Roger Rank

Summary

Affiliation: University of Arkansas for Medical Sciences
Country: USA

Publications

  1. pmc Effect of inflammatory response on in vivo competition between two chlamydial variants in the guinea pig model of inclusion conjunctivitis
    Roger G Rank
    Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, and Arkansas Children s Hospital Research Institute, Little Rock, Arkansas, USA
    Infect Immun 80:612-9. 2012
  2. pmc Host chemokine and cytokine response in the endocervix within the first developmental cycle of Chlamydia muridarum
    Roger G Rank
    Department of Microbiology and Immunology, Biomed Building, Room 506, University of Arkansas for Medical Sciences and Arkansas Children s Hospital Research Institute, Little Rock, AR 72205, USA
    Infect Immun 78:536-44. 2010
  3. doi request reprint Protective immunity to chlamydial genital infection: evidence from animal studies
    Roger G Rank
    Arkansas Children s Hospital Research Institute, Little Rock, AR 72202, USA
    J Infect Dis 201:S168-77. 2010
  4. pmc Effect of Chlamydiaphage phiCPG1 on the course of conjunctival infection with "Chlamydia caviae" in guinea pigs
    Roger G Rank
    Departments of Microbiology and Immunology, University of Arkansas for Medical Sciences and Arkansas Children s Hospital Research Institute, Little Rock, Arkansas 72202, USA
    Infect Immun 77:1216-21. 2009
  5. pmc Chlamydiae and polymorphonuclear leukocytes: unlikely allies in the spread of chlamydial infection
    Roger G Rank
    Department of Microbiology and Immunology, Chlamydia Research Group, Arkansas Children s Hospital Research Institute, AR 72202, USA
    FEMS Immunol Med Microbiol 54:104-13. 2008
  6. pmc Characterization of chlamydial genital infection resulting from sexual transmission from male to female guinea pigs and determination of infectious dose
    Roger G Rank
    Departments of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    Infect Immun 71:6148-54. 2003
  7. pmc In vivo ultrastructural analysis of the intimate relationship between polymorphonuclear leukocytes and the chlamydial developmental cycle
    Roger G Rank
    Department of Microbiology and Immunology, University of Arkansas for Medical Sciences and Arkansas Children s Hospital Research Institute, Little Rock, AR 72202, USA
    Infect Immun 79:3291-301. 2011
  8. pmc Critical role for interleukin-1beta (IL-1beta) during Chlamydia muridarum genital infection and bacterial replication-independent secretion of IL-1beta in mouse macrophages
    Daniel Prantner
    Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    Infect Immun 77:5334-46. 2009
  9. ncbi request reprint Chlamydia trachomatis induces expression of IFN-gamma-inducible protein 10 and IFN-beta independent of TLR2 and TLR4, but largely dependent on MyD88
    Uma M Nagarajan
    Division of Pediatric Infectious Diseases, Arkansas Children s Hospital, Little Rock, AR 72202, USA
    J Immunol 175:450-60. 2005
  10. pmc Impact of azithromycin resistance mutations on the virulence and fitness of Chlamydia caviae in guinea pigs
    Rachel Binet
    Department of Microbiology and Immunology, F Edward Hébert School of Medicine Uniformed Services University of Health Sciences, Bethesda, Maryland 20814 4799, USA
    Antimicrob Agents Chemother 54:1094-101. 2010

Research Grants

Collaborators

Detail Information

Publications15

  1. pmc Effect of inflammatory response on in vivo competition between two chlamydial variants in the guinea pig model of inclusion conjunctivitis
    Roger G Rank
    Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, and Arkansas Children s Hospital Research Institute, Little Rock, Arkansas, USA
    Infect Immun 80:612-9. 2012
    ..Our results suggest that the ability to elicit an inflammatory response is an important factor in the dynamics of mixed infection with strains that display different pathological phenotypes...
  2. pmc Host chemokine and cytokine response in the endocervix within the first developmental cycle of Chlamydia muridarum
    Roger G Rank
    Department of Microbiology and Immunology, Biomed Building, Room 506, University of Arkansas for Medical Sciences and Arkansas Children s Hospital Research Institute, Little Rock, AR 72205, USA
    Infect Immun 78:536-44. 2010
    ..This model provides an ideal opportunity to investigate the mechanisms by which the early inflammatory response is induced in vivo...
  3. doi request reprint Protective immunity to chlamydial genital infection: evidence from animal studies
    Roger G Rank
    Arkansas Children s Hospital Research Institute, Little Rock, AR 72202, USA
    J Infect Dis 201:S168-77. 2010
    ..This review will target the mechanisms responsible for long-term versus short-term immunity and explore the roles of various components of the host response in immunity to chlamydial genital infection...
  4. pmc Effect of Chlamydiaphage phiCPG1 on the course of conjunctival infection with "Chlamydia caviae" in guinea pigs
    Roger G Rank
    Departments of Microbiology and Immunology, University of Arkansas for Medical Sciences and Arkansas Children s Hospital Research Institute, Little Rock, Arkansas 72202, USA
    Infect Immun 77:1216-21. 2009
    ..Modifying the ratio of phage to chlamydiae altered the course of infection and affected phage replication. There was no evidence for the phage increasing the virulence of C. caviae infection...
  5. pmc Chlamydiae and polymorphonuclear leukocytes: unlikely allies in the spread of chlamydial infection
    Roger G Rank
    Department of Microbiology and Immunology, Chlamydia Research Group, Arkansas Children s Hospital Research Institute, AR 72202, USA
    FEMS Immunol Med Microbiol 54:104-13. 2008
    ..We propose that PMNs play an active role in detaching infected cells from the epithelium and that these infected cells eventually die releasing organisms but, in the process, move to new tissue sites via fluid dynamics...
  6. pmc Characterization of chlamydial genital infection resulting from sexual transmission from male to female guinea pigs and determination of infectious dose
    Roger G Rank
    Departments of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    Infect Immun 71:6148-54. 2003
    ..There is currently no other animal model available for any sexually transmitted disease in which the disease or the ability to prevent the disease may be studied in animals infected by the natural means...
  7. pmc In vivo ultrastructural analysis of the intimate relationship between polymorphonuclear leukocytes and the chlamydial developmental cycle
    Roger G Rank
    Department of Microbiology and Immunology, University of Arkansas for Medical Sciences and Arkansas Children s Hospital Research Institute, Little Rock, AR 72202, USA
    Infect Immun 79:3291-301. 2011
    ....
  8. pmc Critical role for interleukin-1beta (IL-1beta) during Chlamydia muridarum genital infection and bacterial replication-independent secretion of IL-1beta in mouse macrophages
    Daniel Prantner
    Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    Infect Immun 77:5334-46. 2009
    ..Additionally, prestimulation of macrophages by chlamydial TLR ligands may account for the elevated levels of pro-IL-1beta mRNA observed in vivo in this cell type...
  9. ncbi request reprint Chlamydia trachomatis induces expression of IFN-gamma-inducible protein 10 and IFN-beta independent of TLR2 and TLR4, but largely dependent on MyD88
    Uma M Nagarajan
    Division of Pediatric Infectious Diseases, Arkansas Children s Hospital, Little Rock, AR 72202, USA
    J Immunol 175:450-60. 2005
    ..Furthermore, the intracellular pathways that lead to chlamydial-induced IFN-beta function through TANK-binding kinase mediated phosphorylation and nuclear translocation of IFN regulatory factor-3...
  10. pmc Impact of azithromycin resistance mutations on the virulence and fitness of Chlamydia caviae in guinea pigs
    Rachel Binet
    Department of Microbiology and Immunology, F Edward Hébert School of Medicine Uniformed Services University of Health Sciences, Bethesda, Maryland 20814 4799, USA
    Antimicrob Agents Chemother 54:1094-101. 2010
    ..The obligate intracellular nature of Chlamydia may therefore limit emergence of resistance in vivo due to the strength of the immune response induced by the wild-type antibiotic-sensitive bacteria at the time of antibiotic treatment...
  11. pmc Local host response to chlamydial urethral infection in male guinea pigs
    Yin Wang
    Department of Microbiology and Immunology, University of Arkansas for Medical Sciences and Arkansas Children s Hospital Research Institute, Little Rock, Arkansas 72205, USA
    Infect Immun 78:1670-81. 2010
    ..This study represents the first comprehensive analysis of the local immune response in the male urethra to a chlamydial genital infection...
  12. pmc A Chlamydia trachomatis-specific Th2 clone does not provide protection against a genital infection and displays reduced trafficking to the infected genital mucosa
    Raymond A Hawkins
    Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
    Infect Immun 70:5132-9. 2002
    ..The data show that the MoPn-specific Th2 cells are important for serum and vaginal antibody production and may accumulate in the GT during chronic infection...
  13. pmc Strain and virulence diversity in the mouse pathogen Chlamydia muridarum
    Kyle H Ramsey
    Department of Microbiology and Immunology, Midwestern University, Downers Grove, IL 60516, USA
    Infect Immun 77:3284-93. 2009
    ..These results prove that there is genotypic and virulence diversity among C. muridarum isolates. These findings can be exploited to determine factors related to chlamydial virulence and immunity...
  14. pmc Inhibition of apoptosis by gamma interferon in cells and mice infected with Chlamydia muridarum (the mouse pneumonitis strain of Chlamydia trachomatis)
    Jean Luc Perfettini
    Unité de Biologie Moléculaire du Gène, INSERM U277, Universite Paris 7, 75724 Paris Cedex 15, France
    Infect Immun 70:2559-65. 2002
    ..These results suggest that IFN-gamma may contribute to pathogenesis of persistent Chlamydia infections in vivo by preventing apoptosis of infected cells...
  15. ncbi request reprint Role of proapoptotic BAX in propagation of Chlamydia muridarum (the mouse pneumonitis strain of Chlamydia trachomatis) and the host inflammatory response
    Jean Luc Perfettini
    Universite Paris 7, Institut Pasteur, Unité de Biologie Moléculaire du Gène, INSERM U277, Paris, France
    J Biol Chem 278:9496-502. 2003
    ..Bax deficiency results in lower infection and an increased inflammatory cytokine response associated with more severe pathology...

Research Grants7

  1. Biennial Meeting of Chlamydia Basic Research Society
    Roger Rank; Fiscal Year: 2007
    ..abstract_text> ..
  2. Host response to Chlamydia genital infection in the male
    Roger Rank; Fiscal Year: 2007
    ..abstract_text> ..