S M Rappaport

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. ncbi request reprint Variability of environmental exposures to volatile organic compounds
    Stephen M Rappaport
    School of Public Health, University of North Carolina, Chapel Hill, NC, USA
    J Expo Anal Environ Epidemiol 14:92-107. 2004
  2. ncbi request reprint Naphthalene and its biomarkers as measures of occupational exposure to polycyclic aromatic hydrocarbons
    Stephen M Rappaport
    Department of Environmental Sciences and Engineering, School of Public Health, CB 7431, University of North Carolina, Chapel Hill, NC 27599 7431, USA
    J Environ Monit 6:413-6. 2004
  3. ncbi request reprint Modeling human metabolism of benzene following occupational and environmental exposures
    Sungkyoon Kim
    School of Public Health, University of North Carolina, CB 7431, Chapel Hill, NC 27599
    Cancer Epidemiol Biomarkers Prev 15:2246-52. 2006
  4. ncbi request reprint Protein adducts as biomarkers of human benzene metabolism
    Stephen M Rappaport
    School of Public Health, University of North Carolina, Chapel Hill, NC 27599 7431, USA
    Chem Biol Interact 153:103-9. 2005
  5. ncbi request reprint On the importance of exposure variability to the doses of volatile organic compounds
    S M Rappaport
    Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina, Chapel Hill, North Carolina 27599 7431, USA
    Toxicol Sci 83:224-36. 2005
  6. ncbi request reprint Protein adducts as dosimeters of human exposure to styrene, styrene-7,8-oxide, and benzene
    S M Rappaport
    School of Public Health, University of North Carolina, Chapel Hill 27599 7400, USA
    Toxicol Lett 108:117-26. 1999
  7. ncbi request reprint An investigation of factors contributing to styrene and styrene-7,8-oxide exposures in the reinforced-plastics industry
    L A Nylander-French
    Department of Environmental Sciences and Engineering, University of North Carolina, Chapel Hill 27599 7400, USA
    Ann Occup Hyg 43:99-105. 1999
  8. pmc Urinary naphthalene and phenanthrene as biomarkers of occupational exposure to polycyclic aromatic hydrocarbons
    J R Sobus
    School of Public Health, University of North Carolina, Chapel Hill, North Carolina, USA
    Occup Environ Med 66:99-104. 2009
  9. pmc Albumin adducts of electrophilic benzene metabolites in benzene-exposed and control workers
    Yu Sheng Lin
    Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina, Chapel Hill, North Carolina 27599 7431, USA
    Environ Health Perspect 115:28-34. 2007
  10. ncbi request reprint Physiological modeling of the relative contributions of styrene-7,8-oxide derived from direct inhalation and from styrene metabolism to the systemic dose in humans
    R Tornero-Velez
    Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7400, USA
    Toxicol Sci 64:151-61. 2001

Collaborators

Detail Information

Publications76

  1. ncbi request reprint Variability of environmental exposures to volatile organic compounds
    Stephen M Rappaport
    School of Public Health, University of North Carolina, Chapel Hill, NC, USA
    J Expo Anal Environ Epidemiol 14:92-107. 2004
    ..Yet, epidemiologists should be wary of investigating environmental VOCs without preliminary data with which to estimate the variance structure of exposure variables...
  2. ncbi request reprint Naphthalene and its biomarkers as measures of occupational exposure to polycyclic aromatic hydrocarbons
    Stephen M Rappaport
    Department of Environmental Sciences and Engineering, School of Public Health, CB 7431, University of North Carolina, Chapel Hill, NC 27599 7431, USA
    J Environ Monit 6:413-6. 2004
    ..Since naphthalene has also been shown to be a respiratory carcinogen in several animal studies, it is also argued that naphthalene exposures should be monitored per se in industries with high levels of PAH...
  3. ncbi request reprint Modeling human metabolism of benzene following occupational and environmental exposures
    Sungkyoon Kim
    School of Public Health, University of North Carolina, CB 7431, Chapel Hill, NC 27599
    Cancer Epidemiol Biomarkers Prev 15:2246-52. 2006
    ..Our results also suggest that GLM + NS models are ideal for evaluating nonlinear relationships between environmental exposures and levels of human biomarkers...
  4. ncbi request reprint Protein adducts as biomarkers of human benzene metabolism
    Stephen M Rappaport
    School of Public Health, University of North Carolina, Chapel Hill, NC 27599 7431, USA
    Chem Biol Interact 153:103-9. 2005
    ..Thus, the biologically effective dose of BO and 1,4-BQ should be proportionally greater in persons exposed to low rather than high levels of benzene...
  5. ncbi request reprint On the importance of exposure variability to the doses of volatile organic compounds
    S M Rappaport
    Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina, Chapel Hill, North Carolina 27599 7431, USA
    Toxicol Sci 83:224-36. 2005
    ....
  6. ncbi request reprint Protein adducts as dosimeters of human exposure to styrene, styrene-7,8-oxide, and benzene
    S M Rappaport
    School of Public Health, University of North Carolina, Chapel Hill 27599 7400, USA
    Toxicol Lett 108:117-26. 1999
    ..Levels of these background adducts were too great to have arisen from non-occupational exposures to styrene or benzene or from cigarette smoking...
  7. ncbi request reprint An investigation of factors contributing to styrene and styrene-7,8-oxide exposures in the reinforced-plastics industry
    L A Nylander-French
    Department of Environmental Sciences and Engineering, University of North Carolina, Chapel Hill 27599 7400, USA
    Ann Occup Hyg 43:99-105. 1999
    ..The type of mixed-models regression analysis employed in this study can be used for clarifying the underlying patterns for exposures to styrene and SO as well as for evaluating preventive measures...
  8. pmc Urinary naphthalene and phenanthrene as biomarkers of occupational exposure to polycyclic aromatic hydrocarbons
    J R Sobus
    School of Public Health, University of North Carolina, Chapel Hill, North Carolina, USA
    Occup Environ Med 66:99-104. 2009
    ..The study investigated the utility of unmetabolised naphthalene (Nap) and phenanthrene (Phe) in urine as surrogates for exposures to mixtures of polycyclic aromatic hydrocarbons (PAHs)...
  9. pmc Albumin adducts of electrophilic benzene metabolites in benzene-exposed and control workers
    Yu Sheng Lin
    Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina, Chapel Hill, North Carolina 27599 7431, USA
    Environ Health Perspect 115:28-34. 2007
    ..Metabolism of benzene produces reactive electrophiles, including benzene oxide (BO), 1,4-benzoquinone (1,4-BQ), and 1,2-benzoquinone (1,2-BQ), that are capable of reacting with blood proteins to produce adducts...
  10. ncbi request reprint Physiological modeling of the relative contributions of styrene-7,8-oxide derived from direct inhalation and from styrene metabolism to the systemic dose in humans
    R Tornero-Velez
    Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7400, USA
    Toxicol Sci 64:151-61. 2001
    ..We conclude that future studies should assess exposures to airborne SO as well as styrene...
  11. pmc Air samples versus biomarkers for epidemiology
    Y S Lin
    Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina, Chapel Hill, North Carolina, USA
    Occup Environ Med 62:750-60. 2005
    ..It has been speculated on theoretical grounds that biomarkers are superior surrogates for chemical exposures to air samples in epidemiology studies...
  12. pmc Predictors of occupational exposure to styrene and styrene-7,8-oxide in the reinforced plastics industry
    B Serdar
    Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7431, USA
    Occup Environ Med 63:707-12. 2006
    ..To identify demographic and work related factors that predict blood levels of styrene and styrene-7,8-oxide (SO) in the fibreglass reinforced plastics (FRP) industry...
  13. ncbi request reprint Relationships between levels of volatile organic compounds in air and blood from the general population
    Y S Lin
    Department of Environmental and Occupational Health, School of Public Health, University of North Texas Health Science Center, Fort Worth, Texas, USA
    J Expo Sci Environ Epidemiol 18:421-9. 2008
    ..Investigators should consider interaction effects of exposure levels and smoking when exploring the blood-air relationships of the BTEX compounds in the general population...
  14. pmc The use of protein adducts to investigate the disposition of reactive metabolites of benzene
    S M Rappaport
    Department of Environmental Sciences and Engineering, University of North Carolina, Chapel Hill 27599 7400, USA
    Environ Health Perspect 104:1235-7. 1996
    ..High background levels of 1,2-BQ and 1,4-BQ adducts were also detected in both species, indicating that the toxic effects of quinone metabolites may only be important at high levels of benzene exposure...
  15. ncbi request reprint Albumin adducts of naphthalene metabolites as biomarkers of exposure to polycyclic aromatic hydrocarbons
    Suramya Waidyanatha
    Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina, Chapel Hill, North Carolina, USA
    Cancer Epidemiol Biomarkers Prev 13:117-24. 2004
    ..A negative relationship between 1,2-NPQ-Alb and age was observed, suggesting that cytochrome P450 c metabolism diminished with age at approximately 3%/year of life...
  16. pmc Benzene and naphthalene in air and breath as indicators of exposure to jet fuel
    P P Egeghy
    Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7431, USA
    Occup Environ Med 60:969-76. 2003
    ..To estimate exposures to benzene and naphthalene among military personnel working with jet fuel (JP-8) and to determine whether naphthalene might serve as a surrogate for JP-8 in studies of health effects...
  17. ncbi request reprint Determination of styrene and styrene-7,8-oxide in human blood by gas chromatography-mass spectrometry
    R Tornero-Velez
    Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina at Chapel Hill, 27599-7400, USA
    J Chromatogr B Biomed Sci Appl 757:59-68. 2001
    ..The two assays for SO in blood appear to be unbiased and to have sufficient sensitivity and specificity for applications involving workers exposed to styrene and SO during the manufacture of reinforced plastics...
  18. ncbi request reprint Protein adducts of 1,4-benzoquinone and benzene oxide among smokers and nonsmokers exposed to benzene in China
    N Rothman
    Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7400, USA
    Cancer Epidemiol Biomarkers Prev 10:831-8. 2001
    ..Interestingly, cigarette smoking increased Alb adducts of 1,4-BQ but not of BO, suggesting that benzene from cigarette smoke was not the primary contributor to the 1,4-BQ adducts...
  19. ncbi request reprint Determination of polycyclic aromatic hydrocarbons in urine of coke oven workers by headspace solid phase microextraction and gas chromatography-mass spectrometry
    Suramya Waidyanatha
    Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina, Chapel Hill, NC 27599 7431, USA
    Chem Biol Interact 145:165-74. 2003
    ..Our results indicate that unmetabolized 2-, 3- and 4-ring PAHs can be measured in urine by HS-SPME. Such measurements can be used to investigate the uptake and metabolism of complex PAH mixtures in humans...
  20. ncbi request reprint Simultaneous determination of urinary 1- and 2-naphthols, 3- and 9-phenanthrols, and 1-pyrenol in coke oven workers
    Berrin Serdar
    Department of Environmental Sciences and Engineering, School of Public Health University of North Carolina, Chapel Hill, NC 27599 7431, USA
    Biomarkers 8:93-109. 2003
    ....
  21. ncbi request reprint Exposure reconstruction for reducing uncertainty in risk assessment: example using MTBE biomarkers and a simple pharmacokinetic model
    J D Pleil
    Human Exposure and Atmospheric Sciences Division, National Exposure Research Laboratory Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, NC, USA
    Biomarkers 12:331-48. 2007
    ..These techniques could be applied to broader ranges of environmental contaminants to assess cumulative exposure risks if ADME (Absorption, Distribution, Metabolization and Excretion) is understood and systemic biomarkers can be measured...
  22. pmc A sandwich enzyme-linked immunosorbent assay for adducts of polycyclic aromatic hydrocarbons with human serum albumin
    Ming Kei Chung
    School of Public Health, University of California, Berkeley, CA 94720, USA
    Anal Biochem 400:123-9. 2010
    ..05). The sandwich ELISA will be useful for screening PAH exposures in large epidemiologic studies and can be extended to other adducts for which capture antibodies are available...
  23. pmc Leukemia-related chromosomal loss detected in hematopoietic progenitor cells of benzene-exposed workers
    L Zhang
    School of Public Health, Division of Environmental Health Sciences, University of California, Berkeley, CA, USA
    Leukemia 26:2494-8. 2012
    ....
  24. ncbi request reprint Characterization of metabolic activation of pentachlorophenol to quinones and semiquinones in rodent liver
    C H Tsai
    Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina, CB7400, Chapel Hill, NC 27599-7400, USA
    Chem Biol Interact 134:55-71. 2001
    ..This implies that, under conditions of oxidative stress, endogenous lipid hydroperoxides may increase PCP metabolism sufficiently to enhance the toxicity and carcinogenicity of PCP...
  25. ncbi request reprint Simultaneous assessment of occupational exposures from multiple worker groups
    M A Weaver
    Department of Biostatistics, School of Public Health, University of North Carolina, Chapel Hill, NC 27599-7400, USA
    Ann Occup Hyg 45:525-42. 2001
    ....
  26. ncbi request reprint Variability of albumin adducts of 1,4-benzoquinone, a toxic metabolite of benzene, in human volunteers
    Y S Lin
    Department of Environmental Sciences and Engineering, University of North Carolina, Chapel Hill, NC 27599, USA
    Biomarkers 11:14-27. 2006
    ..The observations indicate that levels of 1,4-BQ-Alb cover a wide range in the general population, and they support the hypotheses that demographic, diet and lifestyle factors are contributing sources...
  27. ncbi request reprint Application of mixed models to assess exposures monitored by construction workers during hot processes
    S M Rappaport
    School of Public Health, University of North Carolina, Chapel Hill 27599 7400, USA
    Ann Occup Hyg 43:457-69. 1999
    ....
  28. pmc Urinary biomarkers of exposure to jet fuel (JP-8)
    Berrin Serdar
    Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Environ Health Perspect 111:1760-4. 2003
    ..We conclude that urinary naphthalene and the naphthols can serve as biomarkers of exposure to jet fuel. Of these, the naphthols are probably more useful because of their greater abundance and slower elimination kinetics...
  29. ncbi request reprint Rapid determination of six urinary benzene metabolites in occupationally exposed and unexposed subjects
    Suramya Waidyanatha
    Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7431, USA
    Anal Biochem 327:184-99. 2004
    ..Since all metabolites were detected in all control subjects, the method can be applied to persons exposed to environmental levels of benzene...
  30. ncbi request reprint Investigation of cysteinyl protein adducts of benzene diolepoxide
    Suramya Waidyanatha
    Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7400, USA suramya unc edu
    Chem Biol Interact 153:261-6. 2005
    ..Reaction products between these and L-cysteine, and GSH were identified and characterized by mass spectrometry in an attempt to develop an assay to quantify these adducts in serum albumin...
  31. ncbi request reprint Non-linear production of benzene oxide-albumin adducts with human exposure to benzene
    Stephen M Rappaport
    Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7400, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 778:367-74. 2002
    ..To our knowledge, this is the first study to investigate the linearity of human metabolism of a carcinogen based upon protein adducts...
  32. ncbi request reprint Albumin adducts of benzene oxide and 1,4-benzoquinone as measures of human benzene metabolism
    Stephen M Rappaport
    School of Public Health, University of North Carolina, Chapel Hill, North Carolina 27599 7400, USA
    Cancer Res 62:1330-7. 2002
    ..This study illustrates that Alb adducts can be used to investigate the dispositions of reactive metabolites of procarcinogens in humans, provided that exposures are adequately characterized in the month preceding blood collection...
  33. ncbi request reprint Dose-dependent production of urinary naphthols among workers exposed to jet fuel (JP-8)
    Berrin Serdar
    Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7431, USA
    Am J Ind Med 46:234-44. 2004
    ..Jet propulsion fuel-8 (JP-8) is one of the largest sources of chemical exposures among Air Force personnel. Urinary naphthols have been suggested as useful biomarkers of exposure to JP-8...
  34. pmc Comparing urinary biomarkers of airborne and dermal exposure to polycyclic aromatic compounds in asphalt-exposed workers
    Jon R Sobus
    Department of Environmental Sciences and Engineering, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA
    Ann Occup Hyg 53:561-71. 2009
    ....
  35. doi request reprint Hemoglobin and albumin adducts of naphthalene-1,2-oxide, 1,2-naphthoquinone and 1,4-naphthoquinone in Swiss Webster mice
    Suramya Waidyanatha
    Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7431, United States
    Chem Biol Interact 172:105-14. 2008
    ..This suggests that mice could be more susceptible than rats to the toxic effects of naphthalene due to more pronounced depletion of glutathione at a given dose...
  36. ncbi request reprint Evidence for the formation of Michael adducts from reactions of (E,E)-muconaldehyde with glutathione and other thiols
    Alistair P Henderson
    Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7431, USA
    Bioorg Chem 33:363-73. 2005
    ..These experiments suggest that (Z,Z)-muconaldehyde, a putative metabolite of benzene, could lead to the long established urinary metabolite of benzene, (E,E)-muconic acid, via glutathione-mediated isomerization to (E,E)-muconaldehyde...
  37. ncbi request reprint Use of OctoChrome fluorescence in situ hybridization to detect specific aneuploidy among all 24 chromosomes in benzene-exposed workers
    Luoping Zhang
    School of Public Health, 140 Warren Hall, University of California, Berkeley, CA 94720 7360, USA
    Chem Biol Interact 153:117-22. 2005
    ..We are currently investigating potential mechanisms for this induction of selective aneuploidy...
  38. ncbi request reprint Identification of surrogate measures of diesel exhaust exposure in a controlled chamber study
    Jon R Sobus
    School of Public Health, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Environ Sci Technol 42:8822-8. 2008
    ..While Nap and Phe are not validated here as internal biomarkers of DE exposure, we are currently assessing human biological specimens collected during this study and will discuss those results in ensuing papers...
  39. pmc Is house-dust nicotine a good surrogate for household smoking?
    Todd Whitehead
    School of Public Health, University of California, Berkeley, CA 94720, USA
    Am J Epidemiol 169:1113-23. 2009
    ....
  40. pmc Investigation of PAH biomarkers in the urine of workers exposed to hot asphalt
    Jon R Sobus
    Department of Environmental Sciences and Engineering, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA
    Ann Occup Hyg 53:551-60. 2009
    ..These results support the use of U-Nap, U-Phe, OH-Phe, and OH-Pyr, but probably not OH-Nap, as short-term biomarkers of exposure to PAHs emanating from hot asphalt...
  41. pmc Human benzene metabolism following occupational and environmental exposures
    Stephen M Rappaport
    School of Public Health, University of California, Berkeley, CA 94720 7356, USA
    Chem Biol Interact 184:189-95. 2010
    ..1 ppm, 20 and 58% at 1 ppm, and 2.7 and 17% at 10 ppm. This indicates that the putative high-affinity enzyme was active primarily below 1 ppm and favored the ring-opening pathway...
  42. doi request reprint Using liquid chromatography-tandem mass spectrometry to quantify monohydroxylated metabolites of polycyclic aromatic hydrocarbons in urine
    Frank Onyemauwa
    Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7431, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 877:1117-25. 2009
    ..628), presumably due to confounding by smoking. Metabolites of phenanthrene, an abundant PAH and the smallest to possess a bay region, are promising OHPAHs for characterizing both exposures to PAHs and the various metabolic pathways...
  43. ncbi request reprint Determination of dihydroxynaphthalenes in human urine by gas chromatography-mass spectrometry
    Renan Wu
    Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina, Chapel Hill, NC 27599 7431, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 826:206-13. 2005
    ..Since the DHNs are precursors of the naphthoquinones, which have been implicated as toxic products of naphthalene metabolism, measurements of urinary DHNs may have toxicological significance...
  44. ncbi request reprint Measurement of hemoglobin and albumin adducts of naphthalene-1,2-oxide, 1,2-naphthoquinone and 1,4-naphthoquinone after administration of naphthalene to F344 rats
    Suramya Waidyanatha
    Department of Environmental Sciences and Engineering, CB 7400, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7400, USA
    Chem Biol Interact 141:189-210. 2002
    ..Low background levels of 1,2-NPQ-Hb and -Alb and 1,4-NPQ-Hb and -Alb were detected in control animals without known exposure to naphthalene. However, the corresponding NPO-Hb and -Alb adducts were not detected in control animals...
  45. ncbi request reprint Self-collected breath sampling for monitoring low-level benzene exposures among automobile mechanics
    Peter P Egeghy
    Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina at Chapel Hill, 27599 7400, USA
    Ann Occup Hyg 46:489-500. 2002
    ....
  46. ncbi request reprint Use of 'Omic' technologies to study humans exposed to benzene
    Martyn T Smith
    School of Public Health, 140 Warren Hall, University of California, Berkeley, CA 94720 7360, USA
    Chem Biol Interact 153:123-7. 2005
    ..Omic technologies therefore have significant potential in generating novel biomarkers of exposure, susceptibility and response to benzene...
  47. ncbi request reprint Stability of hemoglobin and albumin adducts of naphthalene oxide, 1,2-naphthoquinone, and 1,4-naphthoquinone
    Melissa A Troester
    Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7400, USA
    Toxicol Sci 68:314-21. 2002
    ..In addition, some limitations of current methods for estimating adduct instability were identified...
  48. pmc Evidence that humans metabolize benzene via two pathways
    Stephen M Rappaport
    School of Public Health, University of California at Berkeley, Berkeley, California 94720 7356, USA
    Environ Health Perspect 117:946-52. 2009
    ..This led us to speculate that an unidentified metabolic pathway was mainly responsible for benzene metabolism at ambient levels...
  49. ncbi request reprint Genetic polymorphisms and benzene metabolism in humans exposed to a wide range of air concentrations
    Sungkyoon Kim
    School of Public Health, University of North Carolina, Chapel Hill, NC 27599, USA
    Pharmacogenet Genomics 17:789-801. 2007
    ....
  50. pmc Hemoglobin adducts of benzene oxide in neonatal and adult dried blood spots
    William E Funk
    Department of Environmental Sciences and Engineering, School of Public Health, University of California at Chapel Hill, Chapel Hill, NC, USA
    Cancer Epidemiol Biomarkers Prev 17:1896-901. 2008
    ..Based upon the estimated variance of the benzene oxide-Hb levels, we had 80% power to detect a 1.7-fold difference in geometric mean levels of benzene oxide-Hb in our sample of nine subjects...
  51. pmc Air levels of carcinogenic polycyclic aromatic hydrocarbons after the World Trade Center disaster
    Joachim D Pleil
    Department of Environmental Sciences, School of Public Health, University of North Carolina, Chapel Hill, NC 27599 7431, USA
    Proc Natl Acad Sci U S A 101:11685-8. 2004
    ..Because no PAH-specific air sampling was conducted, this work provides the only systematic measurements, to our knowledge, of ambient PAHs after the WTC disaster...
  52. pmc Dermal exposure to jet fuel JP-8 significantly contributes to the production of urinary naphthols in fuel-cell maintenance workers
    Yi Chun E Chao
    Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7400, USA
    Environ Health Perspect 114:182-5. 2006
    ..Future work on dermal xenobiotic metabolism and toxicokinetic studies are warranted in order to gain additional knowledge on naphthalene metabolism in the skin and the contribution to systemic exposure...
  53. ncbi request reprint Using urinary biomarkers to elucidate dose-related patterns of human benzene metabolism
    Sungkyoon Kim
    School of Public Health, University of North Carolina, Chapel Hill, NC 27599, and National Cancer Institute NCI, National Institutes of Health NIH, Department of Health and Human Services DHHS, Bethesda, MD 20892, USA
    Carcinogenesis 27:772-81. 2006
    ..027 and 15.4 p.p.m. Reductions in metabolite production were most pronounced for CA and PH<1 p.p.m., indicating that metabolism favored production of the toxic metabolites, HQ and MA, at low exposures...
  54. pmc PBTK modeling demonstrates contribution of dermal and inhalation exposure components to end-exhaled breath concentrations of naphthalene
    David Kim
    Department of Environmental Sciences and Engineering, School of Public Health, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7431, USA
    Environ Health Perspect 115:894-901. 2007
    ..However, a quantitative understanding of the relationship between external exposures and end-exhaled air concentrations has not been described for occupational and environmental exposure scenarios...
  55. ncbi request reprint Commentary: two seminal contributions of S. A. Roach to the evaluation and control of hazardous substances in air
    S M Rappaport
    School of Public Health, University of North Carolina, Chapel Hill, NC 27599 7431, USA
    Ann Occup Hyg 47:343-8. 2003
    ..The profession can still learn a great deal from these seminal contributions...
  56. pmc Changes in the peripheral blood transcriptome associated with occupational benzene exposure identified by cross-comparison on two microarray platforms
    Cliona M McHale
    School of Public Health, University of California, Berkeley, CA 94720, USA
    Genomics 93:343-9. 2009
    ..The two-platform approach allows for robust changes in the PBMC transcriptome of benzene-exposed individuals to be identified...
  57. pmc Occupational exposure to formaldehyde, hematotoxicity, and leukemia-specific chromosome changes in cultured myeloid progenitor cells
    Luoping Zhang
    School of Public Health, University of California at Berkeley, Berkeley, California 94720, USA
    Cancer Epidemiol Biomarkers Prev 19:80-8. 2010
    ....
  58. pmc Enrichment of cysteinyl adducts of human serum albumin
    William E Funk
    Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC 27599, USA
    Anal Biochem 400:61-8. 2010
    ..We conclude that thiol-affinity resins can efficiently remove mercaptalbumin from HSA samples prior to characterization and quantitation of protein adducts of reactive systemic electrophiles...
  59. ncbi request reprint Characterization and quantification of cysteinyl adducts of benzene diol epoxide
    Suramya Waidyanatha
    Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7431, USA
    Chem Res Toxicol 18:1178-85. 2005
    ....
  60. ncbi request reprint Excessive exposure to silica in the US construction industry
    S M Rappaport
    School of Public Health, University of North Carolina, Chapel Hill, NC 27599 7431, USA
    Ann Occup Hyg 47:111-22. 2003
    ..It is concluded that urgent action is required to reduce silica exposures in the US construction industry...
  61. ncbi request reprint Fractionation of protein adducts in rats and mice dosed with [14C]pentachlorophenol
    Chin Hsiang Tsai
    Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina, Chapel Hill, NC 27599 7400, USA
    Arch Toxicol 76:628-33. 2002
    ..However, the sum of all quantified adducts accounted for only 7-8% of total cysteinyl binding to Np and 2% to Cp, suggesting that other uncharacterized binding species may be important to the toxicity of PCP...
  62. ncbi request reprint Formation and removal of pentachlorophenol-derived protein adducts in rodent liver under acute, multiple, and chronic dosing regimens
    Chin Hsiang Tsai
    Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina, Chapel Hill 27599 7400, USA
    Toxicol Sci 73:26-35. 2003
    ..812-0.921). These results provide evidence that the kinetics of liver protein adducts were not influenced by the dosing regimen of PCP, a recognized toxicant of the liver...
  63. pmc Systems biology of human benzene exposure
    Luoping Zhang
    Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA 94720 7356, USA
    Chem Biol Interact 184:86-93. 2010
    ....
  64. ncbi request reprint Hematological changes among Chinese workers with a broad range of benzene exposures
    Qingshan Qu
    Nelson Institute of Environmental Medicine, New York University School of Medicine, Tuxedo, New York 10987, USA
    Am J Ind Med 42:275-85. 2002
    ..We examine hematological findings and their possible relations with exposure markers validated in a recent biomarker project conducted in Tianjin, China...
  65. ncbi request reprint Detailed exposure assessment for a molecular epidemiology study of benzene in two shoe factories in China
    Roel Vermeulen
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 6120 Executive Boulevard, Rockville, MD 20892, USA
    Ann Occup Hyg 48:105-16. 2004
    ..Our goal was to identify workers with a broad range of benzene exposures, for an epidemiologic study relating exposure to early biologic effects...
  66. ncbi request reprint Residual indoor contamination from world trade center rubble fires as indicated by polycyclic aromatic hydrocarbon profiles
    Joachim D Pleil
    Methods Development and Applications Branch, HEASD NERL ORD, United States Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Environ Sci Technol 40:1172-7. 2006
    ..We found that random samples collected approximately 3.5 years after the WTC event from occupied indoor spaces (primarily residential) in the New York area are not statistically distinguishable from contemporary city background...
  67. ncbi request reprint Utility of urinary 1-naphthol and 2-naphthol levels to assess environmental carbaryl and naphthalene exposure in an epidemiology study
    John D Meeker
    Department of Environmental Health Sciences, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Expo Sci Environ Epidemiol 17:314-20. 2007
    ..Conversely, studies of naphthalene-related outcomes may utilize 2N levels to estimate exposure...
  68. ncbi request reprint Assessment of dermal exposure to benzene and toluene in shoe manufacturing by activated carbon cloth patches
    Roel Vermeulen
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Rockville, MD 20892, USA
    J Environ Monit 8:1143-8. 2006
    ..The aim of this investigation was to use activated carbon cloth (ACC) patches to study the probability and extent of dermal exposure to benzene and toluene in a shoe factory...
  69. ncbi request reprint Lymphocyte toxicity and T cell receptor excision circles in workers exposed to benzene
    Qing Lan
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 6120 Executive Blvd, EPS 8109, Bethesda, MD 20892 7240, USA
    Chem Biol Interact 153:111-5. 2005
    ..Although our study does not rule out counterbalancing alterations of TREC levels in specific T cell subsets, benzene's lymphotoxicity does not appear to be mediated through diminished thymus function...
  70. ncbi request reprint On modelling metabolism-based biomarkers of exposure: a comparative analysis of nonlinear models with few repeated measurements
    Brent A Johnson
    Department of Biostatistics, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA
    Stat Med 26:1901-19. 2007
    ..Furthermore, the lognormal MLE can exhibit very poor small sample properties even under the true model. All methods are applied in a novel data analysis from a study of benzene-exposed workers in China...
  71. ncbi request reprint Reactions of benzene oxide with thiols including glutathione
    Alistair P Henderson
    School of Natural Sciences Chemistry, Bedson Building, University of Newcastle upon Tyne, Newcastle upon Tyne, NEI 7RU, United Kingdom
    Chem Res Toxicol 18:265-70. 2005
    ..The pathway leading to S-phenylmercapturic acid is necessarily minor on account of the low efficiency of benzene oxide capture by glutathione at pH 7 vs spontaneous rearrangement to phenol...
  72. pmc Hematotoxicity in workers exposed to low levels of benzene
    Qing Lan
    Division of Cancer Epidemiology and Genetics, National Cancer Institute NCI, National Institutes of Health NIH, Department of Health and Human Services DHHS, Bethesda, MD 20892, USA
    Science 306:1774-6. 2004
    ..Thus, hematotoxicity from exposure to benzene occurred at air levels of 1 ppm or less and may be particularly evident among genetically susceptible subpopulations...
  73. ncbi request reprint [Preliminary study on naphthalene-metabolites-albumin adduct as an exposure biomarker for coke oven workers]
    Yu fei Dai
    National Institute for Occupational Health and Poison Control, China Centers for Disease Control and Prevention, Beijing 100050, China
    Zhonghua Yu Fang Yi Xue Za Zhi 38:392-5. 2004
    ....
  74. pmc Health and environmental consequences of the world trade center disaster
    Philip J Landrigan
    Mount Sinai School of Medicine, New York, New York 10029, USA
    Environ Health Perspect 112:731-9. 2004
    ..Continuing follow-up of all exposed populations is required to document the long-term consequences of the disaster...
  75. ncbi request reprint Polymorphisms in genes involved in DNA double-strand break repair pathway and susceptibility to benzene-induced hematotoxicity
    Min Shen
    Division of Cancer Epidemiology and Genetics, NCI, NIH, DHHS, Bethesda, MD 20892, USA
    Carcinogenesis 27:2083-9. 2006
    ..The effect of BRCA2 Ex11 +1487 A > G polymorphism was limited to granulocytes. These results suggest that genetic polymorphisms in WRN, TP53 and BRCA2 that maintain genomic stability impact benzene-induced hematotoxicity...
  76. ncbi request reprint Polymorphisms in cytokine and cellular adhesion molecule genes and susceptibility to hematotoxicity among workers exposed to benzene
    Qing Lan
    Division of Cancer Epidemiology, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, MD 20892 7240, USA
    Cancer Res 65:9574-81. 2005
    ..041) and increased (P = 0.076) CFU-GEMM progenitor cell colony formation in 29 benzene-exposed workers. This is the first report to provide evidence that SNPs in genes that regulate hematopoiesis influence benzene-induced hematotoxicity...