Research Topics
Species | BLAKE RASMUSSENSummaryAffiliation: University of Texas Medical Branch Country: USA Publications
Research Grants
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Detail Information
Publications
Skeletal Muscle Autophagy and Protein Breakdown Following Resistance Exercise are Similar in Younger and Older AdultsChristopher S Fry
Department of Nutrition and Metabolism, Division of Rehabilitation Sciences, University of Texas Medical Branch, Sealy Center on Aging, 301 University Blvd, Galveston, Texas 77555 1144
J Gerontol A Biol Sci Med Sci 68:599-607. 2013..We hypothesize that the ubiquitin proteasome system and the autophagosomal-lysosomal system may regulate the overall rate of MPB during postexercise recovery...
Skeletal muscle protein balance and metabolism in the elderlyChristopher S Fry
University of Texas, Medical Branch Sealy Center on Aging Department of Physical Therapy, Division of Rehabilitation Sciences, Galveston, TX 77555 1144, USA
Curr Aging Sci 4:260-8. 2011..Future research is needed to determine whether these novel interventions will be successful in preventing sarcopenia and improving muscle strength and function in older adults...
Aging impairs contraction-induced human skeletal muscle mTORC1 signaling and protein synthesisChristopher S Fry
Division of Rehabilitation Sciences, University of Texas Medical Branch, Galveston, Texas, 77550 USA
Skelet Muscle 1:11. 2011..abstract:..- Sequential muscle biopsies during a 6-h tracer infusion do not affect human mixed muscle protein synthesis and muscle phenylalanine kineticsElena Volpi
Departments of Internal Medicine, University of Texas Medical Branch, Galveston, Texas 77555 0460, USA
Am J Physiol Endocrinol Metab 295:E959-63. 2008..Thus, when using a sequential study design over this period of time, it is unnecessary to include a saline only control group to account for these variables... - Expression of growth-related genes in young and older human skeletal muscle following an acute stimulation of protein synthesisMicah J Drummond
University of Texas Medical Branch, Department of Physical Therapy, Division of Rehabilitation Sciences, 301 Univ Blvd, Galveston, TX 77555 1144, USA
J Appl Physiol 106:1403-11. 2009..Our data provide new insights into the regulation of genes important for transcription and translation in young and old human skeletal muscle post RE+EAA... - Aging differentially affects human skeletal muscle microRNA expression at rest and after an anabolic stimulus of resistance exercise and essential amino acidsMicah J Drummond
Dept of Physical Therapy, Univ of Texas Medical Branch, Galveston, TX 77555 1144, USA
Am J Physiol Endocrinol Metab 295:E1333-40. 2008..However, aging is associated with higher basal skeletal muscle primary miRNA expression and a dysregulated miRNA response after the anabolic stimulus... - Dietary protein recommendations and the prevention of sarcopeniaDouglas Paddon-Jones
Department of Physical Therapy, Division of Rehabilitation Sciences The University of Texas Medical Branch 301 University Blvd Galveston, Texas 77555 1144, USA
Curr Opin Clin Nutr Metab Care 12:86-90. 2009..To draw attention to recent work on the role of protein and the amount of protein needed with each meal to preserve skeletal muscle mass in ageing... - Essential amino acids increase microRNA-499, -208b, and -23a and downregulate myostatin and myocyte enhancer factor 2C mRNA expression in human skeletal muscleMicah J Drummond
Department of Physical Therapy, Division of Rehabilitation Science, University of Texas Medical Branch, Galveston, TX 77555, USA
J Nutr 139:2279-84. 2009..Further work is needed to determine whether these miRNA are post-transcriptional regulators of growth-related genes following an anabolic stimulus... - Skeletal muscle protein anabolic response to resistance exercise and essential amino acids is delayed with agingMicah J Drummond
Department of Physical Therapy, Division of Rehabilitation Sciences, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555 1144, USA
J Appl Physiol 104:1452-61. 2008..Notwithstanding, the combination of resistance exercise and EAA ingestion should be a useful strategy to combat sarcopenia... - Leucine-enriched essential amino acid and carbohydrate ingestion following resistance exercise enhances mTOR signaling and protein synthesis in human muscleHans C Dreyer
Department of Physical Therapy, Division of Rehabilitation Sciences, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555 1144, USA
Am J Physiol Endocrinol Metab 294:E392-400. 2008..05). Our data suggest that enhanced activation of the mTOR signaling pathway is playing a role in the greater synthesis of muscle proteins when resistance exercise is followed by EAA+CHO ingestion... - Blood flow restriction during low-intensity resistance exercise increases S6K1 phosphorylation and muscle protein synthesisSatoshi Fujita
Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas, USA
J Appl Physiol 103:903-10. 2007..We conclude that the activation of the mTOR signaling pathway appears to be an important cellular mechanism that may help explain the enhanced muscle protein synthesis during REFR... - Nutrient signalling in the regulation of human muscle protein synthesisSatoshi Fujita
University of Texas Medical Branch, Department of Internal Medicine, Galveston, TX 77555 1144, USA
J Physiol 582:813-23. 2007.... - Basal muscle intracellular amino acid kinetics in women and menSatoshi Fujita
Univ of Texas Medical Branch, Sealy Center on Aging, Dept of Internal Medicine, 301 Univ Blvd, Galveston, TX 77555 0460, USA
Am J Physiol Endocrinol Metab 292:E77-83. 2007..It remains to be determined if there are sex differences in intracellular amino acid metabolism following anabolic or catabolic stimuli... - Resistance exercise increases AMPK activity and reduces 4E-BP1 phosphorylation and protein synthesis in human skeletal muscleHans C Dreyer
University of Texas Medical Branch, Department of Physical Therapy, Division of Rehabilitation Sciences, 301 University Blvd, Galveston, TX 77555 1144, USA
J Physiol 576:613-24. 2006..However, by 1-2 h post-exercise, muscle protein synthesis increased in association with an activation of protein kinase B, mTOR, S6K1 and eEF2... - Effect of insulin on human skeletal muscle protein synthesis is modulated by insulin-induced changes in muscle blood flow and amino acid availabilitySatoshi Fujita
Department of Medicine, University of Southern California, Los Angeles, California, USA
Am J Physiol Endocrinol Metab 291:E745-54. 2006..In conclusion, physiological hyperinsulinemia promotes muscle protein synthesis as long as it concomitantly increases muscle blood flow, amino acid delivery and availability... - Skeletal muscle protein anabolic response to increased energy and insulin is preserved in poorly controlled type 2 diabetesJill A Bell
Department of Kinesiology, University of Southern California, Los Angeles, CA, USA
J Nutr 136:1249-55. 2006..Moreover, the anabolic response to increased insulin and energy availability is maintained in T2DM... - Insulin resistance of muscle protein metabolism in agingBlake B Rasmussen
Department of Kinesiology, University of Southern California, Los Angeles, California, USA
FASEB J 20:768-9. 2006..89; P=0.0001) and blood flow (R=0.90; P<0.0001). In conclusion, skeletal muscle protein synthesis is resistant to the anabolic action of insulin in older subjects, which may be an important contributor to the development of sarcopenia... - Short-term insulin and nutritional energy provision do not stimulate muscle protein synthesis if blood amino acid availability decreasesJill A Bell
Sealy Center on Aging and Stark Diabetes Center, Department of Physical Therapy, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555-1144, USA
Am J Physiol Endocrinol Metab 289:E999-1006. 2005.... - Leg glucose and protein metabolism during an acute bout of resistance exercise in humansWilliam J Durham
Metabolism Unit, Shriners Burns Hospital, Galveston, University of Texas, Galveston, Texas 77550, USA
J Appl Physiol 97:1379-86. 2004..We conclude that lower body resistance exercise potently stimulates leg glucose uptake and lactate release. In addition, muscle protein synthesis is not elevated during a bout of resistance exercise... - Leucine-enriched nutrients and the regulation of mammalian target of rapamycin signalling and human skeletal muscle protein synthesisMicah J Drummond
Division of Rehabilitation Sciences, Department of Physical Therapy, University of Texas Medical Branch, Galveston 77555 1144, USA
Curr Opin Clin Nutr Metab Care 11:222-6. 2008..To highlight recent studies that have examined the cell-signalling mechanisms responsible for the amino acid (primarily leucine and the essential amino acids) stimulation of human skeletal muscle protein synthesis... - A chronic increase in physical activity inhibits fed-state mTOR/S6K1 signaling and reduces IRS-1 serine phosphorylation in rat skeletal muscleErin L Glynn
Division of Rehabilitation Sciences, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555 1144, USA
Appl Physiol Nutr Metab 33:93-101. 2008.... - Amino acids are necessary for the insulin-induced activation of mTOR/S6K1 signaling and protein synthesis in healthy and insulin resistant human skeletal muscleMicah J Drummond
Departments of Physical Therapy, University of Texas Medical Branch, Galveston, TX, USA
Clin Nutr 27:447-56. 2008..Amino acids (AA) activate the mammalian target of rapamycin (mTOR) signaling pathway but overactivation has a negative feedback effect on insulin signaling which may lead to insulin resistance and type 2 diabetes (T2DM)... - Human muscle gene expression following resistance exercise and blood flow restrictionMicah J Drummond
Department of Physical Therapy, University of Texas Medical Branch, Galveston, TX, USA
Med Sci Sports Exerc 40:691-8. 2008..However, there are limited data describing the molecular adaptations that occur after REFR... - Gene and protein expression associated with protein synthesis and breakdown in paraplegic skeletal muscleMicah J Drummond
Department of Physical Therapy, University of Texas Medical Branch, Galveston, TX 77555, USA
Muscle Nerve 37:505-13. 2008..Clinical interventions designed to increase muscle protein synthesis may be helpful in preventing excessive muscle loss during long-term paraplegia... - Chronic paraplegia-induced muscle atrophy downregulates the mTOR/S6K1 signaling pathwayHans C Dreyer
Department of Physical Therapy, University of Texas Medical Branch, Galveston, Texas 77555 1144, USA
J Appl Physiol 104:27-33. 2008..Therefore, in addition to upregulation of atrophy signaling during muscle wasting, downregulation of muscle cell growth/hypertrophy-associated signaling appears to be an important component of long-term muscle loss... - Aerobic exercise overcomes the age-related insulin resistance of muscle protein metabolism by improving endothelial function and Akt/mammalian target of rapamycin signalingSatoshi Fujita
Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas 77555 0460, USA
Diabetes 56:1615-22. 2007..05). In conclusion, a bout of aerobic exercise restores the anabolic response of muscle proteins to insulin by improving endothelial function and Akt/mTOR signaling in older subjects... - Contractile and nutritional regulation of human muscle growthBlake B Rasmussen
Department of Kinesiology, University of Southern California, Los Angeles 90089 0652, USA
Exerc Sport Sci Rev 31:127-31. 2003..The focus of this review is on the regulation of muscle anabolism in humans after resistance exercise, nutritional provision, and a combination of the two... - Malonyl coenzyme A and the regulation of functional carnitine palmitoyltransferase-1 activity and fat oxidation in human skeletal muscleBlake B Rasmussen
Department of Surgery, University of Texas Medical Branch, Galveston, Texas, USA
J Clin Invest 110:1687-93. 2002..07 nmol/g during hyperglycemia with hyperinsulinemia. We conclude that hyperglycemia with hyperinsulinemia increases malonyl-CoA, inhibits functional CPT-1 activity, and shunts LCFA away from oxidation and toward storage in human muscle...
Research Grants
- Nutritional and Contractile Regulation of Muscle GrowthBLAKE RASMUSSEN; Fiscal Year: 2007..abstract_text> ..
- Nutritional and Contractile Regulation of Muscle GrowthBLAKE RASMUSSEN; Fiscal Year: 2009....
- Nutritional and Contractile Regulation of Muscle GrowthBlake B Rasmussen; Fiscal Year: 2010....