Rama Ranganathan

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. ncbi request reprint Dynamic scaffolding in a G protein-coupled signaling system
    Prashant Mishra
    Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390 9050, USA
    Cell 131:80-92. 2007
  2. ncbi request reprint PDZ domain proteins: scaffolds for signaling complexes
    R Ranganathan
    Howard Hughes Medical Institute, Department of Pharmacology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75235 9041, USA
    Curr Biol 7:R770-3. 1997
  3. ncbi request reprint Cell biology. A matter of life or death
    Rama Ranganathan
    Howard Hughes Medical Institute, Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Science 299:1677-9. 2003
  4. doi request reprint Evolution-based design of proteins
    Kimberly A Reynolds
    Green Center for Systems Biology, Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Methods Enzymol 523:213-35. 2013
  5. doi request reprint The spatial architecture of protein function and adaptation
    Richard N McLaughlin
    Green Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9050, USA
    Nature 491:138-42. 2012
  6. ncbi request reprint Biochemistry. Signaling across the cell membrane
    Rama Ranganathan
    Green Center for Systems Biology and Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Science 318:1253-4. 2007
  7. pmc Local complexity of amino acid interactions in a protein core
    Rajul K Jain
    Howard Hughes Medical Institute and Department of Pharmacology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9050, USA
    Proc Natl Acad Sci U S A 101:111-6. 2004
  8. ncbi request reprint Structural determinants of allosteric ligand activation in RXR heterodimers
    Andrew I Shulman
    Howard Hughes Medical Institute, Department of Pharmacology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Cell 116:417-29. 2004
  9. pmc Allosteric determinants in guanine nucleotide-binding proteins
    Mark E Hatley
    Department of Pharmacology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9050, USA
    Proc Natl Acad Sci U S A 100:14445-50. 2003
  10. ncbi request reprint Evolutionarily conserved networks of residues mediate allosteric communication in proteins
    Gürol M Süel
    Howard Hughes Medical Institute and Department of Pharmacology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9050, USA
    Nat Struct Biol 10:59-69. 2003

Collaborators

  • Walraj S Gosal
  • Michael Yaffe
  • STEPHEN BENKOVIC
  • William P Russ
  • Michael Socolich
  • Prashant Mishra
  • Kimberly A Reynolds
  • Richard N McLaughlin
  • Alain Pumir
  • Jeeyeon Lee
  • Jennifer Graves
  • Mark A Wall
  • Rajul K Jain
  • Andrew I Shulman
  • Gürol M Süel
  • Mark E Hatley
  • Steve W Lockless
  • Arjun Raman
  • Frank J Poelwijk
  • Tina Vo
  • Madhusudan Natarajan
  • Boris I Shraiman
  • Vishal C Nashine
  • ZiFen Wang
  • Drew M Lowery
  • David J Mangelsdorf
  • Christopher Larson
  • Alfred G Gilman
  • Scott K Gibson

Detail Information

Publications13

  1. ncbi request reprint Dynamic scaffolding in a G protein-coupled signaling system
    Prashant Mishra
    Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390 9050, USA
    Cell 131:80-92. 2007
    ....
  2. ncbi request reprint PDZ domain proteins: scaffolds for signaling complexes
    R Ranganathan
    Howard Hughes Medical Institute, Department of Pharmacology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75235 9041, USA
    Curr Biol 7:R770-3. 1997
    ..Extensive conservation of PDZ domains suggests that these motifs have a general role in organizing diverse signaling complexes...
  3. ncbi request reprint Cell biology. A matter of life or death
    Rama Ranganathan
    Howard Hughes Medical Institute, Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Science 299:1677-9. 2003
  4. doi request reprint Evolution-based design of proteins
    Kimberly A Reynolds
    Green Center for Systems Biology, Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Methods Enzymol 523:213-35. 2013
    ..By this process, we hope to understand how the constraints on fold, function, and other aspects of fitness are organized within natural proteins, a first step in understanding the process of "design" by evolution...
  5. doi request reprint The spatial architecture of protein function and adaptation
    Richard N McLaughlin
    Green Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9050, USA
    Nature 491:138-42. 2012
    ..The localization of functional constraint and adaptive variation within the sector has important implications for understanding and engineering proteins...
  6. ncbi request reprint Biochemistry. Signaling across the cell membrane
    Rama Ranganathan
    Green Center for Systems Biology and Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Science 318:1253-4. 2007
  7. pmc Local complexity of amino acid interactions in a protein core
    Rajul K Jain
    Howard Hughes Medical Institute and Department of Pharmacology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9050, USA
    Proc Natl Acad Sci U S A 101:111-6. 2004
    ..The data indicate that, even in highly stable proteins, the core contains sufficient plasticity in packing to uncouple high-order energetic interactions of residues, a property that is likely general in proteins...
  8. ncbi request reprint Structural determinants of allosteric ligand activation in RXR heterodimers
    Andrew I Shulman
    Howard Hughes Medical Institute, Department of Pharmacology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Cell 116:417-29. 2004
    ..These results reveal a structural network required for RXR heterodimer allosteric communication and suggest that the specificity of ligand response and permissivity coevolved to enable signal discrimination...
  9. pmc Allosteric determinants in guanine nucleotide-binding proteins
    Mark E Hatley
    Department of Pharmacology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9050, USA
    Proc Natl Acad Sci U S A 100:14445-50. 2003
    ..The network of residues identified by the SCA appears to comprise a core allosteric mechanism conferring nucleotide-dependent switching; the specific features of different G protein family members are built on this core...
  10. ncbi request reprint Evolutionarily conserved networks of residues mediate allosteric communication in proteins
    Gürol M Süel
    Howard Hughes Medical Institute and Department of Pharmacology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9050, USA
    Nat Struct Biol 10:59-69. 2003
    ..The data suggest that evolutionarily conserved sparse networks of amino acid interactions represent structural motifs for allosteric communication in proteins...
  11. pmc Systems analysis of the single photon response in invertebrate photoreceptors
    Alain Pumir
    Laboratoire J A Dieudonne, Centre National de la Recherche Scientifique and Université de Nice, 06108 Nice, France
    Proc Natl Acad Sci U S A 105:10354-9. 2008
    ..The system-level analysis enabled by modeling phototransduction provides a foundation for understanding G protein signaling pathways less amenable to quantitative approaches...
  12. pmc Surface sites for engineering allosteric control in proteins
    Jeeyeon Lee
    Department of Chemistry, Pennsylvania State University, University Park, PA 16802, USA
    Science 322:438-42. 2008
    ..PAS-DHFR serves as a proof of concept for engineering regulatory activities into proteins through interface design at conserved allosteric sites...
  13. ncbi request reprint Natural-like function in artificial WW domains
    William P Russ
    Howard Hughes Medical Institute and Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9050, USA
    Nature 437:579-83. 2005
    ..The ability to recapitulate natural-like function in designed sequences shows that a relatively small quantity of sequence information is sufficient to specify the global energetics of amino acid interactions...