Shane L Rea

Summary

Affiliation: University of Texas Health Science Center
Country: USA

Publications

  1. ncbi Bacteria, yeast, worms, and flies: exploiting simple model organisms to investigate human mitochondrial diseases
    Shane L Rea
    Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, San Antonio, TX 78245 3207, USA
    Dev Disabil Res Rev 16:200-18. 2010
  2. ncbi Relationship between mitochondrial electron transport chain dysfunction, development, and life extension in Caenorhabditis elegans
    Shane L Rea
    Institute for Behavioral Genetics, University of Colorado at Boulder, Boulder, Colorado, corrected United States of America corrected
    PLoS Biol 5:e259. 2007
  3. ncbi p53/CEP-1 increases or decreases lifespan, depending on level of mitochondrial bioenergetic stress
    Natascia Ventura
    Institute for Behavioral Genetics, University of Colorado at Boulder, 80309, USA
    Aging Cell 8:380-93. 2009
  4. ncbi Mortality shifts in Caenorhabditis elegans: remembrance of conditions past
    Deqing Wu
    Institute for Behavioral Genetics, University of Colorado at Boulder, Boulder, CO 80309, USA
    Aging Cell 8:666-75. 2009
  5. ncbi Long-lived C. elegans mitochondrial mutants as a model for human mitochondrial-associated diseases
    Natascia Ventura
    Institute for Behavioral Genetics, University of Colorado, Boulder, CO 80302, USA
    Exp Gerontol 41:974-91. 2006
  6. ncbi Visualizing hidden heterogeneity in isogenic populations of C. elegans
    Deqing Wu
    Institute for Behavioral Genetics, University of Colorado at Boulder, 1480 30th Street, Boulder, CO 80309, USA
    Exp Gerontol 41:261-70. 2006
  7. ncbi Long-lived mitochondrial (Mit) mutants of Caenorhabditis elegans utilize a novel metabolism
    Jeffrey A Butler
    Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
    FASEB J 24:4977-88. 2010
  8. ncbi Proteasomal dysfunction activates the transcription factor SKN-1 and produces a selective oxidative-stress response in Caenorhabditis elegans
    Nate W Kahn
    Institute for Behavioral Genetics, University of Colorado at Boulder, Box 447, Boulder, CO 80309, USA
    Biochem J 409:205-13. 2008
  9. ncbi Caenorhabditis elegans mitochondrial mutants as an investigative tool to study human neurodegenerative diseases associated with mitochondrial dysfunction
    Natascia Ventura
    Institute for Behavioral Genetics, University of Colorado at Boulder, Boulder, CO, USA
    Biotechnol J 2:584-95. 2007
  10. ncbi Breaking Caenorhabditis elegans the easy way using the Balch homogenizer: an old tool for a new application
    Shylesh Bhaskaran
    Barshop Institute for Longevity and Aging Studies and Department of Physiology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78240, USA
    Anal Biochem 413:123-32. 2011

Research Grants

  1. Alternate Modes of Energy Production and clk-1 Life Extension
    Shane Rea; Fiscal Year: 2007

Collaborators

Detail Information

Publications16

  1. ncbi Bacteria, yeast, worms, and flies: exploiting simple model organisms to investigate human mitochondrial diseases
    Shane L Rea
    Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, San Antonio, TX 78245 3207, USA
    Dev Disabil Res Rev 16:200-18. 2010
    ..The respective strengths and limitations of each species relative to mitochondrial studies are explored. In addition, an overview is provided of major discoveries made in mitochondrial biology in each of these four model systems...
  2. ncbi Relationship between mitochondrial electron transport chain dysfunction, development, and life extension in Caenorhabditis elegans
    Shane L Rea
    Institute for Behavioral Genetics, University of Colorado at Boulder, Boulder, Colorado, corrected United States of America corrected
    PLoS Biol 5:e259. 2007
    ..elegans, lead us to propose that cell cycle checkpoint control plays a key role in specifying longevity of mitochondrial mutants...
  3. ncbi p53/CEP-1 increases or decreases lifespan, depending on level of mitochondrial bioenergetic stress
    Natascia Ventura
    Institute for Behavioral Genetics, University of Colorado at Boulder, 80309, USA
    Aging Cell 8:380-93. 2009
    ....
  4. ncbi Mortality shifts in Caenorhabditis elegans: remembrance of conditions past
    Deqing Wu
    Institute for Behavioral Genetics, University of Colorado at Boulder, Boulder, CO 80309, USA
    Aging Cell 8:666-75. 2009
    ..However, 'b' (the rate of mortality increase with age) is always specified by the current conditions...
  5. ncbi Long-lived C. elegans mitochondrial mutants as a model for human mitochondrial-associated diseases
    Natascia Ventura
    Institute for Behavioral Genetics, University of Colorado, Boulder, CO 80302, USA
    Exp Gerontol 41:974-91. 2006
    ..The identification of such compensatory pathways opens a window of possibility for future preventative therapies for many HMADs. They may also provide a way of potentially extending human life span...
  6. ncbi Visualizing hidden heterogeneity in isogenic populations of C. elegans
    Deqing Wu
    Institute for Behavioral Genetics, University of Colorado at Boulder, 1480 30th Street, Boulder, CO 80309, USA
    Exp Gerontol 41:261-70. 2006
    ..Each of these classes results from a mix of two distinct, heterogeneous classes of worms and the addition of more classes does not result in a better fit...
  7. ncbi Long-lived mitochondrial (Mit) mutants of Caenorhabditis elegans utilize a novel metabolism
    Jeffrey A Butler
    Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
    FASEB J 24:4977-88. 2010
    ..Our study suggests long-lived, genetically specified Mit mutants employ a novel metabolism and that life span may well arise as a function of metabolic state...
  8. ncbi Proteasomal dysfunction activates the transcription factor SKN-1 and produces a selective oxidative-stress response in Caenorhabditis elegans
    Nate W Kahn
    Institute for Behavioral Genetics, University of Colorado at Boulder, Box 447, Boulder, CO 80309, USA
    Biochem J 409:205-13. 2008
    ....
  9. ncbi Caenorhabditis elegans mitochondrial mutants as an investigative tool to study human neurodegenerative diseases associated with mitochondrial dysfunction
    Natascia Ventura
    Institute for Behavioral Genetics, University of Colorado at Boulder, Boulder, CO, USA
    Biotechnol J 2:584-95. 2007
    ..In the present report, we describe our progress in using the Mit mutants as an investigative tool to study some of the processes potentially employed by human cells to offset pathological mitochondrial dysfunction...
  10. ncbi Breaking Caenorhabditis elegans the easy way using the Balch homogenizer: an old tool for a new application
    Shylesh Bhaskaran
    Barshop Institute for Longevity and Aging Studies and Department of Physiology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78240, USA
    Anal Biochem 413:123-32. 2011
    ..Finally, we used the tool to isolate coupled mitochondria and polysomes. The reusable Balch homogenizer represents a quick and convenient solution for undertaking biochemical studies on C. elegans...
  11. ncbi The role of MAP4K3 in lifespan regulation of Caenorhabditis elegans
    Maruf H Khan
    Barshop Institute for Longevity and Aging Studies, Department of Physiology, University of Texas Health Science Center, San Antonio, TX 78240, USA
    Biochem Biophys Res Commun 425:413-8. 2012
    ..Our results show a small but significant increase in mean lifespan in MAP4K3 deficient worms. MAP4K3 thus represents a new target in the TOR pathway that can be targeted for pharmacological intervention to control lifespan...
  12. ncbi A metabolic signature for long life in the Caenorhabditis elegans Mit mutants
    Jeffrey A Butler
    Barshop Institute for Longevity and Aging Studies and the Department of Physiology, University of Texas Health Science Center, San Antonio, TX 78240, USA
    Aging Cell 12:130-8. 2013
    ..Our findings provide novel insight into the origin of the Mit phenotype...
  13. ncbi Metabolism in the Caenorhabditis elegans Mit mutants
    Shane L Rea
    Institute for Behavioral Genetics, University of Colorado, Campus Box 447, Boulder, CO 80309 0447, USA
    Exp Gerontol 40:841-9. 2005
    ..The effects of using such pathways on residual mitochondrial functionality, reactive radical species production, and longevity will also be explored...
  14. ncbi Profiling the anaerobic response of C. elegans using GC-MS
    Jeffrey A Butler
    The Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, United States of America
    PLoS ONE 7:e46140. 2012
    ..We also describe a procedure for collecting highly volatile compounds from C. elegans. We are distributing our mass spectral library in an effort to facilitate wider use of metabolomics...
  15. ncbi Applications of mass spectrometry to metabolomics and metabonomics: detection of biomarkers of aging and of age-related diseases
    Robert J Mishur
    Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78245, USA
    Mass Spectrom Rev 31:70-95. 2012
    ....
  16. ncbi A stress-sensitive reporter predicts longevity in isogenic populations of Caenorhabditis elegans
    Shane L Rea
    Institute for Behavioral Genetics, University of Colorado at Boulder, Box 447, Boulder, Colorado 80309, USA
    Nat Genet 37:894-8. 2005
    ....

Research Grants1

  1. Alternate Modes of Energy Production and clk-1 Life Extension
    Shane Rea; Fiscal Year: 2007
    ..It is conceivable that similar settings may also work for our own cells. ..