Research Topics
| Parmjeet RandhawaSummaryAffiliation: University of Pittsburgh Country: USA Publications
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Detail Information
Publications
Anti-BK virus activity of nucleoside analogsParmjeet Randhawa
Division of Transplantation Pathology, Department of Pathology, University of Pittsburgh, Room Medical Center, Pittsburgh, PA 15213, USA
Antimicrob Agents Chemother 52:1519-21. 2008....- BK Virus replication in vitro: limited effect of drugs interfering with viral uptake and intracellular transportParmjeet Randhawa
Division of Transplantation Pathology, Department of Pathology, University of Pittsburgh, UPMC Montefiore Hospital, Pittsburgh, PA 15213, USA
Antimicrob Agents Chemother 51:4492-4. 2007..In vitro studies demonstrated slight antiviral activity for chloroquine and nystatin. A sialic acid derivative, BTB11968, was identified as a lead compound for further development... - Impact of genomic sequence variability on quantitative PCR assays for diagnosis of polyomavirus BK infectionP Randhawa
Division of Transplant Pathology, University of Pittsburgh, Department of Pathology, E737 UPMC Montefiore Hospital, 3459 Fifth Ave, Pittsburgh, PA 15213, USA
J Clin Microbiol 49:4072-6. 2011..Physicians need to be cognizant of these effects when interpreting the results of quantitative PCR testing in transplant recipients, particularly if there is a discrepancy between the clinical impression and the measured viral load... - Identification of species-specific and cross-reactive epitopes in human polyomavirus capsids using monoclonal antibodiesParmjeet Randhawa
Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15213, USA
J Gen Virol 90:634-9. 2009..7 and JC-7.9) and two of 13 SV40 antibodies (VP1-H2 and VP1-I2) recognized linear buried epitopes common to all three viruses and (iii) SV40 antibody VP1-E5 recognized a linear surface epitope on JCV pseudocapsids... 
The significance of renal C4d staining in patients with BK viruria, viremia, and nephropathyIbrahim Batal
Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
Mod Pathol 22:1468-76. 2009..A subset of biopsies with BK nephropathy shows tubular basement membrane C4d staining, which correlates with marked viral cytopathic effect...- Clinical significance of the distribution of C4d deposits in different anatomic compartments of the allograft kidneyIbrahim Batal
Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
Mod Pathol 21:1490-8. 2008..Finally, C4d deposits preferentially in lesions of chronic transplant glomerulopathy and arteriolar hyalinosis... - Clinicopathologic analysis of patients with BK viruria and rejection-like graft dysfunctionIbrahim Batal
Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
Hum Pathol 40:1312-9. 2009..08) and with significant development of viremia after antirejection treatment (5/9 [56%] versus 0/24 [0%] in patients with low VL, P < .001)... - Measurements of global cell-mediated immunity in renal transplant recipients with BK virus reactivationIbrahim Batal
Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
Am J Clin Pathol 129:587-91. 2008..Within the viruria group, lower ICF values were associated with higher urinary viral load (P= .037). These results show that a decreased ICF test result correlates with active viral replication in kidney transplant recipients... - Antihuman leukocyte antigen–specific antibody strength determined by complement-dependent or solid-phase assays can predict positive donor-specific crossmatchesIbrahim Batal
Departments of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
Arch Pathol Lab Med 134:1534-40. 2010..The association of circulating donor-specific antibody (DSA) strength with crossmatch results is of potential interest to predict allograft outcome... - Neutrophilic tubulitis as a marker for urinary tract infection in renal allograft biopsies with C4d depositionGaurav Gupta
Department of Internal Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
Transplantation 87:1013-8. 2009..This study evaluated the incidence of UTI in biopsies with concurrent neutrophilic tubulitis and PTC C4d staining... - Putative episodes of T-cell-mediated rejection in patients with sustained BK viruria but no viremiaKosuke Masutani
Division of Transplant Pathology, Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15213, USA
Transplantation 94:43-9. 2012..Polyomavirus BK (BKV) infection characterized by viruria alone is considered to be of little clinical significance, but this issue has not been systematically studied... - Correlates of quantitative measurement of BK polyomavirus (BKV) DNA with clinical course of BKV infection in renal transplant patientsParmjeet Randhawa
Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
J Clin Microbiol 42:1176-80. 2004..In conclusion, serial measurement of viral loads by quantitative PCR is a useful tool in monitoring the course of BK virus infection. The results should be interpreted in conjunction with the clinical picture and biopsy findings... 
Quantitation of DNA of polyomaviruses BK and JC in human kidneysParmjeet Randhawa
Division of Transplantation Pathology, Department of Pathology, University of Pittsburgh, PA 15213, USA
J Infect Dis 192:504-9. 2005..Because virus in urine can be derived from the kidneys, ureter, or urinary bladder, we evaluated whether measurement of intrarenal concentrations of viral DNA might serve as a more reliable monitoring tool...- A comparative study of BK and JC virus infections in organ transplant recipientsParmjeet Randhawa
Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
J Med Virol 77:238-43. 2005..BKV viremia was seen in kidney but not liver recipients. The mechanisms underlying these notable phenomena remain to be investigated... - Immunohistochemical markers of tissue injury in biopsies with transplant glomerulitisIbrahim Batal
Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
Hum Pathol 43:69-80. 2012..Mesangial- or interstitial-von Willebrand factor identified cases with more severe microcirculation injury... - Ether lipid ester derivatives of cidofovir inhibit polyomavirus BK replication in vitroParmjeet Randhawa
Division of Transplantation Pathology, Department of Pathology, University of Pittsburgh Medical Center Montefiore Hospital, 3459 Fifth Ave, Pittsburgh, PA 15213, USA
Antimicrob Agents Chemother 50:1564-6. 2006..Esterification of cidofovir with hexadecyloxypropyl, octadecyloxyethyl, and oleyloxyethyl groups results in up to a 3-log lowering of the 50% effective concentration and an increased selectivity index... - VP-1 quasispecies in human infection with polyomavirus BKChunqing Luo
Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
J Med Virol 84:152-61. 2012..Quasispecies occur even in healthy subjects with viruria, but evolutionary selection pressure directed at the viral capsid protein (VP-1) is seen only in patients with viremia or nephropathy... - Phylogenetic analysis of polyomavirus BK sequencesPreety M Sharma
Division of Transplant Pathology, E737 UPMC-Montefiore Hospital, 3459 Fifth Ave, Pittsburgh, PA 15213, USA
J Virol 80:8869-79. 2006..However, within the kidney transplant population, BKV strains derived from patients with asymptomatic viruria did not show complete separation from strains associated with allograft nephropathy... - Monitoring of human liver and kidney allograft tolerance: a tissue/histopathology perspectiveAnthony J Demetris
Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, PA 15213, USA
Transpl Int 22:120-41. 2009.... - Effect of leflunomide and cidofovir on replication of BK virus in an in vitro culture systemNoush Afarin Farasati
Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
Transplantation 79:116-8. 2005..3+/-11.7, and 2.3+/-0.8 microg/mL. CONCLUSIONS: The in vitro activity of Cidofovir and Leflunomide is modest, and the selectivity index is low. There is a need to develop more effective and less toxic anti-BK virus drugs for clinical use... - Emerging role of donor-specific anti-human leukocyte antigen antibody determination for clinical management after solid organ transplantationAdriana Zeevi
Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Hum Immunol 70:645-50. 2009..These cases exemplify the rationale for all patients to be monitored for DSA post-transplantation, with the frequency adjusted based on the individual risk for AMR... - Monitoring for polyomavirus BK And JC in urine: comparison of quantitative polymerase chain reaction with urine cytologyParmjeet Randhawa
Division of Transplant Pathology, Department of Pathology, University of Pittsburgh, PA 15213, USA
Transplantation 79:984-6. 2005..Compared with PCR, urine cytology is a less sensitive technique, which requires morphologically intact cells, and cannot distinguish BKV from JC virus... - Genotyping schemes for polyomavirus BK, using gene-specific phylogenetic trees and single nucleotide polymorphism analysisChunqing Luo
Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
J Virol 83:2285-97. 2009..Interstrain genetic recombination between distant loci in the VP1 and LTA areas is not a common event... - Cold heparinized lactated Ringers with procaine (HeLP) preservation fluid in 266 living donor kidney transplantationsHenkie P Tan
the Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
Transplantation 83:1134-6. 2007..This study documents the effectiveness of cold HeLP as a flushing and short-term preservation fluid for living donor kidney transplantation with excellent results and significant cost benefit because of its low cost... - Long-term effects of alemtuzumab on regulatory and memory T-cell subsets in kidney transplantationCamila Macedo
Human Immunology Program, Thomas E Starzl Transplantation Institute and Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA
Transplantation 93:813-21. 2012..It is not fully understood which memory and regulatory T-cell subsets are most affected and how they relate to clinical outcomes... - HLA mismatching increases the risk of BK virus nephropathy in renal transplant recipientsYehia Awadalla
Departments of Pathology and Biostatistics, University of Pittsburgh, Pittsburgh
Am J Transplant 4:1691-6. 2004..We propose that HLA mismatching promotes the development of BKV nephropathy through rejection-related inflammatory processes and heavy immunosuppression which cause virus reactivation and injury of the tubular epithelium... - Validation of BKV large T-antigen ATP-binding site as a target for drug discoveryGang Zeng
Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA
Antiviral Res 81:184-7. 2009..Pilot screening of 300 compounds from the Tim Tec ActiTarg K library identified a compound, STO18584, with selectivity index of 19.2... - Kidney transplantation under minimal immunosuppression after pretransplant lymphoid depletion with Thymoglobulin or CampathRon Shapiro
Thomas E Starzl Transplantation Institute, The University of Pittsburgh Medical Center, PA 15213, USA
J Am Coll Surg 200:505-15; quiz A59-61. 2005..Campath was the more effective agent for pretreatment. Guidelines for spaced weaning need additional refinement... - Serum analysis after transplant nephrectomy reveals restricted antibody specificity patterns against structurally defined HLA class I mismatchesOyedele A Adeyi
Division of Transplantation Pathology and CLSI Tissue Typing Laboratory, Department of Pathology, Thomas E. Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA, 15261 USA
Transpl Immunol 14:53-62. 2005..It provides also opportunities for determining the relative immunogenicity of mismatched triplets... - Renal biopsy findings predicting outcome in scleroderma renal crisisIbrahim Batal
Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
Hum Pathol 40:332-40. 2009..Vascular thrombosis, severe glomerular ischemic collapse, and peritubular capillary C4d deposits in scleroderma renal crisis kidney biopsies correlated with increased risk of failure to recover renal function... - A schema for histologic grading of small intestine allograft acute rejectionTong Wu
Department of Pathology, Thomas E Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Transplantation 75:1241-8. 2003..The primary goal of this study was to develop a histologic grading system for the diagnosis of small bowel allograft acute rejection... - Tolerogenic immunosuppression for organ transplantationThomas E Starzl
Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
Lancet 361:1502-10. 2003..We aimed to apply these principles in recipients of renal and extrarenal organ transplants... - Helicobacter pylori may play a contributory role in the pathogenesis of primary sclerosing cholangitisAlyssa M Krasinskas
Department of Pathology, Division of Anatomic Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
Dig Dis Sci 52:2265-70. 2007.... - Viral regulatory region sequence variations in kidney tissue obtained from patients with BK virus nephropathyParmjeet Randhawa
Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Kidney Int 64:743-7. 2003..We hypothesized that DNA sequence variations in this region play a role in the pathogenesis of BK virus allograft nephropathy (BKVAN)... - Pathogenesis and management of polyomavirus infection in transplant recipientsEun Jeong Kwak
Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
Clin Infect Dis 35:1081-7. 2002..Clinical syndromes related to polyomavirus infection are summarized in the present review, and strategies for the management of patients who receive transplants are discussed... - Conceptual problems in the diagnosis and therapy of acute rejection in patients with polyomavirus nephropathyParmjeet Randhawa
Am J Transplant 4:840. 2004 - Liver biopsy interpretation for causes of late liver allograft dysfunctionAnthony J Demetris
Hepatology 44:489-501. 2006..A discussion of differential diagnosis is also presented... - Polyomavirus-associated nephropathy in renal transplantation: interdisciplinary analyses and recommendationsHans H Hirsch
Transplantation Virology, Institute for Medical Microbiology and Div Infectious Diseases, Universitatsspital Basel, Switzerland
Transplantation 79:1277-86. 2005..25-0.33 mg/kg intravenously biweekly) without probenicid should be considered for refractory cases. Retransplantation after renal allograft loss to PVAN remains a treatment option for patients clearing polyomavirus replication... - Antibody-mediated rejection criteria - an addition to the Banff 97 classification of renal allograft rejectionLorraine C Racusen
The Johns Hopkins University School of Medicine, Baltimore, MD, USA
Am J Transplant 3:708-14. 2003..This classification represents a working formulation, to be revisited as additional data accumulate in this important area of renal transplantation... - The pathobiology of polyomavirus infection in manParmjeet Randhawa
University of Pittsburgh Medical Center, Pennsylvania, USA
Adv Exp Med Biol 577:148-59. 2006..Finally, we present biochemical mechanisms that could potentially explain several key elements of tissue pathology characteristic of BKV mediated damage to human kidney...