Nenoo Rawal

Summary

Affiliation: University of Texas Health Center
Country: USA

Publications

  1. ncbi Formation of high-affinity C5 convertases of the alternative pathway of complement
    N Rawal
    Department of Biochemistry, University of Texas Health Science Center, Tyler, TX 75708, USA
    J Immunol 166:2635-42. 2001
  2. ncbi Structure/function of C5 convertases of complement
    N Rawal
    Department of Biochemistry, University of Texas Health Center at Tyler, 11937 US Highway 271, Tyler, TX 75708 3154, USA
    Int Immunopharmacol 1:415-22. 2001
  3. ncbi Stringent regulation of complement lectin pathway C3/C5 convertase by C4b-binding protein (C4BP)
    Nenoo Rawal
    Department of Biochemistry, University of Texas Health Science Center, 11937, US Highway 271, Tyler, TX 75708, USA
    Mol Immunol 46:2902-10. 2009
  4. ncbi Formation of high affinity C5 convertase of the classical pathway of complement
    Nenoo Rawal
    Department of Biochemistry, University of Texas Health Science Center, Tyler, Texas 75703, USA
    J Biol Chem 278:38476-83. 2003
  5. ncbi Role of the C3b-binding site on C4b-binding protein in regulating classical pathway C5 convertase
    Nenoo Rawal
    Department of Biochemistry, University of Texas Health Science Center, 11937 US Highway 271, Tyler, TX 75708 3154, USA
    Mol Immunol 44:1105-14. 2007
  6. ncbi Activation of complement component C5: comparison of C5 convertases of the lectin pathway and the classical pathway of complement
    Nenoo Rawal
    Department of Biochemistry, University of Texas Health Science Center, Tyler, Texas 75708, USA
    J Biol Chem 283:7853-63. 2008
  7. ncbi Recombinant form of human wild type mannan-binding lectin (MBL/A) but not its structural variant (MBL/C) promotes phagocytosis of zymosan by activating complement
    Rema Rajagopalan
    Department of Biochemistry, University of Texas Health Science Center, 11937, US Highway 271, Tyler, TX 75708, USA
    Mol Immunol 47:2505-14. 2010
  8. ncbi Structure and function of complement C5 convertase enzymes
    M K Pangburn
    Department of Biochemistry, University of Texas Health Science Center, Tyler 75708, USA
    Biochem Soc Trans 30:1006-10. 2002
  9. ncbi Polyanion-induced self-association of complement factor H
    Michael K Pangburn
    Department of Biochemistry, Center for Biomedical Research, University of Texas Health Science Center, Tyler, TX 75708, USA
    J Immunol 182:1061-8. 2009
  10. ncbi New insights on the structural/functional properties of recombinant human mannan-binding lectin and its variants
    Rema Rajagopalan
    Department of Biochemistry, University of Texas Health Science Center, 11937, US Highway 271, Tyler, TX 75708 3154, USA
    Immunol Lett 123:114-24. 2009

Research Grants

  1. Activation and regulation of the lectin pathway
    Nenoo Rawal; Fiscal Year: 2007

Collaborators

  • M K Pangburn
  • Viviana P Ferreira
  • Sreerama Shetty
  • Rema Rajagopalan
  • Veena P Salvi
  • Ankita Garg
  • Takazvida Nyaundi
  • Jens Chr Jensenius
  • David E Griffith
  • Ramakrishna Vankayalapati
  • Shiping Wu
  • Peter F Barnes
  • Jagpreet S Nanda
  • Sugata Roy
  • Angel Porgador
  • William M Girard

Detail Information

Publications11

  1. ncbi Formation of high-affinity C5 convertases of the alternative pathway of complement
    N Rawal
    Department of Biochemistry, University of Texas Health Science Center, Tyler, TX 75708, USA
    J Immunol 166:2635-42. 2001
    ..The catalytic rate of these convertases approaches maximum velocity, thereby switching the enzyme from cleavage of C3 to cleavage of C5, and production of the cytolytic C5b-9 complex...
  2. ncbi Structure/function of C5 convertases of complement
    N Rawal
    Department of Biochemistry, University of Texas Health Center at Tyler, 11937 US Highway 271, Tyler, TX 75708 3154, USA
    Int Immunopharmacol 1:415-22. 2001
    ..The process underlying the formation of high affinity C5 convertases during complement activation is discussed...
  3. ncbi Stringent regulation of complement lectin pathway C3/C5 convertase by C4b-binding protein (C4BP)
    Nenoo Rawal
    Department of Biochemistry, University of Texas Health Science Center, 11937, US Highway 271, Tyler, TX 75708, USA
    Mol Immunol 46:2902-10. 2009
    ....
  4. ncbi Formation of high affinity C5 convertase of the classical pathway of complement
    Nenoo Rawal
    Department of Biochemistry, University of Texas Health Science Center, Tyler, Texas 75703, USA
    J Biol Chem 278:38476-83. 2003
    ....
  5. ncbi Role of the C3b-binding site on C4b-binding protein in regulating classical pathway C5 convertase
    Nenoo Rawal
    Department of Biochemistry, University of Texas Health Science Center, 11937 US Highway 271, Tyler, TX 75708 3154, USA
    Mol Immunol 44:1105-14. 2007
    ..Although deposition of additional C3b molecules is necessary to convert a C3 convertase to a high affinity C5 convertase, the additional C3b molecules play no role in the regulation of C5 convertase by C4BP...
  6. ncbi Activation of complement component C5: comparison of C5 convertases of the lectin pathway and the classical pathway of complement
    Nenoo Rawal
    Department of Biochemistry, University of Texas Health Science Center, Tyler, Texas 75708, USA
    J Biol Chem 283:7853-63. 2008
    ....
  7. ncbi Recombinant form of human wild type mannan-binding lectin (MBL/A) but not its structural variant (MBL/C) promotes phagocytosis of zymosan by activating complement
    Rema Rajagopalan
    Department of Biochemistry, University of Texas Health Science Center, 11937, US Highway 271, Tyler, TX 75708, USA
    Mol Immunol 47:2505-14. 2010
    ..The findings imply that impaired MBL-mediated phagocytosis may put individuals homozygous for the mutant allele MBL/C but not wild type MBL/A at increased risk to infections such as yeast...
  8. ncbi Structure and function of complement C5 convertase enzymes
    M K Pangburn
    Department of Biochemistry, University of Texas Health Science Center, Tyler 75708, USA
    Biochem Soc Trans 30:1006-10. 2002
    ..Thus, after processing sufficient C3 at the surface of a microorganism, the enzymes switch to processing C5, which initiates the formation of the cytolytic membrane attack complex of complement...
  9. ncbi Polyanion-induced self-association of complement factor H
    Michael K Pangburn
    Department of Biochemistry, Center for Biomedical Research, University of Texas Health Science Center, Tyler, TX 75708, USA
    J Immunol 182:1061-8. 2009
    ..The results suggest that recognition of polyanionic markers on host cells and tissues by factor H, and the resulting regulation of complement activation, may involve formation of dimers and tetramers of factor H...
  10. ncbi New insights on the structural/functional properties of recombinant human mannan-binding lectin and its variants
    Rema Rajagopalan
    Department of Biochemistry, University of Texas Health Science Center, 11937, US Highway 271, Tyler, TX 75708 3154, USA
    Immunol Lett 123:114-24. 2009
    ....
  11. ncbi Vimentin expressed on Mycobacterium tuberculosis-infected human monocytes is involved in binding to the NKp46 receptor
    Ankita Garg
    Center for Pulmonary and Infectious Disease Control, University of Texas Health Center, 11937 U S Highway 271, Tyler, TX 75708, USA
    J Immunol 177:6192-8. 2006
    ..ELISA and Far Western blotting showed that recombinant vimentin bound to a NKp46 fusion protein. These results indicate that vimentin is involved in binding of NKp46 to M. tuberculosis H37Ra-infected mononuclear phagocytes...

Research Grants4

  1. Activation and regulation of the lectin pathway
    Nenoo Rawal; Fiscal Year: 2007
    ..abstract_text> ..