David Rawlings

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. pmc Characterization of a late transitional B cell population highly sensitive to BAFF-mediated homeostatic proliferation
    Almut Meyer-Bahlburg
    Department of Pediatrics, University of Washington School of Medicine, Seattle, WA 98195, USA
    J Exp Med 205:155-68. 2008
  2. pmc B cell intrinsic TLR signals amplify but are not required for humoral immunity
    Almut Meyer-Bahlburg
    Seattle Children s Hospital Research Institute, Seattle, WA 98101, USA
    J Exp Med 204:3095-101. 2007
  3. pmc Trypanosoma cruzi trans-sialidase initiates a program independent of the transcription factors RORγt and Ahr that leads to IL-17 production by activated B cells
    Daniela A Bermejo
    Centro de Investigaciones en Bioquimica Clinica e Inmunologia, Consejo Nacional de Investigaciones Cientificas y Tecnicas, Facultad de Ciencias Quimicas, Universidad Nacional de Cordoba, Cordoba, Argentina
    Nat Immunol 14:514-22. 2013
  4. pmc Wiskott-Aldrich syndrome protein deficiency in B cells results in impaired peripheral homeostasis
    Almut Meyer-Bahlburg
    Department of Pediatrics, Seattle Children s Hospital Research Institute, WA, USA
    Blood 112:4158-69. 2008
  5. pmc WASp-deficient B cells play a critical, cell-intrinsic role in triggering autoimmunity
    Shirly Becker-Herman
    Department of Pediatrics, University of Washington School of Medicine, Seattle, WA Seattle Children s Research Institute, Seattle, WA, USA
    J Exp Med 208:2033-42. 2011
  6. pmc Integration of B cell responses through Toll-like receptors and antigen receptors
    David J Rawlings
    Department of Pediatrics, University of Washington School of Medicine, Seattle, Washington 98195, USA
    Nat Rev Immunol 12:282-94. 2012
  7. ncbi request reprint The CARMA1 signalosome links the signalling machinery of adaptive and innate immunity in lymphocytes
    David J Rawlings
    Department of Immunology, Childrens Hospital and Regional Medical Centre, 307 Westlake Avenue North, Suite 300, Seattle, Washington 98109, USA
    Nat Rev Immunol 6:799-812. 2006
  8. pmc Anti-CD3 antibodies modulate anti-factor VIII immune responses in hemophilia A mice after factor VIII plasmid-mediated gene therapy
    Baowei Peng
    Department of Pediatrics, Seattle Children s Research Institute and University of Washington, Seattle, WA 98101, USA
    Blood 114:4373-82. 2009
  9. pmc Transient blockade of the inducible costimulator pathway generates long-term tolerance to factor VIII after nonviral gene transfer into hemophilia A mice
    Baowei Peng
    Department of Pediatrics, Seattle Children s Hospital Research Institute and University of Washington, Seattle, WA 98101, USA
    Blood 112:1662-72. 2008
  10. ncbi request reprint Naked DNA transfer of Factor VIII induced transgene-specific, species-independent immune response in hemophilia A mice
    Peiqing Ye
    Department of Pediatrics and Department of Medicine, University of Washington, Seattle, WA 98195, USA
    Mol Ther 10:117-26. 2004

Research Grants

Collaborators

Detail Information

Publications39

  1. pmc Characterization of a late transitional B cell population highly sensitive to BAFF-mediated homeostatic proliferation
    Almut Meyer-Bahlburg
    Department of Pediatrics, University of Washington School of Medicine, Seattle, WA 98195, USA
    J Exp Med 205:155-68. 2008
    ..These data, in association with the coordinate role for BAFF and microenvironmental cues in determining the mature BCR repertoire, imply that this subset functions as a unique selection point in peripheral B cell development...
  2. pmc B cell intrinsic TLR signals amplify but are not required for humoral immunity
    Almut Meyer-Bahlburg
    Seattle Children s Hospital Research Institute, Seattle, WA 98101, USA
    J Exp Med 204:3095-101. 2007
    ..However, B cell-intrinsic TLR signals are not required for antibody production or maintenance...
  3. pmc Trypanosoma cruzi trans-sialidase initiates a program independent of the transcription factors RORγt and Ahr that leads to IL-17 production by activated B cells
    Daniela A Bermejo
    Centro de Investigaciones en Bioquimica Clinica e Inmunologia, Consejo Nacional de Investigaciones Cientificas y Tecnicas, Facultad de Ciencias Quimicas, Universidad Nacional de Cordoba, Cordoba, Argentina
    Nat Immunol 14:514-22. 2013
    ..Our combined data suggest that the generation of IL-17(+) B cells may be a previously unappreciated feature of innate immune responses required for pathogen control or IL-17-mediated autoimmunity...
  4. pmc Wiskott-Aldrich syndrome protein deficiency in B cells results in impaired peripheral homeostasis
    Almut Meyer-Bahlburg
    Department of Pediatrics, Seattle Children s Hospital Research Institute, WA, USA
    Blood 112:4158-69. 2008
    ..Together, our data provide a better understanding of the clinical phenotype of WAS and suggest that gene therapy might be a useful approach to rescue altered B-cell homeostasis in this disease...
  5. pmc WASp-deficient B cells play a critical, cell-intrinsic role in triggering autoimmunity
    Shirly Becker-Herman
    Department of Pediatrics, University of Washington School of Medicine, Seattle, WA Seattle Children s Research Institute, Seattle, WA, USA
    J Exp Med 208:2033-42. 2011
    ....
  6. pmc Integration of B cell responses through Toll-like receptors and antigen receptors
    David J Rawlings
    Department of Pediatrics, University of Washington School of Medicine, Seattle, Washington 98195, USA
    Nat Rev Immunol 12:282-94. 2012
    ..Here, we highlight the importance of the integration of signalling pathways downstream of BCRs and TLRs in modulating B cell function, focusing when possible on B cell-intrinsic roles...
  7. ncbi request reprint The CARMA1 signalosome links the signalling machinery of adaptive and innate immunity in lymphocytes
    David J Rawlings
    Department of Immunology, Childrens Hospital and Regional Medical Centre, 307 Westlake Avenue North, Suite 300, Seattle, Washington 98109, USA
    Nat Rev Immunol 6:799-812. 2006
    ....
  8. pmc Anti-CD3 antibodies modulate anti-factor VIII immune responses in hemophilia A mice after factor VIII plasmid-mediated gene therapy
    Baowei Peng
    Department of Pediatrics, Seattle Children s Research Institute and University of Washington, Seattle, WA 98101, USA
    Blood 114:4373-82. 2009
    ..Furthermore, anti-CD3 can reduce the titers of preexisting anti-FVIII inhibitory antibodies in hemophilia A mice...
  9. pmc Transient blockade of the inducible costimulator pathway generates long-term tolerance to factor VIII after nonviral gene transfer into hemophilia A mice
    Baowei Peng
    Department of Pediatrics, Seattle Children s Hospital Research Institute and University of Washington, Seattle, WA 98101, USA
    Blood 112:1662-72. 2008
    ..Our data indicate that transient anti-ICOS monoclonal antibody treatment represents a novel single-agent immunomodulatory strategy to overcome the immune responses against transgene product after gene therapy...
  10. ncbi request reprint Naked DNA transfer of Factor VIII induced transgene-specific, species-independent immune response in hemophilia A mice
    Peiqing Ye
    Department of Pediatrics and Department of Medicine, University of Washington, Seattle, WA 98195, USA
    Mol Ther 10:117-26. 2004
    ..Consistent with this idea, in a separate group of mice treated with pBS-HCRHPI-FVIIIA, transient immunosuppression by cyclophosphamide significantly delayed (5/6) or abolished (1/6) inhibitory antibody formation against the transgene...
  11. ncbi request reprint Sustained correction of B-cell development and function in a murine model of X-linked agammaglobulinemia (XLA) using retroviral-mediated gene transfer
    Phyllis W Yu
    Children s Hospital and Regional Medical Center, 307 Westlake Ave North, Suite 300, Seattle, WA 98109, USA
    Blood 104:1281-90. 2004
    ..Together, these data demonstrate that gene transfer into hematopoietic stem cells can reconstitute Btk-dependent B-cell development and function in vivo, and strongly support the feasibility of pursuing Btk gene transfer for XLA...
  12. pmc Calcium signalling and cell-fate choice in B cells
    Andrew M Scharenberg
    Department of Pediatrics, University of Washington School of Medicine and Children s Hospital and Regional Medical Center, Suite 300, 307 Westlake Avenue, Seattle, Washington 98109, USA
    Nat Rev Immunol 7:778-89. 2007
    ....
  13. pmc CD4+FOXP3+ regulatory T cells confer long-term regulation of factor VIII-specific immune responses in plasmid-mediated gene therapy-treated hemophilia mice
    Carol H Miao
    Seattle Children s Research Institute, Seattle, WA 98101, USA
    Blood 114:4034-44. 2009
    ..Antigen-specific Tregs can provide long-lasting protection against immune responses in vivo and limit recall responses induced by a second challenge via infectious tolerance...
  14. pmc Immunomodulation of transgene responses following naked DNA transfer of human factor VIII into hemophilia A mice
    Carol H Miao
    Children s Hospital and Regional Medical Center, Department of Pediatrics, University of Washington, Seattle, WA 98109, USA
    Blood 108:19-27. 2006
    ....
  15. pmc Myc stimulates B lymphocyte differentiation and amplifies calcium signaling
    Tania Habib
    Department of Comparative Medicine, University of Washington, Seattle, WA 98195, USA
    J Cell Biol 179:717-31. 2007
    ....
  16. ncbi request reprint Local increase in thymic stromal lymphopoietin induces systemic alterations in B cell development
    Alexander Astrakhan
    Department of Immunology, University of Washington School of Medicine Seattle, Washington 98195, USA
    Nat Immunol 8:522-31. 2007
    ..These observations suggest that signals mediating localized TSLP expression may modulate systemic B cell development and promote humoral autoimmunity...
  17. pmc Imatinib suppresses cryoglobulinemia and secondary membranoproliferative glomerulonephritis
    Masayuki Iyoda
    Department of Pathology, University of Washington, 1959 NE Pacific Avenue, Box 357470, Seattle, WA 98195, USA
    J Am Soc Nephrol 20:68-77. 2009
    ..These data suggest that treatment with imatinib may be a novel therapeutic approach for cryoglobulinemia and MPGN in humans...
  18. pmc Wiskott-Aldrich syndrome protein is required for homeostasis and function of invariant NKT cells
    Alexander Astrakhan
    Department of Immunology, University of Washington School of Medicine and Seattle Children s Research Institute, Seattle, WA 98101, USA
    J Immunol 182:7370-80. 2009
    ..Our findings highlight the crucial role for WASp in iNKT development, homeostasis, and activation, and identify iNKT dysfunction as an additional factor likely to contribute to the clinical features observed in WAS patients...
  19. pmc Serine 649 phosphorylation within the protein kinase C-regulated domain down-regulates CARMA1 activity in lymphocytes
    Miguel E Moreno-Garcia
    Center for Immunity and Immunotherapies, Seattle Children s Research Institute, University of Washington School of Medicine, Seattle, WA 98109, USA
    J Immunol 183:7362-70. 2009
    ..We propose that early phosphorylation events at S657 and S564 promote the initial assembly of the CARMA1 signalosome, whereas later phosphorylation at S649 triggers CARMA1 down-regulation...
  20. pmc B cell autonomous TLR signaling and autoimmunity
    Almut Meyer-Bahlburg
    Seattle Children s Hospital Research Institute, Seattle, WA 98101, USA
    Autoimmun Rev 7:313-6. 2008
    ..This article gives an overview of TLR signaling in B cells and the possible involvement of such signals in autoimmune diseases...
  21. ncbi request reprint Protein kinase C family functions in B-cell activation
    Beichu Guo
    Department of Immunology, University of Washington School of Medicine, Seattle 98195, USA
    Curr Opin Immunol 16:367-73. 2004
    ..By contrast, the novel PKC isoform PKCdelta is specifically required to maintain the tolerance of self-reactive B cells...
  22. ncbi request reprint Proximal signals controlling B-cell antigen receptor (BCR) mediated NF-kappaB activation
    Miguel E Moreno-Garcia
    Department of Pediatrics, University of Washington School of Medicine, Seattle, WA 98195, USA
    Adv Exp Med Biol 584:89-106. 2006
  23. pmc Stable hematopoietic cell engraftment after low-intensity nonmyeloablative conditioning in patients with immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome
    LAURI M BURROUGHS
    Fred Hutchinson Cancer Research Center, Seattle, Wash 98109 1024, USA
    J Allergy Clin Immunol 126:1000-5. 2010
    ..Hematopoietic cell transplantation is currently the only viable option for long-term survival, but patients are frequently very ill and may not tolerate traditional myeloablative conditioning regimens...
  24. pmc MAGUK-controlled ubiquitination of CARMA1 modulates lymphocyte NF-kappaB activity
    Miguel E Moreno-Garcia
    Center for Immunity and Immunotherapies, Seattle Children s Research Institute, 1900 Ninth Avenue, Seattle, WA 98101, USA
    Mol Cell Biol 30:922-34. 2010
    ..The coordination of degradation with the full activation of the CARMA1 molecule likely provides an intrinsic feedback control mechanism to balance lymphocyte activation upon antigenic stimulation...
  25. pmc Transitional B cells exhibit a B cell receptor-specific nuclear defect in gene transcription
    Sarah F Andrews
    Department of Immunology, University of Washington School of Medicine, Seattle, WA 98195, USA
    J Immunol 182:2868-78. 2009
    ..Our combined findings demonstrate that T1 B cells are programmed for signal- and stage-specific "nuclear nonresponsiveness" upon encounter with self-Ags...
  26. pmc Wiskott-Aldrich syndrome protein is required for regulatory T cell homeostasis
    Stephanie Humblet-Baron
    Department of Pediatrics, University of Washington School of Medicine, Seattle, Washington, USA
    J Clin Invest 117:407-18. 2007
    ..Finally, WASp(+) Tregs exhibited a marked selective advantage in vivo in a WAS patient with a spontaneous revertant mutation, indicating that altered Treg fitness likely explains the autoimmune features in human WAS...
  27. pmc HS1 functions as an essential actin-regulatory adaptor protein at the immune synapse
    Timothy S Gomez
    Department of Immunology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Immunity 24:741-52. 2006
    ..Taken together, our studies show that HS1 is indispensable for signaling events leading to actin assembly and IL-2 production during T cell activation...
  28. ncbi request reprint Emerging roles for PKC isoforms in immune cell function
    Thomas T Su
    The Molecular Biology Institute, University of California Los Angeles, Los Angeles, CA 90095 1752, USA
    Mol Interv 2:141-4. 2002
  29. pmc Dysregulated TCL1 promotes multiple classes of mature B cell lymphoma
    Katrina K Hoyer
    Department of Pathology and Laboratory Medicine, Molecular Biology Institute, Jonsson Comprehensive Cancer Center, and AIDS Institute, University of California School of Medicine, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 99:14392-7. 2002
    ..Together these data demonstrate that TCL1 is a powerful oncogene that, when overexpressed in both B and T cells, predominantly yields mature B cell lymphomas...
  30. ncbi request reprint An exemplum of XLA
    Luigi D Notarangelo
    Division of Immunology, Children s Hospital, Boston, MA, USA
    Clin Immunol 126:137-9. 2008
  31. ncbi request reprint SHP-1 regulates Fcgamma receptor-mediated phagocytosis and the activation of RAC
    Anita M Kant
    Herman B Wells Center for Pediatrics Research, Indiana University School of Medicine, Indianapolis 46202, USA
    Blood 100:1852-9. 2002
    ....
  32. ncbi request reprint B cell developmental requirement for the G alpha i2 gene
    Harnisha Dalwadi
    Department of Pathology and Laboratory Medicine, School of Medicine, University of California Los Angeles, Los Angeles, CA 90095 1732, USA
    J Immunol 170:1707-15. 2003
    ..Collectively, these results reveal a selective role for Galphai2 in MZ and B-1 B cell development. Disorders of this Galphai2-dependent process in B cell development may represent a mechanism for IBD susceptibility...
  33. ncbi request reprint BTK regulates PtdIns-4,5-P2 synthesis: importance for calcium signaling and PI3K activity
    Kan Saito
    Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Immunity 19:669-78. 2003
    ..This enzyme-enzyme interaction provides a shuttling mechanism that allows BTK to stimulate the production of the substrate required by both its upstream activator, PI3K, and its downstream target, PLC-gamma2...
  34. ncbi request reprint Tec kinases mediate sustained calcium influx via site-specific tyrosine phosphorylation of the phospholipase Cgamma Src homology 2-Src homology 3 linker
    Lisa A Humphries
    Molecular Biology Institute and Department of Microbiology and Immunology, UCLA, Los Angeles, California 90095, USA
    J Biol Chem 279:37651-61. 2004
    ..Together, these data support a model whereby Btk/Tec kinases control sustained calcium signaling via site-specific phosphorylation of key residues within the PLCgamma2 SH2-SH3 linker...
  35. ncbi request reprint ATM protein purified from vaccinia virus expression system: DNA binding requirements for kinase activation
    Helen H Chun
    Department of Pathology, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Biochem Biophys Res Commun 322:74-81. 2004
    ..As shown by atomic force microscopy, FLAG-ATM bound to linear DNA both at broken ends and in mid-strands. Vaccinia virus is the most efficient ATM expression system described to date...
  36. ncbi request reprint CD38 signaling regulates B lymphocyte activation via a phospholipase C (PLC)-gamma 2-independent, protein kinase C, phosphatidylcholine-PLC, and phospholipase D-dependent signaling cascade
    Miguel E Moreno-Garcia
    Departments of Cell Biology, Centro de Investigacion y Estudios Avanzados, Mexico D F Mexico
    J Immunol 174:2687-95. 2005
    ..Taken together, these data demonstrate that CD38 initiates a novel signaling cascade leading to Btk-, PC-PLC-, and phospholipase D-dependent, PLC-gamma2-independent, B lymphocyte activation...
  37. pmc Bruton's tyrosine kinase regulates immunoglobulin promoter activation in association with the transcription factor Bright
    Jaya Rajaiya
    Oklahoma Medical Research Foundation, Immunobiology and Cancer Research Program, 825 N E 13th St, Oklahoma City, OK 73104, USA
    Mol Cell Biol 25:2073-84. 2005
    ..Bright was not appreciably phosphorylated by Btk; however, a third tyrosine-phosphorylated protein coprecipitated with Bright. Thus, the ability of Bright to enhance immunoglobulin transcription critically requires functional Btk...
  38. ncbi request reprint Novel suppressive function of transitional 2 B cells in experimental arthritis
    Jamie G Evans
    Centre for Rheumatology Research, Department of Medicine, University College London, 46 Cleveland Street, London, United Kingdom
    J Immunol 178:7868-78. 2007
    ..The ability to regulate an established immune response by T2-MZP B cells endows this subset of B cells with a striking and previously unrecognized immunoregulatory potential...
  39. ncbi request reprint PKC-beta controls I kappa B kinase lipid raft recruitment and activation in response to BCR signaling
    Thomas T Su
    The Molecular Biology Institute, University of California, Los Angeles, CA 90095, USA
    Nat Immunol 3:780-6. 2002
    ..Together, these data define an essential role for PKC-beta in BCR survival signaling and highlight PKC-beta as a key therapeutic target for B-lineage malignancies...

Research Grants43

  1. MODEL FOR GENE THERAPY IN X LINKED AGAMMAGLOBULINEMIA
    David Rawlings; Fiscal Year: 2001
    ..Those vectors demonstrating optimal restoration of Btk function in vivo will be utilized for gene transfer into stem cells or B progenitors in pre-clinical studies of patients with XLA. ..
  2. Lentiviral Gene Therapy of X-linked Agammaglobulinemia
    David Rawlings; Fiscal Year: 2005
    ..Overcoming these technical challenges should also provide insight for development of gene therapy in congenital diseases that lack a selective advantage. ..
  3. REGULATION OF B CELL DEVELOPMENT AND SIGNALING BY BTK
    David Rawlings; Fiscal Year: 2004
    ....
  4. REGULATION OF B CELL DEVELOPMENT AND SIGNALING BY BTK
    David Rawlings; Fiscal Year: 2003
    ..A better understanding of these events will have important implications for both our understanding of normal immune cell development and ultimately for the management of XLA and other primary immunodeficiencies. ..
  5. Lentiviral Gene Therapy for Wiskott-Aldrich Syndrome
    David Rawlings; Fiscal Year: 2009
    ..Our proposed studies will provide nearly all of the key expression, efficacy, and safety data required to move forward with a human gene therapy trial for WAS; and have a very high likelihood for translation into new therapies. ..
  6. MODEL FOR GENE THERAPY IN X LINKED AGAMMAGLOBULINEMIA
    David Rawlings; Fiscal Year: 2001
    ..Those vectors demonstrating optimal restoration of Btk function in vivo will be utilized for gene transfer into stem cells or B progenitors in pre-clinical studies of patients with XLA. ..
  7. REGULATION OF B CELL DEVELOPMENT AND SIGNALING BY BTK
    David Rawlings; Fiscal Year: 2000
    ..A better understanding of these events will have important implications for both our understanding of normal immune cell development and ultimately for the management of XLA and other primary immunodeficiencies. ..
  8. Lentiviral Gene Therapy for Wiskott-Aldrich Syndrome
    David J Rawlings; Fiscal Year: 2010
    ..Our proposed studies will provide nearly all of the key expression, efficacy, and safety data required to move forward with a human gene therapy trial for WAS;and have a very high likelihood for translation into new therapies. ..
  9. Lentiviral Gene Therapy of X-linked Agammaglobulinemia
    David Rawlings; Fiscal Year: 2004
    ..Overcoming these technical challenges should also provide insight for development of gene therapy in congenital diseases that lack a selective advantage. ..
  10. Core--Immune Function Studies
    David Rawlings; Fiscal Year: 2007
    ..abstract_text> ..
  11. Lentiviral Gene Therapy for Wiskott-Aldrich Syndrome
    David Rawlings; Fiscal Year: 2007
    ..abstract_text> ..
  12. Lentiviral Gene Therapy of X-linked Agammaglobulinemia
    David Rawlings; Fiscal Year: 2007
    ..Overcoming these technical challenges should also provide insight for development of gene therapy in congenital diseases that lack a selective advantage. ..
  13. REGULATION OF B CELL DEVELOPMENT AND SIGNALING BY BTK
    David Rawlings; Fiscal Year: 2007
    ....
  14. MODEL FOR GENE THERAPY IN X LINKED AGAMMAGLOBULINEMIA
    David Rawlings; Fiscal Year: 2000
    ..Those vectors demonstrating optimal restoration of Btk function in vivo will be utilized for gene transfer into stem cells or B progenitors in pre-clinical studies of patients with XLA. ..
  15. REGULATION OF B CELL DEVELOPMENT AND SIGNALING BY BTK
    David Rawlings; Fiscal Year: 2001
    ..A better understanding of these events will have important implications for both our understanding of normal immune cell development and ultimately for the management of XLA and other primary immunodeficiencies. ..
  16. REGULATION OF B CELL DEVELOPMENT AND SIGNALING BY BTK
    David Rawlings; Fiscal Year: 1999
    ..A better understanding of these events will have important implications for both our understanding of normal immune cell development and ultimately for the management of XLA and other primary immunodeficiencies. ..
  17. REGULATION OF B CELL DEVELOPMENT AND SIGNALING BY BTK
    David Rawlings; Fiscal Year: 2001
    ..A better understanding of these events will have important implications for both our understanding of normal immune cell development and ultimately for the management of XLA and other primary immunodeficiencies. ..
  18. MODEL FOR GENE THERAPY IN X LINKED AGAMMAGLOBULINEMIA
    David Rawlings; Fiscal Year: 2002
    ..Those vectors demonstrating optimal restoration of Btk function in vivo will be utilized for gene transfer into stem cells or B progenitors in pre-clinical studies of patients with XLA. ..
  19. REGULATION OF B CELL DEVELOPMENT AND SIGNALING BY BTK
    David Rawlings; Fiscal Year: 2002
    ..A better understanding of these events will have important implications for both our understanding of normal immune cell development and ultimately for the management of XLA and other primary immunodeficiencies. ..
  20. MODEL FOR GENE THERAPY IN X LINKED AGAMMAGLOBULINEMIA
    David Rawlings; Fiscal Year: 2003
    ..Those vectors demonstrating optimal restoration of Btk function in vivo will be utilized for gene transfer into stem cells or B progenitors in pre-clinical studies of patients with XLA. ..
  21. MODEL FOR GENE THERAPY IN X LINKED AGAMMAGLOBULINEMIA
    David Rawlings; Fiscal Year: 2002
    ..Those vectors demonstrating optimal restoration of Btk function in vivo will be utilized for gene transfer into stem cells or B progenitors in pre-clinical studies of patients with XLA. ..
  22. MODEL FOR GENE THERAPY IN X LINKED AGAMMAGLOBULINEMIA
    David Rawlings; Fiscal Year: 2003
    ..Those vectors demonstrating optimal restoration of Btk function in vivo will be utilized for gene transfer into stem cells or B progenitors in pre-clinical studies of patients with XLA. ..
  23. Model for Gene Therapy in X-linked Agammaglobulinemia
    David Rawlings; Fiscal Year: 2004
    ..Overcoming these technical challenges will likely provide important insight into therapies for other more common genetic disorders lacking a selective advantage for corrected cells. ..
  24. Model for Gene Therapy in X-linked Agammaglobulinemia
    David Rawlings; Fiscal Year: 2005
    ..Overcoming these technical challenges will likely provide important insight into therapies for other more common genetic disorders lacking a selective advantage for corrected cells. ..
  25. REGULATION OF B CELL DEVELOPMENT AND SIGNALING BY BTK
    David Rawlings; Fiscal Year: 2005
    ....
  26. Model for Gene Therapy in X-linked Agammaglobulinemia
    David Rawlings; Fiscal Year: 2006
    ..Overcoming these technical challenges will likely provide important insight into therapies for other more common genetic disorders lacking a selective advantage for corrected cells. ..
  27. REGULATION OF B CELL DEVELOPMENT AND SIGNALING BY BTK
    David Rawlings; Fiscal Year: 2006
    ....
  28. Lentiviral Gene Therapy of X-linked Agammaglobulinemia
    David Rawlings; Fiscal Year: 2006
    ..Overcoming these technical challenges should also provide insight for development of gene therapy in congenital diseases that lack a selective advantage. ..
  29. Model for Gene Therapy in X-linked Agammaglobulinemia
    David Rawlings; Fiscal Year: 2007
    ..Overcoming these technical challenges will likely provide important insight into therapies for other more common genetic disorders lacking a selective advantage for corrected cells. ..
  30. MODEL FOR GENE THERAPY IN X LINKED AGAMMAGLOBULINEMIA
    David Rawlings; Fiscal Year: 1999
    ..Those vectors demonstrating optimal restoration of Btk function in vivo will be utilized for gene transfer into stem cells or B progenitors in pre-clinical studies of patients with XLA. ..