Drazen Raucher

Summary

Affiliation: University of Mississippi Medical Center
Country: USA

Publications

  1. doi request reprint Therapeutic peptides for cancer therapy. Part II - cell cycle inhibitory peptides and apoptosis-inducing peptides
    Drazen Raucher
    The University of Mississippi Medical Center, Department of Biochemistry, Jackson, 39216, USA
    Expert Opin Drug Deliv 6:1049-64. 2009
  2. ncbi request reprint Thermally targeted delivery of chemotherapeutics and anti-cancer peptides by elastin-like polypeptide
    Drazen Raucher
    University of Mississippi Medical Center, Department of Biochemistry, 2500 North State Street, Jackson, MS 39216, USA
    Expert Opin Drug Deliv 5:353-69. 2008
  3. doi request reprint Targeting a c-Myc inhibitory polypeptide to specific intracellular compartments using cell penetrating peptides
    Gene L Bidwell
    Department of Biochemistry, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USA
    J Control Release 135:2-10. 2009
  4. pmc Inhibition of ovarian cancer cell proliferation by a cell cycle inhibitory peptide fused to a thermally responsive polypeptide carrier
    Iqbal Massodi
    Department of Biochemistry, University of Mississippi Medical Center, Jackson, 39216, USA
    Int J Cancer 126:533-44. 2010
  5. pmc Cell penetrating peptides fused to a thermally targeted biopolymer drug carrier improve the delivery and antitumor efficacy of an acid-sensitive doxorubicin derivative
    Leslie Walker
    University of Mississippi Medical Center, 2500N State St, Jackson, MS 39216, USA
    Int J Pharm 436:825-32. 2012
  6. ncbi request reprint Evaluation of cell penetrating peptides fused to elastin-like polypeptide for drug delivery
    Iqbal Massodi
    Department of Biochemistry, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USA
    J Control Release 108:396-408. 2005
  7. ncbi request reprint A thermally targeted elastin-like polypeptide-doxorubicin conjugate overcomes drug resistance
    Gene L Bidwell
    Department of Biochemistry, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USA
    Invest New Drugs 25:313-26. 2007
  8. ncbi request reprint Development of elastin-like polypeptide for thermally targeted delivery of doxorubicin
    Gene L Bidwell
    The University of Mississippi Medical Center, Jackson, MS 39216, USA
    Biochem Pharmacol 73:620-31. 2007
  9. doi request reprint A thermally responsive biopolymer conjugated to an acid-sensitive derivative of paclitaxel stabilizes microtubules, arrests cell cycle, and induces apoptosis
    Shama Moktan
    University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USA
    Invest New Drugs 30:236-48. 2012
  10. pmc A thermally targeted peptide inhibitor of symmetrical dimethylation inhibits cancer-cell proliferation
    Gene L Bidwell
    Department of Biochemistry, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USA
    Peptides 31:834-41. 2010

Research Grants

Collaborators

Detail Information

Publications24

  1. doi request reprint Therapeutic peptides for cancer therapy. Part II - cell cycle inhibitory peptides and apoptosis-inducing peptides
    Drazen Raucher
    The University of Mississippi Medical Center, Department of Biochemistry, Jackson, 39216, USA
    Expert Opin Drug Deliv 6:1049-64. 2009
    ..Therapeutic peptides have great potential as anticancer agents owing to their ease of rational design and target specificity. However, their utility in vivo is limited by low stability and poor tumor penetration...
  2. ncbi request reprint Thermally targeted delivery of chemotherapeutics and anti-cancer peptides by elastin-like polypeptide
    Drazen Raucher
    University of Mississippi Medical Center, Department of Biochemistry, 2500 North State Street, Jackson, MS 39216, USA
    Expert Opin Drug Deliv 5:353-69. 2008
    ..Further examination of the in vivo biodistribution and efficacy will provide the necessary data to advance ELP technology toward the ultimate goal of human therapeutics...
  3. doi request reprint Targeting a c-Myc inhibitory polypeptide to specific intracellular compartments using cell penetrating peptides
    Gene L Bidwell
    Department of Biochemistry, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USA
    J Control Release 135:2-10. 2009
    ..This data demonstrates that ELP can be targeted to the desired cellular compartment simply by choice of the CPP used, resulting in a more potent nuclear targeted c-Myc inhibitory polypeptide which may be beneficial in cancer therapy...
  4. pmc Inhibition of ovarian cancer cell proliferation by a cell cycle inhibitory peptide fused to a thermally responsive polypeptide carrier
    Iqbal Massodi
    Department of Biochemistry, University of Mississippi Medical Center, Jackson, 39216, USA
    Int J Cancer 126:533-44. 2010
    ..These studies indicate that ELP is a promising macromolecular carrier for the delivery of cell cycle inhibitory peptides to solid tumors...
  5. pmc Cell penetrating peptides fused to a thermally targeted biopolymer drug carrier improve the delivery and antitumor efficacy of an acid-sensitive doxorubicin derivative
    Leslie Walker
    University of Mississippi Medical Center, 2500N State St, Jackson, MS 39216, USA
    Int J Pharm 436:825-32. 2012
    ....
  6. ncbi request reprint Evaluation of cell penetrating peptides fused to elastin-like polypeptide for drug delivery
    Iqbal Massodi
    Department of Biochemistry, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USA
    J Control Release 108:396-408. 2005
    ..This polypeptide was shown to inhibit proliferation of SKOV-3 and HeLa cells by slowing their growth rate...
  7. ncbi request reprint A thermally targeted elastin-like polypeptide-doxorubicin conjugate overcomes drug resistance
    Gene L Bidwell
    Department of Biochemistry, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USA
    Invest New Drugs 25:313-26. 2007
    ..Both cytotoxicity and apoptosis were enhanced by hyperthermia in the Dox resistant cells. The results suggest that ELP-Dox conjugates may provide a means to thermally target solid tumors and to overcome drug resistance in cancer cells...
  8. ncbi request reprint Development of elastin-like polypeptide for thermally targeted delivery of doxorubicin
    Gene L Bidwell
    The University of Mississippi Medical Center, Jackson, MS 39216, USA
    Biochem Pharmacol 73:620-31. 2007
    ..The ELP delivered doxorubicin displayed a cytoplasmic distribution and induced temperature dependent caspase activation...
  9. doi request reprint A thermally responsive biopolymer conjugated to an acid-sensitive derivative of paclitaxel stabilizes microtubules, arrests cell cycle, and induces apoptosis
    Shama Moktan
    University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USA
    Invest New Drugs 30:236-48. 2012
    ..It also inhibits proliferation of a paclitaxel resistant MCF-7 cell line. These data provide an in vitro proof of concept for the use of ELP as a delivery vehicle of paclitaxel...
  10. pmc A thermally targeted peptide inhibitor of symmetrical dimethylation inhibits cancer-cell proliferation
    Gene L Bidwell
    Department of Biochemistry, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USA
    Peptides 31:834-41. 2010
    ..The fusion polypeptide inhibited the interaction of SMN/SmB, inhibited proliferation, and induced apoptosis in HeLa cells...
  11. doi request reprint Application of thermally responsive elastin-like polypeptide fused to a lactoferrin-derived peptide for treatment of pancreatic cancer
    Iqbal Massodi
    Department of Biochemistry, University of Mississippi Medical Center 2500 N State Street Jackson, MS 39216, USA
    Molecules 14:1999-2015. 2009
    ..These results suggest that Tat-ELP1-L12 possesses cytotoxic properties to cancer cells in vitro and may have the potential to provide an effective vehicle to thermally target solid tumors...
  12. pmc Thermally targeted delivery of a c-Myc inhibitory polypeptide inhibits tumor progression and extends survival in a rat glioma model
    Gene L Bidwell
    Department of Neurology, University of Mississippi Medical Center, Jackson, Mississippi, United States of America
    PLoS ONE 8:e55104. 2013
    ..This work demonstrates that a c-Myc inhibitory peptide can be effectively delivered to brain tumors...
  13. pmc Thermal targeting of an acid-sensitive doxorubicin conjugate of elastin-like polypeptide enhances the therapeutic efficacy compared with the parent compound in vivo
    Shama Moktan
    Department of Biochemistry, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA
    Mol Cancer Ther 11:1547-56. 2012
    ..In summary, our findings show that thermal targeting of ELP increases the potency of doxorubicin underlying the potential of exploiting ELPs to enhance the therapeutic efficacy of conventional anticancer drugs...
  14. pmc A thermally targeted c-Myc inhibitory polypeptide inhibits breast tumor growth
    Gene L Bidwell
    Department of Biochemistry, The University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USA
    Cancer Lett 319:136-43. 2012
    ..This work provides a new modality for targeted delivery of a specific oncogene inhibitory peptide, and this strategy may be expanded for delivery of other therapeutic peptides or small molecule drugs...
  15. ncbi request reprint A thermally responsive Tat-elastin-like polypeptide fusion protein induces membrane leakage, apoptosis, and cell death in human breast cancer cells
    Iqbal Massodi
    Department of Biochemistry, University of Mississippi Medical Center, Jackson, MS 39216, USA
    J Drug Target 15:611-22. 2007
    ..We found that Tat-ELP1 combined with hyperthermia caused membrane leakage and apoptosis, resulting in cell death, but no hemolytic effect was observed on murine erythrocytes...
  16. ncbi request reprint Enhancing the antiproliferative effect of topoisomerase II inhibitors using a polypeptide inhibitor of c-Myc
    Gene L Bidwell
    Department of Biochemistry, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, United States
    Biochem Pharmacol 71:248-56. 2006
    ..In summary, our results suggest that polypeptides, which inhibit c-Myc transcriptional function, may prove to be a useful tool in combination therapy with topoisomerase II inhibiting drugs...
  17. doi request reprint Inhibition of ovarian cancer cell metastasis by a fusion polypeptide Tat-ELP
    Iqbal Massodi
    Department of Biochemistry, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USA
    Clin Exp Metastasis 26:251-60. 2009
    ..Since cell attachment is an important step in tumor cell invasion and metastasis, these results suggest a novel role of Tat-ELP as a therapeutic intervention in cancer metastasis...
  18. doi request reprint Therapeutic peptides for cancer therapy. Part I - peptide inhibitors of signal transduction cascades
    Gene L Bidwell
    The University of Mississippi Medical Center, Department of Biochemistry, Jackson, 39216, USA
    Expert Opin Drug Deliv 6:1033-47. 2009
    ..Therapeutic peptides have great potential as anticancer agents owing to their ease of rational design and target specificity. However, their utility in vivo is limited by low stability and poor tumor penetration...
  19. ncbi request reprint Application of thermally responsive polypeptides directed against c-Myc transcriptional function for cancer therapy
    Gene L Bidwell
    Department of Biochemistry, University of Mississippi Medical Center, Jackson, 39216, USA
    Mol Cancer Ther 4:1076-85. 2005
    ..These studies show that genetically engineered elastin-like polypeptide carriers may provide a new way to thermally target specific oncogene inhibitors to solid tumors...
  20. pmc Cell penetrating elastin-like polypeptides for therapeutic peptide delivery
    Gene L Bidwell
    University of Mississippi Medical Center, Department of Biochemistry, Jackson, 39216, USA
    Adv Drug Deliv Rev 62:1486-96. 2010
    ....
  21. pmc Structural and hydrodynamic analysis of a novel drug delivery vector: ELP[V5G3A2-150]
    Daniel F Lyons
    Department of Biochemistry, University of Mississippi Medical Center, Jackson, Mississippi, USA
    Biophys J 104:2009-21. 2013
    ..Labeling ELP[V5G3A2-150] with fluorescein lowers the TT by 3.5°C at 20 μM, whereas ELP[V5G3A2-150] dissolution in physiological media (fetal bovine serum) increases the TT by ∼2.2°C...
  22. doi request reprint Chapter 17: Application of laser tweezers to studies of membrane-cytoskeleton adhesion
    Drazen Raucher
    Department of Biochemistry, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA
    Methods Cell Biol 89:451-66. 2008
    ..Furthermore, this method could be used to establish the link between biochemical function and physical properties of the plasma membrane which drives these dynamic cellular processes...
  23. ncbi request reprint Targeted drug delivery by thermally responsive polymers
    Ashutosh Chilkoti
    Department of Biomedical Engineering, Box 90281, Duke University, Durham, NC 27708 0281, USA
    Adv Drug Deliv Rev 54:613-30. 2002
    ..Preliminary cytotoxicity studies of an ELP-doxorubicin conjugate indicate that the ELP-doxorubicin conjugate has near equivalent cytotoxicity as free doxorubicin in a cell culture assay...
  24. ncbi request reprint Evaluation of an elastin-like polypeptide-doxorubicin conjugate for cancer therapy
    Matthew R Dreher
    Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA
    J Control Release 91:31-43. 2003
    ..These differences are significant because they suggest a different mechanism of cytotoxicity for the conjugate as compared with the free drug...

Research Grants1

  1. Targeted Delivery of c-Myc Inhibitory Polypeptides
    Drazen Raucher; Fiscal Year: 2007
    ..The successful completion of the proposed research will provide In vivo data to move this therapy towards the translational stage of human therapeutics. ..