Dipankar Ray

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. pmc The WW-HECT protein Smurf2 interacts with the Docking Protein NEDD9/HEF1 for Aurora A activation
    Finola E Moore
    Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
    Cell Div 5:22. 2010
  2. doi request reprint CDC25A phosphatase: a rate-limiting oncogene that determines genomic stability
    Dipankar Ray
    Department of Molecular Pharmacology and Biological Chemistry, Robert H Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL 60611, USA
    Cancer Res 68:1251-3. 2008
  3. pmc Cdk2-null mice are resistant to ErbB-2-induced mammary tumorigenesis
    Dipankar Ray
    Molecular Pharmacology and Biological Chemistry, Northwestern University, Chicago, IL 60611, USA
    Neoplasia 13:439-44. 2011
  4. ncbi request reprint CDC25A levels determine the balance of proliferation and checkpoint response
    Dipankar Ray
    Department of Molecular Pharmacology and Biological Chemistry, Northwestern University, Chicago, Illinios, USA
    Cell Cycle 6:3039-42. 2007
  5. pmc In vivo roles of CDC25 phosphatases: biological insight into the anti-cancer therapeutic targets
    Hiroaki Kiyokawa
    Department of Molecular Pharmacology and Biological Chemistry, and Robert H Lurie Comprehensive Cancer Center, Northwestern University, Chicago, Illinois 60611, USA
    Anticancer Agents Med Chem 8:832-6. 2008
  6. ncbi request reprint Hemizygous disruption of Cdc25A inhibits cellular transformation and mammary tumorigenesis in mice
    Dipankar Ray
    Department of Molecular Pharmacology and Biological Chemistry, and Robert H Lurie Comprehensive Cancer Center, Northwestern University, 303 E Superior Street, Chicago, IL 60611, USA
    Cancer Res 67:6605-11. 2007
  7. pmc The HECT E3 ligase Smurf2 is required for Mad2-dependent spindle assembly checkpoint
    Evan C Osmundson
    Department of Molecular Pharmacology and Biological Chemistry, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    J Cell Biol 183:267-77. 2008
  8. pmc Smurf2 as a novel mitotic regulator: From the spindle assembly checkpoint to tumorigenesis
    Evan C Osmundson
    Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Feinberg School of Medicine, 303 E, Chicago Avenue, Chicago, IL 60611, USA
    Cell Div 4:14. 2009
  9. ncbi request reprint Constitutive and UV-induced fibronectin degradation is a ubiquitination-dependent process controlled by beta-TrCP
    Dipankar Ray
    Department of Molecular Pharmacology and Biological Chemistry, Robert H Lurie Comprehensive Cancer Center, Northwestern University, Chicago, Illinois 60611, USA
    J Biol Chem 281:23060-5. 2006

Collaborators

Detail Information

Publications9

  1. pmc The WW-HECT protein Smurf2 interacts with the Docking Protein NEDD9/HEF1 for Aurora A activation
    Finola E Moore
    Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
    Cell Div 5:22. 2010
    ..These observations suggest that the stable complex of Smurf2 and NEDD9 is required for timely entry into mitosis via Aurora A activation...
  2. doi request reprint CDC25A phosphatase: a rate-limiting oncogene that determines genomic stability
    Dipankar Ray
    Department of Molecular Pharmacology and Biological Chemistry, Robert H Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL 60611, USA
    Cancer Res 68:1251-3. 2008
    ..These findings offer a sound foundation to justify development of CDC25A inhibitors for antitumor therapy...
  3. pmc Cdk2-null mice are resistant to ErbB-2-induced mammary tumorigenesis
    Dipankar Ray
    Molecular Pharmacology and Biological Chemistry, Northwestern University, Chicago, IL 60611, USA
    Neoplasia 13:439-44. 2011
    ..Thus, we propose that CDC25A-CDK2 pathway is critical for the oncogenic action of ErbB-2 in mammary epithelial cells, in a manner similar to Cyclin D1/CDK4 pathway...
  4. ncbi request reprint CDC25A levels determine the balance of proliferation and checkpoint response
    Dipankar Ray
    Department of Molecular Pharmacology and Biological Chemistry, Northwestern University, Chicago, Illinios, USA
    Cell Cycle 6:3039-42. 2007
    ..Here we provide our views on the role of CDC25A in cancer development and genomic stability, discussing insights from our recent studies on Cdc25A knockout mice and MMTV-CDC25A transgenic mice...
  5. pmc In vivo roles of CDC25 phosphatases: biological insight into the anti-cancer therapeutic targets
    Hiroaki Kiyokawa
    Department of Molecular Pharmacology and Biological Chemistry, and Robert H Lurie Comprehensive Cancer Center, Northwestern University, Chicago, Illinois 60611, USA
    Anticancer Agents Med Chem 8:832-6. 2008
    ..These biological properties of CDC25 phosphatases provide significant insight into the pathobiology of cancer and scientific foundation for anti-CDC25 therapeutic intervention...
  6. ncbi request reprint Hemizygous disruption of Cdc25A inhibits cellular transformation and mammary tumorigenesis in mice
    Dipankar Ray
    Department of Molecular Pharmacology and Biological Chemistry, and Robert H Lurie Comprehensive Cancer Center, Northwestern University, 303 E Superior Street, Chicago, IL 60611, USA
    Cancer Res 67:6605-11. 2007
    ..These results suggest that Cdc25A plays a rate-limiting role in transformation and tumor initiation mediated by ras activation...
  7. pmc The HECT E3 ligase Smurf2 is required for Mad2-dependent spindle assembly checkpoint
    Evan C Osmundson
    Department of Molecular Pharmacology and Biological Chemistry, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    J Cell Biol 183:267-77. 2008
    ..Mad2 is mislocalized in Smurf2-depleted cells, suggesting that Smurf2 regulates the localization and stability of Mad2. These data indicate that Smurf2 is a novel mitotic regulator...
  8. pmc Smurf2 as a novel mitotic regulator: From the spindle assembly checkpoint to tumorigenesis
    Evan C Osmundson
    Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Feinberg School of Medicine, 303 E, Chicago Avenue, Chicago, IL 60611, USA
    Cell Div 4:14. 2009
    ..Finally, deregulated Smurf2 activity may contribute to carcinogenesis by perturbed mitotic control...
  9. ncbi request reprint Constitutive and UV-induced fibronectin degradation is a ubiquitination-dependent process controlled by beta-TrCP
    Dipankar Ray
    Department of Molecular Pharmacology and Biological Chemistry, Robert H Lurie Comprehensive Cancer Center, Northwestern University, Chicago, Illinois 60611, USA
    J Biol Chem 281:23060-5. 2006
    ..Taken together, constitutive FN degradation, as well as UV-induced degradation, is ubiquitination dependent and controlled by beta-TrCP...