Radhakrishna Rao

Summary

Affiliation: University of Tennessee
Country: USA

Publications

  1. pmc Tyrosine phosphorylation and dissociation of occludin-ZO-1 and E-cadherin-beta-catenin complexes from the cytoskeleton by oxidative stress
    Radhakrishna K Rao
    Department of Physiology, University of Tennessee Health Sciences Center, 894 Union Avenue, Memphis, TN 38163, U S A
    Biochem J 368:471-81. 2002
  2. ncbi request reprint Protein phosphatases 2A and 1 interact with occludin and negatively regulate the assembly of tight junctions in the CACO-2 cell monolayer
    Ankur Seth
    Department of Physiology, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    J Biol Chem 282:11487-98. 2007
  3. doi request reprint Occludin phosphorylation in regulation of epithelial tight junctions
    Radhakrishna Rao
    Department of Physiology, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    Ann N Y Acad Sci 1165:62-8. 2009
  4. ncbi request reprint Oxidative stress-induced disruption of epithelial and endothelial tight junctions
    Radhakrishna Rao
    Department of Physiology, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Front Biosci 13:7210-26. 2008
  5. ncbi request reprint Recent Advances in Alcoholic Liver Disease I. Role of intestinal permeability and endotoxemia in alcoholic liver disease
    R K Rao
    Department of Physiology, University of Tennessee, Memphis, TN 38163, USA
    Am J Physiol Gastrointest Liver Physiol 286:G881-4. 2004
  6. pmc Phosphorylation of Tyr-398 and Tyr-402 in occludin prevents its interaction with ZO-1 and destabilizes its assembly at the tight junctions
    Bertha C Elias
    Department of Physiology, Charles B Stout Neuroscience Mass Spectrometry Laboratory, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    J Biol Chem 284:1559-69. 2009
  7. doi request reprint Protein phosphatase 2A plays a role in hydrogen peroxide-induced disruption of tight junctions in Caco-2 cell monolayers
    Parimal Sheth
    Department of Physiology, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Biochem J 421:59-70. 2009
  8. pmc PKC eta regulates occludin phosphorylation and epithelial tight junction integrity
    Takuya Suzuki
    Department of Physiology, University of Tennessee Health Science Center, 894 Union Avenue, Memphis, TN 38163, USA
    Proc Natl Acad Sci U S A 106:61-6. 2009
  9. pmc Protein kinase Cζ phosphorylates occludin and promotes assembly of epithelial tight junctions
    Suneet Jain
    Department of Physiology, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Biochem J 437:289-99. 2011
  10. pmc Acetaldehyde dissociates the PTP1B-E-cadherin-beta-catenin complex in Caco-2 cell monolayers by a phosphorylation-dependent mechanism
    Parimal Sheth
    Department of Physiology, University of Tennessee Health Science Center, University of Memphis, Memphis, TN 38163, USA
    Biochem J 402:291-300. 2007

Research Grants

  1. MECHANISM OF ENDOTOXIN ABSORPTION IN ALCOHOLISM
    Radhakrishna Rao; Fiscal Year: 2009
  2. MUCOSAL PROTECTIVE FACTORS IN HUMAN MILK
    Radhakrishna Rao; Fiscal Year: 2003
  3. INTESTINAL MUCOSAL PROTECTION BY EPIDERMAL GROWTH FACTOR
    Radhakrishna Rao; Fiscal Year: 2007
  4. MECHANISM OF ENDOTOXIN ABSORPTION IN ALCOHOLISM
    Radhakrishna Rao; Fiscal Year: 2003
  5. INTESTINAL MUCOSAL PROTECTION BY EPIDERMAL GROWTH FACTOR
    Radhakrishna Rao; Fiscal Year: 2002

Collaborators

Detail Information

Publications15

  1. pmc Tyrosine phosphorylation and dissociation of occludin-ZO-1 and E-cadherin-beta-catenin complexes from the cytoskeleton by oxidative stress
    Radhakrishna K Rao
    Department of Physiology, University of Tennessee Health Sciences Center, 894 Union Avenue, Memphis, TN 38163, U S A
    Biochem J 368:471-81. 2002
    ..These results show that oxidative stress induces tyrosine phosphorylation and cellular redistribution of occludin-ZO-1 and E-cadherin-beta-catenin complexes by a tyrosine-kinase-dependent mechanism...
  2. ncbi request reprint Protein phosphatases 2A and 1 interact with occludin and negatively regulate the assembly of tight junctions in the CACO-2 cell monolayer
    Ankur Seth
    Department of Physiology, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    J Biol Chem 282:11487-98. 2007
    ..This study shows that PP2A and PP1 directly interact with occludin and negatively regulate the assembly of TJ by modulating the phosphorylation status of occludin...
  3. doi request reprint Occludin phosphorylation in regulation of epithelial tight junctions
    Radhakrishna Rao
    Department of Physiology, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    Ann N Y Acad Sci 1165:62-8. 2009
    ..It is likely that occludin plays a regulatory role in tight junctions rather than a role in the de novo assembly of tight junctions...
  4. ncbi request reprint Oxidative stress-induced disruption of epithelial and endothelial tight junctions
    Radhakrishna Rao
    Department of Physiology, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Front Biosci 13:7210-26. 2008
    ....
  5. ncbi request reprint Recent Advances in Alcoholic Liver Disease I. Role of intestinal permeability and endotoxemia in alcoholic liver disease
    R K Rao
    Department of Physiology, University of Tennessee, Memphis, TN 38163, USA
    Am J Physiol Gastrointest Liver Physiol 286:G881-4. 2004
    ....
  6. pmc Phosphorylation of Tyr-398 and Tyr-402 in occludin prevents its interaction with ZO-1 and destabilizes its assembly at the tight junctions
    Bertha C Elias
    Department of Physiology, Charles B Stout Neuroscience Mass Spectrometry Laboratory, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    J Biol Chem 284:1559-69. 2009
    ..This study reveals a unique motif in the occludin sequence that is involved in the regulation of ZO-1 binding by reversible phosphorylation of specific Tyr residues...
  7. doi request reprint Protein phosphatase 2A plays a role in hydrogen peroxide-induced disruption of tight junctions in Caco-2 cell monolayers
    Parimal Sheth
    Department of Physiology, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Biochem J 421:59-70. 2009
    ....
  8. pmc PKC eta regulates occludin phosphorylation and epithelial tight junction integrity
    Takuya Suzuki
    Department of Physiology, University of Tennessee Health Science Center, 894 Union Avenue, Memphis, TN 38163, USA
    Proc Natl Acad Sci U S A 106:61-6. 2009
    ..These results reveal an important mechanism of epithelial TJ regulation by PKC eta...
  9. pmc Protein kinase Cζ phosphorylates occludin and promotes assembly of epithelial tight junctions
    Suneet Jain
    Department of Physiology, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Biochem J 437:289-99. 2011
    ..The present study demonstrates that PKCζ phosphorylates occludin on specific threonine residues and promotes assembly of epithelial tight junctions...
  10. pmc Acetaldehyde dissociates the PTP1B-E-cadherin-beta-catenin complex in Caco-2 cell monolayers by a phosphorylation-dependent mechanism
    Parimal Sheth
    Department of Physiology, University of Tennessee Health Science Center, University of Memphis, Memphis, TN 38163, USA
    Biochem J 402:291-300. 2007
    ..These results show that acetaldehyde induces disruption of interactions between E-cadherin, beta-catenin and PTP1B by a phosphorylation-dependent mechanism...
  11. ncbi request reprint Role of phospholipase Cgamma-induced activation of protein kinase Cepsilon (PKCepsilon) and PKCbetaI in epidermal growth factor-mediated protection of tight junctions from acetaldehyde in Caco-2 cell monolayers
    Takuya Suzuki
    Department of Physiology, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    J Biol Chem 283:3574-83. 2008
    ..This study shows that PLCgamma-mediated activation of PKCepsilon and PKCbetaI and intracellular calcium is involved in EGF-mediated protection of tight junctions from acetaldehyde-induced insult...
  12. pmc MAPK interacts with occludin and mediates EGF-induced prevention of tight junction disruption by hydrogen peroxide
    Shyamali Basuroy
    Department of Physiology, University of Tennessee Health Science Center, Memphis, TN, USA
    Biochem J 393:69-77. 2006
    ..Therefore the present study shows that ERK interacts with the C-terminal region of occludin and mediates the prevention of H2O2-induced disruption of TJs by EGF...
  13. pmc Epidermal growth factor protects the apical junctional complexes from hydrogen peroxide in bile duct epithelium
    Srikar R Guntaka
    Department of Physiology, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Lab Invest 91:1396-409. 2011
    ..EGF prevents hydrogen peroxide-induced tight junction disruption by a PLCγ and PKC-dependent mechanism...
  14. pmc CaV1.3 channels and intracellular calcium mediate osmotic stress-induced N-terminal c-Jun kinase activation and disruption of tight junctions in Caco-2 CELL MONOLAYERS
    Geetha Samak
    Department of Physiology, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    J Biol Chem 286:30232-43. 2011
    ..Additionally, inositol 1,4,5-trisphosphate receptor-mediated release of ER Ca(2+) also contributes to osmotic stress-induced tight junction disruption...
  15. pmc Alcohol, intestinal bacterial growth, intestinal permeability to endotoxin, and medical consequences: summary of a symposium
    Vishnudutt Purohit
    Division of Metabolism and Health Effects, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 5635 Fishers Lane, Room 2035, MSC 9304, Bethesda, MD 20892 9304, USA
    Alcohol 42:349-61. 2008
    ..Thus reducing the number of intestinal Gram-negative bacteria and preserving intestinal permeability to endotoxin may attenuate alcoholic liver and other organ injuries...

Research Grants17

  1. MECHANISM OF ENDOTOXIN ABSORPTION IN ALCOHOLISM
    Radhakrishna Rao; Fiscal Year: 2009
    ..abstract_text> ..
  2. MUCOSAL PROTECTIVE FACTORS IN HUMAN MILK
    Radhakrishna Rao; Fiscal Year: 2003
    ..protective factors in breast milk, and provide the basis for further characterization of the mechanisms involved in mucosal protection by breast milk, and their role in preventing neonatal gastrointestinal diseases ..
  3. INTESTINAL MUCOSAL PROTECTION BY EPIDERMAL GROWTH FACTOR
    Radhakrishna Rao; Fiscal Year: 2007
    ..abstract_text> ..
  4. MECHANISM OF ENDOTOXIN ABSORPTION IN ALCOHOLISM
    Radhakrishna Rao; Fiscal Year: 2003
    ....
  5. INTESTINAL MUCOSAL PROTECTION BY EPIDERMAL GROWTH FACTOR
    Radhakrishna Rao; Fiscal Year: 2002
    ....