Research Topics
| CHINTHALAPALLY RAOSummaryAffiliation: University of Oklahoma Health Sciences Center Country: USA Publications
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Publications
Mitosis-targeting natural products for cancer prevention and therapyChinthalapally V Rao
Center for Cancer Prevention and Drug Development, Medical Oncology, Department of Medicine, Stephenson Oklahoma Cancer Center, University of Oklahoma Health Sciences Center OUHSC, Oklahoma City, 73104, USA
Curr Drug Targets 13:1820-30. 2012..These advances help us to identify and develop potential natural agents for the prevention and treatment of cancer. This review will focus on natural products that target mitotic process and/or proteins involved in mitotic progression...
Inhibition of pancreatic intraepithelial neoplasia progression to carcinoma by nitric oxide-releasing aspirin in p48(Cre/+)-LSL-Kras(G12D/+) miceChinthalapally V Rao
Hematology Oncology Section, Center for Cancer Prevention and Drug Development, Peggy and Charles Stephenson Cancer Center, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
Neoplasia 14:778-87. 2012..These results suggest that low-dose NO-aspirin possesses inhibitory activity against pancreatic carcinogenesis by modulating multiple molecular targets...- Early detection and prevention of pancreatic cancer: use of genetically engineered mouse models and advanced imaging technologiesA Mohammed
Center for Chemoprevention and Cancer Drug Development, PCS Oklahoma Cancer Center, 975 NE 10th Street, BRC 1203, OUHSC, Oklahoma City, OK 73104, USA
Curr Med Chem 19:3701-13. 2012..These issues will be considered in the context of recently developed preclinical models of pancreatic cancer... - Triterpenoids for cancer prevention and treatment: current status and future prospectsJagan M R Patlolla
Center for Chemoprevention and Cancer Drug Development, Department of Medicine, Hematology Oncology Section, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
Curr Pharm Biotechnol 13:147-55. 2012.... - Enhanced genomic instabilities caused by deregulated microtubule dynamics and chromosome segregation: a perspective from genetic studies in miceChinthalapally V Rao
Department of Medicine, Hematology Oncology Section, University of Oklahoma Cancer Institute, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
Carcinogenesis 30:1469-74. 2009..Further elucidation of molecular mechanisms of the SAC signaling has the potential for identifying new targets for rational anticancer drug design... - Regulation of COX and LOX by curcuminChinthalapally V Rao
Hematology Oncology Section, University of Oklahoma Cancer Institute, Oklahoma City 73104, USA
Adv Exp Med Biol 595:213-26. 2007..In this review, we discuss evidence that supports the regulation of COX and LOX enzymes by curcumin as the key mechanism for its beneficial effects in preventing various inflammatory diseases... - Suppression of familial adenomatous polyposis by CP-31398, a TP53 modulator, in APCmin/+ miceChinthalapally V Rao
Department of Medicine, Hem Onc Section, University of Oklahoma Cancer Institute, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
Cancer Res 68:7670-5. 2008..Chemopreventive activity of other agents that restore tumor suppressor functions of mutant p53 in tumor cells is currently under investigation... - Colonic tumorigenesis in BubR1+/-ApcMin/+ compound mutant mice is linked to premature separation of sister chromatids and enhanced genomic instabilityChinthalapally V Rao
Department of Medicine, University of Oklahoma Health Science Center, Oklahoma City, OK 73104, USA
Proc Natl Acad Sci U S A 102:4365-70. 2005..Together, our studies suggest that BubR1 and Apc functionally interact in regulating metaphase-anaphase transition, deregulation of which may play a key role in genomic instability and development and progression of colorectal cancer... - Nitric oxide-releasing aspirin and indomethacin are potent inhibitors against colon cancer in azoxymethane-treated rats: effects on molecular targetsChinthalapally V Rao
Department of Medicine, Hem Onc Section, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
Mol Cancer Ther 5:1530-8. 2006..These results pave the way for the rational design of human clinical trials... - Combination of atorvastatin with sulindac or naproxen profoundly inhibits colonic adenocarcinomas by suppressing the p65/β-catenin/cyclin D1 signaling pathway in ratsNanjoo Suh
Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey, USA
Cancer Prev Res (Phila) 4:1895-902. 2011..Our results suggest that low-dose atorvastatin with sulindac or naproxen might potentially be useful combinations for colon cancer prevention in humans... - Chemoprevention of colon and small intestinal tumorigenesis in APC(Min/+) mice by licofelone, a novel dual 5-LOX/COX inhibitor: potential implications for human colon cancer preventionAltaf Mohammed
Department of Medicine, Hem Onc Section, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
Cancer Prev Res (Phila) 4:2015-26. 2011..These observations show that a novel dual 5-LOX/COX inhibitor dramatically suppresses small intestinal and colonic tumor formation in APC(Min/+) mice... - Inhibition of azoxymethane-induced colorectal cancer by CP-31398, a TP53 modulator, alone or in combination with low doses of celecoxib in male F344 ratsChinthalapally V Rao
Department of Medicine, Hem Onc Section, University of Oklahoma Cancer Institute, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
Cancer Res 69:8175-82. 2009.... - Slippage of mitotic arrest and enhanced tumor development in mice with BubR1 haploinsufficiencyWei Dai
Division of Molecular Carcinogenesis, Department of Medicine, New York Medical College, Valhalla, New York, USA
Cancer Res 64:440-5. 2004..BubR1 is thus essential for spindle checkpoint activation and tumor suppression... 
Estrogen receptor-beta as a potential target for colon cancer prevention: chemoprevention of azoxymethane-induced colon carcinogenesis by raloxifene in F344 ratsNaveena B Janakiram
Department of Medicine, Hem Onc Section, OU Cancer Institute, University of Oklahoma Health Sciences Center, 975 Northeast 10th Street, Oklahoma City, OK 73104, USA
Cancer Prev Res (Phila) 2:52-9. 2009..05-0.005) in F344 rats. Our findings suggest that ER-beta acts as a colon tumor promoter and raloxifene as an antagonist to ER-beta, providing protection against colon carcinogenesis...- Beta-escin inhibits colonic aberrant crypt foci formation in rats and regulates the cell cycle growth by inducing p21(waf1/cip1) in colon cancer cellsJagan M R Patlolla
Department of Medicine, OU Cancer Institute, University of Oklahoma Health Sciences Center, 975 Northeast 10th Street, Oklahoma City, OK 73104, USA
Mol Cancer Ther 5:1459-66. 2006..This novel feature of beta-escin, a triterpene saponin, may be a useful candidate agent for colon cancer chemoprevention and treatment... - Chemoprevention of colon carcinogenesis by oleanolic acid and its analog in male F344 rats and modulation of COX-2 and apoptosis in human colon HT-29 cancer cellsNaveena B Janakiram
Department of Medicine, Hem Onc Section, OU Cancer Institute, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
Pharm Res 25:2151-7. 2008..7 macrophage cell lines... - Beta-ionone inhibits colonic aberrant crypt foci formation in rats, suppresses cell growth, and induces retinoid X receptor-alpha in human colon cancer cellsNaveena B Janakiram
Department of Medicine, Hem Onc Section, OU Cancer Institute, University of Oklahoma Health Sciences Center, 975 Northeast 10th Street, BRC Building, Room 1203, Oklahoma City, OK 73104, USA
Mol Cancer Ther 7:181-90. 2008..0001) of foci containing four or more aberrant crypts. Results from in vitro and in vivo bioassay clearly suggest that beta-ionone could be further developed for prevention and treatment of colon cancer... - Curcumin protects retinal cells from light-and oxidant stress-induced cell deathMd Nawajes A Mandal
Department of Ophthalmology, University of Oklahoma Health Sciences Center, Oklahoma City, 73104, USA
Free Radic Biol Med 46:672-9. 2009.... - S-adenosyl L-methionine inhibits azoxymethane-induced colonic aberrant crypt foci in F344 rats and suppresses human colon cancer Caco-2 cell growth in 3D cultureSuresh Guruswamy
Department of Medicine, Hematology Oncology Section, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
Int J Cancer 122:25-30. 2008..0001). These observations demonstrate for the first time that SAM can reduce the occurrence of ACF in AOM treated male F344 rats and suppress formation of human tumor spheroids and expression of COX-2... - BRD8 is a potential chemosensitizing target for spindle poisons in colorectal cancer therapyHiroshi Y Yamada
Department of Medicine, Hematology Oncology Section, University of Oklahoma Health Sciences Center OUHSC, BRC1207, Oklahoma City, OK 73104, USA
Int J Oncol 35:1101-9. 2009..Conversely, at least one isoform of BRD8 gave growth advantage and resistance to taxol when stably overexpressed in HeLa cells. Targeting BRD8 would improve therapy outcome against aggressive/metastatic colorectal cancers... - Genes that modulate the sensitivity for anti-microtubule drug-mediated chemotherapyH Y Yamada
Department of Medicine, Hematology Oncology Section, University of Oklahoma Health Sciences Center OUHSC, Oklahoma City, OK 73104, USA
Curr Cancer Drug Targets 10:623-33. 2010..Understanding signaling pathways involved in drug efficacy will aid to rationally develop synergistic chemotherapy strategy... - Chemopreventive effects of Frondanol A5, a Cucumaria frondosa extract, against rat colon carcinogenesis and inhibition of human colon cancer cell growthNaveena B Janakiram
Department of Medicine, University of Oklahoma Cancer Institute, University of Oklahoma Health Sciences Center, Oklahoma City, 73104, USA
Cancer Prev Res (Phila) 3:82-91. 2010..Overall, Frondanol A5 exhibits potential chemopreventive properties for colon carcinogenesis, which suggests further development of this sea cucumber extract... - Chemoprevention of familial adenomatous polyposis by low doses of atorvastatin and celecoxib given individually and in combination to APCMin miceMalisetty V Swamy
Department of Medicine, Hem Onc Section, University of Oklahoma Cancer Institute, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
Cancer Res 66:7370-7. 2006..These observations show that atorvastatin inhibits intestinal tumorigenesis and that, importantly, when given together with low doses of celecoxib, it significantly increases the chemopreventive efficacy in an APC(min) mice... - Synergistic effects of lovastatin and celecoxib on caveolin-1 and its down-stream signaling molecules: Implications for colon cancer preventionSuresh Guruswamy
Department of Medicine, Hem Onc Section, University of Oklahoma Cancer Institute, OUHSC, Oklahoma City, OK 73104, USA
Int J Oncol 35:1037-43. 2009..Overall, our data suggest that a combination of COX-2 and HMG-R inhibitors synergistically inhibits caveolin-1 and its associated signaling pathways... - Prevention and treatment of pancreatic cancer by curcumin in combination with omega-3 fatty acidsMalisetty V Swamy
Department of Medicine, Hem Onc Section, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA
Nutr Cancer 60:81-9. 2008..The preceding results evidence for the first time that curcumin combined with omega-3 fatty acids provide synergistic pancreatic tumor inhibitory properties... - Role of lipoxins and resolvins as anti-inflammatory and proresolving mediators in colon cancerNaveena B Janakiram
Department of Medicine, Hem Onc Section, OU Cancer Institute, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
Curr Mol Med 9:565-79. 2009..In this review, we explore the mechanisms that trigger formation of LXs and Rvs, to highlight the relative importance of LXs and Rvs in carcinogenesis in relation to pro-inflammatory mediators... - Molecular markers and targets for colorectal cancer preventionNaveena B Janakiram
Department of Medicine, Hem Onc Section, OU Cancer Institute, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
Acta Pharmacol Sin 29:1-20. 2008..Importance of emerging new platforms siRNAs and miRNAs technology for colorectal cancer therapeutics is reviewed... - Pharmacokinetic and pharmacodynamic study of NO-donating aspirin in F344 ratsChinthalapally V Rao
Department of Medicine, Hematology Oncology Section, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
Int J Oncol 33:799-805. 2008..These findings may have practical utility for the administration of NO-ASA to humans... - Identification of a novel putative pancreatic stem/progenitor cell marker DCAMKL-1 in normal mouse pancreasRandal May
Dept of Medicine, Univ of Oklahoma Health Sciences Center, Oklahoma City, 73104, USA
Am J Physiol Gastrointest Liver Physiol 299:G303-10. 2010..This may represent a novel tool for regenerative medicine and a target for anti-stem cell-based therapeutics in pancreatic cancer... - Chemopreventive properties of a selective inducible nitric oxide synthase inhibitor in colon carcinogenesis, administered alone or in combination with celecoxib, a selective cyclooxygenase-2 inhibitorChinthalapally V Rao
Chemoprevention Program, American Health Foundation, Valhalla, New York 10595, USA
Cancer Res 62:165-70. 2002..These findings support the hypothesis that selective iNOS inhibitors may have chemopreventive properties and that coadministration with a selective COX-2 inhibitor may have additional chemopreventive potential... - Novel approaches for colon cancer prevention by cyclooxygenase-2 inhibitorsBandaru S Reddy
Nutritional Carcinogenesis and Chemoprevention Program, American Health Foundation, Valhalla, NY 10595, USA
J Environ Pathol Toxicol Oncol 21:155-64. 2002..Of further importance would be to identify molecular targets that are critical in the growth and survival of the malignant colorectal cell and are modulated by NSAIDs and COX-2 inhibitors... - Correlation between electron-donating ability of a series of 3-nitroflavones and their efficacy to inhibit the onset and progression of aberrant crypt foci in the rat colonVernon E Steele
Division of Cancer Prevention, National Cancer Institute, NIH, Bethesda, Maryland 20892 7322, USA
Cancer Res 62:6506-9. 2002..The above correlations may be of predictive value in the search for new chemoprotective agents. The overall molecular mechanism of the inhibition of ACF by the 3-nitroflavones under study appears to involve redox reactions... - Chemopreventive effect of farnesol and lanosterol on colon carcinogenesisChinthalapally V Rao
Division of Nutritional Carcinogenesis, American Health Foundation, One Dana Road, Valhalla, NY 10595, USA
Cancer Detect Prev 26:419-25. 2002..01) levels. That farnesol and lanosterol significantly suppress colonic ACF formation and crypt multiplicity strengthens the hypothesis that these agents possess chemopreventive activity against colon carcinogenesis... - Inhibition of COX-2 in colon cancer cell lines by celecoxib increases the nuclear localization of active p53Malisetty V Swamy
Chemoprevention Program, Institute for Cancer Prevention, American Health Foundation Cancer Center, Valhalla, New York 10595, USA
Cancer Res 63:5239-42. 2003..Inhibition of COX-2 by celecoxib appears to alleviate this effect on p53 by reducing electrophilic PG synthesis. Thus, COX-2 inhibition of electrophilic PG formation appears to protect p53 tumor suppressor function... - NSAIDs and chemopreventionChinthalapally V Rao
Chemoprevention Program, Institute for Cancer Prevention, American Health Foundation Cancer Center, 1 Dana Road, Valhalla, NY 10595, USA
Curr Cancer Drug Targets 4:29-42. 2004..There is growing optimism for the view that full exploration of the role of NSAIDs in the prevention and treatment of epithelial cancers will serve towards reducing of mortality and morbidity from various cancers... - Modulation of cyclooxygenase-2 activities by the combined action of celecoxib and decosahexaenoic acid: novel strategies for colon cancer prevention and treatmentMalisetty V Swamy
Chemoprevention and Nutritional Carcinogenesis Program, Institute for Cancer Prevention, American Health Foundation-Cancer Center, Valhalla, NY, USA
Mol Cancer Ther 3:215-21. 2004..We are currently testing this concept in preclinical models... - Down-regulation of PLK3 gene expression by types and amount of dietary fat in rat colon tumorsWei Dai
American Health Foundation, Valhalla, NY 10595, USA
Int J Oncol 20:121-6. 2002..These observations suggest for the first time that a decreased activity of PLK3 may play a key role in colon tumor development as well as in HFCO-induced colon tumorigenesis... - Diosgenin, a steroid saponin of Trigonella foenum graecum (Fenugreek), inhibits azoxymethane-induced aberrant crypt foci formation in F344 rats and induces apoptosis in HT-29 human colon cancer cellsJayadev Raju
Division of Nutritional Carcinogenesis, Institute for Cancer Prevention, American Health Foundation Cancer Center, 1 Dana Road, Valhalla, NY 10595, USA
Cancer Epidemiol Biomarkers Prev 13:1392-8. 2004..On the basis of these findings, the fenugreek constituent diosgenin seems to have potential as a novel colon cancer preventive agent... - Prevention of azoxymethane-induced colon cancer by combination of low doses of atorvastatin, aspirin, and celecoxib in F 344 ratsBandaru S Reddy
Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA
Cancer Res 66:4542-6. 2006..These observations are of clinical significance because this can pave the way for the use of combinations of these agents in small doses against colon cancer... - Low doses of beta-carotene and lutein inhibit AOM-induced rat colonic ACF formation but high doses augment ACF incidenceJayadev Raju
Chemoprevention Program, Institute for Cancer Prevention, American Health Foundation Cancer Center, Valhalla, NY, USA
Int J Cancer 113:798-802. 2005..Taken together these data indicate that the chemopreventive activity of beta-carotene and lutein against colon carcinogenesis depends on the dose level... - Prevention of colon cancer by low doses of celecoxib, a cyclooxygenase inhibitor, administered in diet rich in omega-3 polyunsaturated fatty acidsBandaru S Reddy
Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers State University of New Jersey, Piscataway, New Jersey 08854, USA
Cancer Res 65:8022-7. 2005..These studies support the use of low doses of celecoxib in omega-3 PUFA-rich diet as a promising approach for clinical trials... - Cyclooxygenase-2 expression influences the growth of human large and small cell lung carcinoma lines in athymic mice: impact of an organoselenium compound on growth regulationKaram El-Bayoumy
American Health Foundation, Valhalla, NY 10595, USA
Int J Oncol 20:557-61. 2002..Therefore, inhibition of COX-2 expression by agents such as p-XSC provides a strong rationale for the development of future clinical prevention trials... - Lamin B, caspase-3 activity, and apoptosis induction by a combination of HMG-CoA reductase inhibitor and COX-2 inhibitors: a novel approach in developing effective chemopreventive regimensMalisetty V Swamy
Chemoprevention Program, Division of Nutritional Carcinogenesis, American Health Foundation, Valhalla, NY 10595, USA
Int J Oncol 20:753-9. 2002.... - Molecular targets of the chemopreventive agent 1,4-phenylenebis (methylene)-selenocyanate in human non-small cell lung cancerKaram El-Bayoumy
Penn State College of Medicine, 500 University Drive, Hershey, PA 17033, USA
Carcinogenesis 27:1369-76. 2006.... - Chemoprophylaxis of colon cancerBandaru S Reddy
Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
Curr Gastroenterol Rep 7:389-95. 2005.... - Nitric oxide signaling in colon cancer chemopreventionChinthalapally V Rao
Chemoprevention Program, American Health Foundation Cancer Center, Institute for Cancer Prevention, Valhalla, NY 10595, USA
Mutat Res 555:107-19. 2004..Chemoprevention studies at preclinical level with several selective inhibitors of iNOS in both chemically and transgenic models of colon cancer are encouraging... - Do irradiated foods cause or promote colon cancer?Chinthalapally V Rao
Division of Nutritional Carcinogenesis, Institute for Cancer Prevention, American Health Foundation Cancer Center, Valhalla, NY 10595, USA
Nutr Cancer 46:107-9. 2003 - Overexpression of caveolin-1 in experimental colon adenocarcinomas and human colon cancer cell linesJagan M R Patlolla
Chemoprevention Program, Institute for Cancer Prevention, American Health Foundation Cancer Center, Valhalla, NY 10595, USA
Oncol Rep 11:957-63. 2004....
Research Grants
- PREVENTION OF COLORECTAL CANCER BY iNOS AND COX-2 SELECTIVE INHIBITORSCHINTHALAPALLY RAO; Fiscal Year: 2007..abstract_text> ..
- HMG CoA REDUCTASE AND COX2 INHIBITORS IN COLON CANCERCHINTHALAPALLY RAO; Fiscal Year: 2006..Finally, we will study the effects of these agents on cell proliferation, and apoptosis during different stages of colon carcinogenesis. ..
- MECHANISMS FOR CHEMOPREVENTION OF COLON CANCERCHINTHALAPALLY RAO; Fiscal Year: 2004..Tissue distribution and comparative metabolism studies of curcumin and PEMC will be studied with synthetic [3H] curcumin and [3H]-PEMC in vivo in male F-344 rats. ..
- HMG-CoA Reductase and Polyamine Inhibitors for Prevention of Colorectal CancerChinthalapally V Rao; Fiscal Year: 2010....