Lawrence P Reagan

Summary

Affiliation: University of South Carolina
Country: USA

Publications

  1. pmc Insulin signaling effects on memory and mood
    Lawrence P Reagan
    Department of Pharmacology, Physiology and Neuroscience, School of Medicine, University of South Carolina, 6439 Garners Ferry Road, Columbia, SC 29208, USA
    Curr Opin Pharmacol 7:633-7. 2007
  2. doi request reprint Tianeptine modulates amygdalar glutamate neurochemistry and synaptic proteins in rats subjected to repeated stress
    Gerardo G Piroli
    Department of Pharmacology, Physiology and Neuroscience, School of Medicine, University of South Carolina, 6439 Garners Ferry Rd, Columbia, SC 29208, USA
    Exp Neurol 241:184-93. 2013
  3. pmc Obesity/hyperleptinemic phenotype impairs structural and functional plasticity in the rat hippocampus
    Claudia A Grillo
    Department of Pharmacology, Physiology and Neuroscience, University of South Carolina School of Medicine, 6439 Garners Ferry Road, Columbia, SC 29208, USA
    Physiol Behav 105:138-44. 2011
  4. doi request reprint Effects of acute and repeated restraint stress on GABA efflux in the rat basolateral and central amygdala
    Leah R Reznikov
    Department of Pharmacology, Physiology and Neuroscience, University of South Carolina School of Medicine, 6439 Garner s Ferry Road, D 4, Columbia, SC 29208, USA
    Brain Res 1256:61-8. 2009
  5. pmc Obesity/hyperleptinemic phenotype adversely affects hippocampal plasticity: effects of dietary restriction
    Claudia A Grillo
    Department of Pharmacology, Physiology and Neuroscience, School of Medicine, University of South Carolina, Columbia, SC 29208, USA
    Physiol Behav 104:235-41. 2011
  6. doi request reprint The antidepressant agomelatine inhibits stress-mediated changes in amino acid efflux in the rat hippocampus and amygdala
    Lawrence P Reagan
    Department of Pharmacology, Physiology and Neuroscience, University of South Carolina School of Medicine, 6439 Garners Ferry Rd, Columbia, SC 29208, USA
    Brain Res 1466:91-8. 2012
  7. pmc Food for thought: the role of appetitive peptides in age-related cognitive decline
    Jim R Fadel
    Department of Pharmacology, Physiology and Neuroscience, School of Medicine, University of South Carolina, 6439 Garners Ferry Road, Columbia, SC 29208, USA
    Ageing Res Rev 12:764-76. 2013
  8. pmc A look inside the diabetic brain: Contributors to diabetes-induced brain aging
    Shayna A Wrighten
    Department of Pharmacology, Physiology and Neuroscience University of South Carolina, School of Medicine, Columbia, SC 29208, USA
    Biochim Biophys Acta 1792:444-53. 2009
  9. ncbi request reprint Glucocorticoid regulation of GLT-1 glutamate transporter isoform expression in the rat hippocampus
    Anita E Autry
    Department of Pharmacology, Physiology and Neuroscience, School of Medicine, University of South Carolina, Columbia, SC 29208, USA
    Neuroendocrinology 83:371-9. 2006
  10. pmc Dietary restriction reverses obesity-induced anhedonia
    Claudia A Grillo
    Department of Pharmacology, Physiology and Neuroscience, University of South Carolina School of Medicine, Columbia, SC, United States
    Physiol Behav 128:126-32. 2014

Collaborators

Detail Information

Publications29

  1. pmc Insulin signaling effects on memory and mood
    Lawrence P Reagan
    Department of Pharmacology, Physiology and Neuroscience, School of Medicine, University of South Carolina, 6439 Garners Ferry Road, Columbia, SC 29208, USA
    Curr Opin Pharmacol 7:633-7. 2007
    ....
  2. doi request reprint Tianeptine modulates amygdalar glutamate neurochemistry and synaptic proteins in rats subjected to repeated stress
    Gerardo G Piroli
    Department of Pharmacology, Physiology and Neuroscience, School of Medicine, University of South Carolina, 6439 Garners Ferry Rd, Columbia, SC 29208, USA
    Exp Neurol 241:184-93. 2013
    ....
  3. pmc Obesity/hyperleptinemic phenotype impairs structural and functional plasticity in the rat hippocampus
    Claudia A Grillo
    Department of Pharmacology, Physiology and Neuroscience, University of South Carolina School of Medicine, 6439 Garners Ferry Road, Columbia, SC 29208, USA
    Physiol Behav 105:138-44. 2011
    ..We will discuss these findings in the context of how hyperleptinemia and hypertriglyceridemia may represent mechanistic mediators of the neurological consequences of impaired hippocampal synaptic plasticity in obesity...
  4. doi request reprint Effects of acute and repeated restraint stress on GABA efflux in the rat basolateral and central amygdala
    Leah R Reznikov
    Department of Pharmacology, Physiology and Neuroscience, University of South Carolina School of Medicine, 6439 Garner s Ferry Road, D 4, Columbia, SC 29208, USA
    Brain Res 1256:61-8. 2009
    ..Collectively, these data demonstrate that acute stress elicits unique and region-specific increases in GABA efflux in the rat amygdala, and that prior repeated stress differentially modifies this response...
  5. pmc Obesity/hyperleptinemic phenotype adversely affects hippocampal plasticity: effects of dietary restriction
    Claudia A Grillo
    Department of Pharmacology, Physiology and Neuroscience, School of Medicine, University of South Carolina, Columbia, SC 29208, USA
    Physiol Behav 104:235-41. 2011
    ..Collectively, these data support the hypothesis that obesity impairs hippocampal synaptic transmission and support the hypothesis that these deficits are mediated through the impairment of hippocampal leptin activity...
  6. doi request reprint The antidepressant agomelatine inhibits stress-mediated changes in amino acid efflux in the rat hippocampus and amygdala
    Lawrence P Reagan
    Department of Pharmacology, Physiology and Neuroscience, University of South Carolina School of Medicine, 6439 Garners Ferry Rd, Columbia, SC 29208, USA
    Brain Res 1466:91-8. 2012
    ..These data suggest that agomelatine modulates amino acid efflux in limbic structures implicated in major depressive disorder...
  7. pmc Food for thought: the role of appetitive peptides in age-related cognitive decline
    Jim R Fadel
    Department of Pharmacology, Physiology and Neuroscience, School of Medicine, University of South Carolina, 6439 Garners Ferry Road, Columbia, SC 29208, USA
    Ageing Res Rev 12:764-76. 2013
    ..Collectively, these studies support the hypothesis that leptin and insulin resistance, concepts normally associated with the hypothalamus, are also applicable to the hippocampus. ..
  8. pmc A look inside the diabetic brain: Contributors to diabetes-induced brain aging
    Shayna A Wrighten
    Department of Pharmacology, Physiology and Neuroscience University of South Carolina, School of Medicine, Columbia, SC 29208, USA
    Biochim Biophys Acta 1792:444-53. 2009
    ..This review summarizes the findings of the literature as they relate to the relationship between diabetes and dementia and discusses some of the potential contributors to diabetes-induced CNS impairments...
  9. ncbi request reprint Glucocorticoid regulation of GLT-1 glutamate transporter isoform expression in the rat hippocampus
    Anita E Autry
    Department of Pharmacology, Physiology and Neuroscience, School of Medicine, University of South Carolina, Columbia, SC 29208, USA
    Neuroendocrinology 83:371-9. 2006
    ..These studies suggest that GLT-1b expression is regulated by stress levels of glucocorticoids (GCs) and GLT-1 expression is regulated by stress-induced increases in extracellular glutamate levels in the CA3 region...
  10. pmc Dietary restriction reverses obesity-induced anhedonia
    Claudia A Grillo
    Department of Pharmacology, Physiology and Neuroscience, University of South Carolina School of Medicine, Columbia, SC, United States
    Physiol Behav 128:126-32. 2014
    ..Collectively, these results demonstrate that obesity-induced anhedonia is a reversible process and identify some potential mechanistic mediators that may be responsible for co-morbid depression in obesity. ..
  11. pmc The As and Ds of stress: metabolic, morphological and behavioral consequences
    Lawrence P Reagan
    Department of Pharmacology, Physiology and Neuroscience, University of South Carolina School of Medicine, Columbia, SC 29208, USA
    Eur J Pharmacol 585:64-75. 2008
    ..The aim of the current review will be to discuss the mechanisms through which limbic structures such as the hippocampus and amygdala respond and adapt to the deleterious consequences of chronic stress and hyperglycemia...
  12. pmc Chronic restraint stress up-regulates GLT-1 mRNA and protein expression in the rat hippocampus: reversal by tianeptine
    Lawrence P Reagan
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 101:2179-84. 2004
    ....
  13. ncbi request reprint Diabetes, but not stress, reduces neuronal nitric oxide synthase expression in rat hippocampus: implications for hippocampal synaptic plasticity
    Lawrence P Reagan
    Haroldand Margaret Milliken Hatch Laboratory of Neuroendocrinology, Rockefeller University, New York, NY 10021, USA
    Neuroreport 13:1801-4. 2002
    ....
  14. ncbi request reprint Tianeptine increases brain-derived neurotrophic factor expression in the rat amygdala
    Lawrence P Reagan
    Department of Pharmacology, Physiology and Neuroscience, University of South Carolina School of Medicine, 6439 Garner s Ferry Road, D40, Columbia, SC 29208, United States
    Eur J Pharmacol 565:68-75. 2007
    ....
  15. pmc Diabetes as a chronic metabolic stressor: causes, consequences and clinical complications
    Lawrence P Reagan
    Department of Pharmacology, Physiology and Neuroscience, University of South Carolina School of Medicine, Columbia, SC 29208, USA
    Exp Neurol 233:68-78. 2012
    ....
  16. pmc Downregulation of hypothalamic insulin receptor expression elicits depressive-like behaviors in rats
    Claudia A Grillo
    Department of Pharmacology, Physiology and Neuroscience, University of South Carolina School of Medicine, 6439 Garner s Ferry Road, D40, Columbia, SC 29208, United States
    Behav Brain Res 222:230-5. 2011
    ..Collectively, these data support the hypothesis for an increased risk for mood disorders in obesity, which may be related to decreased expression of hippocampal and amygdalar BDNF...
  17. ncbi request reprint Acute stress-mediated increases in extracellular glutamate levels in the rat amygdala: differential effects of antidepressant treatment
    Leah R Reznikov
    Department of Pharmacology, Physiology and Neuroscience, School of Medicine, University of South Carolina, 6439 Garners Ferry Rd, D40 Columbia, SC 29208, USA
    Eur J Neurosci 25:3109-14. 2007
    ....
  18. doi request reprint Activation of phenotypically distinct neuronal subpopulations in the anterior subdivision of the rat basolateral amygdala following acute and repeated stress
    Leah R Reznikov
    Department of Pharmacology, Physiology and Neuroscience, School of Medicine, University of South Carolina, Columbia, South Carolina 29208, USA
    J Comp Neurol 508:458-72. 2008
    ..These results demonstrate that distinct neuronal phenotypes in the basolateral amygdala are activated by acute restraint stress and that prior repeated restraint stress differentially affects this response...
  19. ncbi request reprint Corticosterone impairs insulin-stimulated translocation of GLUT4 in the rat hippocampus
    Gerardo G Piroli
    Department of Pharmacology, Physiology and Neuroscience, University of South Carolina School of Medicine, Columbia, SC 29208, USA
    Neuroendocrinology 85:71-80. 2007
    ..In the central nervous system, stress produces neuroanatomical and neurochemical changes in the hippocampus that are associated with cognitive impairments...
  20. ncbi request reprint Neuronal insulin signal transduction mechanisms in diabetes phenotypes
    Lawrence P Reagan
    Department of Pharmacology, Physiology and Neuroscience, University of South Carolina School of Medicine, 6439 Garners Ferry Road, VA Building 1, Room D40, Columbia, SC 29208, USA
    Neurobiol Aging 26:56-9. 2005
    ....
  21. ncbi request reprint Peripheral glucose administration stimulates the translocation of GLUT8 glucose transporter to the endoplasmic reticulum in the rat hippocampus
    Gerardo G Piroli
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY 10021, USA
    J Comp Neurol 452:103-14. 2002
    ....
  22. ncbi request reprint Studies of hormone action in the hippocampal formation: possible relevance to depression and diabetes
    Bruce S McEwen
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, Box 165, 1230 York Avenue, New York, NY 10021, USA
    J Psychosom Res 53:883-90. 2002
    ..The hippocampus is also vulnerable to damage by stroke and head trauma and susceptible to damage during aging and repeated stress, and is sensitive to the effects of diabetes...
  23. ncbi request reprint Glucose, stress, and hippocampal neuronal vulnerability
    Lawrence P Reagan
    Laboratory of Neuroendocrinology, Rockefeller University, New York 10021, USA
    Int Rev Neurobiol 51:289-324. 2002
  24. ncbi request reprint Acute and chronic restraint stress alter the incidence of social conflict in male rats
    Gwendolyn E Wood
    Laboratory of Neuroendocrinology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Horm Behav 43:205-13. 2003
    ..These results indicate that acute and chronic restraint stress alter the incidence of aggression, and emphasize the relevance of this model of chronic stress to studies of stress-responsive disorders characterized by aggressive behavior...
  25. pmc Stress-induced structural remodeling in hippocampus: prevention by lithium treatment
    Gwendolyn E Wood
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 101:3973-8. 2004
    ....
  26. ncbi request reprint Biphasic effects of stress upon GLUT8 glucose transporter expression and trafficking in the diabetic rat hippocampus
    Gerardo G Piroli
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Brain Res 1006:28-35. 2004
    ....
  27. ncbi request reprint Memory impairment in obese Zucker rats: an investigation of cognitive function in an animal model of insulin resistance and obesity
    Gordon Winocur
    Department of Psychology, Trent University, Peterborough, Ontario, Canada
    Behav Neurosci 119:1389-95. 2005
    ..These results parallel those of human studies in pointing to the susceptibility of the hippocampus and related structures to the adverse environment of diabetes mellitus...
  28. ncbi request reprint Glucose transporter expression in the central nervous system: relationship to synaptic function
    Bruce S McEwen
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY 10021, USA
    Eur J Pharmacol 490:13-24. 2004
    ..In addition, we will discuss the regulation, activity and insulin-stimulated trafficking of GLUTs in the CNS, especially in relation to the centrally mediated actions of insulin and glucose...
  29. ncbi request reprint GLUT8 glucose transporter is localized to excitatory and inhibitory neurons in the rat hippocampus
    Lawrence P Reagan
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, Box 165, 1230 York Avenue, New York, NY 10021, USA
    Brain Res 932:129-34. 2002
    ..These results demonstrate that GLUT8 is a neuron-specific glucose transporter expressed in the neuronal cell bodies of excitatory and inhibitory neurons in the rat hippocampus...