Matthew N Rasband

Summary

Affiliation: University of Connecticut Health Center
Country: USA

Publications

  1. pmc A central role for Necl4 (SynCAM4) in Schwann cell-axon interaction and myelination
    Ivo Spiegel
    Department of Molecular Cell Biology, The Weizmann Institute of Science, POB 26, Rehovot 76100, Israel
    Nat Neurosci 10:861-9. 2007
  2. pmc betaIV spectrin is recruited to axon initial segments and nodes of Ranvier by ankyrinG
    Yang Yang
    Department of Neuroscience, University of Connecticut Health Center, University of Connecticut, Farmington, CT 06032, USA
    J Cell Biol 176:509-19. 2007
  3. ncbi request reprint Neuron-glia interactions at the node of Ranvier
    Matthew N Rasband
    Department of Neuroscience, University of Connecticut Health Center, Farmington 06030 3401, USA
    Results Probl Cell Differ 43:129-49. 2006
  4. ncbi request reprint Dysregulation of axonal sodium channel isoforms after adult-onset chronic demyelination
    Matthew N Rasband
    Department of Biochemistry and Cell Biology, State University of New York at Stony Brook, Stony Brook, New York, USA
    J Neurosci Res 73:465-70. 2003
  5. ncbi request reprint Paranodal transverse bands are required for maintenance but not initiation of Nav1.6 sodium channel clustering in CNS optic nerve axons
    Matthew N Rasband
    Department of Neuroscience, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    Glia 44:173-82. 2003
  6. ncbi request reprint It's "juxta" potassium channel!
    Matthew N Rasband
    Department of Neuroscience, University of Connecticut Health Center, Farmington, 06032, USA
    J Neurosci Res 76:749-57. 2004
  7. pmc ADAM22, a Kv1 channel-interacting protein, recruits membrane-associated guanylate kinases to juxtaparanodes of myelinated axons
    Yasuhiro Ogawa
    Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 30:1038-48. 2010
  8. pmc Three mechanisms assemble central nervous system nodes of Ranvier
    Keiichiro Susuki
    Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA
    Neuron 78:469-82. 2013
  9. ncbi request reprint BetaIV spectrins are essential for membrane stability and the molecular organization of nodes of Ranvier
    Yang Yang
    Department of Neuroscience, University of Connecticut Health Center, Farmington, Connecticut 06030 3401, USA
    J Neurosci 24:7230-40. 2004
  10. pmc Na+ channel-dependent recruitment of Navβ4 to axon initial segments and nodes of Ranvier
    Shelly A Buffington
    Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 33:6191-202. 2013

Collaborators

Detail Information

Publications47

  1. pmc A central role for Necl4 (SynCAM4) in Schwann cell-axon interaction and myelination
    Ivo Spiegel
    Department of Molecular Cell Biology, The Weizmann Institute of Science, POB 26, Rehovot 76100, Israel
    Nat Neurosci 10:861-9. 2007
    ..These results suggest that Necl proteins are important for mediating axon-glia contact during myelination in peripheral nerves...
  2. pmc betaIV spectrin is recruited to axon initial segments and nodes of Ranvier by ankyrinG
    Yang Yang
    Department of Neuroscience, University of Connecticut Health Center, University of Connecticut, Farmington, CT 06032, USA
    J Cell Biol 176:509-19. 2007
    ..Finally, using adenovirus for transgene delivery into myelinated neurons, we demonstrate that betaIV spectrin recruitment to nodes of Ranvier also depends on binding to ankG...
  3. ncbi request reprint Neuron-glia interactions at the node of Ranvier
    Matthew N Rasband
    Department of Neuroscience, University of Connecticut Health Center, Farmington 06030 3401, USA
    Results Probl Cell Differ 43:129-49. 2006
    ..This review will discuss several examples illustrating how myelinating glia actively regulate the excitable properties of axons including the kinds of channels expressed and their subcellular localization...
  4. ncbi request reprint Dysregulation of axonal sodium channel isoforms after adult-onset chronic demyelination
    Matthew N Rasband
    Department of Biochemistry and Cell Biology, State University of New York at Stony Brook, Stony Brook, New York, USA
    J Neurosci Res 73:465-70. 2003
    ..The altered Nav channel isoform localization and complement induced by demyelination may contribute to the pathophysiology of demyelinating disorders and nerve injury...
  5. ncbi request reprint Paranodal transverse bands are required for maintenance but not initiation of Nav1.6 sodium channel clustering in CNS optic nerve axons
    Matthew N Rasband
    Department of Neuroscience, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    Glia 44:173-82. 2003
    ..6 clusters. Thus, transverse bands are not required for Nav1.6 clustering and localization at nodes or for exclusion of Nav1.2 from myelinated nerve fibers, but are required for the maintenance of nodal Nav1.6 cluster size and density...
  6. ncbi request reprint It's "juxta" potassium channel!
    Matthew N Rasband
    Department of Neuroscience, University of Connecticut Health Center, Farmington, 06032, USA
    J Neurosci Res 76:749-57. 2004
    ..Recent advances in our understanding of the composition of juxtaparanodal Kv1 channel protein complexes as well as the cellular and molecular mechanisms underlying their localization at juxtaparanodes are discussed...
  7. pmc ADAM22, a Kv1 channel-interacting protein, recruits membrane-associated guanylate kinases to juxtaparanodes of myelinated axons
    Yasuhiro Ogawa
    Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 30:1038-48. 2010
    ..2 and Caspr2 clustering is normal in ADAM22-null mice. Thus, ADAM22 is an axonal component of the Kv1 K(+) channel complex that recruits MAGUKs to juxtaparanodes...
  8. pmc Three mechanisms assemble central nervous system nodes of Ranvier
    Keiichiro Susuki
    Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA
    Neuron 78:469-82. 2013
    ..Our results demonstrate that ECM, paranodal, and axonal cytoskeletal mechanisms ensure robust CNS nodal Na⁺ channel clustering...
  9. ncbi request reprint BetaIV spectrins are essential for membrane stability and the molecular organization of nodes of Ranvier
    Yang Yang
    Department of Neuroscience, University of Connecticut Health Center, Farmington, Connecticut 06030 3401, USA
    J Neurosci 24:7230-40. 2004
    ..These results show that quivering mutations disrupt betaIV spectrin retention and stability at nodes and that distinct protein domains regulate nodal structural integrity and molecular organization...
  10. pmc Na+ channel-dependent recruitment of Navβ4 to axon initial segments and nodes of Ranvier
    Shelly A Buffington
    Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 33:6191-202. 2013
    ..Based on these results, we propose that differences in the specific composition of the Na(+) channel complexes enriched at the AIS and nodes contribute to the diverse physiologies observed among cell types...
  11. pmc Disruption of the axon initial segment cytoskeleton is a new mechanism for neuronal injury
    Dorothy P Schafer
    Department of Neuroscience, University of Connecticut Health Center, Farmington, Connecticut 06032, USA
    J Neurosci 29:13242-54. 2009
    ..We conclude that loss of AIS ion channel clusters and neuronal polarity are important contributors to neuronal dysfunction after injury, and that strategies to facilitate recovery must preserve or repair the AIS cytoskeleton...
  12. pmc Proteomic analysis of optic nerve lipid rafts reveals new paranodal proteins
    Yasuhiro Ogawa
    Department of Neuroscience, Baylor College of Medicine, Houston, Texas, USA
    J Neurosci Res 87:3502-10. 2009
    ..Finally, we describe their distribution in dysmyelinating TremblerJ mice, a model for the peripheral neuropathy Charcot-Marie-Tooth disease...
  13. pmc Postsynaptic density-93 clusters Kv1 channels at axon initial segments independently of Caspr2
    Yasuhiro Ogawa
    Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 28:5731-9. 2008
    ..In contrast, Caspr2, which mediates Kv1 channel clustering at the juxtaparanode, is not required for localization of Kv1 channels at the AIS. These results show PSD-93 mediates AIS accumulation of Kv1 channels independently of Caspr2...
  14. ncbi request reprint CNP is required for maintenance of axon-glia interactions at nodes of Ranvier in the CNS
    Matthew N Rasband
    Department of Neuroscience, University of Connecticut Health Center, Farmington, Connecticut 06032, USA
    Glia 50:86-90. 2005
    ..We suggest that CNP is a glial protein required for maintaining the integrity of paranodes and that disrupted axoglial signaling at this site underlies progressive axonal degeneration, observed later in the CNS of Cnp1-null mice...
  15. ncbi request reprint Spectrins and ankyrinB constitute a specialized paranodal cytoskeleton
    Yasuhiro Ogawa
    Department of Neuroscience, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    J Neurosci 26:5230-9. 2006
    ..Our results demonstrate that the paranodal junction contains specialized cytoskeletal components that may be important to stabilize axon-glia interactions and contribute to the membrane protein diffusion barrier found at paranodes...
  16. pmc A distal axonal cytoskeleton forms an intra-axonal boundary that controls axon initial segment assembly
    Mauricio R Galiano
    Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA
    Cell 149:1125-39. 2012
    ..Thus, the distal axonal cytoskeleton functions as an intra-axonal boundary restricting ankG to the AIS...
  17. pmc Neurofascin assembles a specialized extracellular matrix at the axon initial segment
    Kristian L Hedstrom
    Department of Neuroscience, University of Connecticut Health Center, Farmington, CT 06032, USA
    J Cell Biol 178:875-86. 2007
    ..Thus, NF-186 assembles and links the specialized brevican-containing AIS extracellular matrix to the intracellular cytoskeleton...
  18. pmc Schwann cell spectrins modulate peripheral nerve myelination
    Keiichiro Susuki
    Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 108:8009-14. 2011
    ..Therefore, we propose αII and βII spectrin in Schwann cells integrate the neuron-glia interactions mediated by membrane proteins into the actin-dependent cytoskeletal rearrangements necessary for myelination...
  19. pmc Genetic reduction of the α1 subunit of Na/K-ATPase corrects multiple hippocampal phenotypes in Angelman syndrome
    Hanoch Kaphzan
    Center for Neural Science, New York University, New York, NY 10003, USA
    Cell Rep 4:405-12. 2013
    ..These findings strongly suggest that increased expression of α1-NaKA plays an important role in a broad range of abnormalities in the hippocampus of AS model mice...
  20. ncbi request reprint Does paranode formation and maintenance require partitioning of neurofascin 155 into lipid rafts?
    Dorothy P Schafer
    Department of Neuroscience, University of Connecticut Health Center, Farmington, Connecticut 06032, USA
    J Neurosci 24:3176-85. 2004
    ..Together, these results suggest that trans interactions between oligodendroglial NF-155 and axonal ligands result in cross-linking, stabilization, and formation of paranodal lipid raft assemblies...
  21. pmc Molecular mechanisms of node of Ranvier formation
    Keiichiro Susuki
    Department of Neuroscience, Baylor College of Medicine, One Baylor Plaza, Houston TX 77030, USA
    Curr Opin Cell Biol 20:616-23. 2008
    ..In the central nervous system, both glial soluble factors and paranodal axoglial junctions may function in a complementary manner to contribute to node formation...
  22. doi request reprint Spectrin and ankyrin-based cytoskeletons at polarized domains in myelinated axons
    Keiichiro Susuki
    Department of Neuroscience, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Exp Biol Med (Maywood) 233:394-400. 2008
    ..Increased insights into the role of the cytoskeleton could provide important clues about the pathophysiology of various neurological disorders...
  23. pmc Where is the spike generator of the cochlear nerve? Voltage-gated sodium channels in the mouse cochlea
    Waheeda A Hossain
    Department of Neuroscience, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    J Neurosci 25:6857-68. 2005
    ....
  24. pmc The axon initial segment in nervous system disease and injury
    Shelly A Buffington
    Department of Neuroscience, Baylor College of Medicine, One Baylor Plaza, BCM295, Houston, TX 77030, USA
    Eur J Neurosci 34:1609-19. 2011
    ..Here, we consider the role of the AIS in nervous system disease and injury...
  25. pmc AnkyrinG is required for maintenance of the axon initial segment and neuronal polarity
    Kristian L Hedstrom
    Department of Neuroscience, University of Connecticut Health Center, Farmington, CT 06032, USA
    J Cell Biol 183:635-40. 2008
    ..Our results demonstrate that the loss of ankG causes axons to acquire the molecular characteristics of dendrites; thus, ankG is required for the maintenance of neuronal polarity and molecular organization of the AIS...
  26. ncbi request reprint Intrinsic and extrinsic determinants of ion channel localization in neurons
    Kristian L Hedstrom
    Department of Neuroscience, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    J Neurochem 98:1345-52. 2006
    ....
  27. doi request reprint The functional organization and assembly of the axon initial segment
    Yasuhiro Ogawa
    Department of Neuroscience, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Curr Opin Neurobiol 18:307-13. 2008
    ....
  28. pmc Clustering of neuronal potassium channels is independent of their interaction with PSD-95
    Matthew N Rasband
    Department of Biochemistry and Cell Biology, State University of New York at Stony Brook, Stony Brook, NY 11794, USA
    J Cell Biol 159:663-72. 2002
    ..These data suggest that the primary function of PSD-95 at juxtaparanodes lies outside of its accepted role in mediating the high density clustering of Kv1 potassium channels at these sites...
  29. ncbi request reprint The myelin-axolemmal complex: biochemical dissection and the role of galactosphingolipids
    Krishna Menon
    Department of Neuroscience, University of Connecticut Medical School, Farmington, Connecticut 06030 3401, USA
    J Neurochem 87:995-1009. 2003
    ..These results suggest a paradigm for identification of proteins involved in neuroglial signaling...
  30. pmc Alterations in intrinsic membrane properties and the axon initial segment in a mouse model of Angelman syndrome
    Hanoch Kaphzan
    Center for Neural Science, New York University, New York, New York 10003, USA
    J Neurosci 31:17637-48. 2011
    ..These findings are the first evidence for pathology of intrinsic membrane properties and AIS-specific changes in AS, a neurodevelopmental disorder associated with autism...
  31. pmc Dysfunction of nodes of Ranvier: a mechanism for anti-ganglioside antibody-mediated neuropathies
    Keiichiro Susuki
    Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA
    Exp Neurol 233:534-42. 2012
    ..Thus, nodal disruption may be a common mechanism in immune-mediated neuropathies associated with autoantibodies to gangliosides GM1, GD1a, or GD1b, providing an explanation for the continuous spectrum of AMAN, AMSAN, and ASAN...
  32. ncbi request reprint Glial regulation of the axonal membrane at nodes of Ranvier
    Dorothy P Schafer
    Department of Neuroscience, University of Connecticut Health Center, 263 Farmington Avenue, Farmington CT 06032, USA
    Curr Opin Neurobiol 16:508-14. 2006
    ..Subsequently, within each domain, axonal cell adhesion molecules are stabilized and retained through interactions with cytoskeletal and scaffolding proteins, including ankyrins and spectrins...
  33. doi request reprint Cytoskeleton: axons earn their stripes
    Matthew N Rasband
    Department of Neuroscience, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Curr Biol 23:R197-8. 2013
    ..New 'super-resolution' imaging of the submembranous axonal cytoskeleton reveals that it is organized in a periodic, ladder-like structure with alternating rings of actin linked together by intervening complexes of spectrin...
  34. pmc IκBα is not required for axon initial segment assembly
    Shelly A Buffington
    Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA
    Mol Cell Neurosci 50:1-9. 2012
    ..Our results indicate that pIκBα is neither enriched at the AIS nor required for AIS assembly...
  35. pmc Electrical excitability of early neurons in the human cerebral cortex during the second trimester of gestation
    Anna R Moore
    Department of Neuroscience, University of Connecticut Health Center, Farmington, CT 06030, USA
    Cereb Cortex 19:1795-805. 2009
    ..These results yield the first physiological characterization of developing human fetal cortical neurons with preserved morphologies in intact surrounding brain tissue...
  36. pmc Na+ channels get anchored...with a little help
    Matthew N Rasband
    Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA
    J Cell Biol 183:975-7. 2008
    ..The presence of CK2 at the axon initial segment and nodes of Ranvier provides a mechanism to regulate the specific accumulation and retention of Na(+) channels within these important domains...
  37. ncbi request reprint The axon initial segment and the maintenance of neuronal polarity
    Matthew N Rasband
    Department of Neuroscience, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Nat Rev Neurosci 11:552-62. 2010
    ..Here, I review the role of the AIS in the development and maintenance of neuronal polarity and discuss how disrupted polarity may be a common component of many diseases and injuries that affect the nervous system...
  38. pmc Proteomic mapping provides powerful insights into functional myelin biology
    Christopher M Taylor
    Department of Neuroscience, MC 3401, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030 3401, USA
    Proc Natl Acad Sci U S A 101:4643-8. 2004
    ..This proteomic map has been applied to analyses of the localization and function of selected proteins, providing a powerful tool to investigate the diverse functions of myelin...
  39. ncbi request reprint Gangliosides contribute to stability of paranodal junctions and ion channel clusters in myelinated nerve fibers
    Keiichiro Susuki
    Department of Neurology, Dokkyo Medical University School of Medicine, Kitakobayashi 880, Mibu, Shimotsuga, Tochigi 321 0293, Japan
    Glia 55:746-57. 2007
    ..These results indicate that gangliosides are lipid raft components that contribute to stability and maintenance of neuron-glia interactions at paranodes...
  40. ncbi request reprint Anti-GM1 antibodies cause complement-mediated disruption of sodium channel clusters in peripheral motor nerve fibers
    Keiichiro Susuki
    Department of Neurology and Research Institute for Neuroimmunological Diseases, Dokkyo Medical University School of Medicine, Tochigi 321 0293, Japan
    J Neurosci 27:3956-67. 2007
    ..Our findings support the idea that acute motor axonal neuropathy is a disease that specifically disrupts the nodes of Ranvier...
  41. pmc Blast wave exposure impairs memory and decreases axon initial segment length
    Kelli L Baalman
    Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurotrauma 30:741-51. 2013
    ..These results support the conclusion that exposure to a single blast wave can lead to mTBI with accompanying cognitive impairment and subcellular changes in the molecular organization of neurons...
  42. pmc Integrin-linked kinase is required for laminin-2-induced oligodendrocyte cell spreading and CNS myelination
    Soo Jin Chun
    Department of Neurology, Beth Israel Deaconess Medical Center, Center for Neurodegeneration and Repair and the Program in Neuroscience, Harvard Medical School, Boston, MA 02115, USA
    J Cell Biol 163:397-408. 2003
    ..A dominant negative ILK inhibits LN-2-induced myelinlike membrane formation. A critical component of the myelination signaling cascade includes LN-2 and integrin signals through ILK...
  43. pmc Neurofascin as a novel target for autoantibody-mediated axonal injury
    Emily K Mathey
    Department of Medicine and Therapeutics, Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, Scotland, UK
    J Exp Med 204:2363-72. 2007
    ..Collectively, these results identify a novel mechanism of immune-mediated axonal injury that can contribute to axonal pathology in MS...
  44. ncbi request reprint Age-related molecular reorganization at the node of Ranvier
    Jason D Hinman
    Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Comp Neurol 495:351-62. 2006
    ..Thus, age-dependent myelin alterations affect axonal protein localization and may be detrimental to maintenance of axonal conduction...
  45. pmc BetaIVSigma1 spectrin stabilizes the nodes of Ranvier and axon initial segments
    Sandra Lacas-Gervais
    Medical School, University of Technology Dresden, Fetscherstrasse 74, 01307 Dresden, Germany
    J Cell Biol 166:983-90. 2004
    ..These ultrastructural changes can explain the motor and auditory neuropathies present in betaIVSigma1 -/- mice and point to the betaIVSigma1 spectrin isoform as a master-stabilizing factor of AIS/NR membranes...
  46. ncbi request reprint WAVE1 is required for oligodendrocyte morphogenesis and normal CNS myelination
    Hyun Ju Kim
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 26:5849-59. 2006
    ..Together, these data demonstrate a role for WAVE1 in oligodendrocyte morphogenesis and myelination...
  47. ncbi request reprint alphaII-spectrin is essential for assembly of the nodes of Ranvier in myelinated axons
    Matthew G Voas
    Department of Developmental Biology, Stanford University School of Medicine, 279 Campus Drive, Stanford, California 94305
    Curr Biol 17:562-8. 2007
    ..Our results provide functional evidence that alphaII-spectrin in the axonal cytoskeleton is essential for stabilizing nascent sodium-channel clusters and assembling the mature node of Ranvier...