A P Raval

Summary

Affiliation: University of Miami
Country: USA

Publications

  1. ncbi request reprint Epsilon protein kinase C mediated ischemic tolerance requires activation of the extracellular regulated kinase pathway in the organotypic hippocampal slice
    Christian Lange-Asschenfeldt
    Cerebral Vascular Disease Research Center, Department of Neurology and Neuroscience, University of Miami School of Medicine, Miami, Florida, USA
    J Cereb Blood Flow Metab 24:636-45. 2004
  2. ncbi request reprint Resveratrol mimics ischemic preconditioning in the brain
    Ami P Raval
    Department of Neurology and Neuroscience Program, Cerebral Vascular Disease Research Center, University of Miami School of Medicine, Florida 33101, USA
    J Cereb Blood Flow Metab 26:1141-7. 2006
  3. ncbi request reprint Oral contraceptives and nicotine synergistically exacerbate cerebral ischemic injury in the female brain
    Ami P Raval
    Cerebral Vascular Disease Research Center, Department of Neurology, Leonard M Miller School of Medicine, University of Miami, Two Story Lab TSL, Room 230A, 1420 NW 9th Avenue, Miami, FL, 33101, USA
    Transl Stroke Res 4:402-12. 2013
  4. pmc Periodic 17β-estradiol pretreatment protects rat brain from cerebral ischemic damage via estrogen receptor-β
    Ami P Raval
    Cerebral Vascular Disease Research Laboratories, Department of Neurology, University of Miami, Miami, Florida, USA
    PLoS ONE 8:e60716. 2013
  5. doi request reprint Chronic nicotine exposure inhibits estrogen-mediated synaptic functions in hippocampus of female rats
    Ami P Raval
    Cerebral Vascular Disease Research Laboratories, Department of Neurology, Leonard M Miller School of Medicine, University of Miami, Miami, FL 33136, USA
    Neurosci Lett 517:41-6. 2012
  6. doi request reprint Synergistic inhibitory effect of nicotine plus oral contraceptive on mitochondrial complex-IV is mediated by estrogen receptor-β in female rats
    Ami P Raval
    Cerebral Vascular Disease Research Laboratories, Leonard M Miller School of Medicine, University of Miami, Miami, FL 33136, USA
    J Neurochem 121:157-67. 2012
  7. pmc EF1alpha and RPL13a represent normalization genes suitable for RT-qPCR analysis of bone marrow derived mesenchymal stem cells
    Kevin M Curtis
    Geriatric Research, Education, and Clinical Center, Veterans Affairs Medical Center and The Geriatrics Institute, 1201 NW 16th Street, Miami, Florida 33125 USA
    BMC Mol Biol 11:61. 2010
  8. doi request reprint Chronic nicotine exposure inhibits 17beta-estradiol-mediated protection of the hippocampal CA1 region against cerebral ischemia in female rats
    Ami P Raval
    Cerebral Vascular Disease Research Center, Department of Neurology, Leonard M Miller School of Medicine, University of Miami, Miami, FL 33101, USA
    Neurosci Lett 458:65-9. 2009
  9. pmc epsilonPKC phosphorylates the mitochondrial K(+) (ATP) channel during induction of ischemic preconditioning in the rat hippocampus
    Ami P Raval
    Cerebral Vascular Disease Research Center, Department of Neurology and Neuroscience Program, University of Miami Leonard M Miller School of Medicine, Miami, FL 33101, USA
    Brain Res 1184:345-53. 2007
  10. ncbi request reprint Estrogen preconditioning protects the hippocampal CA1 against ischemia
    A P Raval
    Cerebral Vascular Disease Research Center, Department of Neurology and Neuroscience Program D4 5, P O Box 016960, University of Miami School of Medicine, Miami, FL 33101, USA
    Neuroscience 141:1721-30. 2006

Collaborators

Detail Information

Publications33

  1. ncbi request reprint Epsilon protein kinase C mediated ischemic tolerance requires activation of the extracellular regulated kinase pathway in the organotypic hippocampal slice
    Christian Lange-Asschenfeldt
    Cerebral Vascular Disease Research Center, Department of Neurology and Neuroscience, University of Miami School of Medicine, Miami, Florida, USA
    J Cereb Blood Flow Metab 24:636-45. 2004
    ..In conclusion, we demonstrate that epsilonPKC activation after IPC/PPC is essential for neuroprotection against oxygen/glucose deprivation in organotypic slice cultures and that the ERK pathway is downstream to epsilonPKC...
  2. ncbi request reprint Resveratrol mimics ischemic preconditioning in the brain
    Ami P Raval
    Department of Neurology and Neuroscience Program, Cerebral Vascular Disease Research Center, University of Miami School of Medicine, Florida 33101, USA
    J Cereb Blood Flow Metab 26:1141-7. 2006
    ..A better understanding of the mechanisms by which resveratrol induces ischemic tolerance in a prophylactic manner may provide a novel therapy against stroke or neurosurgical procedures...
  3. ncbi request reprint Oral contraceptives and nicotine synergistically exacerbate cerebral ischemic injury in the female brain
    Ami P Raval
    Cerebral Vascular Disease Research Center, Department of Neurology, Leonard M Miller School of Medicine, University of Miami, Two Story Lab TSL, Room 230A, 1420 NW 9th Avenue, Miami, FL, 33101, USA
    Transl Stroke Res 4:402-12. 2013
    ..In the present review we highlight possible mechanisms by which OC and nicotine inhibits estrogen signaling that could be responsible for severe ischemic damage in females. ..
  4. pmc Periodic 17β-estradiol pretreatment protects rat brain from cerebral ischemic damage via estrogen receptor-β
    Ami P Raval
    Cerebral Vascular Disease Research Laboratories, Department of Neurology, University of Miami, Miami, Florida, USA
    PLoS ONE 8:e60716. 2013
    ..This study emphasizes the need to investigate a periodic estrogen replacement regimen to reduce cognitive decline and cerebral ischemia incidents/impact in post-menopausal women...
  5. doi request reprint Chronic nicotine exposure inhibits estrogen-mediated synaptic functions in hippocampus of female rats
    Ami P Raval
    Cerebral Vascular Disease Research Laboratories, Department of Neurology, Leonard M Miller School of Medicine, University of Miami, Miami, FL 33136, USA
    Neurosci Lett 517:41-6. 2012
    ..However, determining the exact molecular mechanisms of chronic nicotine exposure on synaptic plasticity specific to the female brain require further investigation...
  6. doi request reprint Synergistic inhibitory effect of nicotine plus oral contraceptive on mitochondrial complex-IV is mediated by estrogen receptor-β in female rats
    Ami P Raval
    Cerebral Vascular Disease Research Laboratories, Leonard M Miller School of Medicine, University of Miami, Miami, FL 33136, USA
    J Neurochem 121:157-67. 2012
    ..Overall, these results suggest that mitochondrial ER-β loss is responsible for mitochondrial malfunction after NOC...
  7. pmc EF1alpha and RPL13a represent normalization genes suitable for RT-qPCR analysis of bone marrow derived mesenchymal stem cells
    Kevin M Curtis
    Geriatric Research, Education, and Clinical Center, Veterans Affairs Medical Center and The Geriatrics Institute, 1201 NW 16th Street, Miami, Florida 33125 USA
    BMC Mol Biol 11:61. 2010
    ..Therefore, this study focuses on putative housekeeping genes for the normalization of RT-qPCR data between heterogeneous commercially available human MSC, compared with more homogeneous populations of MSC such as MIAMI and RS-1 cells...
  8. doi request reprint Chronic nicotine exposure inhibits 17beta-estradiol-mediated protection of the hippocampal CA1 region against cerebral ischemia in female rats
    Ami P Raval
    Cerebral Vascular Disease Research Center, Department of Neurology, Leonard M Miller School of Medicine, University of Miami, Miami, FL 33101, USA
    Neurosci Lett 458:65-9. 2009
    ..Nicotine exposure decreased ERbeta but not ERalpha protein levels in the hippocampus, suggesting a role for ERbeta in increased post-ischemic neurodegeneration from nicotine exposure...
  9. pmc epsilonPKC phosphorylates the mitochondrial K(+) (ATP) channel during induction of ischemic preconditioning in the rat hippocampus
    Ami P Raval
    Cerebral Vascular Disease Research Center, Department of Neurology and Neuroscience Program, University of Miami Leonard M Miller School of Medicine, Miami, FL 33101, USA
    Brain Res 1184:345-53. 2007
    ..2 as a phosphorylation target of epsilonPKC or its downstream effectors. Our results support the hypothesis that the brain mtK(+)(ATP) channel is an important target of IPC and the signal transduction pathways initiated by epsilonPKC...
  10. ncbi request reprint Estrogen preconditioning protects the hippocampal CA1 against ischemia
    A P Raval
    Cerebral Vascular Disease Research Center, Department of Neurology and Neuroscience Program D4 5, P O Box 016960, University of Miami School of Medicine, Miami, FL 33101, USA
    Neuroscience 141:1721-30. 2006
    ..Future investigations in estrogen preconditioning may suggest new estrogen regimens that avoid potential side effects of chronic estrogen treatment for stroke patients...
  11. pmc Pretreatment with a single estradiol-17beta bolus activates cyclic-AMP response element binding protein and protects CA1 neurons against global cerebral ischemia
    A P Raval
    Cerebral Vascular Disease Research Center, Department of Neurology D4 5, Leonard M Miller School of Medicine, University of Miami, Miami, FL 33101, USA
    Neuroscience 160:307-18. 2009
    ..These results suggest that an exogenous bolus of 17beta-estradiol to ovariectomized rats protects hippocampus against ischemia via activation of the CREB pathway in a manner similar to the endogenous estrous cycle...
  12. doi request reprint Nicotine and estrogen synergistically exacerbate cerebral ischemic injury
    A P Raval
    Cerebral Vascular Disease Research Laboratories, Department of Neurology, Leonard M Miller School of Medicine, University of Miami, Miami, FL 33136, USA
    Neuroscience 181:216-25. 2011
    ..Thus, nicotine can affect the outcome of cerebral ischemia by influencing brain endocrine function directly rather than through indirect systemic effects...
  13. doi request reprint Nicotine addiction causes unique detrimental effects on women's brains
    Ami P Raval
    Cerebral Vascular Disease Research Center, Department of Neurology, 1501NW9th Avenue, NPF 3015, LeonardM Miller School of Medicine, University of Miami, Miami, FL 33136, USA
    J Addict Dis 30:149-58. 2011
    ....
  14. pmc Derangements of post-ischemic cerebral blood flow by protein kinase C delta
    H W Lin
    Cerebral Vascular Disease Research Center, Department of Neurology, University of Miami, Miller School of Medicine, Miami, FL 33136, USA
    Neuroscience 171:566-76. 2010
    ..These results suggest possible therapeutic potential of δPKC in modulating CBF and neuronal damage after cerebral ischemia...
  15. pmc Resveratrol pretreatment protects rat brain from cerebral ischemic damage via a sirtuin 1-uncoupling protein 2 pathway
    D Della-Morte
    Cerebral Vascular Disease Research Center, Department of Neurology, Leonard M Miller School of Medicine, University of Miami, Miami, FL 33136, USA
    Neuroscience 159:993-1002. 2009
    ..In conclusion, in vivo resveratrol pretreatment confers neuroprotection similar to IPC via the SIRT1-UCP2 pathway...
  16. pmc Post-ischemic activation of protein kinase C ε protects the hippocampus from cerebral ischemic injury via alterations in cerebral blood flow
    D Della-Morte
    Department of Neurology, University of Miami, Miami, FL 33101, USA
    Neurosci Lett 487:158-62. 2011
    ..Our results suggest that ɛPKC can protect the rat brain against ischemic damage by regulating CBF. Thus, ɛPKC may be one of the treatment modalities against ischemic injury...
  17. ncbi request reprint Ischemic tolerance induction in organotypic hippocampal slices: role for the GABA(A) receptor?
    Christian Lange-Asschenfeldt
    Cerebral Vascular Disease Research Center, Department of Neurology and Neuroscience, University of Miami School of Medicine, Miami, FL 33101, USA
    Neurosci Lett 384:87-92. 2005
    ..The results are discussed in light of the intrinsic excitatory-inhibitory balance of glutamate and GABA...
  18. ncbi request reprint Ischemic preconditioning ameliorates excitotoxicity by shifting glutamate/gamma-aminobutyric acid release and biosynthesis
    Kunjan R Dave
    Cerebral Vascular Disease Research Center, Department of Neurology and Neuroscience, University of Miami School of Medicine, Miami, Florida 33101, USA
    J Neurosci Res 82:665-73. 2005
    ..Specific activation of GABAB receptor contributes significantly to neuroprotection against ischemia in organotypic hippocampal slices...
  19. pmc Ischemic preconditioning via epsilon protein kinase C activation requires cyclooxygenase-2 activation in vitro
    E Kim
    Cerebral Vascular Disease Research Center, Department of Neurology and Neuroscience Program, University of Miami Miller School of Medicine, Miami, FL 33101, USA
    Neuroscience 145:931-41. 2007
    ..These results demonstrate a crucial role for the epsilonPKC-->ERK1/2-->COX-2 pathway in the induction of neuroprotection via ischemic preconditioning...
  20. ncbi request reprint Aberrant deltaPKC activation in the spinal cord of Wobbler mouse: a model of motor neuron disease
    Kunjan R Dave
    Department of Neurology, University of Miami School of Medicine, Miami, FL 33101, USA
    Neurobiol Dis 18:126-33. 2005
    ..We hypothesize from these results that caspase-3 activation cleaves deltaPKC, which in turn promotes an aberrant signal transduction pathway in the Wobbler spinal cord...
  21. ncbi request reprint Epsilon PKC is required for the induction of tolerance by ischemic and NMDA-mediated preconditioning in the organotypic hippocampal slice
    Ami P Raval
    Cerebral Vascular Disease Research Center, Department of Neurology and Neuroscience, University of Miami School of Medicine, Miami, Florida 33101, USA
    J Neurosci 23:384-91. 2003
    ..These results demonstrated that the epsilonPKC isozyme played a key role in both IPC- and NMDA-induced tolerance...
  22. pmc GABA synapses mediate neuroprotection after ischemic and epsilonPKC preconditioning in rat hippocampal slice cultures
    R Anthony DeFazio
    Cerebral Vascular Disease Research Center, Department of Neurology, Leonard M Miller School of Medicine, University of Miami, Miami, Florida 33101, USA
    J Cereb Blood Flow Metab 29:375-84. 2009
    ..We conclude that neuroprotection conferred by preconditioning depends on functional modifications of GABA synapses...
  23. pmc Protein kinase C epsilon activation delays neuronal depolarization during cardiac arrest in the euthermic arctic ground squirrel
    Kunjan R Dave
    Department of Neurology, Cerebral Vascular Disease Research Center, Leonard M Miller School of Medicine, University of Miami, Miami, Florida 33101, USA
    J Neurochem 110:1170-9. 2009
    ..These results support the hypothesis that epsilonPKC activation delays the collapse of ion homeostasis during ischemia in AGS...
  24. ncbi request reprint Protein kinase C delta cleavage initiates an aberrant signal transduction pathway after cardiac arrest and oxygen glucose deprivation
    Ami P Raval
    Department of Neurology and Neuroscience Program, Cerebral Vascular Disease Research Center, University of Miami School of Medicine, Florida 33101, USA
    J Cereb Blood Flow Metab 25:730-41. 2005
    ..Our results support the deleterious role of deltaPKC in reperfusion injury. We propose that early cytochrome c release and caspase 3 activation promote deltaPKC translocation/cleavage...
  25. ncbi request reprint Role of reactive oxygen species and protein kinase C in ischemic tolerance in the brain
    Miguel A Perez-Pinzon
    Cerebral Vascular Disease Research Center, Department of Neurology and Neuroscience, University of Miami Miller School of Medicine, Miami, FL 33101, USA
    Antioxid Redox Signal 7:1150-7. 2005
    ....
  26. ncbi request reprint Mild cardiopulmonary arrest promotes synaptic dysfunction in rat hippocampus
    Kunjan R Dave
    Department of Neurology and Neuroscience, Cerebral Vascular Disease Research Center, University of Miami School of Medicine, Miami, FL 33101, USA
    Brain Res 1024:89-96. 2004
    ..These data suggest that synaptic dysfunction occurs before and without overt histopathology. We suggest that the synaptic dysfunction precedes and may be an early marker for delayed neuronal cell death in the hippocampus after CA...
  27. pmc Ischemic preconditioning targets the respiration of synaptic mitochondria via protein kinase C epsilon
    Kunjan R Dave
    The Cerebral Vascular Disease Research Center, and The John T MacDonald Center for Medical Genetics, Leonard M Miller School of Medicine, University of Miami, Miami, Florida 33136, USA
    J Neurosci 28:4172-82. 2008
    ..We propose that, at 48 h of reperfusion after ischemic preconditioning, epsilonPKC is poised at synaptic mitochondria to respond to ischemia either by direct phosphorylation or activation of the epsilonPKC signaling pathway...
  28. ncbi request reprint The arctic ground squirrel brain is resistant to injury from cardiac arrest during euthermia
    Kunjan R Dave
    Cerebral Vascular Disease Research Center, Department of Neurology and Neuroscience, Leonard M Miller School of Medicine, University of Miami, Miami, FL 33101, USA
    Stroke 37:1261-5. 2006
    ..The purpose of the present study was to test the hypothesis that the euthermic Arctic ground squirrel (AGS; Spermophillus parryii) is resistant to injury from asphyxial cardiac arrest (CA)...
  29. ncbi request reprint Resveratrol and ischemic preconditioning in the brain
    Ami P Raval
    Department of Neurology, Leonard M Miller School of Medicine, University of Miami, Miami, FL 33136, USA
    Curr Med Chem 15:1545-51. 2008
    ..In this review, we will examine common signaling pathways, cellular targets of resveratrol, and ischemic preconditioning-induced neuroprotection as it relates to the brain...
  30. ncbi request reprint Hyperbaric oxygen therapy protects against mitochondrial dysfunction and delays onset of motor neuron disease in Wobbler mice
    K R Dave
    Department of Neurology, D4 5, University of Miami School of Medicine, P O Box 016960, Miami, FL 33101, USA
    Neuroscience 120:113-20. 2003
    ..6 days (in terms of paw condition). Our data suggest that HBOT significantly ameliorates mitochondrial dysfunction in the motor cortex and spinal cord and greatly delays the onset of the disease in an animal model of motor neuron disease...
  31. pmc Forebrain ischemia triggers GABAergic system degeneration in substantia nigra at chronic stages in rats
    B Lin
    Department of Neurology D4 5, Cerebral Vascular Disease Research Center, University of Miami Miller School of Medicine, P O Box 016960, Miami, FL 33101, USA
    Cardiovasc Psychiatry Neurol 2010:506952. 2010
    ..2 sec versus 11.8 ± 5.4 sec; sham versus ischemia, p < .05, n = 5, and 7, resp.). Our results demonstrate delayed impairment of the GABAergic system components in SN and associated with movement deficits after global ischemia...
  32. pmc Preconditioning mediated by sublethal oxygen-glucose deprivation-induced cyclooxygenase-2 expression via the signal transducers and activators of transcription 3 phosphorylation
    Eun J Kim
    Cerebral Vascular Disease Research Center, University of Miami Miller School of Medicine, Miami, Florida, USA
    J Cereb Blood Flow Metab 28:1329-40. 2008
    ..Therefore, our findings suggest that PC signaling cascade involves STAT3 activation after varepsilonPKC and ERK1/2 activation. Finally, we show that STAT3 activation mediates COX-2 expression and ischemic tolerance...
  33. ncbi request reprint Protein kinase C delta mediates cerebral reperfusion injury in vivo
    Rachel Bright
    Department of Molecular Pharmacology, Stanford Stroke Center, Stanford University School of Medicine, Stanford, California 94305 5174, USA
    J Neurosci 24:6880-8. 2004
    ..These data support a deleterious role for deltaPKC during reperfusion and suggest that deltaV1-1 delivery, even hours after commencement of reperfusion, may provide a therapeutic advantage after cerebral ischemia...