David Raulet

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Posttranslational regulation of the NKG2D ligand Mult1 in response to cell stress
    Timothy J Nice
    Department of Molecular and Cell Biology and Cancer Research Laboratory, University of California, Berkeley, Berkeley, CA 94720, USA
    J Exp Med 206:287-98. 2009
  2. pmc Gene placement and competition control T cell receptor gamma variable region gene rearrangement
    Na Xiong
    Department of Molecular and Cell Biology and Cancer Research Laboratory, University of California, Berkeley, Berkeley, CA 94720, USA
    J Exp Med 205:929-38. 2008
  3. pmc p53-dependent chemokine production by senescent tumor cells supports NKG2D-dependent tumor elimination by natural killer cells
    Alexandre Iannello
    Berkeley, Berkeley, CA 94720
    J Exp Med 210:2057-69. 2013
  4. pmc Mature natural killer cells reset their responsiveness when exposed to an altered MHC environment
    Nathalie T Joncker
    Department of Molecular and Cell Biology, Cancer Research Laboratory, University of California, Berkeley, Berkeley, CA 94720, USA
    J Exp Med 207:2065-72. 2010
  5. pmc RAE-1 ligands for the NKG2D receptor are regulated by E2F transcription factors, which control cell cycle entry
    Heiyoun Jung
    Department of Molecular and Cell Biology, 489 Life Sciences Addition, University of California, Berkeley, Berkeley, CA 94720, USA
    J Exp Med 209:2409-22. 2012
  6. doi request reprint Regulation of ligands for the NKG2D activating receptor
    David H Raulet
    Department of Molecular and Cell Biology and Cancer Research Laboratory, University of California, Berkeley, California 94720 3200, USA
    Annu Rev Immunol 31:413-41. 2013
  7. ncbi request reprint Missing self recognition and self tolerance of natural killer (NK) cells
    David H Raulet
    Department of Molecular and Cell Biology, Cancer Research Laboratory, University of California, Berkeley, CA 94720 3200, USA
    Semin Immunol 18:145-50. 2006
  8. pmc Oncogenic stress sensed by the immune system: role of natural killer cell receptors
    David H Raulet
    Department of Molecular and Cell Biology, Cancer Research Laboratory, 485 Life Science Addition, University of California, Berkeley, California 94720, USA
    Nat Rev Immunol 9:568-80. 2009
  9. pmc Natural killer cells: remembrances of things past
    David H Raulet
    Department of Molecular and Cell Biology and Cancer Research Laboratory, 489 Life Sciences Addition, University of California at Berkeley, Berkeley, CA 94720, USA
    Curr Biol 19:R294-6. 2009
  10. ncbi request reprint Self-tolerance of natural killer cells
    David H Raulet
    Department of Molecular and Cell Biology, Cancer Research Laboratory, 485 Life Science Addition, University of California, Berkeley, California 94720, USA
    Nat Rev Immunol 6:520-31. 2006

Research Grants

Collaborators

Detail Information

Publications54

  1. pmc Posttranslational regulation of the NKG2D ligand Mult1 in response to cell stress
    Timothy J Nice
    Department of Molecular and Cell Biology and Cancer Research Laboratory, University of California, Berkeley, Berkeley, CA 94720, USA
    J Exp Med 206:287-98. 2009
    ....
  2. pmc Gene placement and competition control T cell receptor gamma variable region gene rearrangement
    Na Xiong
    Department of Molecular and Cell Biology and Cancer Research Laboratory, University of California, Berkeley, Berkeley, CA 94720, USA
    J Exp Med 205:929-38. 2008
    ..These data provide a mechanism for specialization of the fetal thymus for the production of T cells expressing specific Vgamma genes...
  3. pmc p53-dependent chemokine production by senescent tumor cells supports NKG2D-dependent tumor elimination by natural killer cells
    Alexandre Iannello
    Berkeley, Berkeley, CA 94720
    J Exp Med 210:2057-69. 2013
    ....
  4. pmc Mature natural killer cells reset their responsiveness when exposed to an altered MHC environment
    Nathalie T Joncker
    Department of Molecular and Cell Biology, Cancer Research Laboratory, University of California, Berkeley, Berkeley, CA 94720, USA
    J Exp Med 207:2065-72. 2010
    ..These findings have important implications for how NK cell functions may be curtailed or enhanced in the context of disease...
  5. pmc RAE-1 ligands for the NKG2D receptor are regulated by E2F transcription factors, which control cell cycle entry
    Heiyoun Jung
    Department of Molecular and Cell Biology, 489 Life Sciences Addition, University of California, Berkeley, Berkeley, CA 94720, USA
    J Exp Med 209:2409-22. 2012
    ..These findings suggest that cellular proliferation, as occurs in cancer cells but also other pathological conditions, is a key signal tied to immune reactions mediated by NKG2D-bearing lymphocytes...
  6. doi request reprint Regulation of ligands for the NKG2D activating receptor
    David H Raulet
    Department of Molecular and Cell Biology and Cancer Research Laboratory, University of California, Berkeley, California 94720 3200, USA
    Annu Rev Immunol 31:413-41. 2013
    ....
  7. ncbi request reprint Missing self recognition and self tolerance of natural killer (NK) cells
    David H Raulet
    Department of Molecular and Cell Biology, Cancer Research Laboratory, University of California, Berkeley, CA 94720 3200, USA
    Semin Immunol 18:145-50. 2006
    ..This review summarizes current understanding of NK cell recognition and self tolerance...
  8. pmc Oncogenic stress sensed by the immune system: role of natural killer cell receptors
    David H Raulet
    Department of Molecular and Cell Biology, Cancer Research Laboratory, 485 Life Science Addition, University of California, Berkeley, California 94720, USA
    Nat Rev Immunol 9:568-80. 2009
    ....
  9. pmc Natural killer cells: remembrances of things past
    David H Raulet
    Department of Molecular and Cell Biology and Cancer Research Laboratory, 489 Life Sciences Addition, University of California at Berkeley, Berkeley, CA 94720, USA
    Curr Biol 19:R294-6. 2009
    ..While protective, natural killer cell memory is probably hazier and more fleeting than T cell memory...
  10. ncbi request reprint Self-tolerance of natural killer cells
    David H Raulet
    Department of Molecular and Cell Biology, Cancer Research Laboratory, 485 Life Science Addition, University of California, Berkeley, California 94720, USA
    Nat Rev Immunol 6:520-31. 2006
    ..Recent studies have produced important new information about NK-cell self-tolerance. Here, we review the evidence for and against possible mechanisms of NK-cell self-tolerance, with an emphasis on the role of MHC-specific receptors...
  11. ncbi request reprint The innate immune response to tumors and its role in the induction of T-cell immunity
    Andreas Diefenbach
    Department of Molecular and Cell Biology and Cancer Research Laboratory, University of California, Berkeley, CA 94720, USA
    Immunol Rev 188:9-21. 2002
    ..The recognition of induced-self ligands as a strategy to recognize abnormal self sets a precedent for a new immune recognition strategy of the innate immune system...
  12. pmc Implications of CD94 deficiency and monoallelic NKG2A expression for natural killer cell development and repertoire formation
    Russell E Vance
    Department of Molecular and Cell Biology and Cancer Research Laboratory, University of California, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 99:868-73. 2002
    ..Thus, self-tolerance of neonatal NK cells cannot be attributed to CD94/NKG2A expression. Taken together, the results lead to a reconsideration of current models of NK cell development and self-tolerance...
  13. ncbi request reprint A novel ligand for the NKG2D receptor activates NK cells and macrophages and induces tumor immunity
    Andreas Diefenbach
    Department of Molecular and Cell Biology, Cancer Research Laboratory, University of California, Berkeley 94720 3200, USA
    Eur J Immunol 33:381-91. 2003
    ..Tumor cells ectopically expressing the molecule were efficiently rejected by naive mice, and induced strong protective immunity to the parental, ligand-negative tumor cells...
  14. ncbi request reprint Viral and bacterial infections induce expression of multiple NK cell receptors in responding CD8(+) T cells
    Christopher W McMahon
    Department of Molecular and Cell Biology and Cancer Research Laboratory, University of California, Berkeley, CA 94720, USA
    J Immunol 169:1444-52. 2002
    ..These subtle effects suggest that CD94/NKG2A-mediated inhibition of T cells may be limited to particular circumstances or may synergize with other receptors that are similarly up-regulated...
  15. ncbi request reprint The DNA damage response, immunity and cancer
    Stephan Gasser
    Department of Molecular and Cell Biology and Cancer Research Laboratory, University of California, Berkeley, CA 94720 3200, USA
    Semin Cancer Biol 16:344-7. 2006
    ..In this review we discuss the DNA damage response and its link to the innate immune system and tumor surveillance. These findings might have important implications for the understanding of cancer therapies and for drug development...
  16. pmc Regulation of NK cell responsiveness to achieve self-tolerance and maximal responses to diseased target cells
    Nathalie T Joncker
    Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, CA 94720 3200, USA
    Immunol Rev 224:85-97. 2008
    ....
  17. pmc DNA mismanagement leads to immune system oversight
    Laurent Coscoy
    Department of Molecular and Cell Biology and Cancer Research Laboratory, Life Sciences Addition, University of California at Berkeley, Berkeley, CA 94720, USA
    Cell 131:836-8. 2007
    ....
  18. ncbi request reprint The role of the NKG2D immunoreceptor in immune cell activation and natural killing
    Amanda M Jamieson
    Department of Molecular and Cell Biology and Cancer Research Laboratory, 489 Life Sciences Addition, University of California, Berkeley, 94720, USA
    Immunity 17:19-29. 2002
    ..In contrast, NKG2D costimulates activated CD8(+) T cells. Thus, NKG2D engagement directly stimulates NK cells and macrophages, costimulates CD8(+) T cells, and plays a substantial role in natural killing...
  19. pmc The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor
    Stephan Gasser
    Department of Molecular and Cell Biology and Cancer Research Laboratory, University of California, Berkeley, California 94720 3200, USA
    Nature 436:1186-90. 2005
    ..Thus, the DNA damage response, previously shown to arrest the cell cycle and enhance DNA repair functions, or to trigger apoptosis, may also participate in alerting the immune system to the presence of potentially dangerous cells...
  20. pmc A subset of natural killer cells achieves self-tolerance without expressing inhibitory receptors specific for self-MHC molecules
    Nadine C Fernandez
    Department of Molecular and Cell Biology, Cancer Research Laboratory, University of California, Berkeley, CA 94720, USA
    Blood 105:4416-23. 2005
    ..Thus, self-tolerance of NK cells in normal animals can occur independently of MHC-mediated inhibition, and hyporesponsiveness plays a role in self-tolerance of NK cells, as also proposed for B and T cells...
  21. ncbi request reprint Interplay of natural killer cells and their receptors with the adaptive immune response
    David H Raulet
    Department of Molecular and Cell Biology and Cancer Research Laboratory, University of California, Berkeley, California 94720 3200, USA
    Nat Immunol 5:996-1002. 2004
    ..In addition, 'NK receptors' are frequently expressed by T cells and can directly regulate the functions of these cells. In these distinct ways, NK cells and their receptors influence the adaptive immune response...
  22. ncbi request reprint Roles of the NKG2D immunoreceptor and its ligands
    David H Raulet
    Department of Molecular and Cell Biology and Cancer Research Laboratory, University of California, Berkeley, California 94720 3200, USA
    Nat Rev Immunol 3:781-90. 2003
    ....
  23. ncbi request reprint Innate immune recognition by stimulatory immunoreceptors
    Andreas Diefenbach
    Department of Molecular and Cell Biology and Cancer Research Laboratory, 485 Life Sciences Addition, University of California, Berkeley, CA 94720, USA
    Curr Opin Immunol 15:37-44. 2003
  24. ncbi request reprint Selective associations with signaling proteins determine stimulatory versus costimulatory activity of NKG2D
    Andreas Diefenbach
    Department of Molecular and Cell Biology and Cancer Research Laboratory, University of California, Berkeley, CA 94720 3200, USA
    Nat Immunol 3:1142-9. 2002
    ..This strategy suggests a rationale for the multisubunit structure of stimulatory immunoreceptors...
  25. pmc Missing self-recognition of Ocil/Clr-b by inhibitory NKR-P1 natural killer cell receptors
    James R Carlyle
    Department of Molecular and Cell Biology and Cancer Research Laboratory, University of California, 485 Life Sciences Addition, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 101:3527-32. 2004
    ..Remarkably, Ocil/Clr-b is frequently down-regulated on mouse tumor cell lines, indicating a role for this receptor-ligand system in a new form of "missing self-recognition" of tumor cells...
  26. pmc NKG2D-deficient mice are defective in tumor surveillance in models of spontaneous malignancy
    Nadia Guerra
    Department of Molecular and Cell Biology, 489 Life Sciences Addition, University of California, Berkeley, Berkeley, CA 94720, USA
    Immunity 28:571-80. 2008
    ..These findings provide important genetic evidence for surveillance of primary tumors by an NK receptor...
  27. ncbi request reprint Genomic Ly49A transgenes: basis of variegated Ly49A gene expression and identification of a critical regulatory element
    Dawn M Tanamachi
    Department of Molecular and Cell Biology, and Cancer Research Laboratory, University of California Berkeley, 485 Life Science Addition, Berkeley, CA 94720, USA
    J Immunol 172:1074-82. 2004
    ..Highly related sequence elements were found upstream of other Ly49 genes, suggesting that a similar regulatory element controls each Ly49 gene...
  28. ncbi request reprint The DNA damage response arouses the immune system
    Stephan Gasser
    Cancer Research Laboratory, Department of Molecular and Cell Biology, University of California, Berkeley, California 94720 3200, USA
    Cancer Res 66:3959-62. 2006
    ..This unique arm of the DNA damage response may have implications for understanding therapeutic responses, many of which induce the DNA damage response, and for designing more effective regimens to treat cancer...
  29. pmc Costimulation of dendritic epidermal gammadelta T cells by a new NKG2D ligand expressed specifically in the skin
    Michael I Whang
    Department of Molecular and Cell Biology and Cancer Research Laboratory, University of California, Berkeley, CA 94720, USA
    J Immunol 182:4557-64. 2009
    ..Importantly, it is shown that engagement of NKG2D is not sufficient to activate DETCs, but instead provides a costimulatory signal that is nevertheless essential for activating DETCs in response to stimulation with keratinocytes...
  30. ncbi request reprint Activation and self-tolerance of natural killer cells
    Stephan Gasser
    Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA
    Immunol Rev 214:130-42. 2006
    ..These NK cells are hyporesponsive when stimulatory receptors are engaged, suggesting that alterations in signaling pathways that dampen stimulatory receptor signals contribute to self-tolerance of NK cells...
  31. pmc The genomic arrangement of T cell receptor variable genes is a determinant of the developmental rearrangement pattern
    Na Xiong
    Department of Molecular and Cell Biology and Cancer Research Laboratory, 489 Life Sciences Addition, University of California, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 101:260-5. 2004
    ..The results support a model in which the 3' location is the key determinant of rearrangement in the fetus, after which there is a promoter-dependent inactivation of Vgamma3 rearrangement in favor of Vgamma2 rearrangement...
  32. pmc NK cell responsiveness is tuned commensurate with the number of inhibitory receptors for self-MHC class I: the rheostat model
    Nathalie T Joncker
    Department of Molecular and Cell Biology, University of California, Berkeley, CA 94704, USA
    J Immunol 182:4572-80. 2009
    ....
  33. ncbi request reprint Development and selection of gammadelta T cells
    Na Xiong
    Department of Molecular and Cell Biology, Cancer Research Laboratory, University of California, Berkeley, CA, USA
    Immunol Rev 215:15-31. 2007
    ..This research suggests a coordination of molecularly programmed events and cellular selection, which enables specialization of the thymus for production of distinct T-cell subsets at different stages of development...
  34. ncbi request reprint Positive selection of dendritic epidermal gammadelta T cell precursors in the fetal thymus determines expression of skin-homing receptors
    Na Xiong
    Department of Molecular and Cell Biology, 489 Life Sciences Addition, University of California, Berkeley, 94720, USA
    Immunity 21:121-31. 2004
    ..In vitro activation of irrelevant precursors also led to upregulation of the skin-homing receptor, providing an explanation for how thymic selection is coordinated with development of epidermal gammadelta T cells...
  35. pmc Stress-regulated targeting of the NKG2D ligand Mult1 by a membrane-associated RING-CH family E3 ligase
    Timothy J Nice
    Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, CA 94720 3200, USA
    J Immunol 185:5369-76. 2010
    ..These results identify Mult1 as a target for the MARCH family of E3 ligases and show that induction of Mult1 in response to heat shock is due to regulated association with its E3 ligases...
  36. ncbi request reprint Turnover and proliferation of NK cells in steady state and lymphopenic conditions
    Amanda M Jamieson
    Department of Molecular and Cell Biology, and Cancer Research Laboratory, 485 Life Science Addition, University of California Berkeley, Berkeley, CA 94720, USA
    J Immunol 172:864-70. 2004
    ..Our results provide important basic information concerning the production and replacement of NK cells...
  37. ncbi request reprint Redundant and unique roles of two enhancer elements in the TCRgamma locus in gene regulation and gammadelta T cell development
    Na Xiong
    Cancer Research Laboratory, Department of Molecular and Cell Biology, University of California at Berkeley, 489 Life Sciences Addition, Berkeley, CA 94720, USA
    Immunity 16:453-63. 2002
    ..Thus, the two elements exhibit functional redundancy in thymocytes but also have unique functions in other settings...
  38. ncbi request reprint Blastocyst MHC, a putative murine homologue of HLA-G, protects TAP-deficient tumor cells from natural killer cell-mediated rejection in vivo
    Atsushi Tajima
    Department of Immunology and Obstetrics and Gynecology, Juntendo University School of Medicine, Tokyo, Japan
    J Immunol 171:1715-21. 2003
    ..These results suggested a role for blastocyst MHC in protecting TAP-deficient trophoblasts and tumor cells from NK cell attack in vivo...
  39. ncbi request reprint Amelioration of acute graft-versus-host disease by NKG2A engagement on donor T cells
    Hiroki Kawamura
    Department of Immunology, Niigata University School of Medicine, Niigata, Japan
    Eur J Immunol 35:2358-66. 2005
    ..These results suggested that the CD94/NKG2A inhibitory receptor expressed on host-reactive donor T cells can be a novel target for the amelioration of aGVHD...
  40. ncbi request reprint The lymphoproliferative defect in CTLA-4-deficient mice is ameliorated by an inhibitory NK cell receptor
    Cynthia A Chambers
    Department of Pathology, University of Massachusetts Medical School, Worcester, 01655, USA
    Blood 99:4509-16. 2002
    ..These results demonstrate the importance of inhibitory signals in T-cell homeostasis and suggest the common biochemical basis of inhibitory signaling pathways in T lymphocytes...
  41. ncbi request reprint Orderly and nonstochastic acquisition of CD94/NKG2 receptors by developing NK cells derived from embryonic stem cells in vitro
    Rebecca H Lian
    Terry Fox Laboratory, British Columbia Cancer Agency, University of British Columbia, 601 West 10th Avenue, Vancouver, British Columbia, Canada V5Z 1L3
    J Immunol 168:4980-7. 2002
    ....
  42. ncbi request reprint Expansion and function of CD8+ T cells expressing Ly49 inhibitory receptors specific for MHC class I molecules
    Nicolas Anfossi
    Centre d immunologie de Marseille Luminy, Institut National de la Santé et de la Recherche Médicale INSERM Centre National de la Recherche Scientifique CNRS Université de la Méditerranée, Campus de Luminy, Marseille, France
    J Immunol 173:3773-82. 2004
    ..They further suggest that the size of the Ly49+CD8+ T cell subset marks a history of CD8+ T cell activation that might preferentially result from endogenous inducers of inflammation rather than from microbial infections...
  43. ncbi request reprint NK cells respond to pulmonary infection with Mycobacterium tuberculosis, but play a minimal role in protection
    Ana Paula Junqueira-Kipnis
    Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523, USA
    J Immunol 171:6039-45. 2003
    ....
  44. pmc The role of innate immunity in autoimmunity
    Jean Francois Bach
    INSERM U580, Hopital Necker, Paris, France
    J Exp Med 200:1527-31. 2004
    ....
  45. ncbi request reprint Comparative analysis of human NK cell activation induced by NKG2D and natural cytotoxicity receptors
    Pascale Andre
    Innate Pharma SA, Marseille, France
    Eur J Immunol 34:961-71. 2004
    ..These data thus show that target recognition via NKG2D or NCR triggers all aspects of NK activation, and pave the way for further dissection of the signaling pathways induced by NK cell recognition of ULBP-1 and MICA...
  46. pmc IFN-gamma-mediated negative feedback regulation of NKT-cell function by CD94/NKG2
    Tsuyoshi Ota
    Department of Immunology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Blood 106:184-92. 2005
    ....
  47. pmc Multiplicity and plasticity of natural killer cell signaling pathways
    Sabrina Chiesa
    Centre d immunologie de Marseille Luminy, INSERM CNRS, Universite de la Mediterranee, Marseille Cedex 09, France
    Blood 107:2364-72. 2006
    ....
  48. ncbi request reprint Natural killer cell differentiation driven by Tyro3 receptor tyrosine kinases
    Anouk Caraux
    Laboratoire Cytokines et Développement Lymphoïde, Departement d Immunologie, Institut Pasteur, 75724 Paris Cedex 15, France
    Nat Immunol 7:747-54. 2006
    ..These results collectively suggest that Axl, Tyro3 and Mer transmit signals that are essential for the generation of a functional NK cell repertoire...
  49. ncbi request reprint NK cells developing in vitro from fetal mouse progenitors express at least one member of the Ly49 family that is acquired in a time-dependent and stochastic manner independently of CD94 and NKG2
    Karen P Fraser
    Department of Microbiology and Immunology, The Medical School, Newcastle, GB
    Eur J Immunol 32:868-78. 2002
    ..1, with CD94 invariably being expressed at two different levels. IL-4 differentially inhibited the expression of CD94 and Ly49 receptors, but had little or no effect on the expression of NKRP1 molecules...
  50. ncbi request reprint The combined actions of NK and T lymphocytes are necessary to reject an EGFP+ mesenchymal tumor through mechanisms dependent on NKG2D and IFN gamma
    Ainhoa Arina
    Gene Therapy Unit, Centro de Investigación Médica Aplicada, University of Navarra, Pamplona, Spain
    Int J Cancer 121:1282-95. 2007
    ..Therefore, complete rejection of these mesenchymal tumors requires a concerted set of activities including direct tumor-cell destruction and IFN gamma production that are mediated by both NK and T cells...
  51. pmc The role of NKG2D signaling in inhibition of cytotoxic T-lymphocyte lysis by the Murine cytomegalovirus immunoevasin m152/gp40
    Amelia K Pinto
    Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, OR 97239, USA
    J Virol 81:12564-71. 2007
    ..We conclude that the downregulation of NKG2D ligands by MCMV makes only a small contribution to the impact of m152/gp40 on CTL lysis and only for a small subset of CTL...
  52. ncbi request reprint Coordinated induction by IL15 of a TCR-independent NKG2D signaling pathway converts CTL into lymphokine-activated killer cells in celiac disease
    Bertrand Meresse
    Department of Pathology, University of Chicago, IL 60637, USA
    Immunity 21:357-66. 2004
    ....
  53. ncbi request reprint Upregulation of CD94/NKG2A receptors and Qa-1b ligand during murine cytomegalovirus infection of salivary glands
    Victoria J Cavanaugh
    Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, VA 23501, USA
    J Gen Virol 88:1440-5. 2007
    ..These data indicate that expression of inhibitory CD94/NKG2A receptors does not account for the failure of MCMV-specific CTLs to clear the SMG of infection...
  54. ncbi request reprint Stromal-cell regulation of natural killer cell differentiation
    Claude Roth
    Laboratoire Immunité Cellulaire Antivirale, Departement d Immunologie, Institut Pasteur, 75724, Paris Cedex 15, France
    J Mol Med (Berl) 85:1047-56. 2007
    ..In this review, we provide an overview of the role of bone marrow microenvironment in NK cell differentiation...

Research Grants60

  1. Regulation of MHC Dependence of gamma delta T cells
    David Raulet; Fiscal Year: 2007
    ..An understanding of the role of gamma/delta T cells and the rules that govern their production will undoubtedly aid in efforts marshal the immune system for therapeutic application ..
  2. REGULATION AND MHC DEPENDENCE OF GAMMA DELTA T CELLS
    David Raulet; Fiscal Year: 2003
    ..To determine the roles of HsA and the 3'Ecv1 in TCR-gamma gene rearrangement and expression using mice in which each element, or both simultaneously, are deleted by gene targeting. Factors that regulate the elements will be assessed. ..
  3. Role of NKG2D in immune responses to tumors
    David Raulet; Fiscal Year: 2006
    ..Specific Aim 3: To assess the importance of NKG2D in surveillance of tumors in vivo. Specific Aim 4: To determine the efficacy of NKG2D stimulation as a cancer immunotherapy ..
  4. REGULATION AND MHC DEPENDENCE OF GAMMA DELTA T CELLS
    David Raulet; Fiscal Year: 2002
    ..To determine the roles of HsA and the 3'Ecv1 in TCR-gamma gene rearrangement and expression using mice in which each element, or both simultaneously, are deleted by gene targeting. Factors that regulate the elements will be assessed. ..
  5. Role of MHC molecules in NK recognition
    David Raulet; Fiscal Year: 2006
    ..Specific Aim 3: To determine the relationship of NK cell hyporesponsiveness and cytokine action. ..
  6. Role of MHC molecules in NK recognition
    David Raulet; Fiscal Year: 2005
    ..Specific Aim 3: To determine the relationship of NK cell hyporesponsiveness and cytokine action. ..
  7. Regulation of MHC Dependence of gamma delta T cells
    David Raulet; Fiscal Year: 2006
    ..An understanding of the role of gamma/delta T cells and the rules that govern their production will undoubtedly aid in efforts marshal the immune system for therapeutic application ..
  8. EXPRESSION OF CLASS I-SPECIFIC RECEPTORS IN NK CELLS
    David Raulet; Fiscal Year: 2000
    ..With these diverse approaches, elements associated with subset-specific and allele- specific expression may be identified, and models of how Ly49 genes are regulated by the MHC environment can be tested. ..
  9. REGULATION OF MHC-DEPENDENCE OF GAMMA DELTA T CELLS
    David Raulet; Fiscal Year: 1999
    ..In addition, promoter deletion mutants will be further characterized to assess the role of transcription in rearrangement. ..
  10. Role of MHC molecules in NK recognition
    David Raulet; Fiscal Year: 2004
    ..Specific Aim 3: To determine the relationship of NK cell hyporesponsiveness and cytokine action. ..
  11. REGULATION AND MHC DEPENDENCE OF GAMMA DELTA T CELLS
    David Raulet; Fiscal Year: 2004
    ..To determine the roles of HsA and the 3'Ecv1 in TCR-gamma gene rearrangement and expression using mice in which each element, or both simultaneously, are deleted by gene targeting. Factors that regulate the elements will be assessed. ..
  12. Expression of Class I Specific Receptors in NK Cells
    David Raulet; Fiscal Year: 2001
    ..Specific Aim 4. To employ gene targeting to address the necessity of HSS-1 in Ly49A gene expression, and its role in controlling the developmental staging and extent of variegation of Ly49 gene expression. ..
  13. REGULATION AND MHC DEPENDENCE OF GAMMA DELTA T CELLS
    David Raulet; Fiscal Year: 2005
    ..To determine the roles of HsA and the 3'Ecv1 in TCR-gamma gene rearrangement and expression using mice in which each element, or both simultaneously, are deleted by gene targeting. Factors that regulate the elements will be assessed. ..
  14. Regulation of MHC Dependence of gamma delta T cells
    David H Raulet; Fiscal Year: 2010
    ..An understanding of the role of gamma/delta T cells and the rules that govern their production will undoubtedly aid in efforts marshal the immune system for therapeutic application ..
  15. Expression of Class I Specific Receptors in NK Cells
    David Raulet; Fiscal Year: 2005
    ..Specific Aim 4. To employ gene targeting to address the necessity of HSS-1 in Ly49A gene expression, and its role in controlling the developmental staging and extent of variegation of Ly49 gene expression. ..
  16. Role of NKG2D in immune responses to turmors
    David Raulet; Fiscal Year: 2009
    ..Yet some cancer cells escape recognition by this recognition system. The results of our results will help to guide the design of therapeutic agents that help our immune systems attack cancer. ..
  17. Role of MHC molecules in NK recognition
    David Raulet; Fiscal Year: 2007
    ..Specific Aim 3: To determine the relationship of NK cell hyporesponsiveness and cytokine action. ..
  18. Expression of Class I Specific Receptors in NK Cells
    David Raulet; Fiscal Year: 2007
    ..These studies should advance our understanding of how the immune system surveys cells for loss of genomic integrity and may provide strategies to enhance immunity. ..
  19. Expression of Class I Specific Receptors in NK Cells
    David Raulet; Fiscal Year: 2009
    ..These studies should advance our understanding of how the immune system surveys cells for loss of genomic integrity and may provide strategies to enhance immunity. ..
  20. Role of NKG2D in immune responses to tumors
    David Raulet; Fiscal Year: 2007
    ..Specific Aim 3. To assess the importance of NKG2D in surveillance of tumors in vivo. Specific Aim 4. To determine the efficacy of NKG2D stimulation as a cancer immunotherapy ..
  21. REGULATION AND MHC-DEPENDENCE OF GAMMA DELTA T CELLS
    David Raulet; Fiscal Year: 1993
    ..In addition, further analysis of gamma enhancer and negative regulatory elements is to be addressed...
  22. EXPRESSION OF CLASS I-SPECIFIC RECEPTORS IN NK CELLS
    David Raulet; Fiscal Year: 1999
    ..With these diverse approaches, elements associated with subset-specific and allele- specific expression may be identified, and models of how Ly49 genes are regulated by the MHC environment can be tested. ..
  23. REGULATION AND MHC-DEPENDENCE OF GAMMA DELTA T CELLS
    David Raulet; Fiscal Year: 1992
    ..In addition, further analysis of gamma enhancer and negative regulatory elements is to be addressed...
  24. REGULATION AND MHC DEPENDENCE OF GAMMA DELTA T CELLS
    David Raulet; Fiscal Year: 2001
    ..To determine the roles of HsA and the 3'Ecv1 in TCR-gamma gene rearrangement and expression using mice in which each element, or both simultaneously, are deleted by gene targeting. Factors that regulate the elements will be assessed. ..
  25. MHC MOLECULES AND NK RECOGNITION
    David Raulet; Fiscal Year: 2001
    ..The fourth aim (4) is to determine the role of the MCMV m144 class I homolog protein in preventing NK cell responses and the role of corresponding NK cell receptors in regulating NK immunity to MCMV infection. ..
  26. MHC MOLECULES AND NK RECOGNITION
    David Raulet; Fiscal Year: 2002
    ..The fourth aim (4) is to determine the role of the MCMV m144 class I homolog protein in preventing NK cell responses and the role of corresponding NK cell receptors in regulating NK immunity to MCMV infection. ..
  27. Expression of Class I Specific Receptors in NK Cells
    David Raulet; Fiscal Year: 2003
    ..Specific Aim 4. To employ gene targeting to address the necessity of HSS-1 in Ly49A gene expression, and its role in controlling the developmental staging and extent of variegation of Ly49 gene expression. ..
  28. MHC MOLECULES AND NK RECOGNITION
    David Raulet; Fiscal Year: 2003
    ..The fourth aim (4) is to determine the role of the MCMV m144 class I homolog protein in preventing NK cell responses and the role of corresponding NK cell receptors in regulating NK immunity to MCMV infection. ..
  29. Role of NKG2D in immune responses to tumors
    David Raulet; Fiscal Year: 2003
    ..Specific Aim 3: To assess the importance of NKG2D in surveillance of tumors in vivo. Specific Aim 4: To determine the efficacy of NKG2D stimulation as a cancer immunotherapy ..
  30. Regulation of MHC Dependence of gamma delta T cells
    David Raulet; Fiscal Year: 2009
    ..An understanding of the role of gamma/delta T cells and the rules that govern their production will undoubtedly aid in efforts marshal the immune system for therapeutic application ..
  31. Role of NKG2D in immune responses to turmors
    David H Raulet; Fiscal Year: 2010
    ..Yet some cancer cells escape recognition by this recognition system. The results of our results will help to guide the design of therapeutic agents that help our immune systems attack cancer. ..
  32. Expression of Class I Specific Receptors in NK Cells
    David H Raulet; Fiscal Year: 2010
    ..Our studies will provide new approaches for enhancing the immune response against cancer and infection, and inhibiting its role in autoimmunity. ..
  33. MHC MOLECULES AND NK RECOGNITION
    David Raulet; Fiscal Year: 1999
    ..The fourth aim (4) is to determine the role of the MCMV m144 class I homolog protein in preventing NK cell responses and the role of corresponding NK cell receptors in regulating NK immunity to MCMV infection. ..
  34. MHC MOLECULES AND NK RECOGNITION
    David Raulet; Fiscal Year: 2000
    ..The fourth aim (4) is to determine the role of the MCMV m144 class I homolog protein in preventing NK cell responses and the role of corresponding NK cell receptors in regulating NK immunity to MCMV infection. ..
  35. Expression of Class I Specific Receptors in NK Cells
    David Raulet; Fiscal Year: 2006
    ..These studies should advance our understanding of how the immune system surveys cells for loss of genomic integrity and may provide strategies to enhance immunity. ..
  36. Expression of Class I Specific Receptors in NK Cells
    David Raulet; Fiscal Year: 2004
    ..Specific Aim 4. To employ gene targeting to address the necessity of HSS-1 in Ly49A gene expression, and its role in controlling the developmental staging and extent of variegation of Ly49 gene expression. ..
  37. REGULATION OF MHC-DEPENDENCE OF GAMMA DELTA T CELLS
    David Raulet; Fiscal Year: 2000
    ..In addition, promoter deletion mutants will be further characterized to assess the role of transcription in rearrangement. ..
  38. Expression of Class I Specific Receptors in NK Cells
    David Raulet; Fiscal Year: 2002
    ..Specific Aim 4. To employ gene targeting to address the necessity of HSS-1 in Ly49A gene expression, and its role in controlling the developmental staging and extent of variegation of Ly49 gene expression. ..
  39. MOLECULAR IMMUNOLOGY AND TUMOR BIOLOGY
    David Raulet; Fiscal Year: 2007
    ....