Research Topics
| S M RappaportSummaryAffiliation: University of North Carolina Country: USA Publications
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Publications
Variability of environmental exposures to volatile organic compoundsStephen M Rappaport
School of Public Health, University of North Carolina, Chapel Hill, NC, USA
J Expo Anal Environ Epidemiol 14:92-107. 2004..Yet, epidemiologists should be wary of investigating environmental VOCs without preliminary data with which to estimate the variance structure of exposure variables...- Protein adducts as biomarkers of human benzene metabolismStephen M Rappaport
School of Public Health, University of North Carolina, Chapel Hill, NC 27599 7431, USA
Chem Biol Interact 153:103-9. 2005..Thus, the biologically effective dose of BO and 1,4-BQ should be proportionally greater in persons exposed to low rather than high levels of benzene... - Naphthalene and its biomarkers as measures of occupational exposure to polycyclic aromatic hydrocarbonsStephen M Rappaport
Department of Environmental Sciences and Engineering, School of Public Health, CB 7431, University of North Carolina, Chapel Hill, NC 27599 7431, USA
J Environ Monit 6:413-6. 2004..Since naphthalene has also been shown to be a respiratory carcinogen in several animal studies, it is also argued that naphthalene exposures should be monitored per se in industries with high levels of PAH... - Modeling human metabolism of benzene following occupational and environmental exposuresSungkyoon Kim
School of Public Health, University of North Carolina, CB 7431, Chapel Hill, NC 27599
Cancer Epidemiol Biomarkers Prev 15:2246-52. 2006..Our results also suggest that GLM + NS models are ideal for evaluating nonlinear relationships between environmental exposures and levels of human biomarkers... - On the importance of exposure variability to the doses of volatile organic compoundsS M Rappaport
Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina, Chapel Hill, North Carolina 27599 7431, USA
Toxicol Sci 83:224-36. 2005.... - Protein adducts as dosimeters of human exposure to styrene, styrene-7,8-oxide, and benzeneS M Rappaport
School of Public Health, University of North Carolina, Chapel Hill 27599 7400, USA
Toxicol Lett 108:117-26. 1999..Levels of these background adducts were too great to have arisen from non-occupational exposures to styrene or benzene or from cigarette smoking... - An investigation of factors contributing to styrene and styrene-7,8-oxide exposures in the reinforced-plastics industryL A Nylander-French
Department of Environmental Sciences and Engineering, University of North Carolina, Chapel Hill 27599 7400, USA
Ann Occup Hyg 43:99-105. 1999..The type of mixed-models regression analysis employed in this study can be used for clarifying the underlying patterns for exposures to styrene and SO as well as for evaluating preventive measures... 
Urinary naphthalene and phenanthrene as biomarkers of occupational exposure to polycyclic aromatic hydrocarbonsJ R Sobus
School of Public Health, University of North Carolina, Chapel Hill, North Carolina, USA
Occup Environ Med 66:99-104. 2009..The study investigated the utility of unmetabolised naphthalene (Nap) and phenanthrene (Phe) in urine as surrogates for exposures to mixtures of polycyclic aromatic hydrocarbons (PAHs)...
Albumin adducts of electrophilic benzene metabolites in benzene-exposed and control workersYu Sheng Lin
Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina, Chapel Hill, North Carolina 27599 7431, USA
Environ Health Perspect 115:28-34. 2007..Metabolism of benzene produces reactive electrophiles, including benzene oxide (BO), 1,4-benzoquinone (1,4-BQ), and 1,2-benzoquinone (1,2-BQ), that are capable of reacting with blood proteins to produce adducts...- Physiological modeling of the relative contributions of styrene-7,8-oxide derived from direct inhalation and from styrene metabolism to the systemic dose in humansR Tornero-Velez
Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7400, USA
Toxicol Sci 64:151-61. 2001..We conclude that future studies should assess exposures to airborne SO as well as styrene... - Air samples versus biomarkers for epidemiologyY S Lin
Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina, Chapel Hill, North Carolina, USA
Occup Environ Med 62:750-60. 2005..CONCLUSION: Epidemiologists are encouraged to consider the magnitudes of variance ratios, along with other factors related to practicality and cost, in choosing among candidate surrogate measures of exposure... - Predictors of occupational exposure to styrene and styrene-7,8-oxide in the reinforced plastics industryB Serdar
Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7431, USA
Occup Environ Med 63:707-12. 2006..Also, inverse relations between the intensity of exposure to styrene and SO and years on the job suggest that younger workers with little seniority are typically exposed to higher levels of styrene and SO than their coworkers... - Relationships between levels of volatile organic compounds in air and blood from the general populationY S Lin
Department of Environmental and Occupational Health, School of Public Health, University of North Texas Health Science Center, Fort Worth, Texas, USA
J Expo Sci Environ Epidemiol 18:421-9. 2008..Investigators should consider interaction effects of exposure levels and smoking when exploring the blood-air relationships of the BTEX compounds in the general population... - The use of protein adducts to investigate the disposition of reactive metabolites of benzeneS M Rappaport
Department of Environmental Sciences and Engineering, University of North Carolina, Chapel Hill 27599 7400, USA
Environ Health Perspect 104:1235-7. 1996..High background levels of 1,2-BQ and 1,4-BQ adducts were also detected in both species, indicating that the toxic effects of quinone metabolites may only be important at high levels of benzene exposure... - Albumin adducts of naphthalene metabolites as biomarkers of exposure to polycyclic aromatic hydrocarbonsSuramya Waidyanatha
Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina, Chapel Hill, North Carolina, USA
Cancer Epidemiol Biomarkers Prev 13:117-24. 2004..A negative relationship between 1,2-NPQ-Alb and age was observed, suggesting that cytochrome P450 c metabolism diminished with age at approximately 3%/year of life... - Benzene and naphthalene in air and breath as indicators of exposure to jet fuelP P Egeghy
Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7431, USA
Occup Environ Med 60:969-76. 2003..Among heavily exposed workers, uptake of JP-8 components occurs via both inhalation and dermal contact. Naphthalene in air and breath can serve as useful measures of exposure to JP-8 and uptake of fuel components in the body... - Determination of styrene and styrene-7,8-oxide in human blood by gas chromatography-mass spectrometryR Tornero-Velez
Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina at Chapel Hill, 27599-7400, USA
J Chromatogr B Biomed Sci Appl 757:59-68. 2001..The two assays for SO in blood appear to be unbiased and to have sufficient sensitivity and specificity for applications involving workers exposed to styrene and SO during the manufacture of reinforced plastics... - Protein adducts of 1,4-benzoquinone and benzene oxide among smokers and nonsmokers exposed to benzene in ChinaN Rothman
Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7400, USA
Cancer Epidemiol Biomarkers Prev 10:831-8. 2001..Interestingly, cigarette smoking increased Alb adducts of 1,4-BQ but not of BO, suggesting that benzene from cigarette smoke was not the primary contributor to the 1,4-BQ adducts... - Determination of polycyclic aromatic hydrocarbons in urine of coke oven workers by headspace solid phase microextraction and gas chromatography-mass spectrometrySuramya Waidyanatha
Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina, Chapel Hill, NC 27599-7431, USA
Chem Biol Interact 145:165-74. 2003..Our results indicate that unmetabolized 2-, 3- and 4-ring PAHs can be measured in urine by HS-SPME. Such measurements can be used to investigate the uptake and metabolism of complex PAH mixtures in humans... - Simultaneous determination of urinary 1- and 2-naphthols, 3- and 9-phenanthrols, and 1-pyrenol in coke oven workersBerrin Serdar
Department of Environmental Sciences and Engineering, School of Public Health University of North Carolina, Chapel Hill, NC 27599-7431, USA
Biomarkers 8:93-109. 2003.... - Exposure reconstruction for reducing uncertainty in risk assessment: example using MTBE biomarkers and a simple pharmacokinetic modelJ D Pleil
Human Exposure and Atmospheric Sciences Division, National Exposure Research Laboratory Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, NC, USA
Biomarkers 12:331-48. 2007..These techniques could be applied to broader ranges of environmental contaminants to assess cumulative exposure risks if ADME (Absorption, Distribution, Metabolization and Excretion) is understood and systemic biomarkers can be measured... - A sandwich enzyme-linked immunosorbent assay for adducts of polycyclic aromatic hydrocarbons with human serum albuminMing Kei Chung
School of Public Health, University of California, Berkeley, CA 94720, USA
Anal Biochem 400:123-9. 2010..05). The sandwich ELISA will be useful for screening PAH exposures in large epidemiologic studies and can be extended to other adducts for which capture antibodies are available... - Application of mixed models to assess exposures monitored by construction workers during hot processesS M Rappaport
School of Public Health, University of North Carolina, Chapel Hill 27599 7400, USA
Ann Occup Hyg 43:457-69. 1999.... - Characterization of metabolic activation of pentachlorophenol to quinones and semiquinones in rodent liverC H Tsai
Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina, CB7400, Chapel Hill, NC 27599-7400, USA
Chem Biol Interact 134:55-71. 2001..This implies that, under conditions of oxidative stress, endogenous lipid hydroperoxides may increase PCP metabolism sufficiently to enhance the toxicity and carcinogenicity of PCP... - Simultaneous assessment of occupational exposures from multiple worker groupsM A Weaver
Department of Biostatistics, School of Public Health, University of North Carolina, Chapel Hill, NC 27599-7400, USA
Ann Occup Hyg 45:525-42. 2001.... - Variability of albumin adducts of 1,4-benzoquinone, a toxic metabolite of benzene, in human volunteersY S Lin
Department of Environmental Sciences and Engineering, University of North Carolina, Chapel Hill, NC 27599, USA
Biomarkers 11:14-27. 2006..The observations indicate that levels of 1,4-BQ-Alb cover a wide range in the general population, and they support the hypotheses that demographic, diet and lifestyle factors are contributing sources... - Urinary biomarkers of exposure to jet fuel (JP-8)Berrin Serdar
Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
Environ Health Perspect 111:1760-4. 2003..We conclude that urinary naphthalene and the naphthols can serve as biomarkers of exposure to jet fuel. Of these, the naphthols are probably more useful because of their greater abundance and slower elimination kinetics... 
Hemoglobin and albumin adducts of naphthalene-1,2-oxide, 1,2-naphthoquinone and 1,4-naphthoquinone in Swiss Webster miceSuramya Waidyanatha
Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7431, United States
Chem Biol Interact 172:105-14. 2008..This suggests that mice could be more susceptible than rats to the toxic effects of naphthalene due to more pronounced depletion of glutathione at a given dose...- Use of OctoChrome fluorescence in situ hybridization to detect specific aneuploidy among all 24 chromosomes in benzene-exposed workersLuoping Zhang
School of Public Health, 140 Warren Hall, University of California, Berkeley, CA 94720 7360, USA
Chem Biol Interact 153:117-22. 2005..We are currently investigating potential mechanisms for this induction of selective aneuploidy... - Rapid determination of six urinary benzene metabolites in occupationally exposed and unexposed subjectsSuramya Waidyanatha
Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7431, USA
Anal Biochem 327:184-99. 2004..Since all metabolites were detected in all control subjects, the method can be applied to persons exposed to environmental levels of benzene... - Non-linear production of benzene oxide-albumin adducts with human exposure to benzeneStephen M Rappaport
Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7400, USA
J Chromatogr B Analyt Technol Biomed Life Sci 778:367-74. 2002..To our knowledge, this is the first study to investigate the linearity of human metabolism of a carcinogen based upon protein adducts... - Albumin adducts of benzene oxide and 1,4-benzoquinone as measures of human benzene metabolismStephen M Rappaport
School of Public Health, University of North Carolina, Chapel Hill, North Carolina 27599 7400, USA
Cancer Res 62:1330-7. 2002..This study illustrates that Alb adducts can be used to investigate the dispositions of reactive metabolites of procarcinogens in humans, provided that exposures are adequately characterized in the month preceding blood collection... - Dose-dependent production of urinary naphthols among workers exposed to jet fuel (JP-8)Berrin Serdar
Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7431, USA
Am J Ind Med 46:234-44. 2004..Smokers and nonsmokers metabolized naphthalene at different rates, consistent with induction of at least two metabolic pathways by smoking... - Comparing urinary biomarkers of airborne and dermal exposure to polycyclic aromatic compounds in asphalt-exposed workersJon R Sobus
Department of Environmental Sciences and Engineering, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA
Ann Occup Hyg 53:561-71. 2009.... - Investigation of cysteinyl protein adducts of benzene diolepoxideSuramya Waidyanatha
Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7400, USA. suramya.unc.edu
Chem Biol Interact 153:261-6. 2005..Reaction products between these and L-cysteine, and GSH were identified and characterized by mass spectrometry in an attempt to develop an assay to quantify these adducts in serum albumin... - Evidence for the formation of Michael adducts from reactions of (E,E)-muconaldehyde with glutathione and other thiolsAlistair P Henderson
Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7431, USA
Bioorg Chem 33:363-73. 2005..These experiments suggest that (Z,Z)-muconaldehyde, a putative metabolite of benzene, could lead to the long established urinary metabolite of benzene, (E,E)-muconic acid, via glutathione-mediated isomerization to (E,E)-muconaldehyde... - Identification of surrogate measures of diesel exhaust exposure in a controlled chamber studyJon R Sobus
School of Public Health, University of North Carolina, Chapel Hill, North Carolina 27599, USA
Environ Sci Technol 42:8822-8. 2008..While Nap and Phe are not validated here as internal biomarkers of DE exposure, we are currently assessing human biological specimens collected during this study and will discuss those results in ensuing papers... - Using liquid chromatography-tandem mass spectrometry to quantify monohydroxylated metabolites of polycyclic aromatic hydrocarbons in urineFrank Onyemauwa
Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7431, USA
J Chromatogr B Analyt Technol Biomed Life Sci 877:1117-25. 2009..628), presumably due to confounding by smoking. Metabolites of phenanthrene, an abundant PAH and the smallest to possess a bay region, are promising OHPAHs for characterizing both exposures to PAHs and the various metabolic pathways... - Investigation of PAH biomarkers in the urine of workers exposed to hot asphaltJon R Sobus
Department of Environmental Sciences and Engineering, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA
Ann Occup Hyg 53:551-60. 2009..These results support the use of U-Nap, U-Phe, OH-Phe, and OH-Pyr, but probably not OH-Nap, as short-term biomarkers of exposure to PAHs emanating from hot asphalt... - Human benzene metabolism following occupational and environmental exposuresStephen M Rappaport
School of Public Health, University of California, Berkeley, CA 94720 7356, USA
Chem Biol Interact 184:189-95. 2010..1 ppm, 20 and 58% at 1 ppm, and 2.7 and 17% at 10 ppm. This indicates that the putative high-affinity enzyme was active primarily below 1 ppm and favored the ring-opening pathway... - Is house-dust nicotine a good surrogate for household smoking?Todd Whitehead
School of Public Health, University of California, Berkeley, CA 94720, USA
Am J Epidemiol 169:1113-23. 2009.... - Determination of dihydroxynaphthalenes in human urine by gas chromatography-mass spectrometryRenan Wu
Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina, Chapel Hill, NC 27599-7431, USA
J Chromatogr B Analyt Technol Biomed Life Sci 826:206-13. 2005..Since the DHNs are precursors of the naphthoquinones, which have been implicated as toxic products of naphthalene metabolism, measurements of urinary DHNs may have toxicological significance... - Self-collected breath sampling for monitoring low-level benzene exposures among automobile mechanicsPeter P Egeghy
Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina at Chapel Hill, 27599-7400, USA
Ann Occup Hyg 46:489-500. 2002.... - Stability of hemoglobin and albumin adducts of naphthalene oxide, 1,2-naphthoquinone, and 1,4-naphthoquinoneMelissa A Troester
Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7400, USA
Toxicol Sci 68:314-21. 2002..In addition, some limitations of current methods for estimating adduct instability were identified... - Use of 'Omic' technologies to study humans exposed to benzeneMartyn T Smith
School of Public Health, 140 Warren Hall, University of California, Berkeley, CA 94720 7360, USA
Chem Biol Interact 153:123-7. 2005..Omic technologies therefore have significant potential in generating novel biomarkers of exposure, susceptibility and response to benzene... - Measurement of hemoglobin and albumin adducts of naphthalene-1,2-oxide, 1,2-naphthoquinone and 1,4-naphthoquinone after administration of naphthalene to F344 ratsSuramya Waidyanatha
Department of Environmental Sciences and Engineering, CB 7400, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7400, USA
Chem Biol Interact 141:189-210. 2002..Low background levels of 1,2-NPQ-Hb and -Alb and 1,4-NPQ-Hb and -Alb were detected in control animals without known exposure to naphthalene. However, the corresponding NPO-Hb and -Alb adducts were not detected in control animals... - Leukemia-related chromosomal loss detected in hematopoietic progenitor cells of benzene-exposed workersL Zhang
School of Public Health, Division of Environmental Health Sciences, University of California, Berkeley, CA, USA
Leukemia 26:2494-8. 2012.... - Hemoglobin adducts of benzene oxide in neonatal and adult dried blood spotsWilliam E Funk
Department of Environmental Sciences and Engineering, School of Public Health, University of California at Chapel Hill, Chapel Hill, NC, USA
Cancer Epidemiol Biomarkers Prev 17:1896-901. 2008..Based upon the estimated variance of the benzene oxide-Hb levels, we had 80% power to detect a 1.7-fold difference in geometric mean levels of benzene oxide-Hb in our sample of nine subjects... - Evidence that humans metabolize benzene via two pathwaysStephen M Rappaport
School of Public Health, University of California at Berkeley, Berkeley, California 94720 7356, USA
Environ Health Perspect 117:946-52. 2009..This led us to speculate that an unidentified metabolic pathway was mainly responsible for benzene metabolism at ambient levels... - PBTK modeling demonstrates contribution of dermal and inhalation exposure components to end-exhaled breath concentrations of naphthaleneDavid Kim
Department of Environmental Sciences and Engineering, School of Public Health, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7431, USA
Environ Health Perspect 115:894-901. 2007..However, a quantitative understanding of the relationship between external exposures and end-exhaled air concentrations has not been described for occupational and environmental exposure scenarios... - Air levels of carcinogenic polycyclic aromatic hydrocarbons after the World Trade Center disasterJoachim D Pleil
Department of Environmental Sciences, School of Public Health, University of North Carolina, Chapel Hill, NC 27599-7431, USA
Proc Natl Acad Sci U S A 101:11685-8. 2004..Because no PAH-specific air sampling was conducted, this work provides the only systematic measurements, to our knowledge, of ambient PAHs after the WTC disaster... - Dermal exposure to jet fuel JP-8 significantly contributes to the production of urinary naphthols in fuel-cell maintenance workersYi-Chun E Chao
Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7400, USA
Environ Health Perspect 114:182-5. 2006..Future work on dermal xenobiotic metabolism and toxicokinetic studies are warranted in order to gain additional knowledge on naphthalene metabolism in the skin and the contribution to systemic exposure... - Using urinary biomarkers to elucidate dose-related patterns of human benzene metabolismSungkyoon Kim
School of Public Health, University of North Carolina, Chapel Hill, NC 27599, and National Cancer Institute (NCI, National Institutes of Health (NIH, Department of Health and Human Services (DHHS, Bethesda, MD 20892, USA
Carcinogenesis 27:772-81. 2006..027 and 15.4 p.p.m. Reductions in metabolite production were most pronounced for CA and PH<1 p.p.m., indicating that metabolism favored production of the toxic metabolites, HQ and MA, at low exposures... - Genetic polymorphisms and benzene metabolism in humans exposed to a wide range of air concentrationsSungkyoon Kim
School of Public Health, University of North Carolina, Chapel Hill, NC 27599, USA
Pharmacogenet Genomics 17:789-801. 2007.... - Commentary: two seminal contributions of S. A. Roach to the evaluation and control of hazardous substances in airS M Rappaport
School of Public Health, University of North Carolina, Chapel Hill, NC 27599-7431, USA
Ann Occup Hyg 47:343-8. 2003..The profession can still learn a great deal from these seminal contributions... - Occupational exposure to formaldehyde, hematotoxicity, and leukemia-specific chromosome changes in cultured myeloid progenitor cellsLuoping Zhang
School of Public Health, University of California at Berkeley, Berkeley, California 94720, USA
Cancer Epidemiol Biomarkers Prev 19:80-8. 2010.... - Enrichment of cysteinyl adducts of human serum albuminWilliam E Funk
Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC 27599, USA
Anal Biochem 400:61-8. 2010..We conclude that thiol-affinity resins can efficiently remove mercaptalbumin from HSA samples prior to characterization and quantitation of protein adducts of reactive systemic electrophiles... - Changes in the peripheral blood transcriptome associated with occupational benzene exposure identified by cross-comparison on two microarray platformsCliona M McHale
School of Public Health, University of California, Berkeley, CA 94720, USA
Genomics 93:343-9. 2009..The two-platform approach allows for robust changes in the PBMC transcriptome of benzene-exposed individuals to be identified... - Characterization and quantification of cysteinyl adducts of benzene diol epoxideSuramya Waidyanatha
Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7431, USA
Chem Res Toxicol 18:1178-85. 2005.... - Excessive exposure to silica in the US construction industryS M Rappaport
School of Public Health, University of North Carolina, Chapel Hill, NC 27599-7431, USA
Ann Occup Hyg 47:111-22. 2003..It is concluded that urgent action is required to reduce silica exposures in the US construction industry... - Formation and removal of pentachlorophenol-derived protein adducts in rodent liver under acute, multiple, and chronic dosing regimensChin-Hsiang Tsai
Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina, Chapel Hill 27599-7400, USA
Toxicol Sci 73:26-35. 2003..812-0.921). These results provide evidence that the kinetics of liver protein adducts were not influenced by the dosing regimen of PCP, a recognized toxicant of the liver... - Systems biology of human benzene exposureLuoping Zhang
Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA 94720 7356, USA
Chem Biol Interact 184:86-93. 2010.... - Fractionation of protein adducts in rats and mice dosed with [14C]pentachlorophenolChin-Hsiang Tsai
Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina, Chapel Hill, NC 27599-7400, USA
Arch Toxicol 76:628-33. 2002..However, the sum of all quantified adducts accounted for only 7-8% of total cysteinyl binding to Np and 2% to Cp, suggesting that other uncharacterized binding species may be important to the toxicity of PCP... - Health and environmental consequences of the world trade center disasterPhilip J Landrigan
Mount Sinai School of Medicine, New York, New York 10029, USA
Environ Health Perspect 112:731-9. 2004..Continuing follow-up of all exposed populations is required to document the long-term consequences of the disaster... - Residual indoor contamination from world trade center rubble fires as indicated by polycyclic aromatic hydrocarbon profilesJoachim D Pleil
Methods Development and Applications Branch, HEASD NERL ORD, United States Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
Environ Sci Technol 40:1172-7. 2006..We found that random samples collected approximately 3.5 years after the WTC event from occupied indoor spaces (primarily residential) in the New York area are not statistically distinguishable from contemporary city background... - Utility of urinary 1-naphthol and 2-naphthol levels to assess environmental carbaryl and naphthalene exposure in an epidemiology studyJohn D Meeker
Department of Environmental Health Sciences, University of Michigan, Ann Arbor, Michigan 48109, USA
J Expo Sci Environ Epidemiol 17:314-20. 2007..Conversely, studies of naphthalene-related outcomes may utilize 2N levels to estimate exposure... - Hematological changes among Chinese workers with a broad range of benzene exposuresQingshan Qu
Nelson Institute of Environmental Medicine, New York University School of Medicine, Tuxedo, New York 10987, USA
Am J Ind Med 42:275-85. 2002..We examine hematological findings and their possible relations with exposure markers validated in a recent biomarker project conducted in Tianjin, China... - Lymphocyte toxicity and T cell receptor excision circles in workers exposed to benzeneQing Lan
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 6120 Executive Blvd, EPS 8109, Bethesda, MD 20892 7240, USA
Chem Biol Interact 153:111-5. 2005..Although our study does not rule out counterbalancing alterations of TREC levels in specific T cell subsets, benzene's lymphotoxicity does not appear to be mediated through diminished thymus function... - Assessment of dermal exposure to benzene and toluene in shoe manufacturing by activated carbon cloth patchesRoel Vermeulen
Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Rockville, MD 20892, USA
J Environ Monit 8:1143-8. 2006..The aim of this investigation was to use activated carbon cloth (ACC) patches to study the probability and extent of dermal exposure to benzene and toluene in a shoe factory... - Reactions of benzene oxide with thiols including glutathioneAlistair P Henderson
School of Natural Sciences Chemistry, Bedson Building, University of Newcastle upon Tyne, Newcastle upon Tyne, NEI 7RU, United Kingdom
Chem Res Toxicol 18:265-70. 2005..The pathway leading to S-phenylmercapturic acid is necessarily minor on account of the low efficiency of benzene oxide capture by glutathione at pH 7 vs spontaneous rearrangement to phenol... - On modelling metabolism-based biomarkers of exposure: a comparative analysis of nonlinear models with few repeated measurementsBrent A Johnson
Department of Biostatistics, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA
Stat Med 26:1901-19. 2007..Furthermore, the lognormal MLE can exhibit very poor small sample properties even under the true model. All methods are applied in a novel data analysis from a study of benzene-exposed workers in China... - Hematotoxicity in workers exposed to low levels of benzeneQing Lan
Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI, National Institutes of Health (NIH, Department of Health and Human Services (DHHS, Bethesda, MD 20892, USA
Science 306:1774-6. 2004..Thus, hematotoxicity from exposure to benzene occurred at air levels of 1 ppm or less and may be particularly evident among genetically susceptible subpopulations... - [Preliminary study on naphthalene-metabolites-albumin adduct as an exposure biomarker for coke oven workers.]Yu-Fei Dai
National Institute for Occupational Health and Poison Control, China Centers for Disease Control and Prevention, Beijing 100050, China
Zhonghua Yu Fang Yi Xue Za Zhi 38:392-5. 2004.... - Detailed exposure assessment for a molecular epidemiology study of benzene in two shoe factories in ChinaRoel Vermeulen
Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 6120 Executive Boulevard, Rockville, MD 20892, USA
Ann Occup Hyg 48:105-16. 2004..Our goal was to identify workers with a broad range of benzene exposures, for an epidemiologic study relating exposure to early biologic effects... - Polymorphisms in genes involved in DNA double-strand break repair pathway and susceptibility to benzene-induced hematotoxicityMin Shen
Division of Cancer Epidemiology and Genetics, NCI, NIH, DHHS, Bethesda, MD 20892, USA
Carcinogenesis 27:2083-9. 2006..The effect of BRCA2 Ex11 +1487 A > G polymorphism was limited to granulocytes. These results suggest that genetic polymorphisms in WRN, TP53 and BRCA2 that maintain genomic stability impact benzene-induced hematotoxicity... - Polymorphisms in cytokine and cellular adhesion molecule genes and susceptibility to hematotoxicity among workers exposed to benzeneQing Lan
Division of Cancer Epidemiology, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, MD 20892 7240, USA
Cancer Res 65:9574-81. 2005..041) and increased (P = 0.076) CFU-GEMM progenitor cell colony formation in 29 benzene-exposed workers. This is the first report to provide evidence that SNPs in genes that regulate hematopoiesis influence benzene-induced hematotoxicity...