BRUCE ROBERT RANSOM

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. ncbi request reprint Does astrocytic glycogen benefit axon function and survival in CNS white matter during glucose deprivation?
    B R Ransom
    Department of Neurology, University of Washington School of Medicine, Seattle 98195 6465, USA
    Glia 21:134-41. 1997
  2. ncbi request reprint New roles for astrocytes (stars at last)
    Bruce Ransom
    Department of Neurology, University of Washington, 1959 NE Pacific, Room RR650, Box 356465, Seattle, WA 98195, USA
    Trends Neurosci 26:520-2. 2003
  3. ncbi request reprint Astrocyte glycogen metabolism is required for neural activity during aglycemia or intense stimulation in mouse white matter
    Angus M Brown
    Department of Neurology, University of Washington, Seattle, WA, USA
    J Neurosci Res 79:74-80. 2005
  4. ncbi request reprint Functional hemichannels in astrocytes: a novel mechanism of glutamate release
    Zu Cheng Ye
    Department of Neurology, University of Washington School of Medicine, Seattle, Washington 98195 6465, USA
    J Neurosci 23:3588-96. 2003
  5. ncbi request reprint Transfer of glycogen-derived lactate from astrocytes to axons via specific monocarboxylate transporters supports mouse optic nerve activity
    Selva Baltan Tekkök
    Department of Neurology, University of Washington School of Medicine, Seattle, Washington, USA
    J Neurosci Res 81:644-52. 2005
  6. ncbi request reprint Excitotoxic mechanisms of ischemic injury in myelinated white matter
    Selva Baltan Tekkök
    Department of Neurology, Harborview Medical Center, University of Washington School of Medicine, Seattle, Washington 98104, USA
    J Cereb Blood Flow Metab 27:1540-52. 2007
  7. ncbi request reprint Anoxia effects on CNS function and survival: regional differences
    Selva Baltan Tekkök
    Department of Neurology, University of Washington School of Medicine, Seattle, WA 98104, USA
    Neurochem Res 29:2163-9. 2004
  8. doi request reprint White matter vulnerability to ischemic injury increases with age because of enhanced excitotoxicity
    Selva Baltan
    Department of Neurology, Harborview Medical Center, Seattle, Washington 98104, USA
    J Neurosci 28:1479-89. 2008
  9. pmc Pharmacological "cross-inhibition" of connexin hemichannels and swelling activated anion channels
    Zu Cheng Ye
    Department of Neurology, University of Washington School of Medicine, Seattle, Washington 98104, USA
    Glia 57:258-69. 2009
  10. ncbi request reprint Energy transfer from astrocytes to axons: the role of CNS glycogen
    Angus M Brown
    Department of Neurology, University of Washington School of Medicine, Box 3356465, 1959 NE Pacific St, Seattle, WA 98195, USA
    Neurochem Int 45:529-36. 2004

Research Grants

  1. NEURONS AND GLIA IN VITRO
    Bruce Ransom; Fiscal Year: 2007
  2. Research Training in Neurology
    Bruce Ransom; Fiscal Year: 2007
  3. NEURONS AND GLIA IN VITRO
    Bruce Ransom; Fiscal Year: 2002
  4. NEURONS AND GLIA IN VITRO
    BRUCE ROBERT RANSOM; Fiscal Year: 2010

Collaborators

Detail Information

Publications23

  1. ncbi request reprint Does astrocytic glycogen benefit axon function and survival in CNS white matter during glucose deprivation?
    B R Ransom
    Department of Neurology, University of Washington School of Medicine, Seattle 98195 6465, USA
    Glia 21:134-41. 1997
    ..The emerging picture would be no surprise to Camillo Golgi, who predicted a close facsimile of this glial-neuronal interaction more than a century ago...
  2. ncbi request reprint New roles for astrocytes (stars at last)
    Bruce Ransom
    Department of Neurology, University of Washington, 1959 NE Pacific, Room RR650, Box 356465, Seattle, WA 98195, USA
    Trends Neurosci 26:520-2. 2003
    ..But now, at last, astrocytes have our attention...
  3. ncbi request reprint Astrocyte glycogen metabolism is required for neural activity during aglycemia or intense stimulation in mouse white matter
    Angus M Brown
    Department of Neurology, University of Washington, Seattle, WA, USA
    J Neurosci Res 79:74-80. 2005
    ..The CAP area declined more rapidly when glycogen metabolism was inhibited by isofagomine, explicitly showing an important physiological role for glycogen metabolism during neural activity...
  4. ncbi request reprint Functional hemichannels in astrocytes: a novel mechanism of glutamate release
    Zu Cheng Ye
    Department of Neurology, University of Washington School of Medicine, Seattle, Washington 98195 6465, USA
    J Neurosci 23:3588-96. 2003
    ..Our results indicated that astrocyte hemichannels could influence CNS levels of extracellular glutamate with implications for normal and pathological brain function...
  5. ncbi request reprint Transfer of glycogen-derived lactate from astrocytes to axons via specific monocarboxylate transporters supports mouse optic nerve activity
    Selva Baltan Tekkök
    Department of Neurology, University of Washington School of Medicine, Seattle, Washington, USA
    J Neurosci Res 81:644-52. 2005
    ....
  6. ncbi request reprint Excitotoxic mechanisms of ischemic injury in myelinated white matter
    Selva Baltan Tekkök
    Department of Neurology, Harborview Medical Center, University of Washington School of Medicine, Seattle, Washington 98104, USA
    J Cereb Blood Flow Metab 27:1540-52. 2007
    ..Regional differences appear to exist in the specific glutamate receptors that mediate WM ischemic injury. Therapy for ischemic WM injury must be designed accordingly...
  7. ncbi request reprint Anoxia effects on CNS function and survival: regional differences
    Selva Baltan Tekkök
    Department of Neurology, University of Washington School of Medicine, Seattle, WA 98104, USA
    Neurochem Res 29:2163-9. 2004
    ..Mammalian WM, independent of myelination, is remarkably tolerant of anoxia implying that CNS axons generate enough ATP by anaerobic energy metabolism to sustain function...
  8. doi request reprint White matter vulnerability to ischemic injury increases with age because of enhanced excitotoxicity
    Selva Baltan
    Department of Neurology, Harborview Medical Center, Seattle, Washington 98104, USA
    J Neurosci 28:1479-89. 2008
    ..The observation that WM vulnerability to ischemic injury is age dependent has possible implications for the pathogenesis of other age-related CNS conditions...
  9. pmc Pharmacological "cross-inhibition" of connexin hemichannels and swelling activated anion channels
    Zu Cheng Ye
    Department of Neurology, University of Washington School of Medicine, Seattle, Washington 98104, USA
    Glia 57:258-69. 2009
    ..Given the overlap in function of these two types of channels, great care must be exerted in using pharmacological blockers to identify one channel from the other...
  10. ncbi request reprint Energy transfer from astrocytes to axons: the role of CNS glycogen
    Angus M Brown
    Department of Neurology, University of Washington School of Medicine, Box 3356465, 1959 NE Pacific St, Seattle, WA 98195, USA
    Neurochem Int 45:529-36. 2004
    ....
  11. ncbi request reprint Parkinson's disease
    Ali Samii
    Department of Neurology, University of Washington School of Medicine, Seattle, WA, USA
    Lancet 363:1783-93. 2004
    ..This Seminar covers the basics, from terminology to aspects of diagnosis, treatment, and pathogenesis...
  12. ncbi request reprint Axon function persists during anoxia in mammalian white matter
    Selva Baltan Tekkök
    Department of Neurology, University of Washington School of Medicine, Seattle, Washington, USA
    J Cereb Blood Flow Metab 23:1340-7. 2003
    ..These observations have implications for white matter energy metabolism and susceptibility to injury during focal ischemia...
  13. ncbi request reprint Neuroprotective effects of increased extracellular Ca(2+) during aglycemia in white matter
    Angus M Brown
    Department of Neurology, University of Washington School of Medicine, Seattle, Washington 98195, USA
    J Neurophysiol 88:1302-7. 2002
    ..These effects are theorized to be mediated by divalent cation screening...
  14. pmc Glycogen regulation and functional role in mouse white matter
    Angus M Brown
    Department of Neurology, Box 356465, 1959 Pacific St N E, University of Washington School of Medicine, Seattle, WA 98195, USA
    J Physiol 549:501-12. 2003
    ..In summary, these experiments indicated that glycogen content was under dynamic control and that glycogen was used to support the energy needs of CNS axons during both physiological as well as pathological processes...
  15. ncbi request reprint New light on white matter
    Mark P Goldberg
    Center for the Study of Nervous System Injury, Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Stroke 34:330-2. 2003
  16. ncbi request reprint Intracellular Ca2+ release and ischemic axon injury: the Trojan horse is back
    Bruce R Ransom
    Department of Neurology, University of Washington Medical School, Seattle, WA 98195, USA
    Neuron 40:2-4. 2003
    ....
  17. ncbi request reprint The youngest reported case of corticobasal degeneration
    Anna DePold Hohler
    Department of Neurology, Madigan Army Medical Center, Tacoma, WA, USA
    Parkinsonism Relat Disord 10:47-50. 2003
    ..The chronic, progressive course, asymmetric limb rigidity, apraxia, focal dystonia, and lack of response to levodopa suggest CBD. To our knowledge, this is the youngest reported case of clinically probable CBD...
  18. pmc Uniquely hominid features of adult human astrocytes
    Nancy Ann Oberheim
    Center for Translational Neuromedicine, Department of Neurology, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Neurosci 29:3276-87. 2009
    ..On this basis, we posit that this astrocytic complexity has permitted the increased functional competence of the adult human brain...
  19. ncbi request reprint Increased cytotoxic potential of microglia from ALS-transgenic mice
    Patrick Weydt
    Department of Neurology, University of Washington, Seattle, Washington 98195, USA
    Glia 48:179-82. 2004
    ..Neonatal microglia, however, showed no differences. Our findings suggest an increased cytotoxic potential of adult mtSOD1 microglia, which only becomes apparent after microglial activation...
  20. ncbi request reprint Fructose supports energy metabolism of some, but not all, axons in adult mouse optic nerve
    Lynne Allen
    MRC Applied Neuroscience Group, School of Biomedical Sciences, Queens Medical Centre, University of Nottingham, Nottingham, NG7 2UH, UK
    J Neurophysiol 95:1917-25. 2006
    ..We conclude that fructose is unable to support function of the larger axons contributing to the first CAP peak, thus enabling us to identify a distinct population of axons that contributes to that peak...
  21. ncbi request reprint Astrocyte glycogen and brain energy metabolism
    Angus M Brown
    School of Biomedical Sciences, Queens Medical Centre, University of Nottingham, Nottingham, NG7 2UH, United Kingdom
    Glia 55:1263-71. 2007
    ..These emerging principles about the roles of astrocyte glycogen contradict the long held belief that this metabolic pool has little or no functional significance...
  22. ncbi request reprint Fructose metabolism in the adult mouse optic nerve, a central white matter tract
    Paul J Meakin
    MRC Applied Neuroscience Group, School of Biomedical Sciences, Queens Medical Centre, University of Nottingham, Nottingham, UK
    J Cereb Blood Flow Metab 27:86-99. 2007
    ....
  23. pmc Reduced sodium channel density, altered voltage dependence of inactivation, and increased susceptibility to seizures in mice lacking sodium channel beta 2-subunits
    Chunling Chen
    Departments of Pharmacology and Neurology, and Transgenic Animal Model Core Laboratory, University of Michigan, Ann Arbor, MI 48109, USA
    Proc Natl Acad Sci U S A 99:17072-7. 2002
    ..Our observations show that beta2-subunits play an important role in the regulation of sodium channel density and function in neurons in vivo and are required for normal action potential generation and control of excitability...

Research Grants11

  1. NEURONS AND GLIA IN VITRO
    Bruce Ransom; Fiscal Year: 2007
    ..The proposed studies will provide useful new information about astrocyte HCs, a neglected channel with unique characteristics. These results will have implications for both normal as well as pathological brain function. ..
  2. Research Training in Neurology
    Bruce Ransom; Fiscal Year: 2007
    ..The goal of the program is that every trainee will have obtained the next appropriate level of research funding and an academic position on completion of two or three years in the training program. ..
  3. NEURONS AND GLIA IN VITRO
    Bruce Ransom; Fiscal Year: 2002
    ..They will also assess the importance of astrocytic glycogen for neural function during and for recovery after periods of hypoglycemia, and may suggest novel strategies to stave off neural injury under these conditions. ..
  4. NEURONS AND GLIA IN VITRO
    BRUCE ROBERT RANSOM; Fiscal Year: 2010
    ..The proposed studies will provide useful new information about astrocyte HCs, a neglected channel with unique characteristics. These results will have implications for both normal as well as pathological brain function. ..