Lara A Ray

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi Subjective response to alcohol among alcohol-dependent individuals: effects of the mu-opioid receptor (OPRM1) gene and alcoholism severity
    Lara A Ray
    Department of Psychology, University of California, Los Angeles, Los Angeles, California 90095 1563, USA
    Alcohol Clin Exp Res 37:E116-24. 2013
  2. ncbi Pharmacogenetics of naltrexone in asian americans: a randomized placebo-controlled laboratory study
    Lara A Ray
    Department of Psychology, University of California Los Angeles, Los Angeles, CA 90095 1563, USA
    Neuropsychopharmacology 37:445-55. 2012
  3. ncbi The role of the Asn40Asp polymorphism of the mu opioid receptor gene (OPRM1) on alcoholism etiology and treatment: a critical review
    Lara A Ray
    Department of Psychology, University of California, Los Angeles, California 90095 1563, USA
    Alcohol Clin Exp Res 36:385-94. 2012
  4. ncbi Quetiapine for the treatment of alcoholism: scientific rationale and review of the literature
    Lara A Ray
    Department of Psychology, University of California, Los Angeles, CA 90095 1563, USA
    Drug Alcohol Rev 29:568-75. 2010
  5. ncbi Clinical correlates of desire for treatment for current alcohol dependence among patients with a primary psychiatric disorder
    Lara A Ray
    Department of Psychology, University of California, Los Angeles, Los Angeles, CA 90095 1563, USA
    Am J Drug Alcohol Abuse 37:105-10. 2011
  6. ncbi Self-Rating of the Effects of Alcohol (SRE): Predictive utility and reliability across interview and self-report administrations
    Lara A Ray
    University of California, Los Angeles, Department of Psychology, 90095, United States
    Addict Behav 36:241-3. 2011
  7. ncbi Naltrexone for the treatment of alcohol dependence among African Americans: results from the COMBINE Study
    Lara A Ray
    University of California Los Angeles, Department of Psychology, 1285 Franz Hall, Box 951563, Los Angeles, CA 90095 1563, United States
    Drug Alcohol Depend 105:256-8. 2009
  8. ncbi Catching the alcohol buzz: an examination of the latent factor structure of subjective intoxication
    Lara A Ray
    Department of Psychology, University of California Los Angeles, CA 90095 1563, USA
    Alcohol Clin Exp Res 33:2154-61. 2009
  9. ncbi Posttraumatic stress disorder with and without alcohol use disorders: diagnostic and clinical correlates in a psychiatric sample
    Lara A Ray
    University of California Los Angeles, Department of Psychology, Los Angeles, CA, USA
    Psychiatry Res 170:278-81. 2009
  10. ncbi Polymorphisms of the mu-opioid receptor and dopamine D4 receptor genes and subjective responses to alcohol in the natural environment
    Lara A Ray
    Center for Alcohol and Addiction Studies, Brown University and Department of Psychology, University of California, Los Angeles, Los Angeles, CA 90095 1563, USA
    J Abnorm Psychol 119:115-25. 2010

Detail Information

Publications53

  1. ncbi Subjective response to alcohol among alcohol-dependent individuals: effects of the mu-opioid receptor (OPRM1) gene and alcoholism severity
    Lara A Ray
    Department of Psychology, University of California, Los Angeles, Los Angeles, California 90095 1563, USA
    Alcohol Clin Exp Res 37:E116-24. 2013
    ..A secondary aim of this study is to examine alcoholism severity as a predictor of subjective responses to alcohol...
  2. ncbi Pharmacogenetics of naltrexone in asian americans: a randomized placebo-controlled laboratory study
    Lara A Ray
    Department of Psychology, University of California Los Angeles, Los Angeles, CA 90095 1563, USA
    Neuropsychopharmacology 37:445-55. 2012
    ..These findings help further delineate the biobehavioral mechanisms of naltrexone and its pharmacogenetics...
  3. ncbi The role of the Asn40Asp polymorphism of the mu opioid receptor gene (OPRM1) on alcoholism etiology and treatment: a critical review
    Lara A Ray
    Department of Psychology, University of California, Los Angeles, California 90095 1563, USA
    Alcohol Clin Exp Res 36:385-94. 2012
    ..Together, these lines of research seek to elucidate the effects of this functional polymorphism on alcoholism etiology and treatment response...
  4. ncbi Quetiapine for the treatment of alcoholism: scientific rationale and review of the literature
    Lara A Ray
    Department of Psychology, University of California, Los Angeles, CA 90095 1563, USA
    Drug Alcohol Rev 29:568-75. 2010
    ....
  5. ncbi Clinical correlates of desire for treatment for current alcohol dependence among patients with a primary psychiatric disorder
    Lara A Ray
    Department of Psychology, University of California, Los Angeles, Los Angeles, CA 90095 1563, USA
    Am J Drug Alcohol Abuse 37:105-10. 2011
    ....
  6. ncbi Self-Rating of the Effects of Alcohol (SRE): Predictive utility and reliability across interview and self-report administrations
    Lara A Ray
    University of California, Los Angeles, Department of Psychology, 90095, United States
    Addict Behav 36:241-3. 2011
    ..70 to .80). Results support the predictive utility of the SRE and provide initial evidence that the self-report and interview formats produce reliable results and may be combined and/or used interchangeably...
  7. ncbi Naltrexone for the treatment of alcohol dependence among African Americans: results from the COMBINE Study
    Lara A Ray
    University of California Los Angeles, Department of Psychology, 1285 Franz Hall, Box 951563, Los Angeles, CA 90095 1563, United States
    Drug Alcohol Depend 105:256-8. 2009
    ..Implications for pharmacogenetic studies of naltrexone are discussed...
  8. ncbi Catching the alcohol buzz: an examination of the latent factor structure of subjective intoxication
    Lara A Ray
    Department of Psychology, University of California Los Angeles, CA 90095 1563, USA
    Alcohol Clin Exp Res 33:2154-61. 2009
    ..The goal of this study was to examine the latent structure among measures of alcohol-induced subjective feelings of intoxication from a behavioral pharmacology perspective...
  9. ncbi Posttraumatic stress disorder with and without alcohol use disorders: diagnostic and clinical correlates in a psychiatric sample
    Lara A Ray
    University of California Los Angeles, Department of Psychology, Los Angeles, CA, USA
    Psychiatry Res 170:278-81. 2009
    ..PTSD+AUD patients were more likely to meet criteria for Borderline and Antisocial Personality Disorders. Emotion dysregulation may help account for the relationship between PTSD and AUD...
  10. ncbi Polymorphisms of the mu-opioid receptor and dopamine D4 receptor genes and subjective responses to alcohol in the natural environment
    Lara A Ray
    Center for Alcohol and Addiction Studies, Brown University and Department of Psychology, University of California, Los Angeles, Los Angeles, CA 90095 1563, USA
    J Abnorm Psychol 119:115-25. 2010
    ..This study extends findings on subjective intoxication, urge to drink, and their genetic bases from controlled laboratory to naturalistic settings...
  11. ncbi Naltrexone for the treatment of alcoholism: clinical findings, mechanisms of action, and pharmacogenetics
    Lara A Ray
    Department of Psychology, University of California Los Angeles, CA 90095 1563, USA
    CNS Neurol Disord Drug Targets 9:13-22. 2010
    ..Limitations and future directions in the research and practice of naltrexone for alcoholism are also outlined...
  12. ncbi Stress-induced and cue-induced craving for alcohol in heavy drinkers: Preliminary evidence of genetic moderation by the OPRM1 and CRH-BP genes
    Lara A Ray
    Department of Psychology, University of California, Los Angeles, 90095 1563, USA
    Alcohol Clin Exp Res 35:166-74. 2011
    ....
  13. ncbi Naltrexone selectively elevates GABAergic neuroactive steroid levels in heavy drinkers with the Asp40 allele of the OPRM1 gene: a pilot investigation
    Lara A Ray
    Department of Psychology, University of California Los Angeles, Los Angeles, California 90095 1563, USA
    Alcohol Clin Exp Res 34:1479-87. 2010
    ....
  14. ncbi Subjective responses to alcohol consumption as endophenotypes: advancing behavioral genetics in etiological and treatment models of alcoholism
    Lara A Ray
    Department of Psychology, University of California, Los Angeles, CA 90095 1563, USA
    Subst Use Misuse 45:1742-65. 2010
    ....
  15. ncbi Associations among GABRG1, level of response to alcohol, and drinking behaviors
    Lara A Ray
    Department of Psychology, University of California, Los Angeles, California 90095 1563, USA
    Alcohol Clin Exp Res 33:1382-90. 2009
    ....
  16. ncbi Diagnosing alcohol abuse in alcohol dependent individuals: diagnostic and clinical implications
    Lara A Ray
    Department of Psychology, University of California, Los Angeles, 1285 Franz Hall, Box 951563, Los Angeles, CA 90095 1563, United States
    Addict Behav 34:587-92. 2009
    ..Future studies are needed to establish whether these differences are clinically significant in terms of the course of the disorder and response to treatment...
  17. ncbi A preliminary pharmacogenetic investigation of adverse events from topiramate in heavy drinkers
    Lara A Ray
    Center for Alcohol and Addiction Studies, Brown University, Providence, RI, USA
    Exp Clin Psychopharmacol 17:122-9. 2009
    ..Genes underlying glutamatergic neurotransmission, such as the GRIK1 gene, may help predict heterogeneity in topiramate-induced side effects. Future studies in larger samples are needed to more fully establish these preliminary findings...
  18. ncbi A human laboratory study of the effects of quetiapine on subjective intoxication and alcohol craving
    Lara A Ray
    Department of Psychology, University of California Los Angeles, 1285 Franz Hall, Box 951563, Los Angeles, CA 90095 1563, USA
    Psychopharmacology (Berl) 217:341-51. 2011
    ....
  19. ncbi Effects of naltrexone on cortisol levels in heavy drinkers
    Lara A Ray
    Department of Psychology, University of California Los Angeles UCLA, Los Angeles, CA 90095 1563, USA
    Pharmacol Biochem Behav 91:489-94. 2009
    ..These results suggest that naltrexone alters cortisol levels in heavy drinkers and that its effects on subjective responses to alcohol may be related, in part, to naltrexone's ability to activate the HPA-axis...
  20. ncbi Application of human laboratory models to pharmacotherapy development for alcohol dependence
    Lara A Ray
    University of California, Los Angeles, Psychology Department, 1285 Franz Hall, Box 951563, Los Angeles, CA 90095 1563, USA
    Curr Pharm Des 16:2149-58. 2010
    ..Limitations and future directions are discussed...
  21. ncbi Effects of naltrexone during the descending limb of the blood alcohol curve
    Lara A Ray
    Center for Alcohol and Addiction Studies, Brown University, Providence, Rhode Island 02912, USA Lara
    Am J Addict 17:257-64. 2008
    ..Additionally, these results highlight the potential utility of considering limb of blood alcohol curve when examining the mechanisms of action of pharmacotherapies thought to alter subjective responses to alcohol...
  22. ncbi Effects of naltrexone on alcohol sensitivity and genetic moderators of medication response: a double-blind placebo-controlled study
    Lara A Ray
    Department of Psychology, University of Colorado at Boulder, Boulder, Colorado, USA
    Arch Gen Psychiatry 64:1069-77. 2007
    ..However, the mechanism by which naltrexone may be differentially effective as a function of the OPRM1 genotype is unclear...
  23. ncbi Alcohol demand, delayed reward discounting, and craving in relation to drinking and alcohol use disorders
    James MacKillop
    Department of Psychology, University of Georgia, and Center for Alcohol and Addiction Studies, Brown University, USA
    J Abnorm Psychol 119:106-14. 2010
    ..These findings further emphasize the relevance of behavioral economic indices of motivation to AUDs and the potential importance of craving for alcohol in this relationship...
  24. ncbi Diagnostic orphans for alcohol use disorders in a treatment-seeking psychiatric sample
    Lara A Ray
    Center for Alcohol and Addiction Studies, Brown University, Providence, RI, USA
    Drug Alcohol Depend 96:187-91. 2008
    ..Taken together, these results generally do not support combining diagnostic orphans to individuals with alcohol abuse...
  25. ncbi Pharmacological effects of naltrexone and intravenous alcohol on craving for cigarettes among light smokers: a pilot study
    Lara A Ray
    Department of Psychology, University of Colorado at Boulder, Muenzinger Psychology Building, 345 UCB, Boulder, CO 80309 0345, USA
    Psychopharmacology (Berl) 193:449-56. 2007
    ..Although naltrexone has been widely researched in the context of drinking and smoking behaviors, with each substance studied separately, little is known about the effects of naltrexone on craving for cigarettes during alcohol intoxication...
  26. ncbi Behavioral economic analysis of cue-elicited craving for alcohol
    James MacKillop
    Department of Psychology, University of Georgia, Athens, GA 30602, USA
    Addiction 105:1599-607. 2010
    ..The current study tested this hypothesis via a multidimensional assessment of alcohol demand over the course of an alcohol cue reactivity procedure...
  27. ncbi Anhedonia and amotivation in psychiatric outpatients with fully remitted stimulant use disorder
    Adam M Leventhal
    Center for Alcohol and Addiction Studies, Brown University, Providence, Rhode Island, USA
    Am J Addict 17:218-23. 2008
    ..These findings suggest that anhedonia may be a preexisting risk factor or protracted effect of stimulant misuse...
  28. ncbi The factor structure and severity of DSM-IV alcohol abuse and dependence symptoms in psychiatric outpatients
    Lara A Ray
    Center for Alcohol and Addiction Studies, Box G S121 4, Brown University, Providence, Rhode Island 02912, USA
    J Stud Alcohol Drugs 69:496-9. 2008
    ..The goal of the present study was to examine the factor structure and estimated severity of alcohol-use disorder (AUD) symptoms in a sample of treatment-seeking psychiatric outpatients...
  29. ncbi Blood glucose level, alcohol heavy drinking, and alcohol craving during treatment for alcohol dependence: results from the Combined Pharmacotherapies and Behavioral Interventions for Alcohol Dependence (COMBINE) Study
    Lorenzo Leggio
    Center for Alcohol and Addiction Studies, Brown University, Providence, RI 02912, USA
    Alcohol Clin Exp Res 33:1539-44. 2009
    ..Heavy drinking may increase blood glucose levels. Moreover, in alcohol-dependent subjects, glucose may play a putative role in alcohol preference...
  30. ncbi Understanding naltrexone mechanism of action and pharmacogenetics in Asian Americans via behavioral economics: a preliminary study
    Spencer Bujarski
    Department of Psychology, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Exp Clin Psychopharmacol 20:181-90. 2012
    ..This preliminary report provides further evidence for the effectiveness of naltrexone and supports the utility of a behavioral economic approach to alcoholism pharmacotherapy development...
  31. ncbi The neuroeconomics of nicotine dependence: a preliminary functional magnetic resonance imaging study of delay discounting of monetary and cigarette rewards in smokers
    James MacKillop
    Department of Psychology, University of Georgia, Athens, GA, USA
    Psychiatry Res 202:20-9. 2012
    ..These findings provide initial evidence in support of applying a neuroeconomic approach to understanding nicotine dependence...
  32. ncbi Latent structure of facets of alcohol reinforcement from a behavioral economic demand curve
    James MacKillop
    Department of Psychology, University of Georgia, Athens, GA, 30602, USA
    Psychopharmacology (Berl) 203:33-40. 2009
    ..Demand curves provide a multidimensional assessment of reinforcement, but the relationships among the various indices of reinforcement have been largely unstudied...
  33. ncbi The dopamine D Receptor (DRD4) gene exon III polymorphism, problematic alcohol use and novelty seeking: direct and mediated genetic effects
    Lara A Ray
    Brown University, Center for Alcohol and Addiction Studies, USA
    Addict Biol 14:238-44. 2009
    ..These findings may also help elucidate the specific pathways of risk associated with genetic influences on alcohol use and abuse phenotypes...
  34. ncbi Relations between anhedonia and smoking motivation
    Adam M Leventhal
    Center for Alcohol and Addiction Studies, Brown University, Providence, RI 02912, USA
    Nicotine Tob Res 11:1047-54. 2009
    ....
  35. ncbi Refining the depression-nicotine dependence link: patterns of depressive symptoms in psychiatric outpatients with current, past, and no history of nicotine dependence
    Adam M Leventhal
    Center for Alcohol and Addiction Studies, Brown Medical School, Brown University, Providence, RI 02912, USA
    Addict Behav 34:297-303. 2009
    ..Certain vegetative, melancholic and dysphoric depressive symptoms are closely associated with nicotine dependence and could play an important etiological role in depression-nicotine dependence comorbidity...
  36. ncbi The relationship between measures of impulsivity and alcohol misuse: an integrative structural equation modeling approach
    Kelly E Courtney
    From the Department of Psychology, University of California, Los Angeles, CA 90095 1563, USA
    Alcohol Clin Exp Res 36:923-31. 2012
    ..This study simultaneously tested the following dimensions of impulsivity as determinants of alcohol use and alcohol problems: risky decision making, self-reported risk-attitudes, response inhibition, and impulsive decision making...
  37. ncbi Risk-taking and alcohol use disorders symptomatology in a sample of problem drinkers
    James R Ashenhurst
    Interdepartmental Neuroscience Program, Brain Research Institute, University of California, Los Angeles 90095 1563, USA
    Exp Clin Psychopharmacol 19:361-70. 2011
    ..Furthermore, our results demonstrate the importance of inclusion of neurocognitive covariates (IQ), as well as demographic variables (age) when using this task...
  38. ncbi Quetiapine improves response inhibition in alcohol dependent patients: a placebo-controlled pilot study
    Nathasha Moallem
    Department of Psychology, University of California, Los Angeles, CA 90095 1563, USA
    Pharmacol Biochem Behav 100:490-3. 2012
    ....
  39. ncbi Dimensions of impulsivity among heavy drinkers, smokers, and heavy drinking smokers: singular and combined effects
    Nathasha R Moallem
    University of California, Los Angeles, Department of Psychology, CA 90095 1563, USA
    Addict Behav 37:871-4. 2012
    ..Future studies should examine these constructs longitudinally, as well as incorporate genetic and/or a neuroimaging component to these group comparisons in order to ascertain the biological bases of these behavioral findings...
  40. ncbi The relationship between prospective self-rating of alcohol sensitivity and craving and experimental results from two alcohol challenge studies
    Lara A Ray
    University of Colorado, Department of Psychology, Boulder, CO, USA
    J Stud Alcohol Drugs 68:379-84. 2007
    ....
  41. ncbi A prospective study of stress and alcohol craving in heavy drinkers
    Molly A Tartter
    Department of Psychology, University of California, Los Angeles, CA, USA
    Pharmacol Biochem Behav 101:625-31. 2012
    ..The current study supports and extends laboratory research describing phenotypes of stress-induced alcohol craving...
  42. ncbi Risk factors for alcohol misuse: examining heart rate reactivity to alcohol, alcohol sensitivity, and personality constructs
    Lara A Ray
    University of Colorado at Boulder, Department of Psychology, CO 80309 0345, United States
    Addict Behav 31:1959-73. 2006
    ....
  43. ncbi Delayed reward discounting and addictive behavior: a meta-analysis
    James MacKillop
    Department of Psychology, University of Georgia, Athens, GA 30602, USA
    Psychopharmacology (Berl) 216:305-21. 2011
    ..To synthesize the findings across the literature, the current review is a meta-analysis of studies comparing DRD between criterion groups exhibiting addictive behavior and control groups...
  44. ncbi Anhedonia associated with stimulant use and dependence in a population-based sample of American adults
    Adam M Leventhal
    Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA
    Exp Clin Psychopharmacol 18:562-9. 2010
    ..Future research utilizing longitudinal and experimental designs are warranted to clarify the underpinnings of this association...
  45. ncbi Further validation of a cigarette purchase task for assessing the relative reinforcing efficacy of nicotine in college smokers
    James MacKillop
    Center for Alcohol and Addiction Studies, Brown University, Providence, RI 02912, USA
    Exp Clin Psychopharmacol 16:57-65. 2008
    ..Theoretical implications of the findings, limitations, and future directions are also discussed...
  46. ncbi Alcohol use and protective sexual behaviors among high-risk adolescents
    Angela Bryan
    Department of Psychology, 345 UCB, University of Colorado, Boulder, CO 80309 0345, USA
    J Stud Alcohol Drugs 68:327-35. 2007
    ..The following potential moderators were examined: sex-related alcohol expectancies, gender, relationship type, level of alcohol use, and impulsive sensation seeking...
  47. ncbi Delta and kappa opioid receptor polymorphisms influence the effects of naltrexone on subjective responses to alcohol
    James R Ashenhurst
    Interdepartmental Neuroscience Program, University of California, Los Angeles, USA
    Pharmacol Biochem Behav 103:253-9. 2012
    ..These findings suggest that additional pharmacogenetic effects in the opioid receptor system may account for individual differences in response to naltrexone in the human laboratory...
  48. ncbi Genetic and environmental influences on the association between depressive symptom dimensions and smoking initiation among Chinese adolescent twins
    Adam M Leventhal
    Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA
    Nicotine Tob Res 14:559-68. 2012
    ....
  49. ncbi Cognitive-behavioral treatment with adult alcohol and illicit drug users: a meta-analysis of randomized controlled trials
    Molly Magill
    Center for Alcohol and Addiction Studies, Brown University, Box G S121 4, Providence, Rhode Island 02912, USA
    J Stud Alcohol Drugs 70:516-27. 2009
    ..The aims were to provide an overall picture of CBT treatment efficacy and to identify client or treatment factors predictive of CBT effect magnitude...
  50. ncbi Binge eating and binge drinking: an integrative review
    Caitlin Ferriter
    Department of Psychology, University of California, Los Angeles, CA 90095 1563, United States
    Eat Behav 12:99-107. 2011
    ..Implications for understanding potentially common etiological pathways and development of interventions designed to target multiple behaviors are discussed...
  51. ncbi Fronto-striatal functional connectivity during response inhibition in alcohol dependence
    Kelly E Courtney
    Department of Psychology, University of California, Los Angeles, Los Angeles, CA, USA
    Addict Biol 18:593-604. 2013
    ..These findings suggest that the fronto-striatal pathway underlying response inhibition is weakened as alcoholism progresses...
  52. ncbi The effects of drinking goal on treatment outcome for alcoholism
    Spencer Bujarski
    Department of Psychology, University of California, Los Angeles, CA 90095 1563, USA
    J Consult Clin Psychol 81:13-22. 2013
    ..The objective in this study was to elucidate the contribution of drinking goal to treatment outcome in the context of specific behavioral and pharmacological interventions...
  53. ncbi The Effects of Naltrexone Among Alcohol Non-Abstainers: Results from the COMBINE Study
    Lara A Ray
    Department of Psychology, University of California at Los Angeles Los Angeles, CA, USA
    Front Psychiatry 1:26. 2010
    ..Naltrexone may be effective in the context of controlled-drinking approaches, even among very frequent drinkers...