Uma Rao

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. pmc Electroencephalographic sleep and hypothalamic-pituitary-adrenal changes from episode to recovery in depressed adolescents
    Uma Rao
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9101, USA
    J Child Adolesc Psychopharmacol 18:607-13. 2008
  2. ncbi Links between depression and substance abuse in adolescents: neurobiological mechanisms
    Uma Rao
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas 75390 9101, USA
    Am J Prev Med 31:S161-74. 2006
  3. pmc Mechanisms underlying the comorbidity between depressive and addictive disorders in adolescents: interactions between stress and HPA activity
    Uma Rao
    Department of Psychiatry, UT Southwestern Medical Center, Dallas, TX 75390 9101, USA
    Am J Psychiatry 166:361-9. 2009
  4. pmc Risk markers for depression in adolescents: sleep and HPA measures
    Uma Rao
    Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, TX 75390 9101, USA
    Neuropsychopharmacology 34:1936-45. 2009
  5. pmc Characteristics, correlates, and outcomes of childhood and adolescent depressive disorders
    Uma Rao
    Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9101, USA
    Dialogues Clin Neurosci 11:45-62. 2009
  6. ncbi Neurobiological and psychosocial processes associated with depressive and substance-related disorders in adolescents
    Uma Rao
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390 9101, USA
    Curr Drug Abuse Rev 1:68-80. 2008
  7. pmc Contribution of hypothalamic-pituitary-adrenal activity and environmental stress to vulnerability for smoking in adolescents
    Uma Rao
    Department of Psychiatry, UT Southwestern Medical Center, Dallas, TX 75390 9101, USA
    Neuropsychopharmacology 34:2721-32. 2009
  8. ncbi REM sleep and cortisol responses to scopolamine during depression and remission in women
    Uma Rao
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390 8589, USA
    Int J Neuropsychopharmacol 7:265-74. 2004
  9. pmc Hippocampal changes associated with early-life adversity and vulnerability to depression
    Uma Rao
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, 75390 9101, USA
    Biol Psychiatry 67:357-64. 2010
  10. pmc Longitudinal course of adolescent depression: neuroendocrine and psychosocial predictors
    Uma Rao
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390 9101, USA
    J Am Acad Child Adolesc Psychiatry 49:141-51. 2010

Collaborators

Detail Information

Publications30

  1. pmc Electroencephalographic sleep and hypothalamic-pituitary-adrenal changes from episode to recovery in depressed adolescents
    Uma Rao
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9101, USA
    J Child Adolesc Psychopharmacol 18:607-13. 2008
    ..The study examined electroencephalographic (EEG) sleep and hypothalamic-pituitary-adrenal (HPA) changes associated with depressive episode and during recovery in adolescent depression...
  2. ncbi Links between depression and substance abuse in adolescents: neurobiological mechanisms
    Uma Rao
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas 75390 9101, USA
    Am J Prev Med 31:S161-74. 2006
    ....
  3. pmc Mechanisms underlying the comorbidity between depressive and addictive disorders in adolescents: interactions between stress and HPA activity
    Uma Rao
    Department of Psychiatry, UT Southwestern Medical Center, Dallas, TX 75390 9101, USA
    Am J Psychiatry 166:361-9. 2009
    ....
  4. pmc Risk markers for depression in adolescents: sleep and HPA measures
    Uma Rao
    Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, TX 75390 9101, USA
    Neuropsychopharmacology 34:1936-45. 2009
    ..The findings that REM sleep abnormalities and elevated HPA activity occur before the onset of depression in at-risk adolescents suggest that these variables serve as vulnerability markers for the illness...
  5. pmc Characteristics, correlates, and outcomes of childhood and adolescent depressive disorders
    Uma Rao
    Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9101, USA
    Dialogues Clin Neurosci 11:45-62. 2009
    ..Characterization of the developmental differences will be helpful in developing more specific and effective interventions for youngsters, thereby allowing them to reach their full potential as adults...
  6. ncbi Neurobiological and psychosocial processes associated with depressive and substance-related disorders in adolescents
    Uma Rao
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390 9101, USA
    Curr Drug Abuse Rev 1:68-80. 2008
    ....
  7. pmc Contribution of hypothalamic-pituitary-adrenal activity and environmental stress to vulnerability for smoking in adolescents
    Uma Rao
    Department of Psychiatry, UT Southwestern Medical Center, Dallas, TX 75390 9101, USA
    Neuropsychopharmacology 34:2721-32. 2009
    ..High evening/night-time cortisol levels and stressful experiences accounted, at least partially, for the association between depressive illness and smoking behavior...
  8. ncbi REM sleep and cortisol responses to scopolamine during depression and remission in women
    Uma Rao
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390 8589, USA
    Int J Neuropsychopharmacol 7:265-74. 2004
    ..The results also suggest that the central cholinergic system(s) that regulate(s) REM sleep may be more sensitive to dysregulation than the cholinergic system(s) that control(s) nocturnal cortisol secretion...
  9. pmc Hippocampal changes associated with early-life adversity and vulnerability to depression
    Uma Rao
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, 75390 9101, USA
    Biol Psychiatry 67:357-64. 2010
    ..Hippocampal changes may mediate the relationship between early-life adversity and depressive illness in a subset of patients. However, there are no reports of longitudinal clinical studies that have examined this issue...
  10. pmc Longitudinal course of adolescent depression: neuroendocrine and psychosocial predictors
    Uma Rao
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390 9101, USA
    J Am Acad Child Adolesc Psychiatry 49:141-51. 2010
    ..Furthermore, the study evaluated whether the relationship between cortisol and clinical course is moderated by environmental stress and/or social support...
  11. pmc Relationship between adolescent risk preferences on a laboratory task and behavioral measures of risk-taking
    Uma Rao
    Department of Psychiatry, University of Texas Southwestern Medical Center, 5223 Harry Hiles Blvd, Dallas, TX 75390 9101, USA
    J Adolesc Health 48:151-8. 2011
    ..The second aim was to evaluate whether the laboratory-based risk-taking behavior is associated with other behavioral and psychological measures associated with risk-taking behavior...
  12. pmc Effects of early and recent adverse experiences on adrenal response to psychosocial stress in depressed adolescents
    Uma Rao
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9101, USA
    Biol Psychiatry 64:521-6. 2008
    ..The variability in HPA findings may be attributed to experiential factors...
  13. ncbi Effect of bupropion on nocturnal urinary free cortisol and its association with antidepressant response
    Uma Rao
    Department of Psychiatry, UT Southwestern Medical Center, Dallas, TX, USA
    J Psychiatr Res 39:183-90. 2005
    ..One possible mechanism for the association between the NUFC response to acute bupropion challenge and antidepressant efficacy might be linked through dopaminergic and/or noradrenergic mechanisms...
  14. pmc White matter disruptions in adolescents exposed to childhood maltreatment and vulnerability to psychopathology
    Hao Huang
    Advanced Imaging Research Center, The University of Texas Southwestern Medical Center, Dallas, TX, USA
    Neuropsychopharmacology 37:2693-701. 2012
    ....
  15. pmc Neurobiological processes in adolescent addictive disorders
    Ty S Schepis
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Am J Addict 17:6-23. 2008
    ..A clearer understanding of adolescent neurobiology is a necessary step in the development of prevention and treatment interventions for adolescent SUD...
  16. doi Impulsivity, neural deficits, and the addictions: the "oops" factor in relapse
    Bryon Adinoff
    Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas and VA North Texas Health Care System, Dallas, TX 75390 8564, USA
    J Addict Dis 26:25-39. 2007
    ..Empirical investigations documenting the hypothesized relationship between specific deficits in impulsive behaviors, coupled with their neurobiological correlates, and relapse should be the focus of future studies...
  17. pmc White matter changes in healthy adolescents at familial risk for unipolar depression: a diffusion tensor imaging study
    Hao Huang
    Advanced Imaging Research Center, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Neuropsychopharmacology 36:684-91. 2011
    ..Altered white matter integrity in healthy adolescents at familial risk for unipolar depression suggests that it might serve as a vulnerability marker for the illness...
  18. ncbi Epidemiology and etiology of adolescent smoking
    Ty S Schepis
    University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA
    Curr Opin Pediatr 17:607-12. 2005
    ..This review summarizes the recent research concerning the psychosocial and physiologic risk and protective factors associated with adolescent smoking...
  19. ncbi Smoking cessation for adolescents: a review of pharmacological and psychosocial treatments
    Ty S Schepis
    Department of Psychiatry, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9101, USA
    Curr Drug Abuse Rev 1:142-55. 2008
    ..With the current state of the literature as a guide, future directions for research into smoking cessation for adolescents will be proposed...
  20. pmc Gray matter differences between healthy and depressed adolescents: a voxel-based morphometry study
    Mujeeb U Shad
    Department of Psychiatry, University of Texas Health Sciences Center at Houston, Houston, TX 77054, USA
    J Child Adolesc Psychopharmacol 22:190-7. 2012
    ..However, little is known about the neurobiology of adolescent depression. A better understanding of the neurobiology will be helpful in developing more effective preventive and treatment interventions for this highly disabling illness...
  21. doi Serum NPY and BNDF response to a behavioral stressor in alcohol-dependent and healthy control participants
    Donna Meng
    Department of Psychiatry, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 8564, USA
    Psychopharmacology (Berl) 218:59-67. 2011
    ..However, few studies have assessed the NPY and BDNF response to stress in alcohol-dependent participants and the concurrent measure of NPY and BDNF has not been reported in human participants...
  22. ncbi Depressive symptoms predict hospitalization for adolescents with type 1 diabetes mellitus
    Sunita M Stewart
    Department of Psychiatry, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 8589, USA
    Pediatrics 115:1315-9. 2005
    ..To examine the role of self-reported depressive symptoms in predicting hospitalization for complications of diabetes mellitus over a period of up to 2 years...
  23. ncbi Depression and diabetes in children and adolescents
    Sunita M Stewart
    Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA
    Curr Opin Pediatr 17:626-31. 2005
    ....
  24. ncbi Effect of treatment with bupropion on EEG sleep: relationship to antidepressant response
    Geoffrey E Ott
    Interdepartmental Training Program for Neuroscience, UCLA, CA 90048, USA
    Int J Neuropsychopharmacol 7:275-81. 2004
    ..Differential response to treatment was associated with changes in REM activity and density, but not with REM latency. However, in contrast to many other antidepressants, REM sleep was not suppressed...
  25. ncbi Effect of bupropion-SR on REM sleep: relationship to antidepressant response
    Geoffrey E Ott
    Interdepartmental Training Program for Neuroscience, UCLA, Los Angeles, CA 90024, USA
    Psychopharmacology (Berl) 165:29-36. 2002
    ..However, newer AD agents, which appear to have different effects on sleep, have not been evaluated systematically for their usefulness in predicting treatment response...
  26. ncbi Repeat suicide attempts in Hong Kong community adolescents
    Joy P S Wong
    University of Hong Kong, Hong Kong
    Soc Sci Med 66:232-41. 2008
    ..These findings are consistent with the "crescendo" model proposing that the risk of repeat attempts is enhanced following a previous suicide attempt...
  27. ncbi Exposure to suicide and suicidal behaviors among Hong Kong adolescents
    Joy P S Wong
    Department of Community Medicine, University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong
    Soc Sci Med 61:591-9. 2005
    ..Furthermore, those youths who experience depressive symptoms or suicidal ideation are at particularly high risk for engaging in suicidal behaviors when an exposure to suicide attempt occurs...
  28. ncbi A pooled analysis of eastern cooperative oncology group and intergroup trials of adjuvant high-dose interferon for melanoma
    John M Kirkwood
    University of Pittsburgh Medical Center, Department of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Clin Cancer Res 10:1670-7. 2004
    ..The objectives of this study were to update the analyses of each individual trial and to analyze prognostic factors and treatment effects based on pooled data...
  29. ncbi Depressive symptoms and smoking among Hong Kong Chinese adolescents
    T H Lam
    Department of Community Medicine, The University of Hong Kong, China
    Addiction 100:1003-11. 2005
    ..To examine associations among depressive symptoms, smoking, smoking trajectories and quitting smoking in Hong Kong...
  30. ncbi Heterogeneity in EEG sleep findings in adolescent depression: unipolar versus bipolar clinical course
    Uma Rao
    Department of Psychiatry and Biobehavioral Sciences, UCLA, Los Angeles, CA 90024 1759, USA
    J Affect Disord 70:273-80. 2002
    ..This investigation was designed to assess whether some of the observed variability is related to undifferentiated unipolar and bipolar disorders in a sample that was reported previously...

Research Grants31

  1. Treatment Prediction in Adolescent and Adult Depression
    Uma Rao; Fiscal Year: 2006
    ....
  2. Markers of Risk for Nicotine Dependence in Youngsters
    Uma Rao; Fiscal Year: 2006
    ..Even if only a small subgroup of youngsters at risk for ND can be identified by such means, because of the many direct as well as indirect negative consequences associated with ND, this will be of great public health importance. ..
  3. Risk for Substance Abuse in Depressed Adolescents
    Uma Rao; Fiscal Year: 2006
    ..More focused and effective treatments potentially might be helpful in reducing the risk for SUD in depressed youth. Moreover, such treatment strategies can be extended for testing in non-depressed youth. ..
  4. Treatment Prediction in Adolescent and Adult Depression
    Uma Rao; Fiscal Year: 2009
    ....
  5. Stress and Risk for Substance Abuse in Adolescents
    Uma Rao; Fiscal Year: 2007
    ..The identification of specific vulnerabilities and associated biological alterations will aid in the development of more focused and effective pharmacological and psychosocial interventions to reduce the risk of SUD in such youth. ..
  6. Stress Response and Smoking Cessation in Depressed Youth
    Uma Rao; Fiscal Year: 2007
    ..Results of the proposed study might lead to treatment for both depression and nicotine dependence in adolescent patients. ..
  7. Neuronal Risk Markers for Nicotine Dependence in Youth
    Uma Rao; Fiscal Year: 2010
    ..abstract_text> ..