Research Topics
| David A RaskoSummaryAffiliation: University of Texas Southwestern Medical Center Country: USA Publications
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Detail Information
Publications
The first decade of microbial genomics: what have we learned and where are we going next?David A Rasko
The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
Genome Biol 6:341. 2005- Complete sequence analysis of novel plasmids from emetic and periodontal Bacillus cereus isolates reveals a common evolutionary history among the B. cereus-group plasmids, including Bacillus anthracis pXO1David A Rasko
The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, Maryland 20850, USA
J Bacteriol 189:52-64. 2007..This study demonstrates that the pXO1-like plasmids may define pathogenic B. cereus isolates in the same way that pXO1 and pXO2 define the B. anthracis species... - Whole genome comparisons of serotype 4b and 1/2a strains of the food-borne pathogen Listeria monocytogenes reveal new insights into the core genome components of this speciesKaren E Nelson
The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
Nucleic Acids Res 32:2386-95. 2004..Whole genome comparative analyses revealed that the L.monocytogenes genomes are essentially syntenic, with the majority of genomic differences consisting of phage insertions, transposable elements and SNPs... - Major structural differences and novel potential virulence mechanisms from the genomes of multiple campylobacter speciesDerrick E Fouts
The Institute for Genomic Research, Rockville, Maryland, United States of America
PLoS Biol 3:e15. 2005.... - The genome sequence of Bacillus cereus ATCC 10987 reveals metabolic adaptations and a large plasmid related to Bacillus anthracis pXO1David A Rasko
The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
Nucleic Acids Res 32:977-88. 2004..The chromosomal similarity of B.cereus ATCC 10987 to B.anthracis Ames, as well as the fact that it contains a large pXO1-like plasmid, may make it a possible model for studying B.anthracis plasmid biology and regulatory cross-talk... - The complete genome sequence of Bacillus anthracis Ames "Ancestor"Jacques Ravel
The Institute for Genomic Research, Rockville, Maryland 20850, USA
J Bacteriol 191:445-6. 2009..This study describes the complete genome sequence of that original isolate, derived from a sample kept in cold storage since 1981... 
Genomics of the Bacillus cereus group of organismsDavid A Rasko
The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
FEMS Microbiol Rev 29:303-29. 2005..Genomic data have spurred functional studies that combined microarrays and proteomics. Recent advances are reviewed in this article and highlight the advantages of genomic approaches to the study of this important group of bacteria...- Skewed genomic variability in strains of the toxigenic bacterial pathogen, Clostridium perfringensGarry S A Myers
The Institute for Genomic Research, Rockville, Maryland 20850, USA
Genome Res 16:1031-40. 2006.... - Sequencing Bacillus anthracis typing phages gamma and cherry reveals a common ancestryDerrick E Fouts
The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, Maryland 20850, USA
J Bacteriol 188:3402-8. 2006..The genomes of these two phages were identical except at three variable loci, which showed heterogeneity within individual lysates and among Cherry, Wbeta, Fah, and four Gamma bacteriophage sequences... - Visualization of comparative genomic analyses by BLAST score ratioDavid A Rasko
The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
BMC Bioinformatics 6:2. 2005..This massive influx of data provides the opportunity to obtain biological insights through comparative genomics. However few tools are available for this scale of comparative analysis... - Investigating the genome diversity of B. cereus and evolutionary aspects of B. anthracis emergenceLeka Papazisi
Pathogen Functional Genomics Resource Center PFGRC, The J Craig Venter Institute JCVI, Rockville, MD 20850, USA
Genomics 98:26-39. 2011..anthracis, the evolution of this species and its close relatives was associated with an overall shift in the fraction of genes devoted to energy metabolism, cellular processes, transport, as well as virulence... - Bugs N the 'hoodDavid A Rasko
Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20580, USA
Trends Microbiol 12:155-6. 2004 - Formation and composition of the Bacillus anthracis endosporeHongbin Liu
Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA
J Bacteriol 186:164-78. 2004..This study also highlights the complementary nature of genomic and proteomic analyses and the benefits of combining these approaches in a single study... - Identification of anthrax toxin genes in a Bacillus cereus associated with an illness resembling inhalation anthraxAlex R Hoffmaster
Epidemiologic Investigations Laboratory, Meningitis and Special Pathogens Branch, Centers for Disease Control and Prevention, 1600 Clifton Road, MS G34, Atlanta, GA 30333, USA
Proc Natl Acad Sci U S A 101:8449-54. 2004..In this study, we combined a public health approach with genome analysis to provide insight into the correlation of phenotypic characteristics and their genetic basis... - The pangenome structure of Escherichia coli: comparative genomic analysis of E. coli commensal and pathogenic isolatesDavid A Rasko
Institute for Genome Sciences, Department of Microbiology and Immunology, University of Maryland School of Medicine, 20 Penn Street, Baltimore, MD 21201, USA
J Bacteriol 190:6881-93. 2008..This comparative study of the species E. coli, while descriptive, should provide the basis for future functional work on this important group of pathogens... - The complete genome sequence of Yersinia pseudotuberculosis IP31758, the causative agent of Far East scarlet-like feverMark Eppinger
J Craig Venter Institute The Institute for Genomic Research, Microbial Genomics, Rockville, Maryland, United States of America
PLoS Genet 3:e142. 2007.... - Global effects of the cell-to-cell signaling molecules autoinducer-2, autoinducer-3, and epinephrine in a luxS mutant of enterohemorrhagic Escherichia coliMelissa M Kendall
University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9048, USA
Infect Immun 75:4875-84. 2007..This study began to examine the global signaling networks in EHEC and revealed expression profiles that are signal and pathogen specific... - Metabolic analysis of Moraxella catarrhalis and the effect of selected in vitro growth conditions on global gene expressionWei Wang
Department of Microbiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9048, USA
Infect Immun 75:4959-71. 2007..These results indicate that growth of M. catarrhalis in a biofilm results in increased expression of gene products which can function not only in energy generation but also in resisting certain elements of the innate immune response... - QseA and GrlR/GrlA regulation of the locus of enterocyte effacement genes in enterohemorrhagic Escherichia coliRegan M Russell
University of Texas Southwestern Medical Center, Department of Microbiology, Dallas, TX 75390 9048, USA
J Bacteriol 189:5387-92. 2007..This work demonstrates that GrlR/GrlA activate LEE2 transcription in a Ler-independent fashion, whereas transcription of grlRA is activated by QseA in both Ler-dependent and -independent manners... - Development of novel plasmid vectors and a promoter trap system in Francisella tularensis compatible with the pFLN10 based plasmidsDavid A Rasko
University of Texas Southwestern Medical Center at Dallas, Department of Microbiology, 6000 Harry Hines Blvd, Room NA6 138, Dallas, TX 75235 9048, USA
Plasmid 58:159-66. 2007..tularensis genetics. Our promoter trap can identify promoters that are activated during intracellular growth and survival. These new vectors provide additional tools for the genetic manipulation of F. tularensis... - Defining genomic islands and uropathogen-specific genes in uropathogenic Escherichia coliAmanda L Lloyd
Department of Microbiology and Immunology, University of Michigan Medical School, 5641 Medical Science Bldg II, 1150 West Medical Center Dr, Ann Arbor, MI 48109 0620, USA
J Bacteriol 189:3532-46. 2007..The large number of hypothetical genes in the CFT073 genome, especially those shown to be UPEC specific, strongly suggests that many urovirulence factors remain uncharacterized... - Genome sequence of Silicibacter pomeroyi reveals adaptations to the marine environmentMary Ann Moran
Department of Marine Sciences, University of Georgia, Athens, Georgia 30602, USA
Nature 432:910-3. 2004..This bacterium has a physiology distinct from that of marine oligotrophs, adding a new strategy to the recognized repertoire for coping with a nutrient-poor ocean... - Patellamide A and C biosynthesis by a microcin-like pathway in Prochloron didemni, the cyanobacterial symbiont of Lissoclinum patellaEric W Schmidt
Department of Medicinal Chemistry, University of Utah, Salt Lake City, UT 84112, USA
Proc Natl Acad Sci U S A 102:7315-20. 2005..In addition, a related cluster was identified in Trichodesmium erythraeum IMS101, an important bloom-forming cyanobacterium...