Research Topics
Species | Wendy RaskindSummaryAffiliation: University of Washington Country: USA Publications
Research Grants
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Publications
Linkage analyses of four regions previously implicated in dyslexia: confirmation of a locus on chromosome 15qNicola H Chapman
Department of Medicine, University of Washington, Seattle, Washington 98195, USA
Am J Med Genet B Neuropsychiatr Genet 131:67-75. 2004....
Integrative analysis of RUNX1 downstream pathways and target genesJoelle Michaud
Molecular Medicine Division, The Walter and Eliza Hall Institute of Medical Research, Parkville 3050, Victoria, Australia
BMC Genomics 9:363. 2008..We have used multiple microarray platforms and bioinformatic techniques to help identify these biological pathways to aid in the understanding of why RUNX1 mutations lead to leukemia...- Frequent loss of heterozygosity for markers on chromosome arm 10q in chondrosarcomasW H Raskind
Department of Medicine, University of Washington, Seattle 98195, USA
Genes Chromosomes Cancer 16:138-43. 1996..LOH on chromosome arm 10q was found in early-stage chondrosarcomas and did not correlate with grade or prognosis. Inactivation or alteration of a gene located at this site may be an early event in the development of these tumors... - Familial dyskinesia and facial myokymia (FDFM): Follow-up of a large family and linkage to chromosome 3p21-3q21Wendy H Raskind
Department of Medicine, University of Washington School of Medicine, Seattle, Washington 98195 7720, USA
Am J Med Genet B Neuropsychiatr Genet 150:570-4. 2009..Identification of additional families with FDFM may narrow the critical region and facilitate the choice of candidate genes for further analysis... - A genome scan in multigenerational families with dyslexia: Identification of a novel locus on chromosome 2q that contributes to phonological decoding efficiencyW H Raskind
Department of Medicine, University of Washington, Seattle, WA, USA
Mol Psychiatry 10:699-711. 2005..89. The consistency of results from three analytic approaches provides strong evidence for a locus on chromosome 2 that influences speed but not accuracy of phonological decoding... - Evaluation of locus heterogeneity and EXT1 mutations in 34 families with hereditary multiple exostosesW H Raskind
Department of Medicine, University of Washington, Seattle 98195, USA
Hum Mutat 11:231-9. 1998..Combined mutational and heterogeneity analyses in this set of families with multiple exostoses suggest that 66% of our total sample, including 45% of isolated and 77% of familial cases, are attributable to abnormalities in EXT1... - Further localization of a gene for paroxysmal dystonic choreoathetosis to a 5-cM region on chromosome 2q34W H Raskind
Department of Medicine, University of Washington, Seattle 98195, USA
Hum Genet 102:93-7. 1998..However, identifying a third family whose disease maps to the same region and narrowing the critical region will facilitate identification of the 2q-linked PDC gene... - Familial aggregation of dyslexia phenotypesW H Raskind
Department of Medicine, University of Washington, Seattle 98195 7720, USA
Behav Genet 30:385-96. 2000..These measures are thus good candidates for more sophisticated segregation analyses that can formulate models for incorporation into linkage analyses... 
A multidisciplinary approach to understanding developmental dyslexia within working-memory architecture: genotypes, phenotypes, brain, and instructionVirginia W Berninger
Educational Psychology, University of Washington, Seattle, WA 98195 3600, USA
Dev Neuropsychol 33:707-44. 2008..Impaired executive functions may interfere with the efficiency of working memory in processing oral and written language...- Writing problems in developmental dyslexia: under-recognized and under-treatedVirginia W Berninger
Educational Psychology, University of Washington Seattle, WA 98195 3600, USA
J Sch Psychol 46:1-21. 2008.... - IFRD1 is a candidate gene for SMNA on chromosome 7q22-q23Zoran Brkanac
Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA 98104, USA
Am J Hum Genet 84:692-7. 2009..Mutation analysis of IFRD1 in additional patients with similar phenotypes is needed for demonstration of causality and further evaluation of its importance in neurological diseases... - Familial aggregation patterns in mathematical abilityEllen M Wijsman
Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, Washington 98195 7720, USA
Behav Genet 34:51-62. 2004.... - Genome scan of a nonword repetition phenotype in families with dyslexia: evidence for multiple lociZoran Brkanac
Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA 98195 6560, USA
Behav Genet 38:462-75. 2008..These results warrant further studies of phonological memory and chromosomal regions identified here in other datasets... - Genomewide scan for real-word reading subphenotypes of dyslexia: novel chromosome 13 locus and genetic complexityRobert P Igo
Department of Medicine, University of Washington, Seattle, WA 98195-7720, USA
Am J Med Genet B Neuropsychiatr Genet 141:15-27. 2006..Taken together, these results indicate a locus for efficiency and accuracy of RWR on chromosome 13, and a complex model for inheritance of RWR accuracy with loci on chromosomes 12 and 15... - Presence of alanine-to-valine substitutions in myofibrillogenesis regulator 1 in paroxysmal nonkinesigenic dyskinesia: confirmation in 2 kindredsDong Hui Chen
Department of Neurology, University of Washington, Seattle, 98195 7720, USA
Arch Neurol 62:597-600. 2005..An autosomal dominant form of this disorder was mapped to chromosome 2q33-36, and different missense mutations in exon 1 of the myofibrillogenesis regulator 1 (MR1) gene were identified recently in 2 kindreds... - Presence of large deletions in kindreds with autismChang-En Yu
Geriatrics Research Education and Clinical Center, Puget Sound Veterans Affairs Medical Center, University of Washington, Seattle 98108, USA
Am J Hum Genet 71:100-15. 2002..An alternative hypothesis is that autism-susceptibility alleles elsewhere cause the deletions detected here, possibly by inducing errors during meiosis... - Gender differences in severity of writing and reading disabilitiesVirginia W Berninger
Educational Psychology, University of Washington, Seattle, WA 98195 3600, USA
J Sch Psychol 46:151-72. 2008.... - Autosomal dominant sensory/motor neuropathy with Ataxia (SMNA): Linkage to chromosome 7q22-q32Zoran Brkanac
Department of Psychiatry, University of Washington School of Medicine, Seattle, Washington 98108, USA
Am J Med Genet 114:450-7. 2002..Because this disorder does not easily fall into either the SCA or HSN categories, it is designated sensory/motor neuropathy with ataxia (SMNA)... - A novel X-linked four-repeat tauopathy with Parkinsonism and spasticityParvoneh Poorkaj
Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington 98195, USA
Mov Disord 25:1409-17. 2010..In conclusion, we have identified a unique X-linked parkinsonian syndrome with variable spasticity and four-repeat tau pathology, and defined a novel candidate gene locus spanning approximately 28 Mb from Xp11.2-Xq13.3... - Converging evidence for triple word form theory in children with dyslexiaTodd L Richards
Department of Radiology, University of Washington, Seattle, WA 98195, USA
Dev Neuropsychol 30:547-89. 2006..In the 3rd part we discuss the next steps in this programmatic research to move beyond word form alone... - X-linked thrombocytopenia with thalassemia from a mutation in the amino finger of GATA-1 affecting DNA binding rather than FOG-1 interactionChanning Yu
Division of Hematology Oncology, Department of Medicine, Children s Hospital, 300 Longwood Avenue, Boston, MA 02115, USA
Blood 100:2040-5. 2002..This is also the first example of beta-thalassemia in humans caused by a mutation in an erythroid transcription factor... - Evaluation of candidate genes for DYX1 and DYX2 in families with dyslexiaZoran Brkanac
Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington 98198 7720, USA
Am J Med Genet B Neuropsychiatr Genet 144:556-60. 2007..We observed a slight tendency for an intronic deletion in DCDC2 to be associated with worse performance on some quantitative measures of dyslexia in the probands in our sample, but not in their parents... - Familial aggregation of dyslexia phenotypes. II: paired correlated measuresLi Hsu
Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
Am J Med Genet 114:471-8. 2002.... - A new dominant spinocerebellar ataxia linked to chromosome 19q13.4-qterZoran Brkanac
Department of Psychiatry, University of Washington, Seattle, WA 98195 7720, USA
Arch Neurol 59:1291-5. 2002..Although molecular genetic studies have so far implicated 16 loci in the etiology of these diseases, approximately 30% of families with SCAs remain unlinked... - A novel mutation in FHL1 in a family with X-linked scapuloperoneal myopathy: phenotypic spectrum and structural study of FHL1 mutationsDong Hui Chen
Department of Neurology, University of Washington, Seattle, WA, USA
J Neurol Sci 296:22-9. 2010..However, recognizing the typical scapuloperoneal phenotype and X-linked inheritance pattern will help clinicians arrive at the correct diagnosis... - Sensorineural deafness, distinctive facial features, and abnormal cranial bones: a new variant of Waardenburg syndrome?Alona Gad
Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, Washington 98195 7720, USA
Am J Med Genet A 146:1880-5. 2008..All sinuses were hypoplastic, and the cochlea were small. No sequence alteration in PAX3 was found. These observations broaden the clinical range of WS and suggest there may be genetic heterogeneity even within the CDHS subtype... - Genetic evaluation and counseling of couples with recurrent miscarriage: recommendations of the National Society of Genetic CounselorsMercy Y Laurino
Department of Medicine, Division of Medical Genetics, University of Washington, Seattle, Washington 98195, USA
J Genet Couns 14:165-81. 2005..The professional judgment of a health care provider, familiar with the circumstances of a specific case, should always supersede these recommendations... - Phenotype and X inactivation in 45,X/46,X,r(X) casesKathleen A Leppig
Genetic Services, Group Health Permanente, Seattle, Washington 98112, USA
Am J Med Genet A 128:276-84. 2004.... - Missense mutations in the regulatory domain of PKC gamma: a new mechanism for dominant nonepisodic cerebellar ataxiaDong Hui Chen
Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA 98195, USA
Am J Hum Genet 72:839-49. 2003..These results strongly support a new mechanism for neuronal cell dysfunction and death in hereditary ataxias and suggest that there may be a common pathway for PKC gamma-related and polyglutamine-related neurodegeneration... - In vitro analyses of known and novel RUNX1/AML1 mutations in dominant familial platelet disorder with predisposition to acute myelogenous leukemia: implications for mechanisms of pathogenesisJoelle Michaud
Division of Medical Genetics, Geneva University Medical School, Switzerland
Blood 99:1364-72. 2002.... - Spinocerebellar ataxia type 14 caused by a mutation in protein kinase C gammaIchiro Yabe
Department of Neurology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
Arch Neurol 60:1749-51. 2003..Different PRKCG mutations were found in another family with SCA and in a sporadic case from the United States. Axial myoclonus was not observed in any of these US families...
Research Grants
- Genetics Contributions to Endophenotypes of DyslexiaWendy Raskind; Fiscal Year: 2007....
- Genetics Contributions to Endophenotypes of DyslexiaWendy Raskind; Fiscal Year: 2009....
- Next Generation gene discovery in neurogeneticsWendy H Raskind; Fiscal Year: 2010..This new approach can rapidly identify the causes of many rare genetic diseases in humans.) ) ..
- Genetics Contributions to Endophenotypes of DyslexiaWendy H Raskind; Fiscal Year: 2010....