Genomes and Genes
Erik A Ranheim
Affiliation: University of Wisconsin
- Frizzled 9 knock-out mice have abnormal B-cell developmentErik A Ranheim
Departments of Pathology and Genetics, Stanford University School of Medicine, Stanford, CA, USA
Blood 105:2487-94. 2005..Mature B cells are present in normal numbers in lymph node and spleen. These findings suggest a role for Fzd9 signaling in lymphoid development, particularly at points where B cells undergo self-renewal prior to further differentiation...
- Selection of aberrant class II restricted CD8+ T cells in NOD mice expressing a glutamic acid decarboxylase (GAD)65-specific T cell receptor transgeneErik A Ranheim
Department of Pathology, University of Wisconsin, Madison, WI 53792, USA
Autoimmunity 37:555-67. 2004..We find that production of these CD8+ cells is not dependent on NOD thymus or high affinity of the TCR, but is dependent on the atypical TCR transgenic thymic environment...
- Intratumoral treatment of smaller mouse neuroblastoma tumors with a recombinant protein consisting of IL-2 linked to the hu14.18 antibody increases intratumoral CD8+ T and NK cells and improves survivalRichard K Yang
The Department of Human Oncology, University of Wisconsin, Madison, WI 53705, USA
Cancer Immunol Immunother 62:1303-13. 2013..18-IL2 treatment is necessary for long-term survival. This model demonstrates that tumor size is a strong predictor of hu14.18-IL2-induced lymphocyte infiltration and treatment outcome...
- Notch1 Gene Mutations Target KRAS G12D-expressing CD8+ Cells and Contribute to Their Leukemogenic TransformationGuangyao Kong
From the McArdle Laboratory for Cancer Research and
J Biol Chem 288:18219-27. 2013..Notch1 mutations and Kras G12D contribute cooperatively to leukemogenic transformation of normal T-cells. ..
- Naive mouse macrophages become activated following recognition of L5178Y lymphoma cells via concurrent ligation of CD40, NKG2D, and CD18 moleculesIlia N Buhtoiarov
Department of Human Oncology, University of Wisconsin, Madison, WI 53792, USA
J Immunol 182:1940-53. 2009..These results suggest that contact with certain tumor cells via CD40, NKG2D, and CD18 molecules on the Mphi may facilitate Mphi-mediated antitumor immune surveillance...
- NrasG12D/+ promotes leukemogenesis by aberrantly regulating hematopoietic stem cell functionsJinyong Wang
McArdle Laboratory for Cancer Research, University of Wisconsin Madison, Madison, WI
Blood 121:5203-7. 2013..Our data delineate critical mechanisms of oncogenic Nras signaling in HSC function and leukemogenesis. ..
- Dysregulation of Frizzled 6 is a critical component of B-cell leukemogenesis in a mouse model of chronic lymphocytic leukemiaQing Li Wu
Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
Blood 113:3031-9. 2009..Our findings suggest that the self-renewal signals mediated by Wnt/Fzd that are enlisted during B-cell development may be pathologically reactivated in the neoplastic transformation of mature B cells...
- The gene related to anergy in lymphocytes, an E3 ubiquitin ligase, is necessary for anergy induction in CD4 T cellsChristine M Seroogy
Department of Medicine, Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA 94305, USA
J Immunol 173:79-85. 2004..These data provide direct evidence that a biochemical pathway composed of GRAIL and/or GRAIL-interacting proteins is important in the development of the CD4 T cell anergic phenotype in vivo...
- Wnt1 expression induces short-range and long-range cell recruitments that modify mammary tumor development and are not induced by a cell-autonomous beta-catenin effectorYoung Chul Kim
McArdle Laboratory for Cancer Research, School of Medicine and Public Health, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
Cancer Res 68:10145-53. 2008..Thus, localized ectopic expression of the proto-oncogene Wnt1 in mammary glands induces systemic responses, and we propose that this response modifies the tumorigenic outcome...
- Intratumoral hu14.18-IL-2 (IC) induces local and systemic antitumor effects that involve both activated T and NK cells as well as enhanced IC retentionRichard K Yang
Department of Human Oncology, University of Wisconsin, Madison, WI 53705, USA
J Immunol 189:2656-64. 2012..v.-IC. Overall, IT-IC resulted in increased numbers of activated T and NK cells within tumors, better IC retention in the tumor, enhanced inhibition of tumor growth, and improved survival compared with i.v.-IC...
- Distinct requirements of hematopoietic stem cell activity and Nras G12D signaling in different cell types during leukemogenesisJinyong Wang
McArdle Laboratory for Cancer Research, University of Wisconsin Madison, Madison, WI, USA
Cell Cycle 10:2836-9. 2011..Our results suggest that different lineages of hematopoietic cells might have differential requirements of HSC activity and Nras G12D signaling during leukemogenesis...
- Molecular characteristics of mantle cell lymphoma presenting with clonal plasma cell componentCarlo Visco
Department of Pathology, University of Wisconsin School of Medicine and Public Health, Madison, USA
Am J Surg Pathol 35:177-89. 2011..Our findings suggest that MCL can present with a PC component that is often clonally related to the lymphoma, representing a rare but unique biological variant of this tumor...
- Tumoricidal effects of activated macrophages in a mouse model of chronic lymphocytic leukemiaQing Li Wu
Department of Pathology and Laboratory Medicine, Pediatrics University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA
J Immunol 182:6771-8. 2009..Our results suggest a novel immunotherapeutic strategy for CLL that may be effective even in the face of tumor or chemotherapy-induced T cell immunodeficiency...
- Characterization of zebrafish larval inflammatory macrophagesJonathan R Mathias
Department of Medical Microbiology and Immunology, University of Wisconsin Madison, 1550 Linden Drive, Madison, WI 53706, USA
Dev Comp Immunol 33:1212-7. 2009..These findings identify distinct functional and morphological characteristics of inflammatory macrophages in zebrafish larvae...
- Variable hematopoietic graft rejection and graft-versus-host disease in MHC-matched strains of miceThai M Cao
Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
Proc Natl Acad Sci U S A 100:11571-6. 2003..Our results likely extend to all serologically MHC-matched mouse strains used in modern research and highlight the profound and variable influence that non-MHC genetic determinants can have in dictating outcome after HCT...
- Dissection of the Anti-tumor Immune ResponseErik Ranheim; Fiscal Year: 2006..These studies will provide a clearer picture of CD4+ and CD8+ T cell anti-tumor immunity and better direct efforts at tumor immunotherapy in human patients. ..