Martin C Rechsteiner

Summary

Affiliation: University of Utah
Country: USA

Publications

  1. ncbi Mobilizing the proteolytic machine: cell biological roles of proteasome activators and inhibitors
    Martin Rechsteiner
    Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    Trends Cell Biol 15:27-33. 2005
  2. ncbi Ubiquitin-mediated proteolysis: an ideal pathway for systems biology analysis
    Martin C Rechsteiner
    Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT 84112, USA
    Adv Exp Med Biol 547:49-59. 2004
  3. ncbi Hsp90 enhances degradation of oxidized calmodulin by the 20 S proteasome
    Jennifer E Whittier
    Cell Biology and Biochemistry Group, Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington 99352, USA
    J Biol Chem 279:46135-42. 2004
  4. ncbi Tertiary structural rearrangements upon oxidation of Methionine145 in calmodulin promotes targeted proteasomal degradation
    Colette A Sacksteder
    Cell Biology and Biochemistry Group, Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, USA
    Biophys J 91:1480-93. 2006

Research Grants

  1. PROPERTIES OF AN ATP/UBIQUITIN-DEPENDENT PROTEASE
    Martin Rechsteiner; Fiscal Year: 2003
  2. MOLECULAR DISSECTION OF A PROTEASOME ACTIVATOR
    Martin Rechsteiner; Fiscal Year: 2003
  3. Proteasomes, PODs and Polyglutamine Diseases
    Martin Rechsteiner; Fiscal Year: 2007
  4. PROPERTIES OF AN ATP-UBIQUITIN DEPENDENT PROTEASE
    Martin Rechsteiner; Fiscal Year: 1993
  5. PROPERTIES OF AN ATP/UBIQUITIN-DEPENDENT PROTEASE
    Martin Rechsteiner; Fiscal Year: 1999
  6. PURIFICATION OF AN ATP/UBIQUITIN-DEPENDENT PROTEASE
    Martin Rechsteiner; Fiscal Year: 1990

Collaborators

  • Jennifer E Whittier
  • Colette A Sacksteder
  • Yijia Xiong
  • Thomas C Squier
  • Jinhui Li
  • Todd D Williams
  • Diana J Bigelow
  • Nadezhda A Galeva
  • Michael E Jacoby
  • Samuel O Purvine

Detail Information

Publications4

  1. ncbi Mobilizing the proteolytic machine: cell biological roles of proteasome activators and inhibitors
    Martin Rechsteiner
    Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    Trends Cell Biol 15:27-33. 2005
    ..In this article, we briefly review the biochemical data and discuss the possible biological roles of PA28, PA200 and proteasome inhibitors...
  2. ncbi Ubiquitin-mediated proteolysis: an ideal pathway for systems biology analysis
    Martin C Rechsteiner
    Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT 84112, USA
    Adv Exp Med Biol 547:49-59. 2004
    ..Cellular components that activate, transfer, remove, or simply recognize ubiquitin number in the hundreds, perhaps even in the thousands. In light of this complexity the ubiquitin pathway is ideal for a systems biology approach...
  3. ncbi Hsp90 enhances degradation of oxidized calmodulin by the 20 S proteasome
    Jennifer E Whittier
    Cell Biology and Biochemistry Group, Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington 99352, USA
    J Biol Chem 279:46135-42. 2004
    ..These results indicate that Hsp90 in association with the 20 S proteasome can selectively associate with oxidized and partially unfolded CaM to promote degradation by the proteasome...
  4. ncbi Tertiary structural rearrangements upon oxidation of Methionine145 in calmodulin promotes targeted proteasomal degradation
    Colette A Sacksteder
    Cell Biology and Biochemistry Group, Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, USA
    Biophys J 91:1480-93. 2006
    ..e., Met145) promote the degradation of CaM by the proteasome/Hsp90, suggesting a mechanism to regulate cellular metabolism through the targeted modulation of CaM abundance in response to oxidative stress...

Research Grants26

  1. PROPERTIES OF AN ATP/UBIQUITIN-DEPENDENT PROTEASE
    Martin Rechsteiner; Fiscal Year: 2003
    ..For these reasons, increased knowledge of the 26S proteasome should have significant medical implications. ..
  2. MOLECULAR DISSECTION OF A PROTEASOME ACTIVATOR
    Martin Rechsteiner; Fiscal Year: 2003
    ..The precursors will be expressed in mouse LKb cells, and the surface expression of Class I-ovalbumin peptide complexes will be measured using a quantitative monoclonal antibody assay. ..
  3. Proteasomes, PODs and Polyglutamine Diseases
    Martin Rechsteiner; Fiscal Year: 2007
    ..Obtaining such a result would justify the search for therapeutic agents able to convert wild-type proteasome activator to the mutant form. ..
  4. PROPERTIES OF AN ATP-UBIQUITIN DEPENDENT PROTEASE
    Martin Rechsteiner; Fiscal Year: 1993
    ..Finally, two separate enzymes that accurately process pentaUb to Ub have been identified. We will purify each enzyme, and we will continue our studies on poly-ubiquitin metabolism...
  5. PROPERTIES OF AN ATP/UBIQUITIN-DEPENDENT PROTEASE
    Martin Rechsteiner; Fiscal Year: 1999
    ..For these reasons, better understanding of the protease should have significant medical implications. ..
  6. PURIFICATION OF AN ATP/UBIQUITIN-DEPENDENT PROTEASE
    Martin Rechsteiner; Fiscal Year: 1990
    ..Finally, we will continue to analyze the structure of ubiquitin-lysozyme conjugates in an attempt to discover why they are anomalously large...