Stephen M Rappaport

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Low-dose metabolism of benzene in humans: science and obfuscation
    Stephen M Rappaport
    Superfund Research Program and Center for Exposure Biology, School of Public Health, University of California, Berkeley, CA 94720, USA
    Carcinogenesis 34:2-9. 2013
  2. doi request reprint Biomarkers intersect with the exposome
    Stephen M Rappaport
    Center for Exposure Biology, School of Public Health, University of California, Berkeley, CA 94720 7356, USA
    Biomarkers 17:483-9. 2012
  3. doi request reprint Adductomics: characterizing exposures to reactive electrophiles
    Stephen M Rappaport
    Center for Exposure Biology, School of Public Health and College of Chemistry, University of California, Berkeley, CA 94720 7356, USA
    Toxicol Lett 213:83-90. 2012
  4. doi request reprint Implications of the exposome for exposure science
    Stephen M Rappaport
    School of Public Health, University of California, Berkeley, California 4720, USA
    J Expo Sci Environ Epidemiol 21:5-9. 2011
  5. pmc Human benzene metabolism following occupational and environmental exposures
    Stephen M Rappaport
    School of Public Health, University of California, Berkeley, CA 94720 7356, USA
    Chem Biol Interact 184:189-95. 2010
  6. doi request reprint Discovering environmental causes of disease
    Stephen M Rappaport
    School of Public Health, University of California, Berkeley, CA 94720 7356, USA
    J Epidemiol Community Health 66:99-102. 2012
  7. pmc Evidence that humans metabolize benzene via two pathways
    Stephen M Rappaport
    School of Public Health, University of California at Berkeley, Berkeley, California 94720 7356, USA
    Environ Health Perspect 117:946-52. 2009
  8. ncbi request reprint Protein adducts as biomarkers of human benzene metabolism
    Stephen M Rappaport
    School of Public Health, University of North Carolina, Chapel Hill, NC 27599 7431, USA
    Chem Biol Interact 153:103-9. 2005
  9. pmc Albumin adducts of electrophilic benzene metabolites in benzene-exposed and control workers
    Yu Sheng Lin
    Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina, Chapel Hill, North Carolina 27599 7431, USA
    Environ Health Perspect 115:28-34. 2007
  10. ncbi request reprint Using urinary biomarkers to elucidate dose-related patterns of human benzene metabolism
    Sungkyoon Kim
    School of Public Health, University of North Carolina, Chapel Hill, NC 27599, and National Cancer Institute NCI, National Institutes of Health NIH, Department of Health and Human Services DHHS, Bethesda, MD 20892, USA
    Carcinogenesis 27:772-81. 2006

Research Grants

Detail Information

Publications72

  1. pmc Low-dose metabolism of benzene in humans: science and obfuscation
    Stephen M Rappaport
    Superfund Research Program and Center for Exposure Biology, School of Public Health, University of California, Berkeley, CA 94720, USA
    Carcinogenesis 34:2-9. 2013
    ..In addressing these criticisms, we show that the methods and arguments presented by Price et al. are scientifically unsound and that their results are unreliable...
  2. doi request reprint Biomarkers intersect with the exposome
    Stephen M Rappaport
    Center for Exposure Biology, School of Public Health, University of California, Berkeley, CA 94720 7356, USA
    Biomarkers 17:483-9. 2012
    ..Follow-up studies employ knowledge-driven designs to explore disease causality, prevention, diagnosis, prognosis and treatment...
  3. doi request reprint Adductomics: characterizing exposures to reactive electrophiles
    Stephen M Rappaport
    Center for Exposure Biology, School of Public Health and College of Chemistry, University of California, Berkeley, CA 94720 7356, USA
    Toxicol Lett 213:83-90. 2012
    ..Here, we selectively review the literature regarding the potential of adductomics to partially elucidate the human exposome, with particular attention to the HSA-Cys(34) subadductome...
  4. doi request reprint Implications of the exposome for exposure science
    Stephen M Rappaport
    School of Public Health, University of California, Berkeley, California 4720, USA
    J Expo Sci Environ Epidemiol 21:5-9. 2011
    ..By embracing the exposome as its operational paradigm, exposure science can play a major role in discovering and mitigating these exposures...
  5. pmc Human benzene metabolism following occupational and environmental exposures
    Stephen M Rappaport
    School of Public Health, University of California, Berkeley, CA 94720 7356, USA
    Chem Biol Interact 184:189-95. 2010
    ..1 ppm, 20 and 58% at 1 ppm, and 2.7 and 17% at 10 ppm. This indicates that the putative high-affinity enzyme was active primarily below 1 ppm and favored the ring-opening pathway...
  6. doi request reprint Discovering environmental causes of disease
    Stephen M Rappaport
    School of Public Health, University of California, Berkeley, CA 94720 7356, USA
    J Epidemiol Community Health 66:99-102. 2012
    ..Examples of this approach are cited from recent metabolomic studies of several complex chronic diseases...
  7. pmc Evidence that humans metabolize benzene via two pathways
    Stephen M Rappaport
    School of Public Health, University of California at Berkeley, Berkeley, California 94720 7356, USA
    Environ Health Perspect 117:946-52. 2009
    ..This led us to speculate that an unidentified metabolic pathway was mainly responsible for benzene metabolism at ambient levels...
  8. ncbi request reprint Protein adducts as biomarkers of human benzene metabolism
    Stephen M Rappaport
    School of Public Health, University of North Carolina, Chapel Hill, NC 27599 7431, USA
    Chem Biol Interact 153:103-9. 2005
    ..Thus, the biologically effective dose of BO and 1,4-BQ should be proportionally greater in persons exposed to low rather than high levels of benzene...
  9. pmc Albumin adducts of electrophilic benzene metabolites in benzene-exposed and control workers
    Yu Sheng Lin
    Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina, Chapel Hill, North Carolina 27599 7431, USA
    Environ Health Perspect 115:28-34. 2007
    ..Metabolism of benzene produces reactive electrophiles, including benzene oxide (BO), 1,4-benzoquinone (1,4-BQ), and 1,2-benzoquinone (1,2-BQ), that are capable of reacting with blood proteins to produce adducts...
  10. ncbi request reprint Using urinary biomarkers to elucidate dose-related patterns of human benzene metabolism
    Sungkyoon Kim
    School of Public Health, University of North Carolina, Chapel Hill, NC 27599, and National Cancer Institute NCI, National Institutes of Health NIH, Department of Health and Human Services DHHS, Bethesda, MD 20892, USA
    Carcinogenesis 27:772-81. 2006
    ..027 and 15.4 p.p.m. Reductions in metabolite production were most pronounced for CA and PH<1 p.p.m., indicating that metabolism favored production of the toxic metabolites, HQ and MA, at low exposures...
  11. pmc Chromosome-wide aneuploidy study (CWAS) in workers exposed to an established leukemogen, benzene
    Luoping Zhang
    Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA 94720, USA
    Carcinogenesis 32:605-12. 2011
    ..Together, these findings confirm that benzene exposure is associated with specific chromosomal aneuploidies in hematopoietic cells, which suggests that such aneuploidies may play roles in benzene-induced leukemogenesis...
  12. pmc Determinants of polycyclic aromatic hydrocarbon levels in house dust
    Todd Whitehead
    School of Public Health, University of California, Berkeley, California 94720, USA
    J Expo Sci Environ Epidemiol 21:123-32. 2011
    ..As self-reported data and outdoor PAH sources were only marginally predictive of observed PAH levels, we recommend that PAH concentrations be measured directly in dust samples for use in epidemiological studies...
  13. pmc Global gene expression profiling of a population exposed to a range of benzene levels
    Cliona M McHale
    School of Public Health, University of California Berkeley, Berkeley, California 64720, USA
    Environ Health Perspect 119:628-34. 2011
    ..Previously, we identified genes and pathways associated with exposure to high (> 10 ppm) levels of benzene through transcriptomic analyses of blood cells from a small number of occupationally exposed workers...
  14. ncbi request reprint Use of OctoChrome fluorescence in situ hybridization to detect specific aneuploidy among all 24 chromosomes in benzene-exposed workers
    Luoping Zhang
    School of Public Health, 140 Warren Hall, University of California, Berkeley, CA 94720 7360, USA
    Chem Biol Interact 153:117-22. 2005
    ..We are currently investigating potential mechanisms for this induction of selective aneuploidy...
  15. ncbi request reprint Rapid determination of six urinary benzene metabolites in occupationally exposed and unexposed subjects
    Suramya Waidyanatha
    Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7431, USA
    Anal Biochem 327:184-99. 2004
    ..Since all metabolites were detected in all control subjects, the method can be applied to persons exposed to environmental levels of benzene...
  16. ncbi request reprint Genetic polymorphisms and benzene metabolism in humans exposed to a wide range of air concentrations
    Sungkyoon Kim
    School of Public Health, University of North Carolina, Chapel Hill, NC 27599, USA
    Pharmacogenet Genomics 17:789-801. 2007
    ....
  17. doi request reprint Global gene expression response of a population exposed to benzene: a pilot study exploring the use of RNA-sequencing technology
    Reuben Thomas
    School of Public Health, University of California, Berkeley, California 94720 7356, USA
    Environ Mol Mutagen 54:566-73. 2013
    ..Overall, this pilot study shows that RNA-seq can complement the information obtained by microarray in the analysis of changes in transcript expression from chemical exposures...
  18. ncbi request reprint Use of 'Omic' technologies to study humans exposed to benzene
    Martyn T Smith
    School of Public Health, 140 Warren Hall, University of California, Berkeley, CA 94720 7360, USA
    Chem Biol Interact 153:123-7. 2005
    ..Omic technologies therefore have significant potential in generating novel biomarkers of exposure, susceptibility and response to benzene...
  19. pmc A sandwich enzyme-linked immunosorbent assay for adducts of polycyclic aromatic hydrocarbons with human serum albumin
    Ming Kei Chung
    School of Public Health, University of California, Berkeley, CA 94720, USA
    Anal Biochem 400:123-9. 2010
    ..05). The sandwich ELISA will be useful for screening PAH exposures in large epidemiologic studies and can be extended to other adducts for which capture antibodies are available...
  20. pmc PBTK modeling demonstrates contribution of dermal and inhalation exposure components to end-exhaled breath concentrations of naphthalene
    David Kim
    Department of Environmental Sciences and Engineering, School of Public Health, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7431, USA
    Environ Health Perspect 115:894-901. 2007
    ..However, a quantitative understanding of the relationship between external exposures and end-exhaled air concentrations has not been described for occupational and environmental exposure scenarios...
  21. pmc Changes in the peripheral blood transcriptome associated with occupational benzene exposure identified by cross-comparison on two microarray platforms
    Cliona M McHale
    School of Public Health, University of California, Berkeley, CA 94720, USA
    Genomics 93:343-9. 2009
    ..The two-platform approach allows for robust changes in the PBMC transcriptome of benzene-exposed individuals to be identified...
  22. ncbi request reprint Dose-dependent production of urinary naphthols among workers exposed to jet fuel (JP-8)
    Berrin Serdar
    Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7431, USA
    Am J Ind Med 46:234-44. 2004
    ..Jet propulsion fuel-8 (JP-8) is one of the largest sources of chemical exposures among Air Force personnel. Urinary naphthols have been suggested as useful biomarkers of exposure to JP-8...
  23. ncbi request reprint Naphthalene and its biomarkers as measures of occupational exposure to polycyclic aromatic hydrocarbons
    Stephen M Rappaport
    Department of Environmental Sciences and Engineering, School of Public Health, CB 7431, University of North Carolina, Chapel Hill, NC 27599 7431, USA
    J Environ Monit 6:413-6. 2004
    ..Since naphthalene has also been shown to be a respiratory carcinogen in several animal studies, it is also argued that naphthalene exposures should be monitored per se in industries with high levels of PAH...
  24. ncbi request reprint Albumin adducts of naphthalene metabolites as biomarkers of exposure to polycyclic aromatic hydrocarbons
    Suramya Waidyanatha
    Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina, Chapel Hill, North Carolina, USA
    Cancer Epidemiol Biomarkers Prev 13:117-24. 2004
    ..A negative relationship between 1,2-NPQ-Alb and age was observed, suggesting that cytochrome P450 c metabolism diminished with age at approximately 3%/year of life...
  25. ncbi request reprint Determination of dihydroxynaphthalenes in human urine by gas chromatography-mass spectrometry
    Renan Wu
    Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina, Chapel Hill, NC 27599 7431, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 826:206-13. 2005
    ..Since the DHNs are precursors of the naphthoquinones, which have been implicated as toxic products of naphthalene metabolism, measurements of urinary DHNs may have toxicological significance...
  26. ncbi request reprint Non-linear production of benzene oxide-albumin adducts with human exposure to benzene
    Stephen M Rappaport
    Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7400, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 778:367-74. 2002
    ..To our knowledge, this is the first study to investigate the linearity of human metabolism of a carcinogen based upon protein adducts...
  27. ncbi request reprint Identification of surrogate measures of diesel exhaust exposure in a controlled chamber study
    Jon R Sobus
    School of Public Health, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Environ Sci Technol 42:8822-8. 2008
    ..While Nap and Phe are not validated here as internal biomarkers of DE exposure, we are currently assessing human biological specimens collected during this study and will discuss those results in ensuing papers...
  28. pmc Systems biology of human benzene exposure
    Luoping Zhang
    Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA 94720 7356, USA
    Chem Biol Interact 184:86-93. 2010
    ....
  29. ncbi request reprint Measurement of hemoglobin and albumin adducts of naphthalene-1,2-oxide, 1,2-naphthoquinone and 1,4-naphthoquinone after administration of naphthalene to F344 rats
    Suramya Waidyanatha
    Department of Environmental Sciences and Engineering, CB 7400, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7400, USA
    Chem Biol Interact 141:189-210. 2002
    ..Low background levels of 1,2-NPQ-Hb and -Alb and 1,4-NPQ-Hb and -Alb were detected in control animals without known exposure to naphthalene. However, the corresponding NPO-Hb and -Alb adducts were not detected in control animals...
  30. pmc Polybrominated diphenyl ethers in residential dust: sources of variability
    Todd P Whitehead
    University of California, Berkeley, School of Public Health, 50 University Hall, MC 7360, Berkeley, CA 94720, USA
    Environ Int 57:11-24. 2013
    ..Our findings indicate that it may be feasible to use residential dust for retrospective assessment of PBDE exposures in studies of children's health (e.g., the Northern California Childhood Leukemia Study)...
  31. pmc Dermal exposure to jet fuel JP-8 significantly contributes to the production of urinary naphthols in fuel-cell maintenance workers
    Yi Chun E Chao
    Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7400, USA
    Environ Health Perspect 114:182-5. 2006
    ..Future work on dermal xenobiotic metabolism and toxicokinetic studies are warranted in order to gain additional knowledge on naphthalene metabolism in the skin and the contribution to systemic exposure...
  32. pmc Occupational exposure to formaldehyde, hematotoxicity, and leukemia-specific chromosome changes in cultured myeloid progenitor cells
    Luoping Zhang
    School of Public Health, University of California at Berkeley, Berkeley, California 94720, USA
    Cancer Epidemiol Biomarkers Prev 19:80-8. 2010
    ....
  33. doi request reprint Polychlorinated biphenyls in residential dust: sources of variability
    Todd P Whitehead
    University of California, Berkeley, School of Public Health, 50 University Hall MC 7360, Berkeley, California 94720, United States
    Environ Sci Technol 48:157-64. 2014
    ..Our findings suggest that it may be feasible to use residential dust for retrospective assessment of PCB exposures in studies of children's health. ..
  34. doi request reprint Cys34 adducts of reactive oxygen species in human serum albumin
    Hasmik Grigoryan
    Center for Exposure Biology, School of Public Health and College of Chemistry, University of California, 50 University Hall, Berkeley, CA 94720 7356, USA
    Chem Res Toxicol 25:1633-42. 2012
    ..Parallel measurements of a negative control detected only small amounts of the Cys34 sulfonic acid and the (proposed) sulfinamide and did not detect the sulfinic acid...
  35. ncbi request reprint Formation and removal of pentachlorophenol-derived protein adducts in rodent liver under acute, multiple, and chronic dosing regimens
    Chin Hsiang Tsai
    Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina, Chapel Hill 27599 7400, USA
    Toxicol Sci 73:26-35. 2003
    ..812-0.921). These results provide evidence that the kinetics of liver protein adducts were not influenced by the dosing regimen of PCP, a recognized toxicant of the liver...
  36. pmc Profiling Cys34 adducts of human serum albumin by fixed-step selected reaction monitoring
    He Li
    Center for Exposure Biology, Department of Chemistry, University of California, Berkeley, CA 94720, USA
    Mol Cell Proteomics 10:M110.004606. 2011
    ..With minor modifications, the FS-SRM methodology can be applied to other nucleophilic sites and proteins...
  37. doi request reprint Estimating exposures to indoor contaminants using residential dust
    Todd Whitehead
    School of Public Health, University of California, Berkeley, California 94720, USA
    J Expo Sci Environ Epidemiol 21:549-64. 2011
    ..We conclude our review with a discussion of the current gaps in knowledge of worldwide dust levels and suggestions for how residential-dust measurements could be used to describe human exposures to chemicals in developing countries...
  38. pmc Urinary biomarkers of exposure to jet fuel (JP-8)
    Berrin Serdar
    Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Environ Health Perspect 111:1760-4. 2003
    ..We conclude that urinary naphthalene and the naphthols can serve as biomarkers of exposure to jet fuel. Of these, the naphthols are probably more useful because of their greater abundance and slower elimination kinetics...
  39. pmc Occupational exposure to benzene and chromosomal structural aberrations in the sperm of Chinese men
    Francesco Marchetti
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA
    Environ Health Perspect 120:229-34. 2012
    ..We previously reported that occupational exposures near the U.S. Occupational Safety and Health Administration permissible exposure limit (8 hr) of 1 ppm was associated with sperm aneuploidy...
  40. ncbi request reprint Determination of polycyclic aromatic hydrocarbons in urine of coke oven workers by headspace solid phase microextraction and gas chromatography-mass spectrometry
    Suramya Waidyanatha
    Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina, Chapel Hill, NC 27599 7431, USA
    Chem Biol Interact 145:165-74. 2003
    ..Our results indicate that unmetabolized 2-, 3- and 4-ring PAHs can be measured in urine by HS-SPME. Such measurements can be used to investigate the uptake and metabolism of complex PAH mixtures in humans...
  41. pmc Is house-dust nicotine a good surrogate for household smoking?
    Todd Whitehead
    School of Public Health, University of California, Berkeley, CA 94720, USA
    Am J Epidemiol 169:1113-23. 2009
    ....
  42. doi request reprint Using liquid chromatography-tandem mass spectrometry to quantify monohydroxylated metabolites of polycyclic aromatic hydrocarbons in urine
    Frank Onyemauwa
    Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7431, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 877:1117-25. 2009
    ..628), presumably due to confounding by smoking. Metabolites of phenanthrene, an abundant PAH and the smallest to possess a bay region, are promising OHPAHs for characterizing both exposures to PAHs and the various metabolic pathways...
  43. pmc Hemoglobin adducts of benzene oxide in neonatal and adult dried blood spots
    William E Funk
    Department of Environmental Sciences and Engineering, School of Public Health, University of California at Chapel Hill, Chapel Hill, NC, USA
    Cancer Epidemiol Biomarkers Prev 17:1896-901. 2008
    ..Based upon the estimated variance of the benzene oxide-Hb levels, we had 80% power to detect a 1.7-fold difference in geometric mean levels of benzene oxide-Hb in our sample of nine subjects...
  44. pmc Polycyclic aromatic hydrocarbons in residential dust: sources of variability
    Todd P Whitehead
    School of Public Health, University of California, Berkeley, Berkeley, California, USA
    Environ Health Perspect 121:543-50. 2013
    ..There is interest in using residential dust to estimate human exposure to environmental contaminants...
  45. pmc Levels of nicotine in dust from homes of smokeless tobacco users
    Todd P Whitehead
    School of Public Health, University of California, Berkeley, CA
    Nicotine Tob Res 15:2045-52. 2013
    ....
  46. ncbi request reprint Characterization and quantification of cysteinyl adducts of benzene diol epoxide
    Suramya Waidyanatha
    Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7431, USA
    Chem Res Toxicol 18:1178-85. 2005
    ....
  47. pmc Benzene, the exposome and future investigations of leukemia etiology
    Martyn T Smith
    Genes and Environment Laboratory, School of Public Health, University of California, Berkeley, CA 94720 7356, USA
    Chem Biol Interact 192:155-9. 2011
    ..We propose that we should attempt to characterize the 'exposome' of human leukemia by using unbiased laboratory-based methods to find the unknown 'environmental' factors that contribute to leukemia etiology...
  48. ncbi request reprint Variability of environmental exposures to volatile organic compounds
    Stephen M Rappaport
    School of Public Health, University of North Carolina, Chapel Hill, NC, USA
    J Expo Anal Environ Epidemiol 14:92-107. 2004
    ..Yet, epidemiologists should be wary of investigating environmental VOCs without preliminary data with which to estimate the variance structure of exposure variables...
  49. ncbi request reprint Albumin adducts of benzene oxide and 1,4-benzoquinone as measures of human benzene metabolism
    Stephen M Rappaport
    School of Public Health, University of North Carolina, Chapel Hill, North Carolina 27599 7400, USA
    Cancer Res 62:1330-7. 2002
    ..This study illustrates that Alb adducts can be used to investigate the dispositions of reactive metabolites of procarcinogens in humans, provided that exposures are adequately characterized in the month preceding blood collection...
  50. doi request reprint A sandwich ELISA for measuring benzo[a]pyrene-albumin adducts in human plasma
    Ming Kei Chung
    Center for Exposure Biology, School of Public Health, University of California, Berkeley, CA 94720 7356, USA
    Anal Biochem 435:140-9. 2013
    ..280-2.88 ng BPDE-HSA/mg HSA) and from highway workers with and without exposure to asphalt emissions (range 0.346-13.9 ng BPDE-HSA/mg HSA) detected differences in BPDE-HSA levels in the a priori expected directions...
  51. pmc Air levels of carcinogenic polycyclic aromatic hydrocarbons after the World Trade Center disaster
    Joachim D Pleil
    Department of Environmental Sciences, School of Public Health, University of North Carolina, Chapel Hill, NC 27599 7431, USA
    Proc Natl Acad Sci U S A 101:11685-8. 2004
    ..Because no PAH-specific air sampling was conducted, this work provides the only systematic measurements, to our knowledge, of ambient PAHs after the WTC disaster...
  52. ncbi request reprint Self-collected breath sampling for monitoring low-level benzene exposures among automobile mechanics
    Peter P Egeghy
    Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina at Chapel Hill, 27599 7400, USA
    Ann Occup Hyg 46:489-500. 2002
    ....
  53. doi request reprint Antibody enrichment and mass spectrometry of albumin-cys34 adducts
    Ming Kei Chung
    Center for Exposure Biology, School of Public Health, University of California, Berkeley, California 94720, United States
    Chem Res Toxicol 27:400-7. 2014
    ..Identified peptides included Cys34 oxidation and cysteinylation products and modifications representing losses of water and Lys and transpeptidation of Arg. ..
  54. ncbi request reprint Stability of hemoglobin and albumin adducts of naphthalene oxide, 1,2-naphthoquinone, and 1,4-naphthoquinone
    Melissa A Troester
    Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7400, USA
    Toxicol Sci 68:314-21. 2002
    ..In addition, some limitations of current methods for estimating adduct instability were identified...
  55. ncbi request reprint Evidence for the formation of Michael adducts from reactions of (E,E)-muconaldehyde with glutathione and other thiols
    Alistair P Henderson
    Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7431, USA
    Bioorg Chem 33:363-73. 2005
    ..These experiments suggest that (Z,Z)-muconaldehyde, a putative metabolite of benzene, could lead to the long established urinary metabolite of benzene, (E,E)-muconic acid, via glutathione-mediated isomerization to (E,E)-muconaldehyde...
  56. ncbi request reprint Fractionation of protein adducts in rats and mice dosed with [14C]pentachlorophenol
    Chin Hsiang Tsai
    Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina, Chapel Hill, NC 27599 7400, USA
    Arch Toxicol 76:628-33. 2002
    ..However, the sum of all quantified adducts accounted for only 7-8% of total cysteinyl binding to Np and 2% to Cp, suggesting that other uncharacterized binding species may be important to the toxicity of PCP...
  57. pmc Carpet-dust chemicals as measures of exposure: Implications of variability
    Todd P Whitehead
    Division of Environmental Health Sciences, University of California, Berkeley, CA, USA
    Emerg Themes Epidemiol 9:2. 2012
    ..abstract:..
  58. doi request reprint Statistical modeling to determine sources of variability in exposures to welding fumes
    Sa Liu
    Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA 94720 7356, USA
    Ann Occup Hyg 55:305-18. 2011
    ..Exposures to total particulate matter (TP) and manganese (Mn) received by workers during welding and allied hot processes were analyzed to assess the sources and magnitudes of variability...
  59. ncbi request reprint Hematological changes among Chinese workers with a broad range of benzene exposures
    Qingshan Qu
    Nelson Institute of Environmental Medicine, New York University School of Medicine, Tuxedo, New York 10987, USA
    Am J Ind Med 42:275-85. 2002
    ..We examine hematological findings and their possible relations with exposure markers validated in a recent biomarker project conducted in Tianjin, China...
  60. ncbi request reprint Detailed exposure assessment for a molecular epidemiology study of benzene in two shoe factories in China
    Roel Vermeulen
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 6120 Executive Boulevard, Rockville, MD 20892, USA
    Ann Occup Hyg 48:105-16. 2004
    ..Our goal was to identify workers with a broad range of benzene exposures, for an epidemiologic study relating exposure to early biologic effects...
  61. ncbi request reprint Assessment of dermal exposure to benzene and toluene in shoe manufacturing by activated carbon cloth patches
    Roel Vermeulen
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Rockville, MD 20892, USA
    J Environ Monit 8:1143-8. 2006
    ..The aim of this investigation was to use activated carbon cloth (ACC) patches to study the probability and extent of dermal exposure to benzene and toluene in a shoe factory...
  62. ncbi request reprint On modelling metabolism-based biomarkers of exposure: a comparative analysis of nonlinear models with few repeated measurements
    Brent A Johnson
    Department of Biostatistics, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA
    Stat Med 26:1901-19. 2007
    ..Furthermore, the lognormal MLE can exhibit very poor small sample properties even under the true model. All methods are applied in a novel data analysis from a study of benzene-exposed workers in China...
  63. ncbi request reprint Lymphocyte toxicity and T cell receptor excision circles in workers exposed to benzene
    Qing Lan
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 6120 Executive Blvd, EPS 8109, Bethesda, MD 20892 7240, USA
    Chem Biol Interact 153:111-5. 2005
    ..Although our study does not rule out counterbalancing alterations of TREC levels in specific T cell subsets, benzene's lymphotoxicity does not appear to be mediated through diminished thymus function...
  64. pmc Hematotoxicity in workers exposed to low levels of benzene
    Qing Lan
    Division of Cancer Epidemiology and Genetics, National Cancer Institute NCI, National Institutes of Health NIH, Department of Health and Human Services DHHS, Bethesda, MD 20892, USA
    Science 306:1774-6. 2004
    ..Thus, hematotoxicity from exposure to benzene occurred at air levels of 1 ppm or less and may be particularly evident among genetically susceptible subpopulations...
  65. ncbi request reprint [Preliminary study on naphthalene-metabolites-albumin adduct as an exposure biomarker for coke oven workers]
    Yu fei Dai
    National Institute for Occupational Health and Poison Control, China Centers for Disease Control and Prevention, Beijing 100050, China
    Zhonghua Yu Fang Yi Xue Za Zhi 38:392-5. 2004
    ....
  66. ncbi request reprint Modeling human metabolism of benzene following occupational and environmental exposures
    Sungkyoon Kim
    School of Public Health, University of North Carolina, CB 7431, Chapel Hill, NC 27599
    Cancer Epidemiol Biomarkers Prev 15:2246-52. 2006
    ..Our results also suggest that GLM + NS models are ideal for evaluating nonlinear relationships between environmental exposures and levels of human biomarkers...
  67. ncbi request reprint Simultaneous determination of urinary 1- and 2-naphthols, 3- and 9-phenanthrols, and 1-pyrenol in coke oven workers
    Berrin Serdar
    Department of Environmental Sciences and Engineering, School of Public Health University of North Carolina, Chapel Hill, NC 27599 7431, USA
    Biomarkers 8:93-109. 2003
    ....
  68. ncbi request reprint Polymorphisms in cytokine and cellular adhesion molecule genes and susceptibility to hematotoxicity among workers exposed to benzene
    Qing Lan
    Division of Cancer Epidemiology, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, MD 20892 7240, USA
    Cancer Res 65:9574-81. 2005
    ..041) and increased (P = 0.076) CFU-GEMM progenitor cell colony formation in 29 benzene-exposed workers. This is the first report to provide evidence that SNPs in genes that regulate hematopoiesis influence benzene-induced hematotoxicity...
  69. ncbi request reprint Residual indoor contamination from world trade center rubble fires as indicated by polycyclic aromatic hydrocarbon profiles
    Joachim D Pleil
    Methods Development and Applications Branch, HEASD NERL ORD, United States Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Environ Sci Technol 40:1172-7. 2006
    ..We found that random samples collected approximately 3.5 years after the WTC event from occupied indoor spaces (primarily residential) in the New York area are not statistically distinguishable from contemporary city background...
  70. ncbi request reprint Utility of urinary 1-naphthol and 2-naphthol levels to assess environmental carbaryl and naphthalene exposure in an epidemiology study
    John D Meeker
    Department of Environmental Health Sciences, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Expo Sci Environ Epidemiol 17:314-20. 2007
    ..Conversely, studies of naphthalene-related outcomes may utilize 2N levels to estimate exposure...
  71. ncbi request reprint Polymorphisms in genes involved in DNA double-strand break repair pathway and susceptibility to benzene-induced hematotoxicity
    Min Shen
    Division of Cancer Epidemiology and Genetics, NCI, NIH, DHHS, Bethesda, MD 20892, USA
    Carcinogenesis 27:2083-9. 2006
    ..The effect of BRCA2 Ex11 +1487 A > G polymorphism was limited to granulocytes. These results suggest that genetic polymorphisms in WRN, TP53 and BRCA2 that maintain genomic stability impact benzene-induced hematotoxicity...
  72. pmc Health and environmental consequences of the world trade center disaster
    Philip J Landrigan
    Mount Sinai School of Medicine, New York, New York 10029, USA
    Environ Health Perspect 112:731-9. 2004
    ..Continuing follow-up of all exposed populations is required to document the long-term consequences of the disaster...

Research Grants2

  1. Biological Response Indicators of Environment Stress Centers
    Stephen Rappaport; Fiscal Year: 2007
    ....