ROBERT RAWSON

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. pmc Intriguing parasites and intramembrane proteases
    Robert B Rawson
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Genes Dev 22:1561-6. 2008
  2. ncbi request reprint The SREBP pathway--insights from Insigs and insects
    Robert B Rawson
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA
    Nat Rev Mol Cell Biol 4:631-40. 2003
  3. ncbi request reprint The SREBP pathway in Drosophila: regulation by palmitate, not sterols
    Adam C Seegmiller
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Dev Cell 2:229-38. 2002
  4. ncbi request reprint Isolation of mutant cells lacking Insig-1 through selection with SR-12813, an agent that stimulates degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase
    Navdar Sever
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9046, USA
    J Biol Chem 279:43136-47. 2004
  5. ncbi request reprint Reconstitution of sterol-regulated endoplasmic reticulum-to-Golgi transport of SREBP-2 in insect cells by co-expression of mammalian SCAP and Insigs
    Irina Y Dobrosotskaya
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9046
    J Biol Chem 278:35837-43. 2003
  6. pmc Three mutations in sterol-sensing domain of SCAP block interaction with insig and render SREBP cleavage insensitive to sterols
    Daisuke Yabe
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 99:16672-7. 2002
  7. ncbi request reprint Mutant mammalian cells as tools to delineate the sterol regulatory element-binding protein pathway for feedback regulation of lipid synthesis
    Joseph L Goldstein
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9046, USA
    Arch Biochem Biophys 397:139-48. 2002
  8. ncbi request reprint Regulated intramembrane proteolysis: from the endoplasmic reticulum to the nucleus
    Robert B Rawson
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9046, USA
    Essays Biochem 38:155-68. 2002
  9. doi request reprint Rhomboid proteases: familiar features in unfamiliar phases
    Bilal Amarneh
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, 75390 9046, USA
    Mol Cell 36:922-3. 2009
  10. pmc Alternative processing of sterol regulatory element binding protein during larval development in Drosophila melanogaster
    Krista A Matthews
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9046, USA
    Genetics 181:119-28. 2009

Research Grants

Collaborators

Detail Information

Publications16

  1. pmc Intriguing parasites and intramembrane proteases
    Robert B Rawson
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Genes Dev 22:1561-6. 2008
    ..EhROM1 is found at the base of the cap rather than in the cap proper, suggesting a role in receptor shedding and implying that EhROM1 is crucial for amoebal infection...
  2. ncbi request reprint The SREBP pathway--insights from Insigs and insects
    Robert B Rawson
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA
    Nat Rev Mol Cell Biol 4:631-40. 2003
    ....
  3. ncbi request reprint The SREBP pathway in Drosophila: regulation by palmitate, not sterols
    Adam C Seegmiller
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Dev Cell 2:229-38. 2002
    ..Instead, dSREBP processing is blocked by palmitic acid. These findings suggest that the ancestral SREBP pathway functions to maintain membrane integrity rather than to control cholesterol homeostasis...
  4. ncbi request reprint Isolation of mutant cells lacking Insig-1 through selection with SR-12813, an agent that stimulates degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase
    Navdar Sever
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9046, USA
    J Biol Chem 279:43136-47. 2004
    ..These results provide formal genetic proof for the essential role of Insig-1 in feedback control of lipid synthesis in cultured cells...
  5. ncbi request reprint Reconstitution of sterol-regulated endoplasmic reticulum-to-Golgi transport of SREBP-2 in insect cells by co-expression of mammalian SCAP and Insigs
    Irina Y Dobrosotskaya
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9046
    J Biol Chem 278:35837-43. 2003
    ..They indicate that insect cells can respond to sterols when proper regulatory proteins are expressed...
  6. pmc Three mutations in sterol-sensing domain of SCAP block interaction with insig and render SREBP cleavage insensitive to sterols
    Daisuke Yabe
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 99:16672-7. 2002
    ..Thus, three different point mutations, each within the sterol-sensing domain of SCAP, prevent sterol-induced binding of SCAP to insig proteins and abolish feedback regulation of SREBP processing by sterols...
  7. ncbi request reprint Mutant mammalian cells as tools to delineate the sterol regulatory element-binding protein pathway for feedback regulation of lipid synthesis
    Joseph L Goldstein
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9046, USA
    Arch Biochem Biophys 397:139-48. 2002
    ..Their cDNAs and genes were isolated by genetic complementation or by expression cloning. The somatic cell genetic approach described in this article should prove useful for unraveling other complex biochemical pathways in animal cells...
  8. ncbi request reprint Regulated intramembrane proteolysis: from the endoplasmic reticulum to the nucleus
    Robert B Rawson
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9046, USA
    Essays Biochem 38:155-68. 2002
    ....
  9. doi request reprint Rhomboid proteases: familiar features in unfamiliar phases
    Bilal Amarneh
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, 75390 9046, USA
    Mol Cell 36:922-3. 2009
    ..2009) identify a sequence motif underlying cleavage site specificity for the rhomboid proteases. This sheds light on potential mechanisms by which intramembrane-cleaving proteases cleave their substrates...
  10. pmc Alternative processing of sterol regulatory element binding protein during larval development in Drosophila melanogaster
    Krista A Matthews
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9046, USA
    Genetics 181:119-28. 2009
    ..Despite loss of dS2P, dSREBP is processed in mutant larvae. Therefore, larvae have an alternative cleavage mechanism for producing transcriptionally active dSREBP, and this permits survival of dS2P mutants...
  11. ncbi request reprint An ARC light on lipid metabolism
    Robert B Rawson
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA
    Cell Metab 4:181-3. 2006
    ..present a comprehensive series of experiments, spanning a wide range of disciplines, that identify ARC105 as a component of the ARC complex that interacts directly with SREBP and is necessary for SREBP function (Yang et al., 2006)...
  12. ncbi request reprint Fatty acid auxotrophy in Drosophila larvae lacking SREBP
    Amit S Kunte
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, Texas 75390, USA
    Cell Metab 3:439-48. 2006
    ..The role, if any, of dSREBP in adults is not yet apparent. These data indicate that dSREBP deficiency renders Drosophila larvae auxotrophic for fatty acids...
  13. pmc Activation of sterol regulatory element-binding protein by the caspase Drice in Drosophila larvae
    Bilal Amarneh
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9046, USA
    J Biol Chem 284:9674-82. 2009
    ..Drice-dependent activation of dSREBP explains why flies lacking dS2P are viable, and flies lacking dSREBP itself are not...
  14. pmc Dual roles for cholesterol in mammalian cells
    Fang Xu
    Center for Human Nutrition, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 102:14551-6. 2005
    ....
  15. pmc Activation of sterol regulatory element binding proteins in the absence of Scap in Drosophila melanogaster
    Krista A Matthews
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390 9046, USA
    Genetics 185:189-98. 2010
    ..Thus, dScap and dS2P, essential components of the SREBP activation machinery in mammalian cells, are dispensable in Drosophila owing to different compensatory mechanisms...
  16. pmc COPI activity coupled with fatty acid biosynthesis is required for viral replication
    Sara Cherry
    University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
    PLoS Pathog 2:e102. 2006
    ..Additionally, because these pathways are also limiting in flies and in human cells infected with the related RNA virus poliovirus, they may represent novel targets for antiviral therapies...

Research Grants5

  1. Regulation of Lipid and Membrane Synthesis in Drosophila
    ROBERT RAWSON; Fiscal Year: 2007
    ..These hypotheses will be easier to test in the simpler fly model, thereby complementing rather than duplicating studies of SREBPs ongoing in other laboratories. ..
  2. Regulation of Lipid and Membrane Synthesis in Drosophila
    ROBERT RAWSON; Fiscal Year: 2009
    ..These hypotheses will be easier to test in the simpler fly model, thereby complementing rather than duplicating studies of SREBPs ongoing in other laboratories. ..