Kodi Ravichandran

Summary

Affiliation: University of Virginia
Country: USA

Publications

  1. pmc CXCR4 acts as a costimulator during thymic beta-selection
    Paul C Trampont
    Carter Immunology Center, University of Virginia, Charlottesville, Virginia, USA
    Nat Immunol 11:162-70. 2010
  2. pmc Clearance of apoptotic cells: implications in health and disease
    Michael R Elliott
    Center for Cell Clearance and the Department of Microbiology, University of Virginia, Charlottesville, VA 22908, USA
    J Cell Biol 189:1059-70. 2010
  3. ncbi request reprint Signaling via Shc family adapter proteins
    K S Ravichandran
    Beirne Carter Center for Immunology Research and the Department of Microbiology, University of Virginia, Charlottesville, Virginia, VA 22908, USA
    Oncogene 20:6322-30. 2001
  4. ncbi request reprint Engulfment of apoptotic cells: signals for a good meal
    Kodi S Ravichandran
    Carter Immunology Center and the Department of Microbiology, University of Virginia, Charlottesville, Virginia, 22908, USA
    Nat Rev Immunol 7:964-74. 2007
  5. pmc Find-me and eat-me signals in apoptotic cell clearance: progress and conundrums
    Kodi S Ravichandran
    Center for Cell Clearance, University of Virginia, Charlottesville, VA 22908, USA
    J Exp Med 207:1807-17. 2010
  6. pmc Beginnings of a good apoptotic meal: the find-me and eat-me signaling pathways
    Kodi S Ravichandran
    Department of Microbiology, Immunology, and Cancer Biology, Center for Cell Clearance, University of Virginia, Charlottesville, VA 22908, USA
    Immunity 35:445-55. 2011
  7. ncbi request reprint "Recruitment signals" from apoptotic cells: invitation to a quiet meal
    Kodi S Ravichandran
    Carter Immunology Center and the Department of Microbiology, University of Virginia, Charlottesville, VA 22908, USA
    Cell 113:817-20. 2003
  8. ncbi request reprint Roles of Lck, Syk and ZAP-70 tyrosine kinases in TCR-mediated phosphorylation of the adapter protein Shc
    S F Walk
    Beirne Carter Center for Immunology Research, Department of Microbiology, University of Virginia, Charlottesville 22908, USA
    Eur J Immunol 28:2265-75. 1998
  9. pmc Evidence for a requirement for both phospholipid and phosphotyrosine binding via the Shc phosphotyrosine-binding domain in vivo
    K S Ravichandran
    Beirne Carter Center for Immunology Research and Department of Microbiology, University of Virginia, Charlottesville 22908, USA
    Mol Cell Biol 17:5540-9. 1997
  10. ncbi request reprint p135 src homology 2 domain-containing inositol 5'-phosphatase (SHIPbeta ) isoform can substitute for p145 SHIP in fcgamma RIIB1-mediated inhibitory signaling in B cells
    M E March
    Beirne B Carter Center for Immunology Research and the Department of Microbiology, University of Virginia, Charlottesville, Virginia 22908, USA
    J Biol Chem 275:29960-7. 2000

Research Grants

  1. Role of Shc in T lymphocyte development and function
    Kodi Ravichandran; Fiscal Year: 2006
  2. Inhibitory Signaling via FcgRIIB Receptor on B Cells
    Kodi Ravichandran; Fiscal Year: 2006
  3. Role of ELMO and Dock 180 in signaling to engulfment
    Kodi Ravichandran; Fiscal Year: 2006
  4. Phagocytosis of apoptotic cells: Signaling via GULP
    Kodi Ravichandran; Fiscal Year: 2006
  5. Role of Shc in T lymphocyte development and function
    Kodi Ravichandran; Fiscal Year: 2007
  6. Inhibitory Signaling via FcgRIIB Receptor on B Cells
    Kodi Ravichandran; Fiscal Year: 2007
  7. Phagocytosis of apoptotic cells: Signaling via GULP
    Kodi Ravichandran; Fiscal Year: 2007
  8. Role of ELMO and Dock 180 in signaling to engulfment
    Kodi Ravichandran; Fiscal Year: 2007
  9. Apoptotic Cell Recognition & Clearance 2007 Gordon Research Conference
    Kodi Ravichandran; Fiscal Year: 2007
  10. Role of Shc in T lymphocyte development and function
    Kodi Ravichandran; Fiscal Year: 2009

Collaborators

  • M J Aman
  • Ulrike Lorenz
  • Jason M Kinchen
  • James Casanova
  • W Wang
  • Q Chen
  • James Mandell
  • Kwok Min Hui
  • Amjad Farooq
  • Lorraine C Santy
  • Mingjian Lu
  • Michael R Elliott
  • Lisa B Haney
  • Annie Carole Tosello-Trampont
  • Zhong Ma
  • Cynthia Grimsley
  • Robert S Kiss
  • Cynthia M Grimsley
  • Michael O Hengartner
  • A C Tosello-Trampont
  • Enrico Brugnera
  • John Sondek
  • Colin D deBakker
  • Doris Klingele
  • Li Zhang
  • Paul C Trampont
  • S F Walk
  • M A Gronski
  • Daeho Park
  • Michael J Jarzynka
  • Timothy P Bender
  • Paul Trampont
  • Yves L Marcel
  • Karen N McFarland
  • Noriko Yokoyama
  • Kent L Rossman
  • Kumiko Nakada-Tsukui
  • E Brugnera
  • Jinhu Yin
  • M E March
  • Dan R Littman
  • Yuelei Shen
  • Ann E Sutherland
  • Amanda K Duley
  • I J Juncadella
  • N C Franc
  • Takanori Hirose
  • L B Haney
  • Ifat Bar-Joseph
  • Shi Yuan Cheng
  • Weisong Gu
  • Alexander L Klibanov
  • RuiBai Luo
  • Bo Hu
  • M O Hengartner
  • Ryo Nishikawa
  • Zhongzhen Nie
  • Sarah E Koss
  • Steven R Wilkes
  • Gerard Vassiliou
  • Heidi M McBride
  • W Todd Miller
  • Roland S Annan
  • Francesca Zappacosta
  • Michael J Huddleston
  • Vijay Yajnik
  • Matthew Hall
  • Bin Kuan Chou
  • Sharleen Zhou
  • Yi Chun Wu
  • Colin deBakker
  • Pei Ken Hsu
  • Scott Walk
  • Li Chun Cheng
  • Lisa Haney
  • Anne Blangy
  • Victoria Camerini
  • B Maier
  • M L Hammarskjold
  • M Alexander
  • D M Rekosh
  • D M Lucas

Detail Information

Publications41

  1. pmc CXCR4 acts as a costimulator during thymic beta-selection
    Paul C Trampont
    Carter Immunology Center, University of Virginia, Charlottesville, Virginia, USA
    Nat Immunol 11:162-70. 2010
    ..We also characterize functionally relevant signaling molecules downstream of CXCR4 and the pre-TCR in thymocytes. Our data designate CXCR4 as a costimulator of the pre-TCR during beta-selection...
  2. pmc Clearance of apoptotic cells: implications in health and disease
    Michael R Elliott
    Center for Cell Clearance and the Department of Microbiology, University of Virginia, Charlottesville, VA 22908, USA
    J Cell Biol 189:1059-70. 2010
    ..A better understanding of the apoptotic cell clearance process in healthy and diseased states could offer new therapeutic strategies...
  3. ncbi request reprint Signaling via Shc family adapter proteins
    K S Ravichandran
    Beirne Carter Center for Immunology Research and the Department of Microbiology, University of Virginia, Charlottesville, Virginia, VA 22908, USA
    Oncogene 20:6322-30. 2001
    ..Given the apparently central role that Shc plays signaling via many receptors, delineating the precise mechanism(s) of Shc-mediated signaling may be critical to our understanding of the effects mediated through these receptors...
  4. ncbi request reprint Engulfment of apoptotic cells: signals for a good meal
    Kodi S Ravichandran
    Carter Immunology Center and the Department of Microbiology, University of Virginia, Charlottesville, Virginia, 22908, USA
    Nat Rev Immunol 7:964-74. 2007
    ..This Review focuses on these recent developments and attempts to highlight some of the important questions in this field...
  5. pmc Find-me and eat-me signals in apoptotic cell clearance: progress and conundrums
    Kodi S Ravichandran
    Center for Cell Clearance, University of Virginia, Charlottesville, VA 22908, USA
    J Exp Med 207:1807-17. 2010
    ..This perspective discusses recent exciting progress, gaps in our understanding, and the conflicting issues that arise from the newly acquired knowledge...
  6. pmc Beginnings of a good apoptotic meal: the find-me and eat-me signaling pathways
    Kodi S Ravichandran
    Department of Microbiology, Immunology, and Cancer Biology, Center for Cell Clearance, University of Virginia, Charlottesville, VA 22908, USA
    Immunity 35:445-55. 2011
    ..This review covers the recent progress in the areas of find-me and eat-me signals and how these relate to prompt and immunologically silent clearance of apoptotic cells...
  7. ncbi request reprint "Recruitment signals" from apoptotic cells: invitation to a quiet meal
    Kodi S Ravichandran
    Carter Immunology Center and the Department of Microbiology, University of Virginia, Charlottesville, VA 22908, USA
    Cell 113:817-20. 2003
    ..New observations suggest that corpse clearance is tightly linked to apoptosis and that dying cells use both recruitment and eat-me signals for phagocyte attraction and recognition...
  8. ncbi request reprint Roles of Lck, Syk and ZAP-70 tyrosine kinases in TCR-mediated phosphorylation of the adapter protein Shc
    S F Walk
    Beirne Carter Center for Immunology Research, Department of Microbiology, University of Virginia, Charlottesville 22908, USA
    Eur J Immunol 28:2265-75. 1998
    ..Of the two potential Grb2 binding sites (Y239 and Y317), Y239 appears to play a greater role in recruiting Sos through Grb2. These studies have implications for Ras activation and mitogenic signaling during T cell activation...
  9. pmc Evidence for a requirement for both phospholipid and phosphotyrosine binding via the Shc phosphotyrosine-binding domain in vivo
    K S Ravichandran
    Beirne Carter Center for Immunology Research and Department of Microbiology, University of Virginia, Charlottesville 22908, USA
    Mol Cell Biol 17:5540-9. 1997
    ..Thus, Shc, through its interaction with two different ligands, is able to accomplish both membrane localization and binding to the activated receptor via a single PTB domain...
  10. ncbi request reprint p135 src homology 2 domain-containing inositol 5'-phosphatase (SHIPbeta ) isoform can substitute for p145 SHIP in fcgamma RIIB1-mediated inhibitory signaling in B cells
    M E March
    Beirne B Carter Center for Immunology Research and the Department of Microbiology, University of Virginia, Charlottesville, Virginia 22908, USA
    J Biol Chem 275:29960-7. 2000
    ..These data suggest that SHIPbeta, which is normally expressed in B cells along with SHIPalpha, functions comparably with SHIPalpha and that these two isoforms are not likely to be antagonistic in their function in vivo...
  11. ncbi request reprint A requirement for lipid rafts in B cell receptor induced Ca(2+) flux
    M J Aman
    Carter Immunology Center, University of Virginia, Charlottesville, 22908, USA
    Curr Biol 10:393-6. 2000
    ..An intact raft structure was required for BCR-induced tyrosine phosphorylation of PLCgamma2 and the induction of Ca(2+) flux. Taken together, these data provide a functional role for lipid rafts in BCR signaling...
  12. ncbi request reprint Identification of two signaling submodules within the CrkII/ELMO/Dock180 pathway regulating engulfment of apoptotic cells
    A C Tosello-Trampont
    Beirne Carter Center for Immunology Research and the Department of Microbiology, University of Virginia, Charlottesville, VA 22908, USA
    Cell Death Differ 14:963-72. 2007
    ..Taken together, these data suggest that Dock180/ELMO and CrkII act as two evolutionarily conserved signaling submodules that coordinately regulate engulfment...
  13. ncbi request reprint Evidence for a conserved role for CRKII and Rac in engulfment of apoptotic cells
    A C Tosello-Trampont
    Beirne B. Carter Center for Immunology Research and the Department of Microbiology, University of Virginia, Charlottesville 22908, USA
    J Biol Chem 276:13797-802. 2001
    ..Taken together, these data suggest that CED-2/CrkII and CED-10/Rac are part of an evolutionarily conserved pathway in engulfment of apoptotic cells...
  14. pmc Design and use of an inducibly activated human immunodeficiency virus type 1 Nef to study immune modulation
    S F Walk
    Carter Immunology Center, Myles H. Thaler Center for AIDS and Human Retrovirus Research and the Department of Microbiology, University of Virginia, Charlottesville, Virginia 22908, USA
    J Virol 75:834-43. 2001
    ..These data suggest that HLA-A2 downmodulation may require certain threshold levels of active Nef. The differential timing of CD4 and HLA-A2 downmodulation may have implications for HIV pathogenesis and immune evasion...
  15. pmc An essential role for calcium flux in phagocytes for apoptotic cell engulfment and the anti-inflammatory response
    M A Gronski
    Beirne Carter Center for Immunology, Center for Cell Clearance, and the Department of Microbiology, University of Virginia, Charlottesville, VA 22908, USA
    Cell Death Differ 16:1323-31. 2009
    ....
  16. ncbi request reprint PH domain of ELMO functions in trans to regulate Rac activation via Dock180
    Mingjian Lu
    Beirne Carter Center for Immunology Research, Department of Microbiology, University of Virginia, Charlottesville, Virginia 22908, USA
    Nat Struct Mol Biol 11:756-62. 2004
    ..These data reveal a new mode of action of PH domains and a novel, evolutionarily conserved mechanism by which a bipartite GEF can activate Rac...
  17. pmc Phagosome maturation: going through the acid test
    Jason M Kinchen
    Beirne B Carter Center for Immunology Research and the Department of Microbiology, University of Virginia, Charlottesville, Virginia 22902, USA
    Nat Rev Mol Cell Biol 9:781-95. 2008
    ..This suggests that a machinery that is distinct from receptor-mediated endocytosis is used in phagosome maturation...
  18. ncbi request reprint BAI1 is an engulfment receptor for apoptotic cells upstream of the ELMO/Dock180/Rac module
    Daeho Park
    Department of Cell Biology, University of Virginia, Charlottesville, Virginia 22908, USA
    Nature 450:430-4. 2007
    ..Thus, BAI1 is a phosphatidylserine recognition receptor that can directly recruit a Rac-GEF complex to mediate the uptake of apoptotic cells...
  19. ncbi request reprint Engulfment of apoptotic cells is negatively regulated by Rho-mediated signaling
    Annie Carole Tosello-Trampont
    Beirne Carter Center for Immunology Research and the Department of Microbiology, University of Virginia, Charlottesville, Virginia 22908, USA
    J Biol Chem 278:49911-9. 2003
    ....
  20. pmc A pathway for phagosome maturation during engulfment of apoptotic cells
    Jason M Kinchen
    Beirne Carter Center for Immunology Research, University of Virginia, Charlottesville, VA 22908, USA
    Nat Cell Biol 10:556-66. 2008
    ..Finally, we have also identified a previously undescribed biochemical complex containing Vps34, dynamin and Rab5(GDP), thus providing a mechanism for Rab5 recruitment to the nascent phagosome...
  21. ncbi request reprint Dock180-ELMO cooperation in Rac activation
    Mingjian Lu
    Carter Immunology Center, University of Virginia, Charlottesville, USA
    Methods Enzymol 406:388-402. 2006
    ..Thus, Dock180 and ELMO function together as a bipartite GEF to optimally activate Rac on upstream stimulation to mediate the engulfment of apoptotic cells and cell migration...
  22. ncbi request reprint Coupling of folding and binding in the PTB domain of the signaling protein Shc
    Amjad Farooq
    Structural Biology Program, Department of Physiology and Biophysics, Mount Sinai School of Medicine, New York University, New York, NY 10029, USA
    Structure 11:905-13. 2003
    ..The binding of the ligand appears to reorganize this pocket through local folding events triggering a conformational switch between the free and the complex forms...
  23. ncbi request reprint A nonredundant role for the adapter protein Shc in thymic T cell development
    Li Zhang
    Beirne B Carter Center for Immunology Research and Department of Microbiology University of Virginia, Charlottesville, VA 22908, USA
    Nat Immunol 3:749-55. 2002
    ..Thus, both Shc expression and its tyrosine phosphorylation play an essential and nonredundant role in thymic T cell development...
  24. ncbi request reprint Phagocytosis of apoptotic cells is regulated by a UNC-73/TRIO-MIG-2/RhoG signaling module and armadillo repeats of CED-12/ELMO
    Colin D deBakker
    Department of Microbiology, Beirne Carter Center for Immunology Research, University of Virginia, Charlottesville, VA 22908, USA
    Curr Biol 14:2208-16. 2004
    ..However, the components upstream of ELMO and Dock180 during engulfment remain elusive...
  25. ncbi request reprint Apoptotic cells induce a phosphatidylserine-dependent homeostatic response from phagocytes
    Robert S Kiss
    Lipoprotein and Atherosclerosis Research Group, Department of Pathology, Department of Laboratory Medicine, University of Ottawa Heart Institute, Ottawa K1Y 4W7, Canada
    Curr Biol 16:2252-8. 2006
    ..These data also have implications for macrophage handling of contents derived from apoptotic versus necrotic cells in atherosclerotic lesions...
  26. ncbi request reprint Nuclear localization of the DOCK180/ELMO complex
    Jinhu Yin
    Laboratory of Genetics, National Institute on Aging, National Institutes of Health, Baltimore, MA 21224, USA
    Arch Biochem Biophys 429:23-9. 2004
    ..These studies suggest that DOCK180 may associate with different ELMO proteins to form cell-type specific complexes and may have functions in both the nucleus and the cytoplasm...
  27. ncbi request reprint Dock180 and ELMO1 proteins cooperate to promote evolutionarily conserved Rac-dependent cell migration
    Cynthia M Grimsley
    Beirne Carter Center for Immunology Research and the Department of Microbiology, University of Virginia, Charlottesville, Virginia 22908, USA
    J Biol Chem 279:6087-97. 2004
    ..This finding suggests that Rac activation by the ELMO.Dock180 complex at discrete intracellular locations mediated by the N-terminal 330 amino acids of ELMO1 rather than generalized Rac activation plays a role in cell migration...
  28. ncbi request reprint A Steric-inhibition model for regulation of nucleotide exchange via the Dock180 family of GEFs
    Mingjian Lu
    Beirne Carter Center for Immunology Research, Department of Microbiology, University of Virginia, Charlottesville, VA 22908 USA
    Curr Biol 15:371-7. 2005
    ..This steric-inhibition model may be a general mechanism for regulating multiple SH3-domain-containing Dock180 family members and may have implications for a variety of biological processes...
  29. ncbi request reprint Characterization of a novel interaction between ELMO1 and ERM proteins
    Cynthia M Grimsley
    Beirne Carter Center for Immunology Research, and Department of Microbiology, University of Virginia, Lane Road, Charlottesville, VA 22903, USA
    J Biol Chem 281:5928-37. 2006
    ..Together these data suggest that ELMO1-mediated cytoskeletal changes may be coordinated with ERM protein crosslinking activity during dynamic cellular functions...
  30. pmc ShcA mediates the dominant pathway to extracellular signal-regulated kinase activation during early thymic development
    Paul Trampont
    Carter Immunology Center, MR4 4072D, Box 801386, University of Virginia, Charlottesville, VA 22908, USA
    Mol Cell Biol 26:9035-44. 2006
    ..This work provides the first in vivo demonstration of the relative requirement of upstream adapters in controlling ERK activation during beta selection and suggests a dominant role for ShcA...
  31. pmc Identification of tyrosine residues on ELMO1 that are phosphorylated by the Src-family kinase Hck
    Noriko Yokoyama
    Department of Physiology and Biophysics, School of Medicine, State University of New York at Stony Brook, Stony Brook, New York 11794 8661, USA
    Biochemistry 44:8841-9. 2005
    ..The data suggest that Src family kinase mediated tyrosine phosphorylation of ELMO1 might represent an important regulatory mechanism that controls signaling through the ELMO1/Crk/Dock180 pathway...
  32. ncbi request reprint The DOCK180/Elmo complex couples ARNO-mediated Arf6 activation to the downstream activation of Rac1
    Lorraine C Santy
    Department of Cell Biology, University of Virginia, Charlottesville, Virginia 22908, USA
    Curr Biol 15:1749-54. 2005
    ..Together, these data suggest that ARNO and ARF6 coordinate with the Dock180/Elmo complex to promote Rac activation at the leading edge of migrating cells...
  33. pmc Phagocytic signaling: you can touch, but you can't eat
    Jason M Kinchen
    Beirne Carter Center for Immunology Research, University of Virginia, Charlottesville, VA 22908, USA
    Curr Biol 18:R521-4. 2008
    ....
  34. pmc Death in the CNS: six-microns-under
    Michael R Elliott
    Carter Immunology Center and the Department of Microbiology, University of Virginia, Charlottesville, VA 22908, USA
    Cell 133:393-5. 2008
    ..In this issue, Kurant et al. (2008) describe a new phagocytic receptor, called six-microns-under (SIMU), that promotes engulfment of apoptotic neurons by glial cells in the developing nervous system of Drosophila...
  35. pmc Pallbearer and friends: lending a hand in apoptotic cell clearance
    Michael R Elliott
    Carter Immunology Center and the Department of Microbiology, University of Virginia, Charlottesville, VA 22908, USA
    Trends Cell Biol 18:95-7. 2008
    ..This work provides the first link between the cellular processes of ubiquitylation/proteasomal degradation and the ability to clear apoptotic cells efficiently...
  36. ncbi request reprint Cues for apoptotic cell engulfment: eat-me, don't eat-me and come-get-me signals
    Cynthia Grimsley
    Carter Immunology Center and the Department of Pharmacology, University of Virginia, Charlottesville, VA 22908, USA
    Trends Cell Biol 13:648-56. 2003
    ..Once apoptotic cells are identified, their uptake by phagocytes further depends on the molecular machinery highly conserved from Caenorhabditis elegans to mammals...
  37. ncbi request reprint The lipoprotein receptor-related protein-1 (LRP) adapter protein GULP mediates trafficking of the LRP ligand prosaposin, leading to sphingolipid and free cholesterol accumulation in late endosomes and impaired efflux
    Robert S Kiss
    Lipoprotein and Atherosclerosis Research Group, Department of Pathology and Laboratory Medicine, University of Ottawa Heart Institute, Ottawa K1Y 4W7, Canada
    J Biol Chem 281:12081-92. 2006
    ..Taken together, these data reveal that GULP/LRP/ABCA1 represents a triad of molecules involved in engulfment and cellular lipid homeostasis...
  38. pmc ELMO1 and Dock180, a bipartite Rac1 guanine nucleotide exchange factor, promote human glioma cell invasion
    Michael J Jarzynka
    Cancer Institute and Departments of Pathology and Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Cancer Res 67:7203-11. 2007
    ..These data suggest that the bipartite GEF, ELMO1 and Dock180, play an important role in promoting cancer cell invasion and could be potential therapeutic targets for the treatment of diffuse malignant gliomas...
  39. ncbi request reprint Neural-specific inactivation of ShcA results in increased embryonic neural progenitor apoptosis and microencephaly
    Karen N McFarland
    Department of Pathology Neuropathology, Beirne B Carter Center for Immunology Research, University of Virginia, Charlottesville, Virginia 22908, USA
    J Neurosci 26:7885-97. 2006
    ..Together, these data suggest a critical role for ShcA in neural progenitor survival signaling and in regulating brain size...
  40. pmc Regulation of Arf6 and ACAP1 signaling by the PTB-domain-containing adaptor protein GULP
    Zhong Ma
    Carter Immunology Center, Department of Microbiology, University of Virginia, Charlottesville, Virginia 22908, USA
    Curr Biol 17:722-7. 2007
    ..Because PTB-domain-containing adaptor proteins influence endocytosis and trafficking of membrane proteins and cell migration [15, 16], our data support a model wherein PTB-domain-containing adaptor proteins regulate Arf family proteins...
  41. ncbi request reprint Journey to the grave: signaling events regulating removal of apoptotic cells
    Jason M Kinchen
    Beirne Carter Center for Immunology Research, University of Virginia, Charlottesville, VA 22908, USA
    J Cell Sci 120:2143-9. 2007
    ..The recent molecular delineation of the phagocytic process and the identification of novel signaling proteins involved in engulfment have provided an exciting new platform for future studies into this biologically important process...

Research Grants36

  1. Role of Shc in T lymphocyte development and function
    Kodi Ravichandran; Fiscal Year: 2006
    ..Since Shc has been linked to growth factor and cytokine signaling in lymphocytes and many other cell lineages, these studies would also have a broader importance for understanding signaling pathways affecting growth and differentiation. ..
  2. Inhibitory Signaling via FcgRIIB Receptor on B Cells
    Kodi Ravichandran; Fiscal Year: 2006
    ....
  3. Role of ELMO and Dock 180 in signaling to engulfment
    Kodi Ravichandran; Fiscal Year: 2006
    ..abstract_text> ..
  4. Phagocytosis of apoptotic cells: Signaling via GULP
    Kodi Ravichandran; Fiscal Year: 2006
    ..In these mouse studies, we will determine the effect on engulfment due to the absence of GULP, or disrupted GULP function, and any potential effects on autoimmunity due to defective engulfment. ..
  5. Role of Shc in T lymphocyte development and function
    Kodi Ravichandran; Fiscal Year: 2007
    ..Since Shc has been linked to growth factor and cytokine signaling in lymphocytes and many other cell lineages, these studies would also have a broader importance for understanding signaling pathways affecting growth and differentiation. ..
  6. Inhibitory Signaling via FcgRIIB Receptor on B Cells
    Kodi Ravichandran; Fiscal Year: 2007
    ....
  7. Phagocytosis of apoptotic cells: Signaling via GULP
    Kodi Ravichandran; Fiscal Year: 2007
    ..In these mouse studies, we will determine the effect on engulfment due to the absence of GULP, or disrupted GULP function, and any potential effects on autoimmunity due to defective engulfment. ..
  8. Role of ELMO and Dock 180 in signaling to engulfment
    Kodi Ravichandran; Fiscal Year: 2007
    ..Taken together, through these studies, we expect to gain a better molecular understanding of the fundamentally important process of clearing apoptotic cells and define the role of specific players during engulfment. ..
  9. Apoptotic Cell Recognition & Clearance 2007 Gordon Research Conference
    Kodi Ravichandran; Fiscal Year: 2007
    ..The meeting is purposely held in alternative years with the Apoptosis meeting to encourage participation by all of those with an interest in cell death. ..
  10. Role of Shc in T lymphocyte development and function
    Kodi Ravichandran; Fiscal Year: 2009
    ..Thus, we believe the outcome of these studies could have high degree of significance from a basic science perspective as well as human health. ..
  11. Role of ELMO and Dock 180 in signaling to engulfment
    Kodi Ravichandran; Fiscal Year: 2009
    ..Taken together, through these studies, we expect to gain a better molecular understanding of the fundamentally important process of clearing apoptotic cells and define the role of specific players during engulfment. ..
  12. Role of Shc in T lymphocyte development and function
    Kodi S Ravichandran; Fiscal Year: 2010
    ..Thus, we believe the outcome of these studies could have high degree of significance from a basic science perspective as well as human health. ..
  13. Phagocytosis of apoptotic cells: Signaling via GULP
    Kodi Ravichandran; Fiscal Year: 2005
    ..In these mouse studies, we will determine the effect on engulfment due to the absence of GULP, or disrupted GULP function, and any potential effects on autoimmunity due to defective engulfment. ..
  14. Role of ELMO and Dock 180 in signaling to engulfment
    Kodi Ravichandran; Fiscal Year: 2005
    ..abstract_text> ..
  15. SIGNALING VIA SHC AND THE INOSITOL PHOSPHATASE, SHIP
    Kodi Ravichandran; Fiscal Year: 1999
    ....
  16. INHIBITORY SIGNALING VIA THE FCGRIIB RECEPTOR ON B CELLS
    Kodi Ravichandran; Fiscal Year: 1999
    ..A detailed molecular understanding of FcgammaRIIB-mediated inhibitory signaling may yield important clues to B cell activation and desensitization, and point to possible future therapeutic interventions in certain autoimmune states. ..
  17. SIGNALING VIA SHC AND THE INOSITOL PHOSPHATASE, SHIP
    Kodi Ravichandran; Fiscal Year: 2000
    ....
  18. INHIBITORY SIGNALING VIA THE FCGRIIB RECEPTOR ON B CELLS
    Kodi Ravichandran; Fiscal Year: 2000
    ..A detailed molecular understanding of FcgammaRIIB-mediated inhibitory signaling may yield important clues to B cell activation and desensitization, and point to possible future therapeutic interventions in certain autoimmune states. ..
  19. SIGNALING VIA SHC AND THE INOSITOL PHOSPHATASE, SHIP
    Kodi Ravichandran; Fiscal Year: 2001
    ....
  20. INHIBITORY SIGNALING VIA THE FCGRIIB RECEPTOR ON B CELLS
    Kodi Ravichandran; Fiscal Year: 2001
    ..A detailed molecular understanding of FcgammaRIIB-mediated inhibitory signaling may yield important clues to B cell activation and desensitization, and point to possible future therapeutic interventions in certain autoimmune states. ..
  21. SIGNALING VIA SHC AND THE INOSITOL PHOSPHATASE, SHIP
    Kodi Ravichandran; Fiscal Year: 2002
    ....
  22. INHIBITORY SIGNALING VIA THE FCGRIIB RECEPTOR ON B CELLS
    Kodi Ravichandran; Fiscal Year: 2002
    ..A detailed molecular understanding of FcgammaRIIB-mediated inhibitory signaling may yield important clues to B cell activation and desensitization, and point to possible future therapeutic interventions in certain autoimmune states. ..
  23. Role of ELMO and Dock 180 in signaling to engulfment
    Kodi Ravichandran; Fiscal Year: 2003
    ..abstract_text> ..
  24. Phagocytosis of apoptotic cells: Signaling via GULP
    Kodi Ravichandran; Fiscal Year: 2004
    ..In these mouse studies, we will determine the effect on engulfment due to the absence of GULP, or disrupted GULP function, and any potential effects on autoimmunity due to defective engulfment. ..
  25. Role of Shc in T lymphocyte development and function
    Kodi Ravichandran; Fiscal Year: 2004
    ..Since Shc has been linked to growth factor and cytokine signaling in lymphocytes and many other cell lineages, these studies would also have a broader importance for understanding signaling pathways affecting growth and differentiation. ..
  26. Role of ELMO and Dock 180 in signaling to engulfment
    Kodi Ravichandran; Fiscal Year: 2004
    ..abstract_text> ..
  27. Inhibitory Signaling via FcgRIIB Receptor on B Cells
    Kodi Ravichandran; Fiscal Year: 2004
    ....
  28. Role of Shc in T lymphocyte development and function
    Kodi Ravichandran; Fiscal Year: 2005
    ..Since Shc has been linked to growth factor and cytokine signaling in lymphocytes and many other cell lineages, these studies would also have a broader importance for understanding signaling pathways affecting growth and differentiation. ..
  29. Inhibitory Signaling via FcgRIIB Receptor on B Cells
    Kodi Ravichandran; Fiscal Year: 2005
    ....
  30. Role of ELMO and Dock 180 in signaling to engulfment
    Kodi S Ravichandran; Fiscal Year: 2010
    ..Taken together, through these studies, we expect to gain a better molecular understanding of the fundamentally important process of clearing apoptotic cells and define the role of specific players during engulfment. ..