CHINTHALAPALLY RAO

Summary

Affiliation: University of Oklahoma Health Sciences Center
Country: USA

Publications

  1. ncbi request reprint Mitosis-targeting natural products for cancer prevention and therapy
    Chinthalapally V Rao
    Center for Cancer Prevention and Drug Development, Medical Oncology, Department of Medicine, Stephenson Oklahoma Cancer Center, University of Oklahoma Health Sciences Center OUHSC, Oklahoma City, 73104, USA
    Curr Drug Targets 13:1820-30. 2012
  2. pmc Genomic instability and colon carcinogenesis: from the perspective of genes
    Chinthalapally V Rao
    Department of Medicine, University of Oklahoma Health Sciences Center Oklahoma City, OK, USA
    Front Oncol 3:130. 2013
  3. ncbi request reprint β-Escin inhibits NNK-induced lung adenocarcinoma and ALDH1A1 and RhoA/Rock expression in A/J mice and growth of H460 human lung cancer cells
    Jagan M R Patlolla
    Center for Cancer Prevention and Drug Development, 975 NE 10th Street, BRC 1203, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104 and Jagan M R Patlolla, E mail
    Cancer Prev Res (Phila) 6:1140-9. 2013
  4. doi request reprint Chemopreventive efficacy of raloxifene, bexarotene, and their combination on the progression of chemically induced colon adenomas to adenocarcinomas in rats
    Naveena B Janakiram
    Center for Cancer Prevention and Drug Development, University of Oklahoma Health Sciences Center, 975 NE 10th Street, BRC 1203, Oklahoma City, OK 73104
    Cancer Prev Res (Phila) 6:1251-61. 2013
  5. doi request reprint Benzyl isothiocyanate: double trouble for breast cancer cells
    Chinthalapally V Rao
    Center for Cancer Prevention and Drug Development, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Cancer Prev Res (Phila) 6:760-3. 2013
  6. doi request reprint Prevention of familial adenomatous polyp development in APC min mice and azoxymethane-induced colon carcinogenesis in F344 Rats by ω-3 fatty acid rich perilla oil
    Chinthalapally V Rao
    Center for Cancer Prevention and Drug Development, Department of Medicine, Hem Onc Section, PC Stephenson Cancer Center, Oklahoma City, Oklahoma 73104, USA
    Nutr Cancer 65:54-60. 2013
  7. ncbi request reprint Anti-inflammatory phytochemicals for chemoprevention of colon cancer
    Venkateshwar Madka
    Center for Cancer Prevention and Drug Development, Department of Medicine, Hem Onc Section, PC Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Curr Cancer Drug Targets 13:542-57. 2013
  8. pmc Inhibition of pancreatic intraepithelial neoplasia progression to carcinoma by nitric oxide-releasing aspirin in p48(Cre/+)-LSL-Kras(G12D/+) mice
    Chinthalapally V Rao
    Hematology Oncology Section, Center for Cancer Prevention and Drug Development, Peggy and Charles Stephenson Cancer Center, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Neoplasia 14:778-87. 2012
  9. ncbi request reprint Early detection and prevention of pancreatic cancer: use of genetically engineered mouse models and advanced imaging technologies
    A Mohammed
    Center for Chemoprevention and Cancer Drug Development, PCS Oklahoma Cancer Center, 975 NE 10th Street, BRC 1203, OUHSC, Oklahoma City, OK 73104, USA
    Curr Med Chem 19:3701-13. 2012
  10. ncbi request reprint Triterpenoids for cancer prevention and treatment: current status and future prospects
    Jagan M R Patlolla
    Center for Chemoprevention and Cancer Drug Development, Department of Medicine, Hematology Oncology Section, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Curr Pharm Biotechnol 13:147-55. 2012

Research Grants

  1. MECHANISMS FOR CHEMOPREVENTION OF COLON CANCER
    CHINTHALAPALLY RAO; Fiscal Year: 1999
  2. PREVENTION OF COLORECTAL CANCER BY iNOS AND COX-2 SELECTIVE INHIBITORS
    CHINTHALAPALLY RAO; Fiscal Year: 2007
  3. PREVENTION OF CRC BY iNOS AND COX-2 SELECTIVE INHIBITORS
    CHINTHALAPALLY RAO; Fiscal Year: 2006
  4. HMG CoA REDUCTASE AND COX2 INHIBITORS IN COLON CANCER
    CHINTHALAPALLY RAO; Fiscal Year: 2006
  5. PREVENTION OF CRC BY iNOS AND COX-2 SELECTIVE INHIBITORS
    CHINTHALAPALLY RAO; Fiscal Year: 2005
  6. HMG CoA REDUCTASE AND COX2 INHIBITORS IN COLON CANCER
    CHINTHALAPALLY RAO; Fiscal Year: 2004
  7. MECHANISMS FOR CHEMOPREVENTION OF COLON CANCER
    CHINTHALAPALLY RAO; Fiscal Year: 2004
  8. PREVENTION OF CRC BY iNOS AND COX-2 SELECTIVE INHIBITORS
    CHINTHALAPALLY RAO; Fiscal Year: 2004
  9. HMG CoA REDUCTASE AND COX2 INHIBITORS IN COLON CANCER
    CHINTHALAPALLY RAO; Fiscal Year: 2004
  10. HMG CoA REDUCTASE AND COX2 INHIBITORS IN COLON CANCER
    CHINTHALAPALLY RAO; Fiscal Year: 2003

Collaborators

Detail Information

Publications55

  1. ncbi request reprint Mitosis-targeting natural products for cancer prevention and therapy
    Chinthalapally V Rao
    Center for Cancer Prevention and Drug Development, Medical Oncology, Department of Medicine, Stephenson Oklahoma Cancer Center, University of Oklahoma Health Sciences Center OUHSC, Oklahoma City, 73104, USA
    Curr Drug Targets 13:1820-30. 2012
    ..These advances help us to identify and develop potential natural agents for the prevention and treatment of cancer. This review will focus on natural products that target mitotic process and/or proteins involved in mitotic progression...
  2. pmc Genomic instability and colon carcinogenesis: from the perspective of genes
    Chinthalapally V Rao
    Department of Medicine, University of Oklahoma Health Sciences Center Oklahoma City, OK, USA
    Front Oncol 3:130. 2013
    ..Thus, there is a feedback-type relationship between CAN gene mutations and genomic instability. These genetic/genomic studies have led to emerging efforts to apply the knowledge to colon cancer prognosis and to targeted therapy...
  3. ncbi request reprint β-Escin inhibits NNK-induced lung adenocarcinoma and ALDH1A1 and RhoA/Rock expression in A/J mice and growth of H460 human lung cancer cells
    Jagan M R Patlolla
    Center for Cancer Prevention and Drug Development, 975 NE 10th Street, BRC 1203, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104 and Jagan M R Patlolla, E mail
    Cancer Prev Res (Phila) 6:1140-9. 2013
    ..Our findings suggest that β-escin inhibits tobacco carcinogen-induced lung tumor formation by modulating ALDH1A1-positive cells and RhoA/Rock signaling...
  4. doi request reprint Chemopreventive efficacy of raloxifene, bexarotene, and their combination on the progression of chemically induced colon adenomas to adenocarcinomas in rats
    Naveena B Janakiram
    Center for Cancer Prevention and Drug Development, University of Oklahoma Health Sciences Center, 975 NE 10th Street, BRC 1203, Oklahoma City, OK 73104
    Cancer Prev Res (Phila) 6:1251-61. 2013
    ..The combination of low doses of raloxifene and bexarotene significantly suppressed the progression of colonic adenomas to adenocarcinomas and may be useful for colon cancer prevention and/or treatment in high-risk individuals...
  5. doi request reprint Benzyl isothiocyanate: double trouble for breast cancer cells
    Chinthalapally V Rao
    Center for Cancer Prevention and Drug Development, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Cancer Prev Res (Phila) 6:760-3. 2013
    ..This perspective briefly reviews epidemiologic evidence, preclinical efficacy data, and molecular and cellular mechanistic attributes of BITC. Critical issues relevant to clinical development of BITC are discussed briefly...
  6. doi request reprint Prevention of familial adenomatous polyp development in APC min mice and azoxymethane-induced colon carcinogenesis in F344 Rats by ω-3 fatty acid rich perilla oil
    Chinthalapally V Rao
    Center for Cancer Prevention and Drug Development, Department of Medicine, Hem Onc Section, PC Stephenson Cancer Center, Oklahoma City, Oklahoma 73104, USA
    Nutr Cancer 65:54-60. 2013
    ....
  7. ncbi request reprint Anti-inflammatory phytochemicals for chemoprevention of colon cancer
    Venkateshwar Madka
    Center for Cancer Prevention and Drug Development, Department of Medicine, Hem Onc Section, PC Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Curr Cancer Drug Targets 13:542-57. 2013
    ..In this review we discuss key inflammatory pathways associated with colorectal cancer and promising naturally-occurring phytochemicals as anti-inflammatory agents for the prevention and treatment of colorectal cancer. ..
  8. pmc Inhibition of pancreatic intraepithelial neoplasia progression to carcinoma by nitric oxide-releasing aspirin in p48(Cre/+)-LSL-Kras(G12D/+) mice
    Chinthalapally V Rao
    Hematology Oncology Section, Center for Cancer Prevention and Drug Development, Peggy and Charles Stephenson Cancer Center, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Neoplasia 14:778-87. 2012
    ..These results suggest that low-dose NO-aspirin possesses inhibitory activity against pancreatic carcinogenesis by modulating multiple molecular targets...
  9. ncbi request reprint Early detection and prevention of pancreatic cancer: use of genetically engineered mouse models and advanced imaging technologies
    A Mohammed
    Center for Chemoprevention and Cancer Drug Development, PCS Oklahoma Cancer Center, 975 NE 10th Street, BRC 1203, OUHSC, Oklahoma City, OK 73104, USA
    Curr Med Chem 19:3701-13. 2012
    ..These issues will be considered in the context of recently developed preclinical models of pancreatic cancer...
  10. ncbi request reprint Triterpenoids for cancer prevention and treatment: current status and future prospects
    Jagan M R Patlolla
    Center for Chemoprevention and Cancer Drug Development, Department of Medicine, Hematology Oncology Section, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Curr Pharm Biotechnol 13:147-55. 2012
    ....
  11. pmc Combination of atorvastatin with sulindac or naproxen profoundly inhibits colonic adenocarcinomas by suppressing the p65/β-catenin/cyclin D1 signaling pathway in rats
    Nanjoo Suh
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey, USA
    Cancer Prev Res (Phila) 4:1895-902. 2011
    ..Our results suggest that low-dose atorvastatin with sulindac or naproxen might potentially be useful combinations for colon cancer prevention in humans...
  12. ncbi request reprint Nitric oxide-releasing aspirin and indomethacin are potent inhibitors against colon cancer in azoxymethane-treated rats: effects on molecular targets
    Chinthalapally V Rao
    Department of Medicine, Hem Onc Section, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Mol Cancer Ther 5:1530-8. 2006
    ..These results pave the way for the rational design of human clinical trials...
  13. pmc Suppression of familial adenomatous polyposis by CP-31398, a TP53 modulator, in APCmin/+ mice
    Chinthalapally V Rao
    Department of Medicine, Hem Onc Section, University of Oklahoma Cancer Institute, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    Cancer Res 68:7670-5. 2008
    ..Chemopreventive activity of other agents that restore tumor suppressor functions of mutant p53 in tumor cells is currently under investigation...
  14. pmc Enhanced genomic instabilities caused by deregulated microtubule dynamics and chromosome segregation: a perspective from genetic studies in mice
    Chinthalapally V Rao
    Department of Medicine, Hematology Oncology Section, University of Oklahoma Cancer Institute, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Carcinogenesis 30:1469-74. 2009
    ..Further elucidation of molecular mechanisms of the SAC signaling has the potential for identifying new targets for rational anticancer drug design...
  15. pmc Chemoprevention of colon and small intestinal tumorigenesis in APC(Min/+) mice by licofelone, a novel dual 5-LOX/COX inhibitor: potential implications for human colon cancer prevention
    Altaf Mohammed
    Department of Medicine, Hem Onc Section, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Cancer Prev Res (Phila) 4:2015-26. 2011
    ..These observations show that a novel dual 5-LOX/COX inhibitor dramatically suppresses small intestinal and colonic tumor formation in APC(Min/+) mice...
  16. pmc Colonic tumorigenesis in BubR1+/-ApcMin/+ compound mutant mice is linked to premature separation of sister chromatids and enhanced genomic instability
    Chinthalapally V Rao
    Department of Medicine, University of Oklahoma Health Science Center, Oklahoma City, OK 73104, USA
    Proc Natl Acad Sci U S A 102:4365-70. 2005
    ..Together, our studies suggest that BubR1 and Apc functionally interact in regulating metaphase-anaphase transition, deregulation of which may play a key role in genomic instability and development and progression of colorectal cancer...
  17. ncbi request reprint Regulation of COX and LOX by curcumin
    Chinthalapally V Rao
    Hematology Oncology Section, University of Oklahoma Cancer Institute, Oklahoma City 73104, USA
    Adv Exp Med Biol 595:213-26. 2007
    ..In this review, we discuss evidence that supports the regulation of COX and LOX enzymes by curcumin as the key mechanism for its beneficial effects in preventing various inflammatory diseases...
  18. pmc Inhibition of azoxymethane-induced colorectal cancer by CP-31398, a TP53 modulator, alone or in combination with low doses of celecoxib in male F344 rats
    Chinthalapally V Rao
    Department of Medicine, Hem Onc Section, University of Oklahoma Cancer Institute, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    Cancer Res 69:8175-82. 2009
    ....
  19. ncbi request reprint Slippage of mitotic arrest and enhanced tumor development in mice with BubR1 haploinsufficiency
    Wei Dai
    Division of Molecular Carcinogenesis, Department of Medicine, New York Medical College, Valhalla, New York, USA
    Cancer Res 64:440-5. 2004
    ..BubR1 is thus essential for spindle checkpoint activation and tumor suppression...
  20. doi request reprint Estrogen receptor-beta as a potential target for colon cancer prevention: chemoprevention of azoxymethane-induced colon carcinogenesis by raloxifene in F344 rats
    Naveena B Janakiram
    Department of Medicine, Hem Onc Section, OU Cancer Institute, University of Oklahoma Health Sciences Center, 975 Northeast 10th Street, Oklahoma City, OK 73104, USA
    Cancer Prev Res (Phila) 2:52-9. 2009
    ..05-0.005) in F344 rats. Our findings suggest that ER-beta acts as a colon tumor promoter and raloxifene as an antagonist to ER-beta, providing protection against colon carcinogenesis...
  21. doi request reprint Chemoprevention of colon carcinogenesis by oleanolic acid and its analog in male F344 rats and modulation of COX-2 and apoptosis in human colon HT-29 cancer cells
    Naveena B Janakiram
    Department of Medicine, Hem Onc Section, OU Cancer Institute, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    Pharm Res 25:2151-7. 2008
    ..7 macrophage cell lines...
  22. pmc Curcumin protects retinal cells from light-and oxidant stress-induced cell death
    Md Nawajes A Mandal
    Department of Ophthalmology, University of Oklahoma Health Sciences Center, Oklahoma City, 73104, USA
    Free Radic Biol Med 46:672-9. 2009
    ....
  23. ncbi request reprint Beta-escin inhibits colonic aberrant crypt foci formation in rats and regulates the cell cycle growth by inducing p21(waf1/cip1) in colon cancer cells
    Jagan M R Patlolla
    Department of Medicine, OU Cancer Institute, University of Oklahoma Health Sciences Center, 975 Northeast 10th Street, Oklahoma City, OK 73104, USA
    Mol Cancer Ther 5:1459-66. 2006
    ..This novel feature of beta-escin, a triterpene saponin, may be a useful candidate agent for colon cancer chemoprevention and treatment...
  24. ncbi request reprint BRD8 is a potential chemosensitizing target for spindle poisons in colorectal cancer therapy
    Hiroshi Y Yamada
    Department of Medicine, Hematology Oncology Section, University of Oklahoma Health Sciences Center OUHSC, BRC1207, Oklahoma City, OK 73104, USA
    Int J Oncol 35:1101-9. 2009
    ..Conversely, at least one isoform of BRD8 gave growth advantage and resistance to taxol when stably overexpressed in HeLa cells. Targeting BRD8 would improve therapy outcome against aggressive/metastatic colorectal cancers...
  25. ncbi request reprint Genes that modulate the sensitivity for anti-microtubule drug-mediated chemotherapy
    H Y Yamada
    Department of Medicine, Hematology Oncology Section, University of Oklahoma Health Sciences Center OUHSC, Oklahoma City, OK 73104, USA
    Curr Cancer Drug Targets 10:623-33. 2010
    ..Understanding signaling pathways involved in drug efficacy will aid to rationally develop synergistic chemotherapy strategy...
  26. doi request reprint Beta-ionone inhibits colonic aberrant crypt foci formation in rats, suppresses cell growth, and induces retinoid X receptor-alpha in human colon cancer cells
    Naveena B Janakiram
    Department of Medicine, Hem Onc Section, OU Cancer Institute, University of Oklahoma Health Sciences Center, 975 Northeast 10th Street, BRC Building, Room 1203, Oklahoma City, OK 73104, USA
    Mol Cancer Ther 7:181-90. 2008
    ..0001) of foci containing four or more aberrant crypts. Results from in vitro and in vivo bioassay clearly suggest that beta-ionone could be further developed for prevention and treatment of colon cancer...
  27. ncbi request reprint S-adenosyl L-methionine inhibits azoxymethane-induced colonic aberrant crypt foci in F344 rats and suppresses human colon cancer Caco-2 cell growth in 3D culture
    Suresh Guruswamy
    Department of Medicine, Hematology Oncology Section, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
    Int J Cancer 122:25-30. 2008
    ..0001). These observations demonstrate for the first time that SAM can reduce the occurrence of ACF in AOM treated male F344 rats and suppress formation of human tumor spheroids and expression of COX-2...
  28. ncbi request reprint Chemoprevention of familial adenomatous polyposis by low doses of atorvastatin and celecoxib given individually and in combination to APCMin mice
    Malisetty V Swamy
    Department of Medicine, Hem Onc Section, University of Oklahoma Cancer Institute, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    Cancer Res 66:7370-7. 2006
    ..These observations show that atorvastatin inhibits intestinal tumorigenesis and that, importantly, when given together with low doses of celecoxib, it significantly increases the chemopreventive efficacy in an APC(min) mice...
  29. doi request reprint Chemopreventive effects of Frondanol A5, a Cucumaria frondosa extract, against rat colon carcinogenesis and inhibition of human colon cancer cell growth
    Naveena B Janakiram
    Department of Medicine, University of Oklahoma Cancer Institute, University of Oklahoma Health Sciences Center, Oklahoma City, 73104, USA
    Cancer Prev Res (Phila) 3:82-91. 2010
    ..Overall, Frondanol A5 exhibits potential chemopreventive properties for colon carcinogenesis, which suggests further development of this sea cucumber extract...
  30. ncbi request reprint Synergistic effects of lovastatin and celecoxib on caveolin-1 and its down-stream signaling molecules: Implications for colon cancer prevention
    Suresh Guruswamy
    Department of Medicine, Hem Onc Section, University of Oklahoma Cancer Institute, OUHSC, Oklahoma City, OK 73104, USA
    Int J Oncol 35:1037-43. 2009
    ..Overall, our data suggest that a combination of COX-2 and HMG-R inhibitors synergistically inhibits caveolin-1 and its associated signaling pathways...
  31. ncbi request reprint Molecular markers and targets for colorectal cancer prevention
    Naveena B Janakiram
    Department of Medicine, Hem Onc Section, OU Cancer Institute, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Acta Pharmacol Sin 29:1-20. 2008
    ..Importance of emerging new platforms siRNAs and miRNAs technology for colorectal cancer therapeutics is reviewed...
  32. pmc Identification of a novel putative pancreatic stem/progenitor cell marker DCAMKL-1 in normal mouse pancreas
    Randal May
    Dept of Medicine, Univ of Oklahoma Health Sciences Center, Oklahoma City, 73104, USA
    Am J Physiol Gastrointest Liver Physiol 299:G303-10. 2010
    ..This may represent a novel tool for regenerative medicine and a target for anti-stem cell-based therapeutics in pancreatic cancer...
  33. ncbi request reprint Role of lipoxins and resolvins as anti-inflammatory and proresolving mediators in colon cancer
    Naveena B Janakiram
    Department of Medicine, Hem Onc Section, OU Cancer Institute, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Curr Mol Med 9:565-79. 2009
    ..In this review, we explore the mechanisms that trigger formation of LXs and Rvs, to highlight the relative importance of LXs and Rvs in carcinogenesis in relation to pro-inflammatory mediators...
  34. pmc Pharmacokinetic and pharmacodynamic study of NO-donating aspirin in F344 rats
    Chinthalapally V Rao
    Department of Medicine, Hematology Oncology Section, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Int J Oncol 33:799-805. 2008
    ..These findings may have practical utility for the administration of NO-ASA to humans...
  35. doi request reprint Prevention and treatment of pancreatic cancer by curcumin in combination with omega-3 fatty acids
    Malisetty V Swamy
    Department of Medicine, Hem Onc Section, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA
    Nutr Cancer 60:81-9. 2008
    ..The preceding results evidence for the first time that curcumin combined with omega-3 fatty acids provide synergistic pancreatic tumor inhibitory properties...
  36. ncbi request reprint Diosgenin, a steroid saponin of Trigonella foenum graecum (Fenugreek), inhibits azoxymethane-induced aberrant crypt foci formation in F344 rats and induces apoptosis in HT-29 human colon cancer cells
    Jayadev Raju
    Division of Nutritional Carcinogenesis, Institute for Cancer Prevention, American Health Foundation Cancer Center, 1 Dana Road, Valhalla, NY 10595, USA
    Cancer Epidemiol Biomarkers Prev 13:1392-8. 2004
    ..On the basis of these findings, the fenugreek constituent diosgenin seems to have potential as a novel colon cancer preventive agent...
  37. ncbi request reprint Inhibition of COX-2 in colon cancer cell lines by celecoxib increases the nuclear localization of active p53
    Malisetty V Swamy
    Chemoprevention Program, Institute for Cancer Prevention, American Health Foundation Cancer Center, Valhalla, New York 10595, USA
    Cancer Res 63:5239-42. 2003
    ..Inhibition of COX-2 by celecoxib appears to alleviate this effect on p53 by reducing electrophilic PG synthesis. Thus, COX-2 inhibition of electrophilic PG formation appears to protect p53 tumor suppressor function...
  38. ncbi request reprint Correlation between electron-donating ability of a series of 3-nitroflavones and their efficacy to inhibit the onset and progression of aberrant crypt foci in the rat colon
    Vernon E Steele
    Division of Cancer Prevention, National Cancer Institute, NIH, Bethesda, Maryland 20892 7322, USA
    Cancer Res 62:6506-9. 2002
    ..The above correlations may be of predictive value in the search for new chemoprotective agents. The overall molecular mechanism of the inhibition of ACF by the 3-nitroflavones under study appears to involve redox reactions...
  39. ncbi request reprint Chemopreventive effect of farnesol and lanosterol on colon carcinogenesis
    Chinthalapally V Rao
    Division of Nutritional Carcinogenesis, American Health Foundation, One Dana Road, Valhalla, NY 10595, USA
    Cancer Detect Prev 26:419-25. 2002
    ..01) levels. That farnesol and lanosterol significantly suppress colonic ACF formation and crypt multiplicity strengthens the hypothesis that these agents possess chemopreventive activity against colon carcinogenesis...
  40. ncbi request reprint Novel approaches for colon cancer prevention by cyclooxygenase-2 inhibitors
    Bandaru S Reddy
    Nutritional Carcinogenesis and Chemoprevention Program, American Health Foundation, Valhalla, NY 10595, USA
    J Environ Pathol Toxicol Oncol 21:155-64. 2002
    ..Of further importance would be to identify molecular targets that are critical in the growth and survival of the malignant colorectal cell and are modulated by NSAIDs and COX-2 inhibitors...
  41. ncbi request reprint Chemopreventive properties of a selective inducible nitric oxide synthase inhibitor in colon carcinogenesis, administered alone or in combination with celecoxib, a selective cyclooxygenase-2 inhibitor
    Chinthalapally V Rao
    Chemoprevention Program, American Health Foundation, Valhalla, New York 10595, USA
    Cancer Res 62:165-70. 2002
    ..These findings support the hypothesis that selective iNOS inhibitors may have chemopreventive properties and that coadministration with a selective COX-2 inhibitor may have additional chemopreventive potential...
  42. ncbi request reprint Down-regulation of PLK3 gene expression by types and amount of dietary fat in rat colon tumors
    Wei Dai
    American Health Foundation, Valhalla, NY 10595, USA
    Int J Oncol 20:121-6. 2002
    ..These observations suggest for the first time that a decreased activity of PLK3 may play a key role in colon tumor development as well as in HFCO-induced colon tumorigenesis...
  43. ncbi request reprint NSAIDs and chemoprevention
    Chinthalapally V Rao
    Chemoprevention Program, Institute for Cancer Prevention, American Health Foundation Cancer Center, 1 Dana Road, Valhalla, NY 10595, USA
    Curr Cancer Drug Targets 4:29-42. 2004
    ..There is growing optimism for the view that full exploration of the role of NSAIDs in the prevention and treatment of epithelial cancers will serve towards reducing of mortality and morbidity from various cancers...
  44. ncbi request reprint Modulation of cyclooxygenase-2 activities by the combined action of celecoxib and decosahexaenoic acid: novel strategies for colon cancer prevention and treatment
    Malisetty V Swamy
    Chemoprevention and Nutritional Carcinogenesis Program, Institute for Cancer Prevention, American Health Foundation Cancer Center, Valhalla, NY, USA
    Mol Cancer Ther 3:215-21. 2004
    ..We are currently testing this concept in preclinical models...
  45. ncbi request reprint Prevention of colon cancer by low doses of celecoxib, a cyclooxygenase inhibitor, administered in diet rich in omega-3 polyunsaturated fatty acids
    Bandaru S Reddy
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers State University of New Jersey, Piscataway, New Jersey 08854, USA
    Cancer Res 65:8022-7. 2005
    ..These studies support the use of low doses of celecoxib in omega-3 PUFA-rich diet as a promising approach for clinical trials...
  46. ncbi request reprint Prevention of azoxymethane-induced colon cancer by combination of low doses of atorvastatin, aspirin, and celecoxib in F 344 rats
    Bandaru S Reddy
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA
    Cancer Res 66:4542-6. 2006
    ..These observations are of clinical significance because this can pave the way for the use of combinations of these agents in small doses against colon cancer...
  47. ncbi request reprint Low doses of beta-carotene and lutein inhibit AOM-induced rat colonic ACF formation but high doses augment ACF incidence
    Jayadev Raju
    Chemoprevention Program, Institute for Cancer Prevention, American Health Foundation Cancer Center, Valhalla, NY, USA
    Int J Cancer 113:798-802. 2005
    ..Taken together these data indicate that the chemopreventive activity of beta-carotene and lutein against colon carcinogenesis depends on the dose level...
  48. ncbi request reprint Nitric oxide signaling in colon cancer chemoprevention
    Chinthalapally V Rao
    Chemoprevention Program, American Health Foundation Cancer Center, Institute for Cancer Prevention, Valhalla, NY 10595, USA
    Mutat Res 555:107-19. 2004
    ..Chemoprevention studies at preclinical level with several selective inhibitors of iNOS in both chemically and transgenic models of colon cancer are encouraging...
  49. ncbi request reprint Overexpression of caveolin-1 in experimental colon adenocarcinomas and human colon cancer cell lines
    Jagan M R Patlolla
    Chemoprevention Program, Institute for Cancer Prevention, American Health Foundation Cancer Center, Valhalla, NY 10595, USA
    Oncol Rep 11:957-63. 2004
    ....
  50. ncbi request reprint Lamin B, caspase-3 activity, and apoptosis induction by a combination of HMG-CoA reductase inhibitor and COX-2 inhibitors: a novel approach in developing effective chemopreventive regimens
    Malisetty V Swamy
    Chemoprevention Program, Division of Nutritional Carcinogenesis, American Health Foundation, Valhalla, NY 10595, USA
    Int J Oncol 20:753-9. 2002
    ....
  51. ncbi request reprint Cyclooxygenase-2 expression influences the growth of human large and small cell lung carcinoma lines in athymic mice: impact of an organoselenium compound on growth regulation
    Karam El-Bayoumy
    American Health Foundation, Valhalla, NY 10595, USA
    Int J Oncol 20:557-61. 2002
    ..Therefore, inhibition of COX-2 expression by agents such as p-XSC provides a strong rationale for the development of future clinical prevention trials...
  52. ncbi request reprint Do irradiated foods cause or promote colon cancer?
    Chinthalapally V Rao
    Division of Nutritional Carcinogenesis, Institute for Cancer Prevention, American Health Foundation Cancer Center, Valhalla, NY 10595, USA
    Nutr Cancer 46:107-9. 2003
  53. ncbi request reprint Molecular targets of the chemopreventive agent 1,4-phenylenebis (methylene)-selenocyanate in human non-small cell lung cancer
    Karam El-Bayoumy
    Penn State College of Medicine, 500 University Drive, Hershey, PA 17033, USA
    Carcinogenesis 27:1369-76. 2006
    ....
  54. ncbi request reprint Chemoprophylaxis of colon cancer
    Bandaru S Reddy
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Curr Gastroenterol Rep 7:389-95. 2005
    ....

Research Grants16

  1. MECHANISMS FOR CHEMOPREVENTION OF COLON CANCER
    CHINTHALAPALLY RAO; Fiscal Year: 1999
    ..Tissue distribution and comparative metabolism studies of curcumin and PEMC will be studied with synthetic [3H] curcumin and [3H]-PEMC in vivo in male F-344 rats. ..
  2. PREVENTION OF COLORECTAL CANCER BY iNOS AND COX-2 SELECTIVE INHIBITORS
    CHINTHALAPALLY RAO; Fiscal Year: 2007
    ..abstract_text> ..
  3. PREVENTION OF CRC BY iNOS AND COX-2 SELECTIVE INHIBITORS
    CHINTHALAPALLY RAO; Fiscal Year: 2006
    ..abstract_text> ..
  4. HMG CoA REDUCTASE AND COX2 INHIBITORS IN COLON CANCER
    CHINTHALAPALLY RAO; Fiscal Year: 2006
    ..Finally, we will study the effects of these agents on cell proliferation, and apoptosis during different stages of colon carcinogenesis. ..
  5. PREVENTION OF CRC BY iNOS AND COX-2 SELECTIVE INHIBITORS
    CHINTHALAPALLY RAO; Fiscal Year: 2005
    ..abstract_text> ..
  6. HMG CoA REDUCTASE AND COX2 INHIBITORS IN COLON CANCER
    CHINTHALAPALLY RAO; Fiscal Year: 2004
    ..Finally, we will study the effects of these agents on cell proliferation, and apoptosis during different stages of colon carcinogenesis. ..
  7. MECHANISMS FOR CHEMOPREVENTION OF COLON CANCER
    CHINTHALAPALLY RAO; Fiscal Year: 2004
    ..Tissue distribution and comparative metabolism studies of curcumin and PEMC will be studied with synthetic [3H] curcumin and [3H]-PEMC in vivo in male F-344 rats. ..
  8. PREVENTION OF CRC BY iNOS AND COX-2 SELECTIVE INHIBITORS
    CHINTHALAPALLY RAO; Fiscal Year: 2004
    ..abstract_text> ..
  9. HMG CoA REDUCTASE AND COX2 INHIBITORS IN COLON CANCER
    CHINTHALAPALLY RAO; Fiscal Year: 2004
    ..Finally, we will study the effects of these agents on cell proliferation, and apoptosis during different stages of colon carcinogenesis. ..
  10. HMG CoA REDUCTASE AND COX2 INHIBITORS IN COLON CANCER
    CHINTHALAPALLY RAO; Fiscal Year: 2003
    ..Finally, we will study the effects of these agents on cell proliferation, and apoptosis during different stages of colon carcinogenesis. ..
  11. MECHANISMS FOR CHEMOPREVENTION OF COLON CANCER
    CHINTHALAPALLY RAO; Fiscal Year: 2002
    ..Tissue distribution and comparative metabolism studies of curcumin and PEMC will be studied with synthetic [3H] curcumin and [3H]-PEMC in vivo in male F-344 rats. ..
  12. HMG CoA REDUCTASE AND COX2 INHIBITORS IN COLON CANCER
    CHINTHALAPALLY RAO; Fiscal Year: 2002
    ..Finally, we will study the effects of these agents on cell proliferation, and apoptosis during different stages of colon carcinogenesis. ..
  13. MECHANISMS FOR CHEMOPREVENTION OF COLON CANCER
    CHINTHALAPALLY RAO; Fiscal Year: 2001
    ..Tissue distribution and comparative metabolism studies of curcumin and PEMC will be studied with synthetic [3H] curcumin and [3H]-PEMC in vivo in male F-344 rats. ..
  14. MECHANISMS FOR CHEMOPREVENTION OF COLON CANCER
    CHINTHALAPALLY RAO; Fiscal Year: 2000
    ..Tissue distribution and comparative metabolism studies of curcumin and PEMC will be studied with synthetic [3H] curcumin and [3H]-PEMC in vivo in male F-344 rats. ..
  15. HMG-CoA Reductase and Polyamine Inhibitors for Prevention of Colorectal Cancer
    Chinthalapally V Rao; Fiscal Year: 2010
    ....