Manohar Ratnam

Summary

Affiliation: University of Toledo
Country: USA

Publications

  1. pmc During hormone depletion or tamoxifen treatment of breast cancer cells the estrogen receptor apoprotein supports cell cycling through the retinoic acid receptor α1 apoprotein
    Marcela D Salazar
    Department of Biochemistry and Cancer Biology, Medical University of Ohio, 3000 Arlington Avenue, Toledo, OH 43614, USA
    Breast Cancer Res 13:R18. 2011
  2. pmc Hormone depletion-insensitivity of prostate cancer cells is supported by the AR without binding to classical response elements
    Mesfin Gonit
    Department of Biochemistry and Cancer Biology, Medical University of Ohio, 3035 Arlington Avenue, Toledo, Ohio 43614, USA
    Mol Endocrinol 25:621-34. 2011

Research Grants

Collaborators

  • Robert Trumbly
  • Marcela D Salazar
  • Mesfin Gonit
  • Hongjuan Cui
  • Mugdha Patki
  • Marcela d Alincourt Salazar
  • Ivana Kisovic
  • Mohamed Iman
  • Juan Zhang
  • Aymen Shatnawi

Detail Information

Publications2

  1. pmc During hormone depletion or tamoxifen treatment of breast cancer cells the estrogen receptor apoprotein supports cell cycling through the retinoic acid receptor α1 apoprotein
    Marcela D Salazar
    Department of Biochemistry and Cancer Biology, Medical University of Ohio, 3000 Arlington Avenue, Toledo, OH 43614, USA
    Breast Cancer Res 13:R18. 2011
    ..Regardless of the resistance mechanism, development and progression of the resistant tumors requires the persistence of a basal level of cycling cells during the treatment for which the underlying causes are unclear...
  2. pmc Hormone depletion-insensitivity of prostate cancer cells is supported by the AR without binding to classical response elements
    Mesfin Gonit
    Department of Biochemistry and Cancer Biology, Medical University of Ohio, 3035 Arlington Avenue, Toledo, Ohio 43614, USA
    Mol Endocrinol 25:621-34. 2011
    ..Therefore, a potentially diverse set of ARE-independent mechanisms of AR interactions with target genes must underlie truly hormone depletion-insensitive gene regulation and proliferation in prostate cancer...

Research Grants20

  1. Dissecting the Mechanisms of Tamoxifen Action
    Manohar Ratnam; Fiscal Year: 2009
    ..We propose to further investigate this and other mechanisms of tamoxifen action and in the process, to identify lead compounds whose properties are superior to that of tamoxifen. ..
  2. Modulation of Folate Receptor via the Estrogen Receptor
    Manohar Ratnam; Fiscal Year: 2003
    ..abstract_text> ..
  3. Regulation of a Tumor Target Through Steroid Receptors
    Manohar Ratnam; Fiscal Year: 2007
    ..abstract_text> ..
  4. Gene Regulation for Drug Targeting in AML
    Manohar Ratnam; Fiscal Year: 2009
    ..The studies should provide a solid foundation for designing clinical trials of new AML therapies and should also elucidate a fundamentally novel mechanism of gene regulation by retinoid receptors. ..
  5. Genetic analysis of GPI-protein recycling via membrane *
    Manohar Ratnam; Fiscal Year: 2002
    ..The mechanistic roles of such known and novel proteins in FR-mediated transport will be the subject of future investigations. The studies are expected to provide new insights of a fundamental nature into membrane transport processes. ..
  6. Dissecting the Mechanisms of Tamoxifen Action
    Manohar Ratnam; Fiscal Year: 2010
    ..We propose to further investigate this and other mechanisms of tamoxifen action and in the process, to identify lead compounds whose properties are superior to that of tamoxifen. ..
  7. MECHANISMS CONTROLLING EXPRESSION OF NEW TUMOR TARGETS
    Manohar Ratnam; Fiscal Year: 2002
    ..They further promise to reveal novel mechanisms of tissue/tumor specific gene regulation with potential applications in the broad context of future gene therapy strategies. ..