Research Topics
| Oliver RandoSummaryAffiliation: University of Massachusetts Medical School Country: USA Publications
Research Grants
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Detail Information
Publications
Histone variant H2A.Z marks the 5' ends of both active and inactive genes in euchromatinRyan M Raisner
Department of Biochemistry and Biophysics, University of California, 600 16th Street, San Francisco, California 94143, USA
Cell 123:233-48. 2005..Efficient deposition of H2A.Z is further promoted by a specific pattern of histone H3 and H4 tail acetylation and the bromodomain protein Bdf1, a component of the Swr1 remodeling complex that deposits H2A.Z...
Timescales of genetic and epigenetic inheritanceOliver J Rando
Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA
Cell 128:655-68. 2007..Although these observations do not undermine Darwin's theory, they suggest that selection and variability are less independent than once thought...- Dynamics of replication-independent histone turnover in budding yeastMichael F Dion
Faculty of Arts and Sciences, Center for Systems Biology, Harvard University, Cambridge, MA 02138, USA
Science 315:1405-8. 2007..In addition, rapid histone turnover is found at known chromatin boundary elements. These results suggest that rapid histone turnover serves to functionally separate chromatin domains and prevent spread of histone states... - Chromatin remodelling at promoters suppresses antisense transcriptionIestyn Whitehouse
Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
Nature 450:1031-5. 2007..Our analyses reveal how chromatin is organized on a global scale and advance our understanding of how transcription is regulated... - Daddy issues: paternal effects on phenotypeOliver J Rando
Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA
Cell 151:702-8. 2012..How paternal environmental conditions influence the phenotype of progeny is now a tractable question, and researchers are exploring potential mechanisms underlying such effects... - Combinatorial complexity in chromatin structure and function: revisiting the histone codeOliver J Rando
Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA
Curr Opin Genet Dev 22:148-55. 2012..This review will focus on these contrasting results, and will briefly touch on possible ways to reconcile these conflicting views... - Chromatin 'programming' by sequence--is there more to the nucleosome code than %GC?Amanda Hughes
Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, 364 Plantation Street No, 903, Worcester, MA 01605, USA
J Biol 8:96. 2009..Thus, the rules for predicting nucleosome occupancy from genomic sequence are much less complicated than has been claimed. See research article http://www.biomedcentral.com/1471-2105/10/442... - RNA polymerase mapping during stress responses reveals widespread nonproductive transcription in yeastTae Soo Kim
Department of Biological Chemistry and Molecular Pharmacology, Harvard University, 240 Longwood Avenue, Boston, MA 02115, USA
Genome Biol 11:R75. 2010..However, changes in mRNA abundance reflect the combined effect of changes in RNA production, processing, and degradation, and thus, mRNA levels provide an occluded view of transcriptional regulation... 
Evolution in a test tube: the hatchet before the scalpelOliver J Rando
Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA
Cell 135:789-91. 2008..2008) report that extensive polyploidy and aneuploidy are the initial evolutionary changes in yeast selected in vitro to overcome defects resulting from the loss of a myosin II protein crucial for normal cytokinesis...- Genome-wide views of chromatin structureOliver J Rando
Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA
Annu Rev Biochem 78:245-71. 2009.... - Global patterns of histone modificationsOliver J Rando
Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA
Curr Opin Genet Dev 17:94-9. 2007.... - Chromatin structure in the genomics eraOliver J Rando
Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA
Trends Genet 23:67-73. 2007..These same resources are now being used successfully to study the structure of chromatin. Here, I review some of these new genomics approaches to understanding chromatin structure in eukaryotes... - Genome-wide measurement of histone H3 replacement dynamics in yeastOliver J Rando
Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA, USA
Methods Mol Biol 759:41-60. 2011..With suitable modifications, this protocol could be applied to other organisms, or to replacement dynamics of other DNA-associated proteins... - Nucleosome positioning: how is it established, and why does it matter?Marta Radman-Livaja
Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA
Dev Biol 339:258-66. 2010.... - Rules and regulation in the primary structure of chromatinOliver J Rando
Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA
Curr Opin Cell Biol 19:250-6. 2007..Understanding the positions and dynamic behavior of nucleosomes promises to shed light on why transcription factors bind so many fewer sites than predicted, how histone variants may be targeted, and how chromatin states are delineated... - Chromatin as a potential carrier of heritable informationPaul D Kaufman
Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, MA 01605, USA
Curr Opin Cell Biol 22:284-90. 2010..Here, we briefly review the evidence that some chromatin states are indeed heritable, and then focus on the mechanistic challenges that remain in order to understand how this inheritance can be achieved... - Replication and active demethylation represent partially overlapping mechanisms for erasure of H3K4me3 in budding yeastMarta Radman-Livaja
Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
PLoS Genet 6:e1000837. 2010..Indeed, deletion of the demethylase Jhd2 slowed erasure at most loci. Together, these results indicate overlapping roles for passive dilution and active enzymatic demethylation in erasing ancestral histone methylation states in yeast... - A biologist despairs over the difficulty of demonstrating heritability of chromatin statesOliver Rando
University of Massachusetts, Worcester, USA
Nature 454:141. 2008 - Altered dosage and mislocalization of histone H3 and Cse4p lead to chromosome loss in Saccharomyces cerevisiaeWei Chun Au
Genetics Branch Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20889, USA
Genetics 179:263-75. 2008..Suppression of these phenotypes by histone delta 16H3 and GALCSE4 supports the conclusion that proper stoichiometry affects the localization of histone H3 and Cse4p and is thus essential for accurate chromosome segregation... - Genomic expression programs and the integration of the CD28 costimulatory signal in T cell activationMaximilian Diehn
Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305, USA
Proc Natl Acad Sci U S A 99:11796-801. 2002.... - Second messenger control of chromatin remodelingOliver J Rando
Nat Struct Biol 10:81-3. 2003 - Genomic characterization reveals a simple histone H4 acetylation codeMichael F Dion
Bauer Center for Genomics Research, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA
Proc Natl Acad Sci U S A 102:5501-6. 2005..Thus, acetylation of histone H4 is interpreted by two mechanisms: a specific mechanism for lysine 16 and a nonspecific, cumulative mechanism for lysines 5, 8, and 12... - Genome-scale identification of nucleosome positions in S. cerevisiaeGuo-Cheng Yuan
Bauer Center for Genomics Research, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA
Science 309:626-30. 2005..Most occupied transcription factor binding motifs were devoid of nucleosomes, strongly suggesting that nucleosome positioning is a global determinant of transcription factor access... - Single-nucleosome mapping of histone modifications in S. cerevisiaeChih Long Liu
Bauer Center for Genomics Research, Harvard University, Cambridge, Massachusetts, USA
PLoS Biol 3:e328. 2005..g., promoter nucleosomes) from those at another location (e.g., over the 3' ends of coding regions). These results are consistent with the idea of a simple, redundant histone code, in which multiple modifications share the same role... - Noisy silencing of chromatinOliver J Rando
Bauer Center for Genomics Research, Harvard University, 7 Divinity Avenue, Cambridge, Massachusetts 02138
Dev Cell 11:134-6. 2006.... - Independent and complementary methods for large-scale structural analysis of mammalian chromatinJonathan H Dennis
Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Genome Res 17:928-39. 2007..These results demonstrate the effectiveness of the combined methods for reliable analysis of mammalian chromatin structure in a high-throughput manner... - Phosphatidylinositol-dependent actin filament binding by the SWI/SNF-like BAF chromatin remodeling complexOliver J Rando
Department of Developmental Biology, Howard Hughes Medical Institute, Stanford University Medical School, Stanford, CA 94305, USA
Proc Natl Acad Sci U S A 99:2824-9. 2002..Based on these findings, we propose a model for PIP2 activation of actin binding by relief of intramolecular capping of actin by Brg1...
Research Grants
- Transgenerational effects of diet in mammalsOliver J Rando; Fiscal Year: 2010..Thus, our identification and characterization of pathways linking diet in one generation to effects on the next generation is of key importance for understanding and eventually treating a wide range of human diseases. ..
- Genomic analysis of histone replacement dynamics in yeastOliver J Rando; Fiscal Year: 2010..In this proposal we aim to investigate the mechanisms that enable cells to inherit epigenetic information, with the hope that we may eventually use this information to design more directed therapies against cancer. ..