A P Raval
Affiliation: University of Miami
Raval A, Martinez C, Mejias N, de Rivero Vaccari J. Sexual dimorphism in inflammasome-containing extracellular vesicles and the regulation of innate immunity in the brain of reproductive senescent females. Neurochem Int. 2018;: pubmed publisher
Raval A, Schatz M, Bhattacharya P, d Adesky N, Rundek T, Dietrich W, et al
. Whole Body Vibration Therapy after Ischemia Reduces Brain Damage in Reproductively Senescent Female Rats. Int J Mol Sci. 2018;19: pubmed publisher
..Our results may facilitate a faster translation of the WBV intervention for improved outcome after stroke, particularly among frail women. ..
Raval A, Hirsch N, Dave K, Yavagal D, Bramlett H, Saul I. Nicotine and estrogen synergistically exacerbate cerebral ischemic injury. Neuroscience. 2011;181:216-25 pubmed publisher
..Thus, nicotine can affect the outcome of cerebral ischemia by influencing brain endocrine function directly rather than through indirect systemic effects. ..
d Adesky N, de Rivero Vaccari J, Bhattacharya P, Schatz M, Perez Pinzon M, Bramlett H, et al
. Nicotine Alters Estrogen Receptor-Beta-Regulated Inflammasome Activity and Exacerbates Ischemic Brain Damage in Female Rats. Int J Mol Sci. 2018;19: pubmed publisher
..Overall, this study shows that chronic nicotine exposure exacerbates ischemic brain damage via activation of the inflammasome in the brain of female rats. ..
Raval A, Dave K, DeFazio R, Perez Pinzon M. epsilonPKC phosphorylates the mitochondrial K(+) (ATP) channel during induction of ischemic preconditioning in the rat hippocampus. Brain Res. 2007;1184:345-53 pubmed
..2 as a phosphorylation target of epsilonPKC or its downstream effectors. Our results support the hypothesis that the brain mtK(+)(ATP) channel is an important target of IPC and the signal transduction pathways initiated by epsilonPKC. ..
Raval A, Saul I, Dave K, DeFazio R, Perez Pinzon M, Bramlett H. Pretreatment with a single estradiol-17beta bolus activates cyclic-AMP response element binding protein and protects CA1 neurons against global cerebral ischemia. Neuroscience. 2009;160:307-18 pubmed publisher
..These results suggest that an exogenous bolus of 17beta-estradiol to ovariectomized rats protects hippocampus against ischemia via activation of the CREB pathway in a manner similar to the endogenous estrous cycle. ..