Vijay Rao

Summary

Affiliation: University of Texas Health Center
Country: USA

Publications

  1. ncbi Zinc modulates the interaction of protein C and activated protein C with endothelial cell protein C receptor
    Prosenjit Sen
    Center for Biomedical Research, The University of Texas Health Science Center at Tyler, Tyler, Texas 75708, USA
    J Biol Chem 285:20410-20. 2010
  2. ncbi Tissue factor encryption and decryption: facts and controversies
    L Vijaya Mohan Rao
    Center for Biomedical Research, The University of Texas Health Science Center at Tyler, Tyler, TX, USA
    Thromb Res 129:S13-7. 2012
  3. ncbi Factor VIIa binding to endothelial cell protein C receptor: differences between mouse and human systems
    Prosenjit Sen
    Center for Biomedical Research, The University of Texas Health Science Center at Tyler, Tyler, Texas 75708, USA
    Thromb Haemost 107:951-61. 2012
  4. ncbi Tissue factor: mechanisms of decryption
    L Vijaya Mohan Rao
    Center for Biomedical Research, The University of Texas Health Science Center at Tyler, Tyler, Texas 75708, USA
    Front Biosci (Elite Ed) 4:1513-27. 2012
  5. ncbi K+ channel openers restore verapamil-inhibited lung fluid resolution and transepithelial ion transport
    Dong Yun Han
    Department of Biochemistry, University of Texas Health Science Center at Tyler, Tyler, TX 75708, USA
    Respir Res 11:65. 2010
  6. ncbi Factor VIIa and tissue factor--from cell biology to animal models
    L Vijaya Mohan Rao
    Center for Biomedical Research, The University of Texas Health Science Center at Tyler, TX 75708, USA
    Thromb Res 125:S1-3. 2010
  7. ncbi Factor VIIa binding to endothelial cell protein C receptor
    L Vijaya Mohan Rao
    Center for Biomedical Research, The University of Texas Health Science Center, Tyler, TX, USA
    Thromb Res 122:S3-6. 2008
  8. ncbi Factor VIIIa-induced gene expression: potential implications in pathophysiology
    L V Rao
    Biomedical Research Division, The University of Texas Health Center at Tyler, Tyler, TX 75708, USA
    Trends Cardiovasc Med 11:14-21. 2001
  9. ncbi Tissue factor-factor VIIa signaling
    L Vijaya Mohan Rao
    Biomedical Research Division, The University of Texas Health Center at Tyler, 11937 US Highway 271, Tyler, TX 75708, USA
    Arterioscler Thromb Vasc Biol 25:47-56. 2005
  10. ncbi Regulation of tissue factor-factor VIIa expression on cell surfaces: a role for tissue factor-factor VIIa endocytosis
    L Vijaya Mohan Rao
    Biomedical Research, The University of Texas Health Center at Tyler, Tyler, TX 75708, USA
    Mol Cell Biochem 253:131-40. 2003

Research Grants

  1. INITIATION AND REGULATION OF BLOOD COAGULATION
    VIJAYA MOHAN RAO LELLA; Fiscal Year: 2010
  2. INITIATION AND REGULATION OF BLOOD COAGULATION
    VIJAYA LELLA; Fiscal Year: 2001
  3. INITIATION AND REGULATION OF BLOOD COAGULATION
    VIJAYA LELLA; Fiscal Year: 2007

Collaborators

Detail Information

Publications32

  1. ncbi Zinc modulates the interaction of protein C and activated protein C with endothelial cell protein C receptor
    Prosenjit Sen
    Center for Biomedical Research, The University of Texas Health Science Center at Tyler, Tyler, Texas 75708, USA
    J Biol Chem 285:20410-20. 2010
    ..Overall, our data show that Zn(2+) binds to protein C/APC, which results in conformational changes in protein C/APC that favor their binding to EPCR...
  2. ncbi Tissue factor encryption and decryption: facts and controversies
    L Vijaya Mohan Rao
    Center for Biomedical Research, The University of Texas Health Science Center at Tyler, Tyler, TX, USA
    Thromb Res 129:S13-7. 2012
    ....
  3. ncbi Factor VIIa binding to endothelial cell protein C receptor: differences between mouse and human systems
    Prosenjit Sen
    Center for Biomedical Research, The University of Texas Health Science Center at Tyler, Tyler, Texas 75708, USA
    Thromb Haemost 107:951-61. 2012
    ..Our data suggest that one should consider the use of human FVIIa in mouse models to investigate the significance of FVIIa and EPCR interaction...
  4. ncbi Tissue factor: mechanisms of decryption
    L Vijaya Mohan Rao
    Center for Biomedical Research, The University of Texas Health Science Center at Tyler, Tyler, Texas 75708, USA
    Front Biosci (Elite Ed) 4:1513-27. 2012
    ..In this article, we critically review literature on TF encryption/decryption with specific emphasis on recently published data and provide our perspective on this subject...
  5. ncbi K+ channel openers restore verapamil-inhibited lung fluid resolution and transepithelial ion transport
    Dong Yun Han
    Department of Biochemistry, University of Texas Health Science Center at Tyler, Tyler, TX 75708, USA
    Respir Res 11:65. 2010
    ..We hypothesized that K+ channel openers may restore calcium channel blocker-inhibited alveolar fluid clearance (AFC) by up-regulating both apical and basolateral ion transport...
  6. ncbi Factor VIIa and tissue factor--from cell biology to animal models
    L Vijaya Mohan Rao
    Center for Biomedical Research, The University of Texas Health Science Center at Tyler, TX 75708, USA
    Thromb Res 125:S1-3. 2010
    ..This supplement explores new aspects of TF-FVIIa biology, with a particular focus on structural biology, cell biology and animal models...
  7. ncbi Factor VIIa binding to endothelial cell protein C receptor
    L Vijaya Mohan Rao
    Center for Biomedical Research, The University of Texas Health Science Center, Tyler, TX, USA
    Thromb Res 122:S3-6. 2008
    ..FVIIa binding to EPCR may also contribute to FVIIa clearance. This review summarizes recent data on FVIIa interaction with EPCR and discusses potential physiological significance and consequences of the interaction...
  8. ncbi Factor VIIIa-induced gene expression: potential implications in pathophysiology
    L V Rao
    Biomedical Research Division, The University of Texas Health Center at Tyler, Tyler, TX 75708, USA
    Trends Cardiovasc Med 11:14-21. 2001
    ..In this review, we focus upon TF-VIIa protease-induced gene expression and how the altered gene expression could potentially affect various cellular processes...
  9. ncbi Tissue factor-factor VIIa signaling
    L Vijaya Mohan Rao
    Biomedical Research Division, The University of Texas Health Center at Tyler, 11937 US Highway 271, Tyler, TX 75708, USA
    Arterioscler Thromb Vasc Biol 25:47-56. 2005
    ..In the present article, we review the emerging data on the mechanism of TF-mediated cell signaling and how it regulates various cellular responses, with particular focus on TF-VIIa protease-dependent signaling...
  10. ncbi Regulation of tissue factor-factor VIIa expression on cell surfaces: a role for tissue factor-factor VIIa endocytosis
    L Vijaya Mohan Rao
    Biomedical Research, The University of Texas Health Center at Tyler, Tyler, TX 75708, USA
    Mol Cell Biochem 253:131-40. 2003
    ..In this article, we provide a comprehensive review on the regulation of TF-VIIa functional expression by these other mechanisms, with a particular emphasis on TF-VIIa endocytosis, and our perspective of these studies...
  11. ncbi Endothelial cell protein C receptor cellular localization and trafficking: potential functional implications
    Ramesh C Nayak
    Center for Biomedical Research, University of Texas Health Science Center at Tyler, Tyler, TX 75708, USA
    Blood 114:1974-86. 2009
    ..Overall, our results show that FVIIa or activated protein C binding to EPCR promotes EPCR endocytosis, and EPCR-mediated endocytosis may facilitate the transcytosis of FVIIa and its clearance from the circulation...
  12. ncbi Factor VIIa bound to endothelial cell protein C receptor activates protease activated receptor-1 and mediates cell signaling and barrier protection
    Prosenjit Sen
    Center for Biomedical Research, The University of Texas Health Science Center at Tyler, Tyler, TX, USA
    Blood 117:3199-208. 2011
    ..These findings are novel and of great clinical significance, because FVIIa is used clinically for the prevention of bleeding in hemophilia and other bleeding disorders...
  13. ncbi Factor VIIa interaction with endothelial cells and endothelial cell protein C receptor
    Usha R Pendurthi
    Center for Biomedical Research, The University of Texas Health Science Center at Tyler, TX 75708, USA
    Thromb Res 125:S19-22. 2010
    ....
  14. ncbi Cystine 186-cystine 209 disulfide bond is not essential for the procoagulant activity of tissue factor or for its de-encryption
    Hema Kothari
    Center for Biomedical Research, The University of Texas Health Science Center at Tyler, Tyler, TX 75708, USA
    Blood 115:4273-83. 2010
    ..Our data provide clear evidence that TF lacking the Cys186-Cys209 bond is coagulantly active once it is complexed with FVIIa, and TF de-encryption does not require Cys186-Cys209 disulfide bond formation...
  15. ncbi Modulation of tissue factor-factor VIIa signaling by lipid rafts and caveolae
    Vineet Awasthi
    Biomedical Research Division, The University of Texas Health Center at Tyler, 11937 US Highway 271, Tyler, TX 75708, USA
    Arterioscler Thromb Vasc Biol 27:1447-55. 2007
    ..The objective of the present study is to investigate the role of lipid rafts and caveolae in modulating TF-VIIa signaling and coagulant functions...
  16. ncbi Tissue factor trafficking in fibroblasts: involvement of protease-activated receptor-mediated cell signaling
    Samir K Mandal
    Biomedical Research Division, The University of Texas Health Science Center at Tyler, TX 75708, USA
    Blood 110:161-70. 2007
    ..However, PAR2 activation is found to be critical for the FVIIa-induced TF endocytosis. Overall the data herein provide novel insights into the role of PARs in regulating cell surface TF expression...
  17. ncbi Tissue factor activation: is disulfide bond switching a regulatory mechanism?
    Usha R Pendurthi
    Biomedical Research Division, University of Texas Health Science Center at Tyler, TX 75708, USA
    Blood 110:3900-8. 2007
    ..Overall, the present data undermine the recently proposed hypothesis that PDI-mediated disulfide exchange plays a role in regulating TF procoagulant and cell signaling functions...
  18. ncbi c-Maf-dependent growth of Mycobacterium tuberculosis in a CD14(hi) subpopulation of monocyte-derived macrophages
    Rohan Dhiman
    Center for Pulmonary and Infectious Disease Control, University of Texas Health Science Center, Tyler, TX 75708, USA
    J Immunol 186:1638-45. 2011
    ..tuberculosis...
  19. ncbi Acute cholesterol depletion impairs functional expression of tissue factor in fibroblasts: modulation of tissue factor activity by membrane cholesterol
    Samir K Mandal
    Biomedical Research Division, The University of Texas Health Center at Tyler, Tyler, TX 75708, USA
    Blood 105:153-60. 2005
    ..Overall, the data presented herein suggest that membrane cholesterol functions as a positive regulator of TF function by maintaining TF receptors, probably in noncaveolar lipid rafts, in a high-affinity state for VIIa binding...
  20. ncbi Cellular localization and trafficking of tissue factor
    Samir K Mandal
    Biomedical Research Division, The University of Texas Health Center at Tyler, TX 75708, USA
    Blood 107:4746-53. 2006
    ..This mechanism could play an important role in hemostasis in response to vascular injury by increasing TF activity where and when it is needed...
  21. ncbi Proteolysis of CCN1 by plasmin: functional implications
    Usha R Pendurthi
    Biomedical Research Division, The University of Texas Health Center at Tyler, Tyler, Texas 75708, USA
    Cancer Res 65:9705-11. 2005
    ....
  22. ncbi Role of tissue factor disulfides and lipid rafts in signaling
    Usha R Pendurthi
    Center for Biomedical Research, The University of Texas Health Science Center, Tyler, TX 75708, USA
    Thromb Res 122:S14-8. 2008
    ..The review also discusses the importance of TF localization in lipid rafts and caveolae in maintaining its coagulant and signaling functions...
  23. ncbi Endothelial cell protein C receptor acts as a cellular receptor for factor VIIa on endothelium
    Samit Ghosh
    Biomedical Research Division, The University of Texas Health Center at Tyler, Tyler, Texas 75708, USA
    J Biol Chem 282:11849-57. 2007
    ..Overall, the present data provide convincing evidence that EPCR serves as a cellular binding site for FVII/FVIIa. Further studies are needed to evaluate the pathophysiological consequences and relevance of FVIIa binding to EPCR...
  24. ncbi Tissue factor-factor VIIa-specific up-regulation of IL-8 expression in MDA-MB-231 cells is mediated by PAR-2 and results in increased cell migration
    Gertrud M Hjortoe
    Biomedical Research Division, University of Texas Health Center at Tyler, TX 75708, USA
    Blood 103:3029-37. 2004
    ..In summary, the studies described herein provide insight into how TF may contribute to tumor invasion...
  25. ncbi Analysis of factor VIIa binding to relipidated tissue factor by surface plasmon resonance
    Prosenjit Sen
    The University of Texas Health Science Center at Tyler, Texas 75708, USA
    Blood Coagul Fibrinolysis 21:376-9. 2010
    ..The present data suggest that SPR binding studies using TF embedded in phospholipids is more appropriate for investigating how FVIIa (or FVIIa mutants/derivatives) may interact with TF in physiological settings...
  26. ncbi Factor VIIa interaction with tissue factor and endothelial cell protein C receptor on cell surfaces
    Usha R Pendurthi
    Biomedical Research, The University of Texas Health Center at Tyler, Tyler, TX 75708, USA
    Semin Hematol 45:S21-4. 2008
    ..This article reviews current knowledge of FVIIa interaction with TF and EPCR on cell surfaces with a specific focus on how these interactions may contribute to FVIIa and TF clearance, thereby regulating TF-FVIIa activity...
  27. ncbi Resveratrol suppresses agonist-induced monocyte adhesion to cultured human endothelial cells
    Usha R Pendurthi
    Biomedical Research, The University of Texas Health Center at Tyler, 11937 US Hwy 271, Tyler, TX 75708, USA
    Thromb Res 106:243-8. 2002
  28. ncbi Effect of wine phenolics and stilbene analogues on tissue factor expression in endothelial cells
    Usha R Pendurthi
    Biomedical Research, The University of Texas Health Center at Tyler, 11937 US Highway 271, Tyler, TX 75708, USA
    Thromb Res 106:205-11. 2002
  29. ncbi Plasmin induces Cyr61 gene expression in fibroblasts via protease-activated receptor-1 and p44/42 mitogen-activated protein kinase-dependent signaling pathway
    Usha R Pendurthi
    Biomedical Research, The University of Texas Health Center at Tyler, Tex 75708, USA
    Arterioscler Thromb Vasc Biol 22:1421-6. 2002
    ..The aim of the present study was to elucidate potential mechanisms by which plasmin affects various cellular processes...
  30. ncbi Factor VIIa/tissue factor-induced signaling: a link between clotting and disease
    Usha R Pendurthi
    Biomedical Research, University of Texas Health Center at Tyler, Tyler, Texas 75708, USA
    Vitam Horm 64:323-55. 2002
    ....
  31. ncbi IL-22 produced by human NK cells inhibits growth of Mycobacterium tuberculosis by enhancing phagolysosomal fusion
    Rohan Dhiman
    Center for Pulmonary and Infectious Disease Control, Department of Microbiology and Immunology, University of Texas Health Center, Tyler, TX 75708 3154, USA
    J Immunol 183:6639-45. 2009
    ..tuberculosis through production of IL-22, which inhibits intracellular mycobacterial growth by enhancing phagolysosomal fusion. IL-15 and DAP-10 elicit IL-22 production by NK cells in response to M. tuberculosis...
  32. ncbi Mechanism of resveratrol-mediated suppression of tissue factor gene expression
    Usha R Pendurthi
    Biomedical Research, The University of Texas Health Center at Tyler, 75708, USA
    Thromb Haemost 87:155-62. 2002
    ..In summary, our results indicate that resveratrol does not inhibit the activation or translocation of NF-kappaB/Rel proteins but inhibits NF-kappaB/Rel-dependent transcription by impairing the transactivation potential of p65...

Research Grants9

  1. INITIATION AND REGULATION OF BLOOD COAGULATION
    VIJAYA MOHAN RAO LELLA; Fiscal Year: 2010
    ..abstract_text> ..
  2. INITIATION AND REGULATION OF BLOOD COAGULATION
    VIJAYA LELLA; Fiscal Year: 2001
    ..Such an understanding may lead to the design and application of therapeutic measures aimed at the treatment of hemorrhagic disease and thrombotic complications. ..
  3. INITIATION AND REGULATION OF BLOOD COAGULATION
    VIJAYA LELLA; Fiscal Year: 2007
    ..abstract_text> ..