Riju Ray

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc Convergent evidence that choline acetyltransferase gene variation is associated with prospective smoking cessation and nicotine dependence
    Riju Ray
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA
    Neuropsychopharmacology 35:1374-82. 2010
  2. ncbi request reprint A functional prodynorphin promoter polymorphism and opioid dependence
    Riju Ray
    Department of Pharmacology, University of Pennsylvania, Philadelphia, 19104, USA
    Psychiatr Genet 15:295-8. 2005
  3. doi request reprint Nicotine dependence: biology, behavior, and treatment
    Riju Ray
    Transdisciplinary Tobacco Use Research Center, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Annu Rev Med 60:247-60. 2009
  4. doi request reprint Brain activity and emotional processing in smokers treated with varenicline
    James Loughead
    Brain Behavior Laboratory, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Addict Biol 18:732-8. 2013
  5. pmc Association of the nicotine metabolite ratio and CHRNA5/CHRNA3 polymorphisms with smoking rate among treatment-seeking smokers
    Mary Falcone
    Department of Pharmacology, University of Pennsylvania, Philadelphia, PA, USA
    Nicotine Tob Res 13:498-503. 2011
  6. pmc μ-Opioid receptor availability in the amygdala is associated with smoking for negative affect relief
    Mary Falcone
    Department of Pharmacology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Psychopharmacology (Berl) 222:701-8. 2012
  7. doi request reprint Effects of the alpha4beta2 partial agonist varenicline on brain activity and working memory in abstinent smokers
    James Loughead
    Brain Behavior Laboratory, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Biol Psychiatry 67:715-21. 2010
  8. pmc Human Mu Opioid Receptor (OPRM1 A118G) polymorphism is associated with brain mu-opioid receptor binding potential in smokers
    Riju Ray
    Center for Interdisciplinary Research on Nicotine Addiction, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 108:9268-73. 2011
  9. ncbi request reprint Genetic variation in mu-opioid-receptor-interacting proteins and smoking cessation in a nicotine replacement therapy trial
    Riju Ray
    Department of Pharmacology, and Transdisciplinary Tobacco Use Research Center, University of Pennsylvania, Philadelphia, PA, USA
    Nicotine Tob Res 9:1237-41. 2007
  10. pmc Nicotine abstinence-induced cerebral blood flow changes by genotype
    Ze Wang
    Center for Functional Neuroimaging, Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104, United States
    Neurosci Lett 438:275-80. 2008

Detail Information

Publications19

  1. pmc Convergent evidence that choline acetyltransferase gene variation is associated with prospective smoking cessation and nicotine dependence
    Riju Ray
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA
    Neuropsychopharmacology 35:1374-82. 2010
    ..Additional sequencing and characterization of ChAT may reveal functional variants that contribute to nicotine dependence and smoking cessation...
  2. ncbi request reprint A functional prodynorphin promoter polymorphism and opioid dependence
    Riju Ray
    Department of Pharmacology, University of Pennsylvania, Philadelphia, 19104, USA
    Psychiatr Genet 15:295-8. 2005
    ..We examined this polymorphism for association in our sample of 168 opioid-dependent patients and 122 ethnically and geographically matched controls...
  3. doi request reprint Nicotine dependence: biology, behavior, and treatment
    Riju Ray
    Transdisciplinary Tobacco Use Research Center, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Annu Rev Med 60:247-60. 2009
    ..Enhanced understanding of these dimensions of nicotine dependence may help to advance progress toward lowering the prevalence rate of tobacco use in the U.S. and lowering the rate of tobacco-related morbidity and mortality...
  4. doi request reprint Brain activity and emotional processing in smokers treated with varenicline
    James Loughead
    Brain Behavior Laboratory, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Addict Biol 18:732-8. 2013
    ..Taken together, these results suggest that observed drug effects on brain activity do not reflect affective changes but rather enhanced early processing of perceptual features of facial stimuli. ..
  5. pmc Association of the nicotine metabolite ratio and CHRNA5/CHRNA3 polymorphisms with smoking rate among treatment-seeking smokers
    Mary Falcone
    Department of Pharmacology, University of Pennsylvania, Philadelphia, PA, USA
    Nicotine Tob Res 13:498-503. 2011
    ..We tested the potential interacting effects of these two risk factors on CPD...
  6. pmc μ-Opioid receptor availability in the amygdala is associated with smoking for negative affect relief
    Mary Falcone
    Department of Pharmacology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Psychopharmacology (Berl) 222:701-8. 2012
    ..The perception that smoking relieves negative affect contributes to smoking persistence. Endogenous opioid neurotransmission, and the μ-opioid receptor (MOR) in particular, plays a role in affective regulation and is modulated by nicotine...
  7. doi request reprint Effects of the alpha4beta2 partial agonist varenicline on brain activity and working memory in abstinent smokers
    James Loughead
    Brain Behavior Laboratory, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Biol Psychiatry 67:715-21. 2010
    ..In rodents and humans, cognitive deficits can be reversed by treatment with the alpha4beta2 nicotinic receptor partial agonist varenicline. This neuroimaging study examined the neural mechanisms that underlie these effects...
  8. pmc Human Mu Opioid Receptor (OPRM1 A118G) polymorphism is associated with brain mu-opioid receptor binding potential in smokers
    Riju Ray
    Center for Interdisciplinary Research on Nicotine Addiction, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 108:9268-73. 2011
    ..Future translational investigations can elucidate the role of MORs in nicotine addiction, which may lead to development of novel therapeutics...
  9. ncbi request reprint Genetic variation in mu-opioid-receptor-interacting proteins and smoking cessation in a nicotine replacement therapy trial
    Riju Ray
    Department of Pharmacology, and Transdisciplinary Tobacco Use Research Center, University of Pennsylvania, Philadelphia, PA, USA
    Nicotine Tob Res 9:1237-41. 2007
    ....
  10. pmc Nicotine abstinence-induced cerebral blood flow changes by genotype
    Ze Wang
    Center for Functional Neuroimaging, Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104, United States
    Neurosci Lett 438:275-80. 2008
    ..While preliminary, these results suggest a neural mechanism through which these genetic variants may be linked with nicotine dependence, and provide further support for increased biological vulnerability in these subgroups of smokers...
  11. pmc Identification of pharmacogenetic markers in smoking cessation therapy
    Daniel F Heitjan
    Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Am J Med Genet B Neuropsychiatr Genet 147:712-9. 2008
    ..In a panel of 43 randomly selected control SNPs, none is significant by either the Bayesian or the corrected frequentist test...
  12. doi request reprint Cost-effectiveness of pharmacogenetic testing to tailor smoking-cessation treatment
    D F Heitjan
    Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA 19104 6021, USA
    Pharmacogenomics J 8:391-9. 2008
    ....
  13. pmc Cognitive effects of the acetylcholinesterase inhibitor, donepezil, in healthy, non-treatment seeking smokers: a pilot feasibility study
    Rebecca L Ashare
    University of Pennsylvania Perelman School of Medicine, Department of Psychiatry, Philadelphia, PA 19104, USA
    Drug Alcohol Depend 126:263-7. 2012
    ..This pilot feasibility study tested whether an AChEI, donepezil, enhanced cognitive performance among healthy smokers...
  14. pmc Neuroimaging, genetics and the treatment of nicotine addiction
    Riju Ray
    Trandisciplinary Tobacco Use Research Center, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Behav Brain Res 193:159-69. 2008
    ..The purpose of this review is to provide an outline of the work in neuroimaging, genetics, and nicotine dependence, and to explore the potential for increased integration of these approaches to improve nicotine dependence treatment...
  15. pmc Nicotine dependence pharmacogenetics: role of genetic variation in nicotine-metabolizing enzymes
    Riju Ray
    Abramson Cancer Center and Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Neurogenet 23:252-61. 2009
    ..Inhibition of the CYP2A6 enzyme to slow nicotine metabolism is a promising approach to increase nicotine availability and potentially reduce harm from tobacco smoking...
  16. doi request reprint Translating basic science to improve pharmacotherapy for nicotine dependence
    Jennifer M Phillips
    University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Nicotine Tob Res 9:S583-98. 2007
    ....
  17. ncbi request reprint Pharmacogenetics and smoking cessation with nicotine replacement therapy
    Riju Ray
    Department of Psychiatry, The Transdisciplinary Tobacco Use Research Center and Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA 19104, USA
    CNS Drugs 21:525-33. 2007
    ..Larger-scale investigations that incorporate pathway-based or genome-wide analysis, as well as intermediate measures of nicotine dependence (i.e. 'endophenotypes'), may be necessary to capture the complexity of pharmacogenetic effects...
  18. doi request reprint Dosimetry of 11C-carfentanil, a micro-opioid receptor imaging agent
    Andrew B Newberg
    Department of Radiology, Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Nucl Med Commun 30:314-8. 2009
    ..The study was conducted within a regulatory framework that required its pharmacological safety to be assessed simultaneously...
  19. ncbi request reprint Analysis of variations in the tryptophan hydroxylase-2 (TPH2) gene in cocaine dependence
    John P Dahl
    Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, USA
    Addict Biol 11:76-83. 2006
    ..This work suggests that variations in the TPH2 gene are not a risk factor for the development of cocaine dependence, but these findings require confirmation in larger, independent samples of cocaine-dependent and control subjects...