Affiliation: University of Missouri
Ray A, Ray B. Persistent expression of serum amyloid A during experimentally induced chronic inflammatory condition in rabbit involves differential activation of SAF, NF-kappa B, and C/EBP transcription factors. J Immunol. 1999;163:2143-50 pubmed
..This result suggested that C/EBP, SAF, and NF-kappa B are required for transient acute phase induction of SAA whereas SAF and NF-kappa B activities are necessary for persistent SAA expression during chronic inflammatory conditions. ..
Ray A, Ray P, Guthrie N, Shakya A, Kumar D, Ray B. Protein kinase A signaling pathway regulates transcriptional activity of SAF-1 by unmasking its DNA-binding domains. J Biol Chem. 2003;278:22586-95 pubmed
..PKA-mediated phosphorylation increases transcriptional activity of SAF-1 by unmasking the DNA-binding domain. ..
Ray A, Shakya A, Kumar D, Ray B. Overexpression of serum amyloid A-activating factor 1 inhibits cell proliferation by the induction of cyclin-dependent protein kinase inhibitor p21WAF-1/Cip-1/Sdi-1 expression. J Immunol. 2004;172:5006-15 pubmed
Ray B, Shakya A, Turk J, Apte S, Ray A. Induction of the MMP-14 gene in macrophages of the atherosclerotic plaque: role of SAF-1 in the induction process. Circ Res. 2004;95:1082-90 pubmed
Ray A, Shakya A, Ray B. Inflammation-responsive transcription factors SAF-1 and c-Jun/c-Fos promote canine MMP-1 gene expression. Biochim Biophys Acta. 2005;1732:53-61 pubmed
..These results show that induction and activation of AP-1 and SAF-1 transcription factors are involved in the regulation of MMP-1 expression in the chondrocytes which could be used as therapeutic targets to combat pathogenesis of OA. ..
Ray A, Shakya A, Kumar D, Benson M, Ray B. Inflammation-responsive transcription factor SAF-1 activity is linked to the development of amyloid A amyloidosis. J Immunol. 2006;177:2601-9 pubmed
..Together, these results provide direct evidence that SAF-1 plays a key role in the development of AA amyloidosis, a consequence of chronic inflammation. ..