PRADIPSINH RATHOD

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. pmc A genetically hard-wired metabolic transcriptome in Plasmodium falciparum fails to mount protective responses to lethal antifolates
    Karthikeyan Ganesan
    Department of Chemistry and Global Health, University of Washington, Seattle, Washington, United States of America
    PLoS Pathog 4:e1000214. 2008
  2. pmc Asexual populations of the human malaria parasite, Plasmodium falciparum, use a two-step genomic strategy to acquire accurate, beneficial DNA amplifications
    Jennifer L Guler
    Department of Chemistry, University of Washington, Seattle, Washington, United States of America
    PLoS Pathog 9:e1003375. 2013
  3. pmc Deformability limits of Plasmodium falciparum-infected red blood cells
    Thurston Herricks
    Department of Chemistry, University of Washington, Seattle, WA 98195, USA
    Cell Microbiol 11:1340-53. 2009
  4. pmc Kinetics and ligand-binding preferences of Mycobacterium tuberculosis thymidylate synthases, ThyA and ThyX
    Joshua H Hunter
    Department of Chemistry, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 3:e2237. 2008
  5. ncbi request reprint DNA microarrays for malaria
    Pradipsinh K Rathod
    Dept of Chemistry, University of Washington, Seattle, WA 98195, USA
    Trends Parasitol 18:39-45. 2002
  6. pmc Microfluidic modeling of cell-cell interactions in malaria pathogenesis
    Meher Antia
    Department of Chemistry, University of Washington, Seattle, Washington, United States of America
    PLoS Pathog 3:e99. 2007
  7. pmc Resistance mutations at the lipid substrate binding site of Plasmodium falciparum protein farnesyltransferase
    Richard T Eastman
    Department of Pathobiology, University of Washington, Seattle, WA 98195 7185, USA
    Mol Biochem Parasitol 152:66-71. 2007
  8. ncbi request reprint Resistance to a protein farnesyltransferase inhibitor in Plasmodium falciparum
    Richard T Eastman
    Department of Pathobiology, University of Washington, Seattle, Washington 98195, USA
    J Biol Chem 280:13554-9. 2005
  9. ncbi request reprint Stochastic versus stable transcriptional differences on Plasmodium falciparum DNA microarrays
    Karthikeyan Ganesan
    Department of Chemistry, University of Washington, Seattle, WA 98105, USA
    Int J Parasitol 32:1543-50. 2002
  10. pmc Regulatory hotspots in the malaria parasite genome dictate transcriptional variation
    JOSEPH M GONZALES
    The Eck Institute for Global Health, Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana, USA
    PLoS Biol 6:e238. 2008

Research Grants

  1. Microfluidic platforms for severe malaria
    PRADIPSINH RATHOD; Fiscal Year: 2007

Collaborators

  • M H Gelb
  • Zbynek Bozdech
  • Yongyuth Yuthavong
  • Joseph DeRisi
  • Xin Zhuan Su
  • John White
  • Richard T Eastman
  • Karthikeyan Ganesan
  • Thurston Herricks
  • Meher Antia
  • Lei Jiang
  • Jennifer L Guler
  • Ramesh Gujjar
  • JOSEPH M GONZALES
  • Napawan Ponmee
  • Joshua H Hunter
  • Long Cui
  • Wesley C Van Voorhis
  • Kohei Yokoyama
  • Christophe L M J Verlinde
  • Oliver Hucke
  • Margaret A Phillips
  • Vida Ahyong
  • Daniel L Freeman
  • Rapatbhorn Patrapuvich
  • Asako Tan
  • Jigar J Patel
  • Tetsuya Furuya
  • Jun Miao
  • Michael T Ferdig
  • Xinyi Li
  • Qi Fan
  • Joseph W Fowble
  • Sumalee Kamchonwongpaisan
  • Liwang Cui
  • Prapon Wilairat
  • Cullen K T Pang
  • Steven P Maher
  • Stefan Wuchty
  • Lorena S Beese
  • Michael A Hast
  • Debopam Chakrabarti
  • Kevin Bauer
  • Laxman Nallan

Detail Information

Publications12

  1. pmc A genetically hard-wired metabolic transcriptome in Plasmodium falciparum fails to mount protective responses to lethal antifolates
    Karthikeyan Ganesan
    Department of Chemistry and Global Health, University of Washington, Seattle, Washington, United States of America
    PLoS Pathog 4:e1000214. 2008
    ..In addition, such regulation affects how DNA microarrays are used to understand the mode of action of antimetabolites...
  2. pmc Asexual populations of the human malaria parasite, Plasmodium falciparum, use a two-step genomic strategy to acquire accurate, beneficial DNA amplifications
    Jennifer L Guler
    Department of Chemistry, University of Washington, Seattle, Washington, United States of America
    PLoS Pathog 9:e1003375. 2013
    ..This minimizes the need for meiotic genetic cleansing that can only occur in sexual stage development of the parasite in mosquitoes...
  3. pmc Deformability limits of Plasmodium falciparum-infected red blood cells
    Thurston Herricks
    Department of Chemistry, University of Washington, Seattle, WA 98195, USA
    Cell Microbiol 11:1340-53. 2009
    ..These findings raise important basic questions about the variable pathology of malaria infections and metabolic process that affect volume and surface area of IRBCs...
  4. pmc Kinetics and ligand-binding preferences of Mycobacterium tuberculosis thymidylate synthases, ThyA and ThyX
    Joshua H Hunter
    Department of Chemistry, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 3:e2237. 2008
    ..To facilitate future small molecule inhibitors against these proteins, a detailed enzymatic characterization was necessary...
  5. ncbi request reprint DNA microarrays for malaria
    Pradipsinh K Rathod
    Dept of Chemistry, University of Washington, Seattle, WA 98195, USA
    Trends Parasitol 18:39-45. 2002
    ....
  6. pmc Microfluidic modeling of cell-cell interactions in malaria pathogenesis
    Meher Antia
    Department of Chemistry, University of Washington, Seattle, Washington, United States of America
    PLoS Pathog 3:e99. 2007
    ..The devices are cheap and portable and require small sample volumes; thus, they have the potential to be widely used in research laboratories and at field sites with access to fresh patient samples...
  7. pmc Resistance mutations at the lipid substrate binding site of Plasmodium falciparum protein farnesyltransferase
    Richard T Eastman
    Department of Pathobiology, University of Washington, Seattle, WA 98195 7185, USA
    Mol Biochem Parasitol 152:66-71. 2007
    ..These data provide further support that PFT is the target of THQ inhibitors in P. falciparum and suggest that PFT inhibitors should be combined with other antimalarial agents to minimize the development of resistant parasites...
  8. ncbi request reprint Resistance to a protein farnesyltransferase inhibitor in Plasmodium falciparum
    Richard T Eastman
    Department of Pathobiology, University of Washington, Seattle, Washington 98195, USA
    J Biol Chem 280:13554-9. 2005
    ..These data are consistent with PFT as the target of BMS-388891 in P. falciparum and suggest that PFT inhibitors should be combined with other antimalarial agents for effective therapy...
  9. ncbi request reprint Stochastic versus stable transcriptional differences on Plasmodium falciparum DNA microarrays
    Karthikeyan Ganesan
    Department of Chemistry, University of Washington, Seattle, WA 98105, USA
    Int J Parasitol 32:1543-50. 2002
    ..Reliable RNA transcriptional differences between Dd2 and HB3 could be readily visualised using public algorithms for data normalisation and clustering...
  10. pmc Regulatory hotspots in the malaria parasite genome dictate transcriptional variation
    JOSEPH M GONZALES
    The Eck Institute for Global Health, Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana, USA
    PLoS Biol 6:e238. 2008
    ....
  11. ncbi request reprint Prized malaria drug target nailed
    Pradipsinh K Rathod
    Nat Struct Biol 10:316-8. 2003
  12. pmc Histone acetyltransferase inhibitor anacardic acid causes changes in global gene expression during in vitro Plasmodium falciparum development
    Long Cui
    Department of Entomology, The Pennsylvania State University, 501 ASI Building, University Park, PA 16802, USA
    Eukaryot Cell 7:1200-10. 2008
    ..This study suggests that the parasiticidal effect of AA is at least partially associated with its inhibition of PfGCN5 HAT, resulting in the disturbance of the transcription program in the parasites...

Research Grants11

  1. Microfluidic platforms for severe malaria
    PRADIPSINH RATHOD; Fiscal Year: 2007
    ..2.3. Develop a model to study pitting in obstructed capillaries. In the future, the devices developed here may also find utility in studying adhesion and natural immunity in malaria, and in control of other infectious diseases. ..