Affiliation: University of Illinois at Chicago
Huang S, Fantini D, Merrill B, Bagchi S, Guzman G, Raychaudhuri P. DDB2 Is a Novel Regulator of Wnt Signaling in Colon Cancer. Cancer Res. 2017;77:6562-6575 pubmed publisher
..Our results identify DDB2 as both a partner and regulator of Wnt signaling, with an important role in suppressing colon cancer development. Cancer Res; 77(23); 6562-75. ©2017 AACR. ..
Chand V, Pandey A, Kopanja D, Guzman G, Raychaudhuri P. Opposing Roles of the Fork-head box genes FoxM1 and FoxA2 in Liver Cancer. Mol Cancer Res. 2019;: pubmed publisher
..Implications: The observations provide strong genetic evidence for an opposing role of FoxM1 and FoxA2 in HCC progression. Moreover, FoxM1 drives high grade HCC progression partly by inhibiting the hepatocyte differentiation gene FoxA2. ..
Kopanja D, Pandey A, Kiefer M, Wang Z, Chandan N, Carr J, et al
. Essential roles of FoxM1 in Ras-induced liver cancer progression and in cancer cells with stem cell features. J Hepatol. 2015;63:429-36 pubmed publisher
..In addition, FoxM1 is required for the expression of CD44 in HCC cells. Moreover, FoxM1 plays a critical role in the survival of the HCC cells with stem cell features by regulating ROS. ..
Raychaudhuri P, Park H. FoxM1: a master regulator of tumor metastasis. Cancer Res. 2011;71:4329-33 pubmed publisher
..FoxM1 directly activates genes involved in multiple steps of metastasis. In this review, we discuss the evidence for a master regulatory role of FoxM1 in tumor metastasis. ..
Fantini D, Huang S, Asara J, Bagchi S, Raychaudhuri P. Chromatin association of XRCC5/6 in the absence of DNA damage depends on the XPE gene product DDB2. Mol Biol Cell. 2017;28:192-200 pubmed publisher
..Together our results show that DDB2 is critical for chromatin association of XRCC5/6 in the absence of DNA damage and provide evidence that XRCC5/6 are functional partners of DDB2 in its transcriptional stimulatory activity. ..