BLAKE RASMUSSEN

Summary

Affiliation: University of Texas Medical Branch
Country: USA

Publications

  1. pmc Skeletal muscle autophagy and protein breakdown following resistance exercise are similar in younger and older adults
    Christopher S Fry
    Division of Rehabilitation Sciences, University of Texas Medical Branch, Galveston, Texas 77555 1144, USA
    J Gerontol A Biol Sci Med Sci 68:599-607. 2013
  2. ncbi request reprint Skeletal muscle protein balance and metabolism in the elderly
    Christopher S Fry
    University of Texas, Medical Branch Sealy Center on Aging Department of Physical Therapy, Division of Rehabilitation Sciences, Galveston, TX 77555 1144, USA
    Curr Aging Sci 4:260-8. 2011
  3. pmc Aging impairs contraction-induced human skeletal muscle mTORC1 signaling and protein synthesis
    Christopher S Fry
    Division of Rehabilitation Sciences, University of Texas Medical Branch, Galveston, Texas, 77550 USA
    Skelet Muscle 1:11. 2011
  4. pmc Sequential muscle biopsies during a 6-h tracer infusion do not affect human mixed muscle protein synthesis and muscle phenylalanine kinetics
    Elena Volpi
    Departments of Internal Medicine, University of Texas Medical Branch, Galveston, Texas 77555 0460, USA
    Am J Physiol Endocrinol Metab 295:E959-63. 2008
  5. pmc Expression of growth-related genes in young and older human skeletal muscle following an acute stimulation of protein synthesis
    Micah J Drummond
    University of Texas Medical Branch, Department of Physical Therapy, Division of Rehabilitation Sciences, 301 Univ Blvd, Galveston, TX 77555 1144, USA
    J Appl Physiol (1985) 106:1403-11. 2009
  6. pmc Aging differentially affects human skeletal muscle microRNA expression at rest and after an anabolic stimulus of resistance exercise and essential amino acids
    Micah J Drummond
    Dept of Physical Therapy, Univ of Texas Medical Branch, Galveston, TX 77555 1144, USA
    Am J Physiol Endocrinol Metab 295:E1333-40. 2008
  7. pmc Dietary protein recommendations and the prevention of sarcopenia
    Douglas Paddon-Jones
    Department of Physical Therapy, Division of Rehabilitation Sciences The University of Texas Medical Branch 301 University Blvd Galveston, Texas 77555 1144, USA
    Curr Opin Clin Nutr Metab Care 12:86-90. 2009
  8. pmc Essential amino acids increase microRNA-499, -208b, and -23a and downregulate myostatin and myocyte enhancer factor 2C mRNA expression in human skeletal muscle
    Micah J Drummond
    Department of Physical Therapy, Division of Rehabilitation Science, University of Texas Medical Branch, Galveston, TX 77555, USA
    J Nutr 139:2279-84. 2009
  9. pmc Skeletal muscle protein anabolic response to resistance exercise and essential amino acids is delayed with aging
    Micah J Drummond
    Department of Physical Therapy, Division of Rehabilitation Sciences, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555 1144, USA
    J Appl Physiol (1985) 104:1452-61. 2008
  10. pmc Leucine-enriched essential amino acid and carbohydrate ingestion following resistance exercise enhances mTOR signaling and protein synthesis in human muscle
    Hans C Dreyer
    Department of Physical Therapy, Division of Rehabilitation Sciences, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555 1144, USA
    Am J Physiol Endocrinol Metab 294:E392-400. 2008

Research Grants

Collaborators

Detail Information

Publications28

  1. pmc Skeletal muscle autophagy and protein breakdown following resistance exercise are similar in younger and older adults
    Christopher S Fry
    Division of Rehabilitation Sciences, University of Texas Medical Branch, Galveston, Texas 77555 1144, USA
    J Gerontol A Biol Sci Med Sci 68:599-607. 2013
    ..We hypothesize that the ubiquitin proteasome system and the autophagosomal-lysosomal system may regulate the overall rate of MPB during postexercise recovery...
  2. ncbi request reprint Skeletal muscle protein balance and metabolism in the elderly
    Christopher S Fry
    University of Texas, Medical Branch Sealy Center on Aging Department of Physical Therapy, Division of Rehabilitation Sciences, Galveston, TX 77555 1144, USA
    Curr Aging Sci 4:260-8. 2011
    ..Future research is needed to determine whether these novel interventions will be successful in preventing sarcopenia and improving muscle strength and function in older adults...
  3. pmc Aging impairs contraction-induced human skeletal muscle mTORC1 signaling and protein synthesis
    Christopher S Fry
    Division of Rehabilitation Sciences, University of Texas Medical Branch, Galveston, Texas, 77550 USA
    Skelet Muscle 1:11. 2011
    ..abstract:..
  4. pmc Sequential muscle biopsies during a 6-h tracer infusion do not affect human mixed muscle protein synthesis and muscle phenylalanine kinetics
    Elena Volpi
    Departments of Internal Medicine, University of Texas Medical Branch, Galveston, Texas 77555 0460, USA
    Am J Physiol Endocrinol Metab 295:E959-63. 2008
    ..Thus, when using a sequential study design over this period of time, it is unnecessary to include a saline only control group to account for these variables...
  5. pmc Expression of growth-related genes in young and older human skeletal muscle following an acute stimulation of protein synthesis
    Micah J Drummond
    University of Texas Medical Branch, Department of Physical Therapy, Division of Rehabilitation Sciences, 301 Univ Blvd, Galveston, TX 77555 1144, USA
    J Appl Physiol (1985) 106:1403-11. 2009
    ..Our data provide new insights into the regulation of genes important for transcription and translation in young and old human skeletal muscle post RE+EAA...
  6. pmc Aging differentially affects human skeletal muscle microRNA expression at rest and after an anabolic stimulus of resistance exercise and essential amino acids
    Micah J Drummond
    Dept of Physical Therapy, Univ of Texas Medical Branch, Galveston, TX 77555 1144, USA
    Am J Physiol Endocrinol Metab 295:E1333-40. 2008
    ..However, aging is associated with higher basal skeletal muscle primary miRNA expression and a dysregulated miRNA response after the anabolic stimulus...
  7. pmc Dietary protein recommendations and the prevention of sarcopenia
    Douglas Paddon-Jones
    Department of Physical Therapy, Division of Rehabilitation Sciences The University of Texas Medical Branch 301 University Blvd Galveston, Texas 77555 1144, USA
    Curr Opin Clin Nutr Metab Care 12:86-90. 2009
    ..To draw attention to recent work on the role of protein and the amount of protein needed with each meal to preserve skeletal muscle mass in ageing...
  8. pmc Essential amino acids increase microRNA-499, -208b, and -23a and downregulate myostatin and myocyte enhancer factor 2C mRNA expression in human skeletal muscle
    Micah J Drummond
    Department of Physical Therapy, Division of Rehabilitation Science, University of Texas Medical Branch, Galveston, TX 77555, USA
    J Nutr 139:2279-84. 2009
    ..Further work is needed to determine whether these miRNA are post-transcriptional regulators of growth-related genes following an anabolic stimulus...
  9. pmc Skeletal muscle protein anabolic response to resistance exercise and essential amino acids is delayed with aging
    Micah J Drummond
    Department of Physical Therapy, Division of Rehabilitation Sciences, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555 1144, USA
    J Appl Physiol (1985) 104:1452-61. 2008
    ..Notwithstanding, the combination of resistance exercise and EAA ingestion should be a useful strategy to combat sarcopenia...
  10. pmc Leucine-enriched essential amino acid and carbohydrate ingestion following resistance exercise enhances mTOR signaling and protein synthesis in human muscle
    Hans C Dreyer
    Department of Physical Therapy, Division of Rehabilitation Sciences, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555 1144, USA
    Am J Physiol Endocrinol Metab 294:E392-400. 2008
    ..05). Our data suggest that enhanced activation of the mTOR signaling pathway is playing a role in the greater synthesis of muscle proteins when resistance exercise is followed by EAA+CHO ingestion...
  11. ncbi request reprint Blood flow restriction during low-intensity resistance exercise increases S6K1 phosphorylation and muscle protein synthesis
    Satoshi Fujita
    Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas, USA
    J Appl Physiol (1985) 103:903-10. 2007
    ..We conclude that the activation of the mTOR signaling pathway appears to be an important cellular mechanism that may help explain the enhanced muscle protein synthesis during REFR...
  12. pmc Nutrient signalling in the regulation of human muscle protein synthesis
    Satoshi Fujita
    University of Texas Medical Branch, Department of Internal Medicine, Galveston, TX 77555 1144, USA
    J Physiol 582:813-23. 2007
    ....
  13. pmc Basal muscle intracellular amino acid kinetics in women and men
    Satoshi Fujita
    Univ of Texas Medical Branch, Sealy Center on Aging, Dept of Internal Medicine, 301 Univ Blvd, Galveston, TX 77555 0460, USA
    Am J Physiol Endocrinol Metab 292:E77-83. 2007
    ..It remains to be determined if there are sex differences in intracellular amino acid metabolism following anabolic or catabolic stimuli...
  14. pmc Resistance exercise increases AMPK activity and reduces 4E-BP1 phosphorylation and protein synthesis in human skeletal muscle
    Hans C Dreyer
    University of Texas Medical Branch, Department of Physical Therapy, Division of Rehabilitation Sciences, 301 University Blvd, Galveston, TX 77555 1144, USA
    J Physiol 576:613-24. 2006
    ..However, by 1-2 h post-exercise, muscle protein synthesis increased in association with an activation of protein kinase B, mTOR, S6K1 and eEF2...
  15. pmc Effect of insulin on human skeletal muscle protein synthesis is modulated by insulin-induced changes in muscle blood flow and amino acid availability
    Satoshi Fujita
    Department of Medicine, University of Southern California, Los Angeles, California, USA
    Am J Physiol Endocrinol Metab 291:E745-54. 2006
    ..In conclusion, physiological hyperinsulinemia promotes muscle protein synthesis as long as it concomitantly increases muscle blood flow, amino acid delivery and availability...
  16. pmc Skeletal muscle protein anabolic response to increased energy and insulin is preserved in poorly controlled type 2 diabetes
    Jill A Bell
    Department of Kinesiology, University of Southern California, Los Angeles, CA, USA
    J Nutr 136:1249-55. 2006
    ..Moreover, the anabolic response to increased insulin and energy availability is maintained in T2DM...
  17. pmc Insulin resistance of muscle protein metabolism in aging
    Blake B Rasmussen
    Department of Kinesiology, University of Southern California, Los Angeles, California, USA
    FASEB J 20:768-9. 2006
    ..89; P=0.0001) and blood flow (R=0.90; P<0.0001). In conclusion, skeletal muscle protein synthesis is resistant to the anabolic action of insulin in older subjects, which may be an important contributor to the development of sarcopenia...
  18. pmc Short-term insulin and nutritional energy provision do not stimulate muscle protein synthesis if blood amino acid availability decreases
    Jill A Bell
    Sealy Center on Aging and Stark Diabetes Center, Department of Physical Therapy, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555 1144, USA
    Am J Physiol Endocrinol Metab 289:E999-1006. 2005
    ....
  19. ncbi request reprint Leg glucose and protein metabolism during an acute bout of resistance exercise in humans
    William J Durham
    Metabolism Unit, Shriners Burns Hospital, Galveston, University of Texas, Galveston, Texas 77550, USA
    J Appl Physiol (1985) 97:1379-86. 2004
    ..We conclude that lower body resistance exercise potently stimulates leg glucose uptake and lactate release. In addition, muscle protein synthesis is not elevated during a bout of resistance exercise...
  20. ncbi request reprint Leucine-enriched nutrients and the regulation of mammalian target of rapamycin signalling and human skeletal muscle protein synthesis
    Micah J Drummond
    Division of Rehabilitation Sciences, Department of Physical Therapy, University of Texas Medical Branch, Galveston 77555 1144, USA
    Curr Opin Clin Nutr Metab Care 11:222-6. 2008
    ..To highlight recent studies that have examined the cell-signalling mechanisms responsible for the amino acid (primarily leucine and the essential amino acids) stimulation of human skeletal muscle protein synthesis...
  21. pmc A chronic increase in physical activity inhibits fed-state mTOR/S6K1 signaling and reduces IRS-1 serine phosphorylation in rat skeletal muscle
    Erin L Glynn
    Division of Rehabilitation Sciences, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555 1144, USA
    Appl Physiol Nutr Metab 33:93-101. 2008
    ....
  22. pmc Amino acids are necessary for the insulin-induced activation of mTOR/S6K1 signaling and protein synthesis in healthy and insulin resistant human skeletal muscle
    Micah J Drummond
    Departments of Physical Therapy, University of Texas Medical Branch, Galveston, TX, USA
    Clin Nutr 27:447-56. 2008
    ..Amino acids (AA) activate the mammalian target of rapamycin (mTOR) signaling pathway but overactivation has a negative feedback effect on insulin signaling which may lead to insulin resistance and type 2 diabetes (T2DM)...
  23. ncbi request reprint Human muscle gene expression following resistance exercise and blood flow restriction
    Micah J Drummond
    Department of Physical Therapy, University of Texas Medical Branch, Galveston, TX, USA
    Med Sci Sports Exerc 40:691-8. 2008
    ..However, there are limited data describing the molecular adaptations that occur after REFR...
  24. pmc Gene and protein expression associated with protein synthesis and breakdown in paraplegic skeletal muscle
    Micah J Drummond
    Department of Physical Therapy, University of Texas Medical Branch, Galveston, TX 77555, USA
    Muscle Nerve 37:505-13. 2008
    ..Clinical interventions designed to increase muscle protein synthesis may be helpful in preventing excessive muscle loss during long-term paraplegia...
  25. pmc Chronic paraplegia-induced muscle atrophy downregulates the mTOR/S6K1 signaling pathway
    Hans C Dreyer
    Department of Physical Therapy, University of Texas Medical Branch, Galveston, Texas 77555 1144, USA
    J Appl Physiol (1985) 104:27-33. 2008
    ..Therefore, in addition to upregulation of atrophy signaling during muscle wasting, downregulation of muscle cell growth/hypertrophy-associated signaling appears to be an important component of long-term muscle loss...
  26. pmc Aerobic exercise overcomes the age-related insulin resistance of muscle protein metabolism by improving endothelial function and Akt/mammalian target of rapamycin signaling
    Satoshi Fujita
    Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas 77555 0460, USA
    Diabetes 56:1615-22. 2007
    ..05). In conclusion, a bout of aerobic exercise restores the anabolic response of muscle proteins to insulin by improving endothelial function and Akt/mTOR signaling in older subjects...
  27. ncbi request reprint Contractile and nutritional regulation of human muscle growth
    Blake B Rasmussen
    Department of Kinesiology, University of Southern California, Los Angeles 90089 0652, USA
    Exerc Sport Sci Rev 31:127-31. 2003
    ..The focus of this review is on the regulation of muscle anabolism in humans after resistance exercise, nutritional provision, and a combination of the two...
  28. pmc Malonyl coenzyme A and the regulation of functional carnitine palmitoyltransferase-1 activity and fat oxidation in human skeletal muscle
    Blake B Rasmussen
    Department of Surgery, University of Texas Medical Branch, Galveston, Texas, USA
    J Clin Invest 110:1687-93. 2002
    ..07 nmol/g during hyperglycemia with hyperinsulinemia. We conclude that hyperglycemia with hyperinsulinemia increases malonyl-CoA, inhibits functional CPT-1 activity, and shunts LCFA away from oxidation and toward storage in human muscle...

Research Grants7

  1. Nutritional and Contractile Regulation of Muscle Growth
    BLAKE RASMUSSEN; Fiscal Year: 2009
    ....
  2. Nutritional and Contractile Regulation of Muscle Growth
    Blake B Rasmussen; Fiscal Year: 2010
    ....
  3. Nutritional and Contractile Regulation of Muscle Growth
    BLAKE RASMUSSEN; Fiscal Year: 2004
    ..abstract_text> ..
  4. Nutritional and Contractile Regulation of Muscle Growth
    BLAKE RASMUSSEN; Fiscal Year: 2005
    ..abstract_text> ..
  5. Nutritional and Contractile Regulation of Muscle Growth
    BLAKE RASMUSSEN; Fiscal Year: 2006
    ..abstract_text> ..
  6. Nutritional and Contractile Regulation of Muscle Growth
    BLAKE RASMUSSEN; Fiscal Year: 2007
    ..abstract_text> ..