Research Topics | FABIO C RESummaryAffiliation: University of Tennessee Country: USA Publications
Research Grants
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Detail Information
Publications
Heterogeneity of TLR-induced responses in dendritic cells: from innate to adaptive immunityFabio Re
Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, MA 02115, USA
Immunobiology 209:191-8. 2004..A review of recent literature, unpublished observations, and future challenges is presented here...- IL-10 released by concomitant TLR2 stimulation blocks the induction of a subset of Th1 cytokines that are specifically induced by TLR4 or TLR3 in human dendritic cellsFabio Re
Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, MA 02115, USA
J Immunol 173:7548-55. 2004..Cross-talk between different TLRs may modify the primary responses of TLR to their agonist, adding a further level of complexity to the regulation of innate immunity... - Monomeric recombinant MD-2 binds toll-like receptor 4 tightly and confers lipopolysaccharide responsivenessFabio Re
Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
J Biol Chem 277:23427-32. 2002..Remarkably, although the majority of recombinant MD-2 exists in multimeric form, monomeric MD-2 was found to preferentially bind TLR4 and to confer LPS responsiveness more efficiently than MD-2 multimers... - Separate functional domains of human MD-2 mediate Toll-like receptor 4-binding and lipopolysaccharide responsivenessFabio Re
Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, MA 02115, USA
J Immunol 171:5272-6. 2003..Either of the two functional domains of MD-2 can be disrupted to impair LPS responses and therefore represent attractive targets for therapeutic interventions... - Granulocyte-macrophage colony-stimulating factor induces an expression program in neonatal microglia that primes them for antigen presentationFabio Re
Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
J Immunol 169:2264-73. 2002..This function of GM-CSF is distinct from its primary function in cell proliferation and survival...
Research Grants
- Multimeric MD-2 as an LPS decoyFabio Re; Fiscal Year: 2004..These studies will augment our understanding of the molecular aspects of LPS recognition and cell activation and will characterize mechanisms to inhibit LPS action that might be exploited for therapeutic intervention. ..
- The NLR-inflammasome as mediator of Alum's adjuvanticityFabio Re; Fiscal Year: 2007..A deeper understanding of the mechanisms that determine the immunostimulatory properties of adjuvants is a prerequisite for the rational design of more sophisticated vaccines. ..