F Rastinejad

Summary

Affiliation: University of Virginia
Country: USA

Publications

  1. ncbi request reprint Retinoid X receptor and its partners in the nuclear receptor family
    F Rastinejad
    Department of Pharmacology, X ray Crystallography Laboratory, School of Medicine, University of Virginia, Charlottesville, VA 22908 0735, USA
    Curr Opin Struct Biol 11:33-8. 2001
  2. ncbi request reprint DNA deformability as a recognition feature in the reverb response element
    M L Sierk
    Department of Pharmacology, University of Virginia, Charlottesville, Virginia 22908 0735, USA
    Biochemistry 40:12833-43. 2001
  3. ncbi request reprint Nuclear-receptor interactions on DNA-response elements
    S Khorasanizadeh
    Department of Biochemistry and Molecular Genetics, School of Medicine, University of Virginia, Charlottesville, VA 22908-0733, USA
    Trends Biochem Sci 26:384-90. 2001
  4. pmc Structure of the RXR-RAR DNA-binding complex on the retinoic acid response element DR1
    F Rastinejad
    Department of Pharmacology, University of Virginia, Charlottesville, VA 22908, USA
    EMBO J 19:1045-54. 2000
  5. ncbi request reprint Structural analysis of lipid complexes of GM2-activator protein
    Christine Schubert Wright
    Department of Pharmacology, X ray Laboratory and University of Virginia Health System, PO Box 800735, Charlottesville, VA 22908 0735, USA
    J Mol Biol 331:951-64. 2003
  6. ncbi request reprint Evidence for lipid packaging in the crystal structure of the GM2-activator complex with platelet activating factor
    Christine S Wright
    Department of Pharmacology, X ray Crystallography Laboratory, University of Virginia, Charlottesville, VA 22908 0735, USA
    J Mol Biol 342:585-92. 2004
  7. pmc Structural overview of the nuclear receptor superfamily: insights into physiology and therapeutics
    Pengxiang Huang
    Department of Pharmacology, and Center for Molecular Design, University of Virginia Health System, Charlottesville, VA 22908, USA
    Annu Rev Physiol 72:247-72. 2010
  8. ncbi request reprint Crystal structure analysis of phosphatidylcholine-GM2-activator product complexes: evidence for hydrolase activity
    Christine S Wright
    Department of Pharmacology, X ray Crystallography Laboratory, University of Virginia, Charlottesville, Virginia 22908 0735, USA
    Biochemistry 44:13510-21. 2005
  9. ncbi request reprint Structural elements of an orphan nuclear receptor-DNA complex
    Q Zhao
    Department of Pharmacology, School of Medicine, University of Virginia, Charlottesville 22908, USA
    Mol Cell 1:849-61. 1998
  10. ncbi request reprint DNA binding domains in diverse nuclear receptors function as nuclear export signals
    B E Black
    Center for Cell Signaling, University of Virginia, Charlottesville, VA 22908, USA
    Curr Biol 11:1749-58. 2001

Research Grants

  1. Nuclear Receptor Interactions on DNA
    Fraydoon Rastinejad; Fiscal Year: 2010
  2. Nuclear Receptor Interactions on DNA
    Fraydoon Rastinejad; Fiscal Year: 2005
  3. FXR interactions with ligands and coregulators
    Fraydoon Rastinejad; Fiscal Year: 2007
  4. Nuclear Receptor Interactions on DNA
    Fraydoon Rastinejad; Fiscal Year: 2007
  5. NUCLEAR RECEPTOR INTERACTIONS ON DNA DIRECT REPEATS
    Fraydoon Rastinejad; Fiscal Year: 2001
  6. MOLECULAR RECOGNITION IN STEROID SIGNALING
    Fraydoon Rastinejad; Fiscal Year: 2002

Collaborators

Detail Information

Publications24

  1. ncbi request reprint Retinoid X receptor and its partners in the nuclear receptor family
    F Rastinejad
    Department of Pharmacology, X ray Crystallography Laboratory, School of Medicine, University of Virginia, Charlottesville, VA 22908 0735, USA
    Curr Opin Struct Biol 11:33-8. 2001
    ....
  2. ncbi request reprint DNA deformability as a recognition feature in the reverb response element
    M L Sierk
    Department of Pharmacology, University of Virginia, Charlottesville, Virginia 22908 0735, USA
    Biochemistry 40:12833-43. 2001
    ....
  3. ncbi request reprint Nuclear-receptor interactions on DNA-response elements
    S Khorasanizadeh
    Department of Biochemistry and Molecular Genetics, School of Medicine, University of Virginia, Charlottesville, VA 22908-0733, USA
    Trends Biochem Sci 26:384-90. 2001
    ..These structures also indicate how cooperation between receptors enhances their joint affinity and selectivity for correctly configured sites...
  4. pmc Structure of the RXR-RAR DNA-binding complex on the retinoic acid response element DR1
    F Rastinejad
    Department of Pharmacology, University of Virginia, Charlottesville, VA 22908, USA
    EMBO J 19:1045-54. 2000
    ..Together, these structures illustrate how the nuclear receptor superfamily exploits conformational flexibility and locally induced structures to generate combinatorial transcription factors...
  5. ncbi request reprint Structural analysis of lipid complexes of GM2-activator protein
    Christine Schubert Wright
    Department of Pharmacology, X ray Laboratory and University of Virginia Health System, PO Box 800735, Charlottesville, VA 22908 0735, USA
    J Mol Biol 331:951-64. 2003
    ....
  6. ncbi request reprint Evidence for lipid packaging in the crystal structure of the GM2-activator complex with platelet activating factor
    Christine S Wright
    Department of Pharmacology, X ray Crystallography Laboratory, University of Virginia, Charlottesville, VA 22908 0735, USA
    J Mol Biol 342:585-92. 2004
    ....
  7. pmc Structural overview of the nuclear receptor superfamily: insights into physiology and therapeutics
    Pengxiang Huang
    Department of Pharmacology, and Center for Molecular Design, University of Virginia Health System, Charlottesville, VA 22908, USA
    Annu Rev Physiol 72:247-72. 2010
    ....
  8. ncbi request reprint Crystal structure analysis of phosphatidylcholine-GM2-activator product complexes: evidence for hydrolase activity
    Christine S Wright
    Department of Pharmacology, X ray Crystallography Laboratory, University of Virginia, Charlottesville, Virginia 22908 0735, USA
    Biochemistry 44:13510-21. 2005
    ..Our structural results provide new insights into the biological functions of GM2AP. The combined effect of hydrolytic and lipid transfer properties has profound implications in cellular signaling...
  9. ncbi request reprint Structural elements of an orphan nuclear receptor-DNA complex
    Q Zhao
    Department of Pharmacology, School of Medicine, University of Virginia, Charlottesville 22908, USA
    Mol Cell 1:849-61. 1998
    ..A sequence comparison of orphan receptors suggests that unique minor-groove interactions involving the receptor hinge regions impart the necessary DNA and dimerization specificity...
  10. ncbi request reprint DNA binding domains in diverse nuclear receptors function as nuclear export signals
    B E Black
    Center for Cell Signaling, University of Virginia, Charlottesville, VA 22908, USA
    Curr Biol 11:1749-58. 2001
    ..We propose that NLS-mediated import and DBD-mediated export define a shuttling cycle that integrates the compartmentalization and activity of nuclear receptors...
  11. ncbi request reprint Crystal structure of human GM2-activator protein with a novel beta-cup topology
    C S Wright
    Department of Pharmacology, X ray Crystallography Laboratory, University of Virginia, Charlottesville, VA 22908 0735, USA
    J Mol Biol 304:411-22. 2000
    ..The dimensions of this cavity (12 Ax14 Ax22 A) are suitable for binding 18-carbon lipid acyl chains. Flexible surface loops and a short alpha-helix decorate the mouth of the beta-cup and may control lipid entry to the cavity...
  12. pmc Structure of the heterodimeric ecdysone receptor DNA-binding complex
    Srikripa Devarakonda
    Department of Pharmacology, University of Virginia Health System, Charlottesville, VA 22908, USA
    EMBO J 22:5827-40. 2003
    ..Sequence alignments indicate that the EcR-RXR heterodimer is an important model for understanding how the FXR-RXR heterodimer binds to IR-1 sites...
  13. ncbi request reprint The active site of the SET domain is constructed on a knot
    Steven A Jacobs
    Department of Biochemistry and Molecular Genetics, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    Nat Struct Biol 9:833-8. 2002
    ..A structure-guided comparison of sequences within the SET protein family suggests that the knot substructure and active site environment are conserved features of the SET domain...
  14. ncbi request reprint Structural basis for bile acid binding and activation of the nuclear receptor FXR
    Li Zhi Mi
    Department of Pharmacology, University of Virginia Health System, Charlottesville 22908, USA
    Mol Cell 11:1093-100. 2003
    ..These FXR complexes provide direct insights into the design of therapeutic bile acids for treatment of hyperlipidemia and cholestasis...
  15. pmc Corecognition of DNA and a methylated histone tail by the MSL3 chromodomain
    Daesung Kim
    Department of Biochemistry and Molecular Genetics, University of Virginia Health System, Charlottesville, Virginia, USA
    Nat Struct Mol Biol 17:1027-9. 2010
    ..H4K16 acetylation antagonizes MSL3 binding, suggesting that MSL function is regulated by a combination of post-translational modifications...
  16. pmc Ca2+-dependent nuclear export mediated by calreticulin
    James M Holaska
    Center for Cell Signaling Departments of Microbiology Biochemistry and Molecular Genetics Pharmacology, University of Virginia, Charlottesville, Virginia 22908, USA
    Mol Cell Biol 22:6286-97. 2002
    ..We suggest that signaling events that increase Ca2+ could positively regulate CRT and inhibit GR function through nuclear export...
  17. pmc Molecular implications of evolutionary differences in CHD double chromodomains
    John F Flanagan
    Department of Biochemistry and Molecular Genetics, University of Virginia Health System, Charlottesville, VA 22908, USA
    J Mol Biol 369:334-42. 2007
    ..By using the available structural and biochemical data we highlight the evolutionary specialization of CHD double chromodomains, and provide insights about their targeting capacities...
  18. ncbi request reprint Double chromodomains cooperate to recognize the methylated histone H3 tail
    John F Flanagan
    Department of Biochemistry and Molecular Genetics, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    Nature 438:1181-5. 2005
    ..Furthermore, unique inserts within chromodomain 1 of CHD1 block the expected site of H3 tail binding seen in HP1 and Polycomb, instead directing H3 binding to a groove at the inter-chromodomain junction...
  19. pmc Identification of heme as the ligand for the orphan nuclear receptors REV-ERBalpha and REV-ERBbeta
    Srilatha Raghuram
    Department of Pharmacology and Center for Molecular Design, University of Virginia Health System, 1300 Jefferson Park Avenue, Charlottesville, Virginia 22908 0733, USA
    Nat Struct Mol Biol 14:1207-13. 2007
    ..Our results further indicate that heme regulation of REV-ERBs may link the control of metabolism and the mammalian clock...
  20. pmc Structure of the intact PPAR-gamma-RXR- nuclear receptor complex on DNA
    Vikas Chandra
    Department of Pharmacology, and Center for Molecular Design, University of Virginia Health System, 1300 Jefferson Park Avenue, Charlottesville, Virginia 22908 0735, USA
    Nature 456:350-6. 2008
    ..The PPAR-gamma LBD cooperates with both DNA-binding domains (DBDs) to enhance response-element binding. The A/B segments are highly dynamic, lacking folded substructures despite their gene-activation properties...
  21. ncbi request reprint Structural basis for the coordinated regulation of transglutaminase 3 by guanine nucleotides and calcium/magnesium
    Bijan Ahvazi
    X ray Crystallography Facility Office of Science and Technology, NIAMS, National Institutes of Health, Bethesda, Maryland 20892 8023, USA
    J Biol Chem 279:7180-92. 2004
    ..Hydrolysis of GTP to GDP results in two stable conformations, resembling both the GTP state and the non-nucleotide bound state, the latter of which allows substrate access to the active site...
  22. ncbi request reprint Insights into catalysis by a knotted TrmD tRNA methyltransferase
    Patricia A Elkins
    GlaxoSmithKline, 709 Swedeland Road, UE0447, King of Prussia, PA 19406, USA
    J Mol Biol 333:931-49. 2003
    ..Mutational analyses demonstrate that the knot is important for AdoMet binding and catalytic activity, and that the C-terminal domain is not only required for tRNA binding but plays a functional role in catalytic activity...
  23. ncbi request reprint The emerging structural understanding of transglutaminase 3
    Bijan Ahvazi
    X ray Crystallography Facility, Office of Science and Technology, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892 8023, USA
    J Struct Biol 147:200-7. 2004
    ..A structure based sequence homology among the TGase enzyme family shows that these essential structural features are shared among other members of the TGase family...
  24. ncbi request reprint Plasticity of the ecdysone receptor DNA binding domain
    Marek Orlowski
    Institute of Organic Chemistry, Biochemistry and Biotechnology, Division of Biochemistry, Wrocław University of Technology, 50 370 Wrocław, Poland
    Mol Endocrinol 18:2166-84. 2004
    ....

Research Grants21

  1. Nuclear Receptor Interactions on DNA
    Fraydoon Rastinejad; Fiscal Year: 2010
    ..The second emphasis area is directed at characterizing the ligands, structures and functions of the orphan nuclear receptors: rev-erb alpha/beta which play important roles in psychiatric and metabolic diseases. ..
  2. Nuclear Receptor Interactions on DNA
    Fraydoon Rastinejad; Fiscal Year: 2005
    ..abstract_text> ..
  3. FXR interactions with ligands and coregulators
    Fraydoon Rastinejad; Fiscal Year: 2007
    ..In the fifth aim, we propose to determine the crystal structure of the FXR-RXR heterodimer on its cognate DNA response element, in order to understand how RXR and DNA binding further impact FXR's functional surfaces. ..
  4. Nuclear Receptor Interactions on DNA
    Fraydoon Rastinejad; Fiscal Year: 2007
    ..The second emphasis area is directed at characterizing the ligands, structures and functions of the orphan nuclear receptors: rev-erb alpha/beta which play important roles in psychiatric and metabolic diseases. ..
  5. NUCLEAR RECEPTOR INTERACTIONS ON DNA DIRECT REPEATS
    Fraydoon Rastinejad; Fiscal Year: 2001
    ....
  6. MOLECULAR RECOGNITION IN STEROID SIGNALING
    Fraydoon Rastinejad; Fiscal Year: 2002
    ..abstract_text> ..