Research Topics
Genomes and Genes
| Matthew N RasbandSummaryAffiliation: University of Connecticut Health Center Country: USA Publications
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Detail Information
Publications
A central role for Necl4 (SynCAM4) in Schwann cell-axon interaction and myelinationIvo Spiegel
Department of Molecular Cell Biology, The Weizmann Institute of Science, POB 26, Rehovot 76100, Israel
Nat Neurosci 10:861-9. 2007..These results suggest that Necl proteins are important for mediating axon-glia contact during myelination in peripheral nerves...
Neuron-glia interactions at the node of RanvierMatthew N Rasband
Department of Neuroscience, University of Connecticut Health Center, Farmington 06030 3401, USA
Results Probl Cell Differ 43:129-49. 2006..This review will discuss several examples illustrating how myelinating glia actively regulate the excitable properties of axons including the kinds of channels expressed and their subcellular localization...- Dysregulation of axonal sodium channel isoforms after adult-onset chronic demyelinationMatthew N Rasband
Department of Biochemistry and Cell Biology, State University of New York at Stony Brook, Stony Brook, New York, USA
J Neurosci Res 73:465-70. 2003..The altered Nav channel isoform localization and complement induced by demyelination may contribute to the pathophysiology of demyelinating disorders and nerve injury... - Paranodal transverse bands are required for maintenance but not initiation of Nav1.6 sodium channel clustering in CNS optic nerve axonsMatthew N Rasband
Department of Neuroscience, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
Glia 44:173-82. 2003..6 clusters. Thus, transverse bands are not required for Nav1.6 clustering and localization at nodes or for exclusion of Nav1.2 from myelinated nerve fibers, but are required for the maintenance of nodal Nav1.6 cluster size and density... - It's "juxta" potassium channel!Matthew N Rasband
Department of Neuroscience, University of Connecticut Health Center, Farmington, 06032, USA
J Neurosci Res 76:749-57. 2004..Recent advances in our understanding of the composition of juxtaparanodal Kv1 channel protein complexes as well as the cellular and molecular mechanisms underlying their localization at juxtaparanodes are discussed... - ADAM22, a Kv1 channel-interacting protein, recruits membrane-associated guanylate kinases to juxtaparanodes of myelinated axonsYasuhiro Ogawa
Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
J Neurosci 30:1038-48. 2010..2 and Caspr2 clustering is normal in ADAM22-null mice. Thus, ADAM22 is an axonal component of the Kv1 K(+) channel complex that recruits MAGUKs to juxtaparanodes... - betaIV spectrin is recruited to axon initial segments and nodes of Ranvier by ankyrinGYang Yang
Department of Neuroscience, University of Connecticut Health Center, University of Connecticut, Farmington, CT 06032, USA
J Cell Biol 176:509-19. 2007..Finally, using adenovirus for transgene delivery into myelinated neurons, we demonstrate that betaIV spectrin recruitment to nodes of Ranvier also depends on binding to ankG... - Postsynaptic density-93 clusters Kv1 channels at axon initial segments independently of Caspr2Yasuhiro Ogawa
Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
J Neurosci 28:5731-9. 2008..In contrast, Caspr2, which mediates Kv1 channel clustering at the juxtaparanode, is not required for localization of Kv1 channels at the AIS. These results show PSD-93 mediates AIS accumulation of Kv1 channels independently of Caspr2... - CNP is required for maintenance of axon-glia interactions at nodes of Ranvier in the CNSMatthew N Rasband
Department of Neuroscience, University of Connecticut Health Center, Farmington, Connecticut 06032, USA
Glia 50:86-90. 2005..We suggest that CNP is a glial protein required for maintaining the integrity of paranodes and that disrupted axoglial signaling at this site underlies progressive axonal degeneration, observed later in the CNS of Cnp1-null mice... - Proteomic analysis of optic nerve lipid rafts reveals new paranodal proteinsYasuhiro Ogawa
Department of Neuroscience, Baylor College of Medicine, Houston, Texas, USA
J Neurosci Res 87:3502-10. 2009..Finally, we describe their distribution in dysmyelinating TremblerJ mice, a model for the peripheral neuropathy Charcot-Marie-Tooth disease... - Disruption of the axon initial segment cytoskeleton is a new mechanism for neuronal injuryDorothy P Schafer
Department of Neuroscience, University of Connecticut Health Center, Farmington, Connecticut 06032, USA
J Neurosci 29:13242-54. 2009..We conclude that loss of AIS ion channel clusters and neuronal polarity are important contributors to neuronal dysfunction after injury, and that strategies to facilitate recovery must preserve or repair the AIS cytoskeleton... - A distal axonal cytoskeleton forms an intra-axonal boundary that controls axon initial segment assemblyMauricio R Galiano
Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA
Cell 149:1125-39. 2012..Thus, the distal axonal cytoskeleton functions as an intra-axonal boundary restricting ankG to the AIS... - Neurofascin assembles a specialized extracellular matrix at the axon initial segmentKristian L Hedstrom
Department of Neuroscience, University of Connecticut Health Center, Farmington, CT 06032, USA
J Cell Biol 178:875-86. 2007..Thus, NF-186 assembles and links the specialized brevican-containing AIS extracellular matrix to the intracellular cytoskeleton... - Schwann cell spectrins modulate peripheral nerve myelinationKeiichiro Susuki
Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA
Proc Natl Acad Sci U S A 108:8009-14. 2011..Therefore, we propose αII and βII spectrin in Schwann cells integrate the neuron-glia interactions mediated by membrane proteins into the actin-dependent cytoskeletal rearrangements necessary for myelination... - Where is the spike generator of the cochlear nerve? Voltage-gated sodium channels in the mouse cochleaWaheeda A Hossain
Department of Neuroscience, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
J Neurosci 25:6857-68. 2005.... - Molecular mechanisms of node of Ranvier formationKeiichiro Susuki
Department of Neuroscience, Baylor College of Medicine, One Baylor Plaza, Houston TX 77030, USA
Curr Opin Cell Biol 20:616-23. 2008..In the central nervous system, both glial soluble factors and paranodal axoglial junctions may function in a complementary manner to contribute to node formation... - Spectrins and ankyrinB constitute a specialized paranodal cytoskeletonYasuhiro Ogawa
Department of Neuroscience, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
J Neurosci 26:5230-9. 2006..Our results demonstrate that the paranodal junction contains specialized cytoskeletal components that may be important to stabilize axon-glia interactions and contribute to the membrane protein diffusion barrier found at paranodes... 
Spectrin and ankyrin-based cytoskeletons at polarized domains in myelinated axonsKeiichiro Susuki
Department of Neuroscience, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Exp Biol Med (Maywood) 233:394-400. 2008..Increased insights into the role of the cytoskeleton could provide important clues about the pathophysiology of various neurological disorders...- The axon initial segment in nervous system disease and injuryShelly A Buffington
Department of Neuroscience, Baylor College of Medicine, One Baylor Plaza, BCM295, Houston, TX 77030, USA
Eur J Neurosci 34:1609-19. 2011..Here, we consider the role of the AIS in nervous system disease and injury... - The functional organization and assembly of the axon initial segmentYasuhiro Ogawa
Department of Neuroscience, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Curr Opin Neurobiol 18:307-13. 2008.... - AnkyrinG is required for maintenance of the axon initial segment and neuronal polarityKristian L Hedstrom
Department of Neuroscience, University of Connecticut Health Center, Farmington, CT 06032, USA
J Cell Biol 183:635-40. 2008..Our results demonstrate that the loss of ankG causes axons to acquire the molecular characteristics of dendrites; thus, ankG is required for the maintenance of neuronal polarity and molecular organization of the AIS... - Does paranode formation and maintenance require partitioning of neurofascin 155 into lipid rafts?Dorothy P Schafer
Department of Neuroscience, University of Connecticut Health Center, Farmington, Connecticut 06032, USA
J Neurosci 24:3176-85. 2004..Together, these results suggest that trans interactions between oligodendroglial NF-155 and axonal ligands result in cross-linking, stabilization, and formation of paranodal lipid raft assemblies... - Intrinsic and extrinsic determinants of ion channel localization in neuronsKristian L Hedstrom
Department of Neuroscience, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
J Neurochem 98:1345-52. 2006.... - BetaIV spectrins are essential for membrane stability and the molecular organization of nodes of RanvierYang Yang
Department of Neuroscience, University of Connecticut Health Center, Farmington, Connecticut 06030 3401, USA
J Neurosci 24:7230-40. 2004..These results show that quivering mutations disrupt betaIV spectrin retention and stability at nodes and that distinct protein domains regulate nodal structural integrity and molecular organization... - The myelin-axolemmal complex: biochemical dissection and the role of galactosphingolipidsKrishna Menon
Department of Neuroscience, University of Connecticut Medical School, Farmington, Connecticut 06030-3401, USA
J Neurochem 87:995-1009. 2003..These results suggest a paradigm for identification of proteins involved in neuroglial signaling... - Alterations in intrinsic membrane properties and the axon initial segment in a mouse model of Angelman syndromeHanoch Kaphzan
Center for Neural Science, New York University, New York, New York 10003, USA
J Neurosci 31:17637-48. 2011..These findings are the first evidence for pathology of intrinsic membrane properties and AIS-specific changes in AS, a neurodevelopmental disorder associated with autism... - Dysfunction of nodes of Ranvier: a mechanism for anti-ganglioside antibody-mediated neuropathiesKeiichiro Susuki
Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA
Exp Neurol 233:534-42. 2012..Thus, nodal disruption may be a common mechanism in immune-mediated neuropathies associated with autoantibodies to gangliosides GM1, GD1a, or GD1b, providing an explanation for the continuous spectrum of AMAN, AMSAN, and ASAN... - Glial regulation of the axonal membrane at nodes of RanvierDorothy P Schafer
Department of Neuroscience, University of Connecticut Health Center, 263 Farmington Avenue, Farmington CT 06032, USA
Curr Opin Neurobiol 16:508-14. 2006..Subsequently, within each domain, axonal cell adhesion molecules are stabilized and retained through interactions with cytoskeletal and scaffolding proteins, including ankyrins and spectrins... - Clustering of neuronal potassium channels is independent of their interaction with PSD-95Matthew N Rasband
Department of Biochemistry and Cell Biology, State University of New York at Stony Brook, Stony Brook, NY 11794, USA
J Cell Biol 159:663-72. 2002..These data suggest that the primary function of PSD-95 at juxtaparanodes lies outside of its accepted role in mediating the high density clustering of Kv1 potassium channels at these sites... - IκBα is not required for axon initial segment assemblyShelly A Buffington
Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA
Mol Cell Neurosci 50:1-9. 2012..Our results indicate that pIκBα is neither enriched at the AIS nor required for AIS assembly... - Proteomic mapping provides powerful insights into functional myelin biologyChristopher M Taylor
Department of Neuroscience, MC 3401, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030-3401, USA
Proc Natl Acad Sci U S A 101:4643-8. 2004..This proteomic map has been applied to analyses of the localization and function of selected proteins, providing a powerful tool to investigate the diverse functions of myelin... - Electrical excitability of early neurons in the human cerebral cortex during the second trimester of gestationAnna R Moore
Department of Neuroscience, University of Connecticut Health Center, Farmington, CT 06030, USA
Cereb Cortex 19:1795-805. 2009..These results yield the first physiological characterization of developing human fetal cortical neurons with preserved morphologies in intact surrounding brain tissue... - The axon initial segment and the maintenance of neuronal polarityMatthew N Rasband
Department of Neuroscience, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
Nat Rev Neurosci 11:552-62. 2010..Here, I review the role of the AIS in the development and maintenance of neuronal polarity and discuss how disrupted polarity may be a common component of many diseases and injuries that affect the nervous system... - Na+ channels get anchored...with a little helpMatthew N Rasband
Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA
J Cell Biol 183:975-7. 2008..The presence of CK2 at the axon initial segment and nodes of Ranvier provides a mechanism to regulate the specific accumulation and retention of Na(+) channels within these important domains... - Gangliosides contribute to stability of paranodal junctions and ion channel clusters in myelinated nerve fibersKeiichiro Susuki
Department of Neurology, Dokkyo Medical University School of Medicine, Kitakobayashi 880, Mibu, Shimotsuga, Tochigi 321 0293, Japan
Glia 55:746-57. 2007..These results indicate that gangliosides are lipid raft components that contribute to stability and maintenance of neuron-glia interactions at paranodes... - Anti-GM1 antibodies cause complement-mediated disruption of sodium channel clusters in peripheral motor nerve fibersKeiichiro Susuki
Department of Neurology and Research Institute for Neuroimmunological Diseases, Dokkyo Medical University School of Medicine, Tochigi 321 0293, Japan
J Neurosci 27:3956-67. 2007..Our findings support the idea that acute motor axonal neuropathy is a disease that specifically disrupts the nodes of Ranvier... - Age-related molecular reorganization at the node of RanvierJason D Hinman
Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
J Comp Neurol 495:351-62. 2006..Thus, age-dependent myelin alterations affect axonal protein localization and may be detrimental to maintenance of axonal conduction... - Integrin-linked kinase is required for laminin-2-induced oligodendrocyte cell spreading and CNS myelinationSoo Jin Chun
Department of Neurology, Beth Israel Deaconess Medical Center, Center for Neurodegeneration and Repair and the Program in Neuroscience, Harvard Medical School, Boston, MA 02115, USA
J Cell Biol 163:397-408. 2003..A dominant negative ILK inhibits LN-2-induced myelinlike membrane formation. A critical component of the myelination signaling cascade includes LN-2 and integrin signals through ILK... - Neurofascin as a novel target for autoantibody-mediated axonal injuryEmily K Mathey
Department of Medicine and Therapeutics, Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, Scotland, UK
J Exp Med 204:2363-72. 2007..Collectively, these results identify a novel mechanism of immune-mediated axonal injury that can contribute to axonal pathology in MS... - BetaIVSigma1 spectrin stabilizes the nodes of Ranvier and axon initial segmentsSandra Lacas-Gervais
Medical School, University of Technology Dresden, Fetscherstrasse 74, 01307 Dresden, Germany
J Cell Biol 166:983-90. 2004..These ultrastructural changes can explain the motor and auditory neuropathies present in betaIVSigma1 -/- mice and point to the betaIVSigma1 spectrin isoform as a master-stabilizing factor of AIS/NR membranes... - WAVE1 is required for oligodendrocyte morphogenesis and normal CNS myelinationHyun Ju Kim
Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA
J Neurosci 26:5849-59. 2006..Together, these data demonstrate a role for WAVE1 in oligodendrocyte morphogenesis and myelination... - alphaII-spectrin is essential for assembly of the nodes of Ranvier in myelinated axonsMatthew G Voas
Department of Developmental Biology, Stanford University School of Medicine, 279 Campus Drive, Stanford, California 94305
Curr Biol 17:562-8. 2007..Our results provide functional evidence that alphaII-spectrin in the axonal cytoskeleton is essential for stabilizing nascent sodium-channel clusters and assembling the mature node of Ranvier...