Affiliation: University of Washington
- DNA microarrays for malariaPradipsinh K Rathod
Dept of Chemistry, University of Washington, Seattle, WA 98195, USA
Trends Parasitol 18:39-45. 2002....
- A genetically hard-wired metabolic transcriptome in Plasmodium falciparum fails to mount protective responses to lethal antifolatesKarthikeyan Ganesan
Department of Chemistry and Global Health, University of Washington, Seattle, Washington, United States of America
PLoS Pathog 4:e1000214. 2008..In addition, such regulation affects how DNA microarrays are used to understand the mode of action of antimetabolites...
- Stochastic versus stable transcriptional differences on Plasmodium falciparum DNA microarraysKarthikeyan Ganesan
Department of Chemistry, University of Washington, Seattle, WA 98105, USA
Int J Parasitol 32:1543-50. 2002..Reliable RNA transcriptional differences between Dd2 and HB3 could be readily visualised using public algorithms for data normalisation and clustering...
- Resistance to a protein farnesyltransferase inhibitor in Plasmodium falciparumRichard T Eastman
Department of Pathobiology, University of Washington, Seattle, Washington 98195, USA
J Biol Chem 280:13554-9. 2005..These data are consistent with PFT as the target of BMS-388891 in P. falciparum and suggest that PFT inhibitors should be combined with other antimalarial agents for effective therapy...
- Resistance mutations at the lipid substrate binding site of Plasmodium falciparum protein farnesyltransferaseRichard T Eastman
Department of Pathobiology, University of Washington, Seattle, WA 98195 7185, USA
Mol Biochem Parasitol 152:66-71. 2007..These data provide further support that PFT is the target of THQ inhibitors in P. falciparum and suggest that PFT inhibitors should be combined with other antimalarial agents to minimize the development of resistant parasites...
- Microfluidic modeling of cell-cell interactions in malaria pathogenesisMeher Antia
Department of Chemistry, University of Washington, Seattle, Washington, United States of America
PLoS Pathog 3:e99. 2007..The devices are cheap and portable and require small sample volumes; thus, they have the potential to be widely used in research laboratories and at field sites with access to fresh patient samples...
- Regulatory hotspots in the malaria parasite genome dictate transcriptional variationJOSEPH M GONZALES
The Eck Institute for Global Health, Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana, USA
PLoS Biol 6:e238. 2008....
- Prized malaria drug target nailedPradipsinh K Rathod
Nat Struct Biol 10:316-8. 2003
- Histone acetyltransferase inhibitor anacardic acid causes changes in global gene expression during in vitro Plasmodium falciparum developmentLong Cui
Department of Entomology, The Pennsylvania State University, 501 ASI Building, University Park, PA 16802, USA
Eukaryot Cell 7:1200-10. 2008..This study suggests that the parasiticidal effect of AA is at least partially associated with its inhibition of PfGCN5 HAT, resulting in the disturbance of the transcription program in the parasites...
- Microfluidic platforms for severe malariaPRADIPSINH RATHOD; Fiscal Year: 2007..2.3. Develop a model to study pitting in obstructed capillaries. In the future, the devices developed here may also find utility in studying adhesion and natural immunity in malaria, and in control of other infectious diseases. ..