T R Rebbeck

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc Genetic heterogeneity in hereditary breast cancer: role of BRCA1 and BRCA2
    T R Rebbeck
    Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia 19104 6021, USA
    Am J Hum Genet 59:547-53. 1996
  2. ncbi Molecular epidemiology of the human glutathione S-transferase genotypes GSTM1 and GSTT1 in cancer susceptibility
    T R Rebbeck
    Department of Biostatistics and Epidemiology, University of Pennsylvania, School of Medicine, Philadelphia 19104 6021, USA
    Cancer Epidemiol Biomarkers Prev 6:733-43. 1997
  3. ncbi Modification of clinical presentation of prostate tumors by a novel genetic variant in CYP3A4
    T R Rebbeck
    Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia 19104 6021, USA
    J Natl Cancer Inst 90:1225-9. 1998
  4. ncbi Glutathione S-transferase-mu (GSTM1) and -theta (GSTT1) genotypes in the etiology of prostate cancer
    T R Rebbeck
    Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Cancer Epidemiol Biomarkers Prev 8:283-7. 1999
  5. pmc Modification of BRCA1-associated breast cancer risk by the polymorphic androgen-receptor CAG repeat
    T R Rebbeck
    Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, 904 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104, USA
    Am J Hum Genet 64:1371-7. 1999
  6. ncbi Modification of BRCA1- and BRCA2-associated breast cancer risk by AIB1 genotype and reproductive history
    T R Rebbeck
    Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Cancer Res 61:5420-4. 2001
  7. ncbi Breast cancer risk after bilateral prophylactic oophorectomy in BRCA1 mutation carriers
    T R Rebbeck
    T R Rebbeck, A Eisen, B L Weber, Department of Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    J Natl Cancer Inst 91:1475-9. 1999
  8. pmc Association of HPC2/ELAC2 genotypes and prostate cancer
    T R Rebbeck
    Department of Biostatistics and Epidemiology and Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Am J Hum Genet 67:1014-9. 2000
  9. ncbi Prophylactic oophorectomy in BRCA1 and BRCA2 mutation carriers
    T R Rebbeck
    Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    J Clin Oncol 18:100S-3S. 2000
  10. ncbi Nucleotide substitution in the ectodomain of trail receptor DR4 is associated with lung cancer and head and neck cancer
    M J Fisher
    Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Clin Cancer Res 7:1688-97. 2001

Collaborators

Detail Information

Publications33

  1. pmc Genetic heterogeneity in hereditary breast cancer: role of BRCA1 and BRCA2
    T R Rebbeck
    Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia 19104 6021, USA
    Am J Hum Genet 59:547-53. 1996
    ..BRCA1 and BRCA2 probably explain the majority of hereditary breast cancer that exists in the North American population. However, one or more additional genes may yet be found that explain some proportion of hereditary breast cancer...
  2. ncbi Molecular epidemiology of the human glutathione S-transferase genotypes GSTM1 and GSTT1 in cancer susceptibility
    T R Rebbeck
    Department of Biostatistics and Epidemiology, University of Pennsylvania, School of Medicine, Philadelphia 19104 6021, USA
    Cancer Epidemiol Biomarkers Prev 6:733-43. 1997
    ..However, these genotypes may be less suited for individual cancer risk assessment because of their relatively small contribution to the absolute risk of cancer...
  3. ncbi Modification of clinical presentation of prostate tumors by a novel genetic variant in CYP3A4
    T R Rebbeck
    Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia 19104 6021, USA
    J Natl Cancer Inst 90:1225-9. 1998
    ..The goal of this study was to evaluate the effect of CYP3A4, a gene associated with the oxidative deactivation of testosterone, on the clinical presentation of prostate cancers...
  4. ncbi Glutathione S-transferase-mu (GSTM1) and -theta (GSTT1) genotypes in the etiology of prostate cancer
    T R Rebbeck
    Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Cancer Epidemiol Biomarkers Prev 8:283-7. 1999
    ..GST-theta is highly expressed in the prostate and can produce genotoxic effects upon exposure to specific carcinogens. These results suggest that GSTT1 is associated with CaP risk...
  5. pmc Modification of BRCA1-associated breast cancer risk by the polymorphic androgen-receptor CAG repeat
    T R Rebbeck
    Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, 904 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104, USA
    Am J Hum Genet 64:1371-7. 1999
    ..These results suggest that pathways involving androgen signaling may affect the risk of BRCA1-associated breast cancer...
  6. ncbi Modification of BRCA1- and BRCA2-associated breast cancer risk by AIB1 genotype and reproductive history
    T R Rebbeck
    Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Cancer Res 61:5420-4. 2001
    ..Our results support the hypothesis that pathways involving endocrine signaling, as measured through AIB1 genotype and reproductive history, may have a substantial effect on BRCA1/2-associated breast cancer risk...
  7. ncbi Breast cancer risk after bilateral prophylactic oophorectomy in BRCA1 mutation carriers
    T R Rebbeck
    T R Rebbeck, A Eisen, B L Weber, Department of Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    J Natl Cancer Inst 91:1475-9. 1999
    ..This study was undertaken to evaluate whether bilateral prophylactic oophorectomy is associated with a reduction in breast cancer risk in BRCA1 mutation carriers...
  8. pmc Association of HPC2/ELAC2 genotypes and prostate cancer
    T R Rebbeck
    Department of Biostatistics and Epidemiology and Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Am J Hum Genet 67:1014-9. 2000
    ..These results suggest that common variants at HPC2/ELAC2 are associated with CaP risk in a sample unselected for family history or other factors associated with CaP risk...
  9. ncbi Prophylactic oophorectomy in BRCA1 and BRCA2 mutation carriers
    T R Rebbeck
    Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    J Clin Oncol 18:100S-3S. 2000
    ..However, substantial additional information is required to provide clinically useful information about cancer prevention to women who carry mutations in BRCA1 or BRCA2...
  10. ncbi Nucleotide substitution in the ectodomain of trail receptor DR4 is associated with lung cancer and head and neck cancer
    M J Fisher
    Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Clin Cancer Res 7:1688-97. 2001
    ..Our results suggest that the altered DR4 alleles may be associated with, and should be investigated additionally as potential markers for, predisposition to common malignancies...
  11. doi Non-cancer endpoints in BRCA1/2 carriers after risk-reducing salpingo-oophorectomy
    J V Cohen
    Pennsylvania Hospital, Philadelphia, PA, USA
    Fam Cancer 11:69-75. 2012
    ..Despite the risk reduction RRSO offers, attention should be paid to non-cancer endpoints, particularly bone health, in this population...
  12. ncbi Association of obesity with tumor characteristics and treatment failure of prostate cancer in African-American and European American men
    E Spangler
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6021, USA
    J Urol 178:1939-44; discussion 1945. 2007
    ....
  13. pmc Germline CHEK2*1100delC mutations in breast cancer patients with multiple primary cancers
    J Huang
    Department of Biology, University of Pennsylvania, Philadelphia, PA, USA
    J Med Genet 41:e120. 2004
  14. ncbi Interaction of glutathione S-transferase M1 and T1 genotypes and malignant melanoma
    P A Kanetsky
    Departments of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Cancer Epidemiol Biomarkers Prev 10:509-13. 2001
    ..5; 95% CI, 1.2-73) compared with those without CMM. These data suggest that among persons with hair colors traditionally associated with increased risk for melanoma, absence of both GSTM1 and GSTT1 may act to further elevate CMM risk...
  15. ncbi Population frequencies of single nucleotide polymorphisms (SNPs) in immuno-modulatory genes
    A M Martin
    Laboratory of Molecular Pathology, Department of Pathology, Pennsylvania Hospital, Philadelphia, PA, USA
    Hum Hered 55:171-8. 2003
    ..These allelic variations maybe associated with alterations in immune function and thus susceptibility to a number of complex disease states such as cancer...
  16. ncbi An intronic variant in PTEN is not associated with prostate cancer risk
    K L Nathanson
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104 6021, USA
    Cancer Epidemiol Biomarkers Prev 10:277-8. 2001
  17. ncbi Prophylactic surgery in women with a hereditary predisposition to breast and ovarian cancer
    A Eisen
    Department of Medicine, Biostatistics and Epidemiology, and Genetics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    J Clin Oncol 18:1980-95. 2000
    ....
  18. ncbi Increased transcriptional activity of the CYP3A4*1B promoter variant
    B Amirimani
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6021, USA
    Environ Mol Mutagen 42:299-305. 2003
    ..Therefore, the phenotypic effects of the variant CYP3A4*1B may be associated with enhanced CYP3A4 expression due to reduced binding of a transcriptional repressor...
  19. ncbi Association of prostate cancer family history with histopathological and clinical characteristics of prostate tumors
    E Spangler
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Int J Cancer 113:471-4. 2005
    ..14, 95%CI = 1.06-4.34). Our results suggest that a family history of prostate cancer may be associated with predictors of clinical outcome in prostate cancer cases unselected for a family history of prostate cancer...
  20. ncbi Pharmacogenetic modulation of combined hormone replacement therapy by progesterone-metabolism genotypes in postmenopausal breast cancer risk
    T R Rebbeck
    Center for Clinical Epidemiology and Biostatistics and Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA, USA
    Am J Epidemiol 166:1392-9. 2007
    ..Breast cancer risk in women who have used CHRT may be influenced by genetic factors involved in progestin metabolism...
  21. ncbi Ethnic differences in the frequency of prostate cancer susceptibility alleles at SRD5A2 and CYP3A4
    C M Zeigler-Johnson
    University of Pennsylvania, Philadelphia, PA, USA
    Hum Hered 54:13-21. 2002
    ..Ethnic differences in genotypes for genes associated with androgen metabolism including SRD5A2 and CYP3A4 also may exist. The aim of this study was to evaluate differences in these genotypes by ethnicity...
  22. ncbi Common variant in AMPD1 gene predicts improved clinical outcome in patients with heart failure
    E Loh
    Cardiovascular Division, Department of Medicine, Biostatistics and Epidemiology, Hospital of the University of Pennsylvania, University of Pennsylvania, Philadelphia, PA 19104, USA
    Circulation 99:1422-5. 1999
    ..We hypothesized that inheritance of the mutant AMPD1 allele is associated with increased probability of survival without cardiac transplantation in patients with CHF...
  23. ncbi BAG-1: a novel biomarker predicting long-term survival in early-stage breast cancer
    B C Turner
    Department of Radiation Oncology, Thomas Jefferson University, Philadelphia, PA, USA
    J Clin Oncol 19:992-1000. 2001
    ..We performed a retrospective correlative analysis of BAG-1 protein expression in breast tumors derived from a cohort of early-stage breast cancer patients...
  24. ncbi Differential expression of E-cadherin in lobular and ductal neoplasms of the breast and its biologic and diagnostic implications
    G Acs
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, 6 Founders Pavilion, 3400 Spruce St, Philadelphia, PA 19104, USA
    Am J Clin Pathol 115:85-98. 2001
    ..In tumors with histologically equivocal features, immunohistochemical detection of E-cadherin expression can be a useful diagnostic tool for the differentiation of ductal and lobular carcinomas of the breast...
  25. ncbi Prophylactic oophorectomy in BRCA1 and BRCA2 mutation carriers
    T R Rebbeck
    Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, 904 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104, USA
    Eur J Cancer 38:S15-7. 2002
  26. pmc Association of CYP3A4 genotype with treatment-related leukemia
    C A Felix
    Division of Oncology, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 95:13176-81. 1998
    ..The variant may decrease production of the epipodophyllotoxin catechol metabolite, which is the precursor of the potentially DNA-damaging quinone...
  27. pmc Group sequential methods and sample size savings in biomarker-disease association studies
    R Aplenc
    Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6021, USA
    Genetics 163:1215-9. 2003
    ..In contrast, for GSTT1, which demonstrated a positive association, inappropriate termination occurred in only 6.6%. GSM may provide significant cost and sample savings in molecular epidemiology studies...
  28. ncbi Localization of a hereditary neuroblastoma predisposition gene to 16p12-p13
    M J Weiss
    Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104 4318, USA
    Med Pediatr Oncol 35:526-30. 2000
    ..Hereditary predisposition to develop neuroblastoma segregates as an autosomal dominant Mendelian trait...
  29. ncbi Hereditary neuralgic amyotrophy: evidence for genetic homogeneity and mapping to chromosome 17q25
    J E Pellegrino
    Division of Neurology Research, Abramson Pediatric Research Center, Children s Hospital of Philadelphia, PA 19104, USA
    Hum Genet 101:277-83. 1997
    ..These results support genetic homogeneity within HNA and define a specific interval and a precise cytogenetic location in chromosome 17q25 for this disorder...
  30. ncbi Clinical characteristics of prostate cancer in African Americans, American whites, and Senegalese men
    S M Gueye
    Hôpital Général de Grand Yoff and Université Cheikh Anta Diop, Dakar, Senegal
    Urology 61:987-92. 2003
    ..To describe the clinical features of prostate cancer in Senegalese men and compare these features with those found in African-American and white American men...
  31. pmc Germline TP53 mutations in breast cancer families with multiple primary cancers: is TP53 a modifier of BRCA1?
    A M Martin
    J Med Genet 40:e34. 2003
  32. ncbi The glutathione S-transferase-mu and -theta genotypes in the etiology of prostate cancer: genotype-environment interactions with smoking
    S N Kelada
    Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor 48109, USA
    Cancer Epidemiol Biomarkers Prev 9:1329-34. 2000
    ....
  33. ncbi Sulfation pharmacogenetics: SULT1A1 and SULT1A2 allele frequencies in Caucasian, Chinese and African-American subjects
    E J Carlini
    Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Medical School Mayo Graduate School Mayo Clinic, Rochester, MN 55905, USA
    Pharmacogenetics 11:57-68. 2001
    ..001). These observations represent a step towards determining the possible functional implications for individual variations in sulfate conjugation of common genetic polymorphisms for SULT1A1 and SULT1A2...