in ANG-II dependent hypertension...
  36. ncbi request reprint Testosterone and vascular reactivity
    Radu Iliescu
    Department of Physiology and Biophysics and The Center for Excellence in Cardiovascular Renal Research, University of Mississippi Medical Center, 2500 N State Street, Jackson, MS 39216 4505, USA
    Clin Sci (Lond) 111:251-2. 2006
    ..These studies may shed light on the functional and therapeutic significance of the diverging acute and chronic cardiovascular effects of androgens...
  37. pmc Effects of hyperhomocysteinemia on arterial pressure and nitric oxide production in pregnant rats
    DERRICK L CHANDLER
    Department of Physiology and Biophysics, Center for Excellence in Cardiovascular Renal Research, University of Mississippi Medical Center, Jackson, Mississippi, USA
    Am J Hypertens 22:1115-9. 2009
    ....
  38. doi request reprint Sex and the kidney
    Radu Iliescu
    Hypertension 51:1000-1. 2008
  39. ncbi request reprint Polycystic ovary syndrome: androgens and hypertension
    Jane F Reckelhoff
    Hypertension 49:1220-1. 2007
  40. ncbi request reprint Role of oxidative stress in age-related reduction of NO-cGMP-mediated vascular relaxation in SHR
    Jason A Payne
    Harvard Medical School, VA Boston Healthcare Research, 1400 VFW Parkway, 3 2B123, W Roxbury, MA 02132, USA
    Am J Physiol Regul Integr Comp Physiol 285:R542-51. 2003
    ..The data suggest a role for oxidative stress in the reduction of vascular relaxation and thereby the promotion of vascular contraction and hypertension during the late stages of aging...
  41. ncbi request reprint Cardiovascular disease, estrogen deficiency, and inflammatory cytokines
    Jane F Reckelhoff
    Hypertension 48:372-3. 2006
  42. doi request reprint Menopause and hypertension: an age-old debate
    Megan Coylewright
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Hypertension 51:952-9. 2008

Research Grants16

  1. Gender and susceptibility to kidney damage in high BP.
    JANE RECKELHOFF; Fiscal Year: 2004
    ....
  2. Gender and susceptibility to kidney damage in high BP
    Jane F Reckelhoff; Fiscal Year: 2010
    ....
  3. Humoral factors in gender differences in blood pressure control
    JANE RECKELHOFF; Fiscal Year: 2009
    ....
  4. Gender and susceptibility to kidney damage in high BP
    JANE RECKELHOFF; Fiscal Year: 2009
    ....
  5. Gender and susceptibility to kidney damage in high BP
    JANE RECKELHOFF; Fiscal Year: 2007
    ....
  6. Humoral factors in gender differences in blood pressure control
    JANE RECKELHOFF; Fiscal Year: 2007
    ....
  7. HUMORAL FACTORS IN GENDER DIFFERENCES IN BP CONTROL
    JANE RECKELHOFF; Fiscal Year: 2004
    ..This aim will also address why there are sensitivity differences in the pressor responses to androgens between SHR and normotensive rats. ..