Research Topics
| DENNIS D contact RASMUSSENSummaryAffiliation: University of Washington Country: USA Publications
Research Grants
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Detail Information
Publications
Effects of chronic nicotine treatment and withdrawal on hypothalamic proopiomelanocortin gene expression and neuroendocrine regulationD D Rasmussen
Mental Health Service, VA Puget Sound Health Care System, Seattle, WA, USA
Psychoneuroendocrinology 23:245-59. 1998....- Acoustic startle amplitude predicts vulnerability to develop post-traumatic stress hyper-responsivity and associated plasma corticosterone changes in ratsDennis D Rasmussen
VA Puget Sound Health Care System, Mental Illness Research, Education and Clinical Center, Seattle, WA 98108, USA
Psychoneuroendocrinology 33:282-91. 2008..These results suggest that initial pre-stress acoustic startle response can identify subgroups of rats which are predisposed to, or resistant to, developing a PTSD-like syndrome following subsequent trauma... - Chronic daily ethanol and withdrawal: 6. Effects on rat sympathoadrenal activity during "abstinence"Dennis D Rasmussen
VA Puget Sound Health Care System Mental Illness Research, Education and Clinical Center, University of Washington, Seattle, WA 98108, USA
Alcohol 38:173-7. 2006..These results suggest that daily ethanol consumption can induce persistent increases in sympathoadrenal activation during subsequent "abstinence," which are relatively refractory to further stimulation... - Chronic daily ethanol and withdrawal: 5. Diurnal effects on plasma thyroid hormone levelsDennis D Rasmussen
VA Puget Sound Health Care System Mental Illness Research, Education and Clinical Center and the Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington, USA
Endocrine 22:329-34. 2003..Further investigations with this rat model of daily ethanol consumption and daily withdrawal will help resolve interactions and roles of the HPT axis in alcohol abuse... - Chronic daily ethanol and withdrawal: 4. Long-term changes in plasma testosterone regulation, but no effect on GnRH gene expression or plasma LH concentrationsDennis D Rasmussen
VA Puget Sound Health Care System, S 116 Mental Illness Research, Education and Clinical Center, 1660 S Columbian Way, Seattle, WA, USA
Endocrine 22:143-50. 2003.... - Melatonin effect on rat body weight regulation in response to high-fat diet at middle ageStephaney S Puchalski
VA Puget Sound Health Care System Mental Illness Research, Education and Clinical Center MIRECC and Department of Psychiatry, University of Washington, Seattle, WA 98108, USA
Endocrine 21:163-7. 2003..Thus, melatonin decreased weight gain in response to high-fat diet, decreased plasma leptin levels within 3 wk-before decreasing plasma insulin-and exerted these metabolic effects independent of total food consumption... - Chronic daily ethanol and withdrawal: 3. Forebrain pro-opiomelanocortin gene expression and implications for dependence, relapse, and deprivation effectDennis D Rasmussen
Veterans Affairs Puget Sound Health Care System Mental Illness Research, Education and Clinical Center, Seattle, Washington, USA
Alcohol Clin Exp Res 26:535-46. 2002.... - Chronic daily ethanol and withdrawal: 2. Behavioral changes during prolonged abstinenceD D Rasmussen
Veteran s Assistance Puget Sound Health Care System Mental Illness Research, Education and Clinical Center, Departments of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington, USA
Alcohol Clin Exp Res 25:999-1005. 2001..Accordingly, we have investigated persistent behavioral effects of previous repetitive daily ethanol consumption and withdrawal... - Daily melatonin administration at middle age suppresses male rat visceral fat, plasma leptin, and plasma insulin to youthful levelsD D Rasmussen
VA Puget Sound Health Care System, and Department of Medicine, University of Washington, Seattle 98195, USA
Endocrinology 140:1009-12. 1999.... - Aging-dependent changes in the effect of daily melatonin supplementation on rat metabolic and behavioral responsesD D Rasmussen
VA Puget Sound Health Care System, Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle 98195, USA
J Pineal Res 31:89-94. 2001.... - Chronic daily ethanol and withdrawal: 1. Long-term changes in the hypothalamo-pituitary-adrenal axisD D Rasmussen
VA Puget Sound Health Care System Mental Illness Research, Education and Clinical Center, University of Washington, Seattle, USA
Alcohol Clin Exp Res 24:1836-49. 2000..Consequently, we investigated whether chronic daily ethanol consumption and withdrawal by male Sprague Dawley rats would induce persistent HPA changes consistent with those demonstrated in abstinent alcoholics... - Reduced gene expression for dopamine biosynthesis and transport in midbrain neurons of adult male rats exposed prenatally to ethanolP Szot
Geriatric Research, Education and Clinical Center, Puget Sound Health Care System, and the Department of Psychiatry, University of Washington, Seattle 98108, USA
Alcohol Clin Exp Res 23:1643-9. 1999..Prenatal ethanol exposure affects brain dopaminergic neuronal systems, and many of these alterations are permanent... - Suppression of hypothalamic pro-opiomelanocortin (POMC) gene expression by daily melatonin supplementation in aging ratsDennis D Rasmussen
VA Puget Sound Health Care System Mental Illness Research, Education and Clinical Center DDR, Seattle, Washington 98108, USA
J Pineal Res 34:127-33. 2003..These POMC responses were apparently not dependent on gonadal steroid responses and did not become refractory to melatonin treatment maintained until old age... - Alcoholism, craving, and hormones: the role of leptin, ghrelin, prolactin, and the pro-opiomelanocortin system in modulating ethanol intakeFriedrich Martin Wurst
Christian Doppler Clinic, Department of Psychiatry and Psychotherapy II Addiction Medicine, Paracelsus Medical University, Salzburg, Austria
Alcohol Clin Exp Res 31:1963-7. 2007..The goal of this mini-review is to discuss the results of some recent investigations of the potential interactions of these systems with acute and chronic alcohol responses... - alpha1-noradrenergic receptor antagonism blocks dependence-induced increases in responding for ethanolBrendan M Walker
Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, CA 92037, USA
Alcohol 42:91-7. 2008..None of the doses tested reliably affected concurrent water self-administration. These results suggest the involvement of the noradrenergic system in the excessive alcohol drinking seen during acute withdrawal in ethanol-dependent rats... - Melatonin effects on metabolism independent of gonad functionStephaney S Puchalski
VA Puget Sound Health Care System Mental Illness Research, Education and Clinical Center (MIRECC) and Department of Psychiatry, University of Washington, Seattle, Washington 98108, USA
Endocrine 21:169-73. 2003..These results demonstrate that suppression of body weight, visceral adiposity, and plasma leptin levels by daily melatonin administration to middle-aged rats was independent of gonadal function... - Olanzapine-induced weight gain and increased visceral adiposity is blocked by melatonin replacement therapy in ratsMurray A Raskind
VA Puget Sound Health Care System, Mental Illness Research, Education and Clinical Center, Seattle, WA 98108, USA
Neuropsychopharmacology 32:284-8. 2007....
Research Grants
- Neuroendocrine Therapy of Alcohol AbuseDENNIS RASMUSSEN; Fiscal Year: 2006....
- ALCOHOL EFFECTS ON OPIOMELANOCORTINERGIC REGULATIONDENNIS RASMUSSEN; Fiscal Year: 2009....
- ALCOHOL EFFECTS ON OPIOMELANOCORTINERGIC REGULATIONDENNIS RASMUSSEN; Fiscal Year: 2007....
- Metabolic Changes During Aging: A Role for MelatoninDENNIS RASMUSSEN; Fiscal Year: 2003....
- ALCOHOL EFFECTS ON OPIOMELANOCORTINERGIC REGULATIONDENNIS RASMUSSEN; Fiscal Year: 2001....
- Noradrenergic Agents As Potential New Pharmacotherapies for Alcohol DrinkingDENNIS D contact RASMUSSEN; Fiscal Year: 2010..These studies will also provide the basis for development of additional related medications and paradigms for successfully treating alcohol abuse. ..