P Randhawa

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. pmc Polyomavirus BK neutralizing activity in human immunoglobulin preparations
    Parmjeet S Randhawa
    Division of Transplantation Pathology, Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Transplantation 89:1462-5. 2010
  2. pmc Correlates of quantitative measurement of BK polyomavirus (BKV) DNA with clinical course of BKV infection in renal transplant patients
    Parmjeet Randhawa
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    J Clin Microbiol 42:1176-80. 2004
  3. ncbi request reprint Monitoring for polyomavirus BK And JC in urine: comparison of quantitative polymerase chain reaction with urine cytology
    Parmjeet Randhawa
    Division of Transplant Pathology, Department of Pathology, University of Pittsburgh, PA 15213, USA
    Transplantation 79:984-6. 2005
  4. ncbi request reprint Quantitation of DNA of polyomaviruses BK and JC in human kidneys
    Parmjeet Randhawa
    Division of Transplantation Pathology, Department of Pathology, University of Pittsburgh, PA 15213, USA
    J Infect Dis 192:504-9. 2005
  5. ncbi request reprint A comparative study of BK and JC virus infections in organ transplant recipients
    Parmjeet Randhawa
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Med Virol 77:238-43. 2005
  6. pmc Ether lipid ester derivatives of cidofovir inhibit polyomavirus BK replication in vitro
    Parmjeet Randhawa
    Division of Transplantation Pathology, Department of Pathology, University of Pittsburgh Medical Center Montefiore Hospital, 3459 Fifth Ave, Pittsburgh, PA 15213, USA
    Antimicrob Agents Chemother 50:1564-6. 2006
  7. ncbi request reprint Detection of CD8+ T cells sensitized to BK virus large T antigen in healthy volunteers and kidney transplant recipients
    Parmjeet S Randhawa
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Hum Immunol 67:298-302. 2006
  8. ncbi request reprint BK virus infection in transplant recipients: an overview and update
    P Randhawa
    Department of Pathology, Division of Transplantation Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Am J Transplant 6:2000-5. 2006
  9. pmc Immunoglobulin G, A, and M responses to BK virus in renal transplantation
    Parmjeet S Randhawa
    Department of Pathology, Division of Transplant Pathology, University of Pittsburgh, E 737 UPMC Montefiore Hospital, 3459 Fifth Ave, PA 15213, USA
    Clin Vaccine Immunol 13:1057-63. 2006
  10. pmc longitudinal analysis of levels of immunoglobulins against BK virus capsid proteins in kidney transplant recipients
    P Randhawa
    Department of Pathology, Division of Transplant Pathology, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Clin Vaccine Immunol 15:1564-71. 2008

Research Grants

  1. Polyomavirus Infection after Kidney Transplantation
    Parmjeet Randhawa; Fiscal Year: 2003
  2. Polyomavirus Infection after Kidney Transplantation
    Parmjeet S Randhawa; Fiscal Year: 2010
  3. Immune Response to Polyomavirus Infection
    Parmjeet Randhawa; Fiscal Year: 2009
  4. Polyomavirus Infection after Kidney Transplantation
    Parmjeet Randhawa; Fiscal Year: 2009
  5. Polyomavirus Infection after Kidney Transplantation
    Parmjeet Randhawa; Fiscal Year: 2007
  6. Immune Response to Polyomavirus Infection
    Parmjeet Randhawa; Fiscal Year: 2007
  7. Immune Response to Polyomavirus Infection
    Parmjeet Randhawa; Fiscal Year: 2006
  8. Polyomavirus Infection after Kidney Transplantation
    Parmjeet Randhawa; Fiscal Year: 2005
  9. Polyomavirus Infection after Kidney Transplantation
    Parmjeet Randhawa; Fiscal Year: 2004
  10. Immune Response to Polyomavirus Infection
    Parmjeet S Randhawa; Fiscal Year: 2010

Collaborators

Detail Information

Publications75

  1. pmc Polyomavirus BK neutralizing activity in human immunoglobulin preparations
    Parmjeet S Randhawa
    Division of Transplantation Pathology, Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Transplantation 89:1462-5. 2010
    ..No well-established drug treatment is available at this time. Human intravenous immunoglobulins (IVIG) have been used as an empiric therapy without proof of effectiveness...
  2. pmc Correlates of quantitative measurement of BK polyomavirus (BKV) DNA with clinical course of BKV infection in renal transplant patients
    Parmjeet Randhawa
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    J Clin Microbiol 42:1176-80. 2004
    ..In conclusion, serial measurement of viral loads by quantitative PCR is a useful tool in monitoring the course of BK virus infection. The results should be interpreted in conjunction with the clinical picture and biopsy findings...
  3. ncbi request reprint Monitoring for polyomavirus BK And JC in urine: comparison of quantitative polymerase chain reaction with urine cytology
    Parmjeet Randhawa
    Division of Transplant Pathology, Department of Pathology, University of Pittsburgh, PA 15213, USA
    Transplantation 79:984-6. 2005
    ..Compared with PCR, urine cytology is a less sensitive technique, which requires morphologically intact cells, and cannot distinguish BKV from JC virus...
  4. ncbi request reprint Quantitation of DNA of polyomaviruses BK and JC in human kidneys
    Parmjeet Randhawa
    Division of Transplantation Pathology, Department of Pathology, University of Pittsburgh, PA 15213, USA
    J Infect Dis 192:504-9. 2005
    ..Because virus in urine can be derived from the kidneys, ureter, or urinary bladder, we evaluated whether measurement of intrarenal concentrations of viral DNA might serve as a more reliable monitoring tool...
  5. ncbi request reprint A comparative study of BK and JC virus infections in organ transplant recipients
    Parmjeet Randhawa
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Med Virol 77:238-43. 2005
    ..BKV viremia was seen in kidney but not liver recipients. The mechanisms underlying these notable phenomena remain to be investigated...
  6. pmc Ether lipid ester derivatives of cidofovir inhibit polyomavirus BK replication in vitro
    Parmjeet Randhawa
    Division of Transplantation Pathology, Department of Pathology, University of Pittsburgh Medical Center Montefiore Hospital, 3459 Fifth Ave, Pittsburgh, PA 15213, USA
    Antimicrob Agents Chemother 50:1564-6. 2006
    ..Esterification of cidofovir with hexadecyloxypropyl, octadecyloxyethyl, and oleyloxyethyl groups results in up to a 3-log lowering of the 50% effective concentration and an increased selectivity index...
  7. ncbi request reprint Detection of CD8+ T cells sensitized to BK virus large T antigen in healthy volunteers and kidney transplant recipients
    Parmjeet S Randhawa
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Hum Immunol 67:298-302. 2006
    ..T-antigen-specific T-cytotoxic cells circulate in healthy blood donors, implying that transient expression of T antigen presumably occurs at sites of viral latency and helps maintain a constant pool of circulating CD8+ T memory cells...
  8. ncbi request reprint BK virus infection in transplant recipients: an overview and update
    P Randhawa
    Department of Pathology, Division of Transplantation Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Am J Transplant 6:2000-5. 2006
    ..This is followed by a discussion of clinical features, laboratory monitoring and therapeutic strategies. Finally, we present potential cellular mechanisms that explain the basis of virus-mediated damage to the human kidney...
  9. pmc Immunoglobulin G, A, and M responses to BK virus in renal transplantation
    Parmjeet S Randhawa
    Department of Pathology, Division of Transplant Pathology, University of Pittsburgh, E 737 UPMC Montefiore Hospital, 3459 Fifth Ave, PA 15213, USA
    Clin Vaccine Immunol 13:1057-63. 2006
    ..In conclusion, measurement of anti-BKV antibody titer and class response can be used to detect the onset of viral replication. ELISAs can be quite specific despite considerable sequence homology between BK virus and JC virus...
  10. pmc longitudinal analysis of levels of immunoglobulins against BK virus capsid proteins in kidney transplant recipients
    P Randhawa
    Department of Pathology, Division of Transplant Pathology, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Clin Vaccine Immunol 15:1564-71. 2008
    ..25; P = 0.05). In summary, serial measurements of anti-BKV immunoglobulin class (i) detect onset of viral replication, (ii) document episodes of seroreversion, and (iii) can potentially provide prognostic information...
  11. ncbi request reprint Viral regulatory region sequence variations in kidney tissue obtained from patients with BK virus nephropathy
    Parmjeet Randhawa
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Kidney Int 64:743-7. 2003
    ..We hypothesized that DNA sequence variations in this region play a role in the pathogenesis of BK virus allograft nephropathy (BKVAN)...
  12. ncbi request reprint Quantitation of viral DNA in renal allograft tissue from patients with BK virus nephropathy
    Parmjeet S Randhawa
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Transplantation 74:485-8. 2002
    ..Quantitative polymerase chain reaction (PCR) assay for renal biopsy has not been evaluated as a diagnostic test. Determination of renal BKV load may identify patients at risk for disease before histologic nephropathy...
  13. ncbi request reprint Allograft biopsies in management of pancreas transplant recipients
    P Randhawa
    Division of Transplantation Pathology, Department of Pathology, C903 1 Presbyterian University Hospital, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Postgrad Med 48:56-63. 2002
    ..In addition to its role in establishing the primary diagnosis, a biopsy can grade the severity of pathology present, help determine the most appropriate therapy, and provide information relevant to graft prognosis...
  14. ncbi request reprint DNA sequencing of viral capsid protein VP-1 region in patients with BK virus interstitial nephritis
    Parmjeet S Randhawa
    Division of Transplantation Pathology, Department of Pathology, Children s Hospital of Pittsburgh, Pittsburgh, PA 15213, USA
    Transplantation 73:1090-4. 2002
    ..This study sought to determine whether analogous viral genetic changes occur in human BK virus (BKV) interstitial nephritis (ISN)...
  15. ncbi request reprint JC virus infection in allograft kidneys: analysis by polymerase chain reaction and immunohistochemistry
    P Randhawa
    Department of Pathology, University of Pittsburgh Medical Center, Pennsylvania, USA
    Transplantation 71:1300-3. 2001
    ..Polyoma virus nephropathy after transplantation is believed to be primarily due to the BK virus. We hypothesized that some cases may be associated with the JC polyoma virus (JCV), which is also known to be latent in the kidney...
  16. ncbi request reprint Allograft liver biopsy in patients with Epstein-Barr virus-associated posttransplant lymphoproliferative disease
    P Randhawa
    Division of Transplantation Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Am J Surg Pathol 25:324-30. 2001
    ..Rejection may be treated even if EBV is concurrently present. Long-term graft is suboptimal, because low immunosuppression results in a tendency to develop chronic rejection...
  17. doi request reprint Two hundred living donor kidney transplantations under alemtuzumab induction and tacrolimus monotherapy: 3-year follow-up
    H P Tan
    the Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Am J Transplant 9:355-66. 2009
    ..4% remained steroid-free from the time of transplantation. Infectious complications were uncommon. This experience suggests the 3-year efficacy of this approach...
  18. pmc An analysis of early renal transplant protocol biopsies--the high incidence of subclinical tubulitis
    R Shapiro
    University of Pittsburgh, Thomas E Starzl Transplantation Institute, PA 15213, USA
    Am J Transplant 1:47-50. 2001
    ..This suggests that the true incidence of rejection may be higher than is clinically appreciated...
  19. pmc Living donor renal transplantation using alemtuzumab induction and tacrolimus monotherapy
    H P Tan
    the Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    Am J Transplant 6:2409-17. 2006
    ..5%. This study represents the largest series to date of live donor renal transplant recipients undergoing alemtuzumab induction, and confirms the short-term safety and efficacy of this approach...
  20. ncbi request reprint Reversal of steroid- and anti-lymphocyte antibody-resistant rejection using intravenous immunoglobulin (IVIG) in renal transplant recipients
    P P Luke
    Department of Urology, Thomas E. Starzl Transplantation Institute, University of Pittsburgh Medical Center, 3601 Fifth Avenue, Pittsburgh, PA 15213, USA
    Transplantation 72:419-22. 2001
    ..CONCLUSIONS: IVIG rescue therapy for steroid- or antilymphocyte antibody-resistant rejection is associated with resolution or improvement of rejection severity, stable renal function, and reasonable graft survival...
  21. pmc Recurrent hepatitis C in liver allografts: prospective assessment of diagnostic accuracy, identification of pitfalls, and observations about pathogenesis
    A J Demetris
    Department of Pathology, Division of Transplantation, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Am J Surg Pathol 28:658-69. 2004
    ....
  22. pmc The Banff 2009 Working Proposal for polyomavirus nephropathy: a critical evaluation of its utility as a determinant of clinical outcome
    K Masutani
    Pathology Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Am J Transplant 12:907-18. 2012
    ..The proposal is not superior to existing schemas that include assessment of inflammation, which is a well-known prognostic marker in other renal allograft diseases...
  23. pmc Impact of genomic sequence variability on quantitative PCR assays for diagnosis of polyomavirus BK infection
    P Randhawa
    Division of Transplant Pathology, University of Pittsburgh, Department of Pathology, E737 UPMC Montefiore Hospital, 3459 Fifth Ave, Pittsburgh, PA 15213, USA
    J Clin Microbiol 49:4072-6. 2011
    ..Physicians need to be cognizant of these effects when interpreting the results of quantitative PCR testing in transplant recipients, particularly if there is a discrepancy between the clinical impression and the measured viral load...
  24. ncbi request reprint "Plasma cell hepatitis" in liver allografts: identification and characterization of an IgG4-rich cohort
    M Castillo-Rama
    Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA Department of Pathology, Division of Liver and Transplantation Pathology, Thomas E Starzl Transplantation, University of Pittsburgh, Pittsburgh, PA
    Am J Transplant 13:2966-77. 2013
    ..IgG4+ PCH was associated with fibrosis, but also highly responsive to increased immunosuppression. ..
  25. ncbi request reprint Molecular genotyping of BK and JC viruses in human polyomavirus-associated interstitial nephritis after renal transplantation
    F K Baksh
    Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Am J Kidney Dis 38:354-65. 2001
    ..Simian 40 polyomavirus was not identified in any case. These observations may have pathogenic relevance to the development of an extremely refractory form of polyomavirus interstitial nephritis seen after kidney transplantation...
  26. doi request reprint Measurements of global cell-mediated immunity in renal transplant recipients with BK virus reactivation
    Ibrahim Batal
    Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Am J Clin Pathol 129:587-91. 2008
    ..Within the viruria group, lower ICF values were associated with higher urinary viral load (P= .037). These results show that a decreased ICF test result correlates with active viral replication in kidney transplant recipients...
  27. ncbi request reprint Real-time monitoring of acute liver-allograft rejection using the Banff schema
    A J Demetris
    Department of Pathology, Division of Transplantation, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Transplantation 74:1290-6. 2002
    ..The Banff schema is the internationally accepted standard for grading acute liver-allograft rejection, but it has not been prospectively tested...
  28. ncbi request reprint Steroid-free tacrolimus monotherapy after pretransplantation thymoglobulin or Campath and laparoscopy in living donor renal transplantation
    H P Tan
    Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    Transplant Proc 37:4235-40. 2005
    ..The incidence of new-onset posttransplantation insulin-dependent diabetes was 0.5%. At current follow-up, the use of Campath 1H rather than thymoglobulin for pretreatment seems to have significantly improved the efficacy of our regimen...
  29. pmc Biologic diversity of polyomavirus BK genomic sequences: Implications for molecular diagnostic laboratories
    C Luo
    Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Med Virol 80:1850-7. 2008
    ..Cross reactivity of appropriately selected BKV primers with JCV and SV40 sequences available in current databases was not a significant problem...
  30. doi request reprint A critical appraisal of methods to grade transplant glomerulitis in renal allograft biopsies
    I Batal
    Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Am J Transplant 10:2442-52. 2010
    ..In conclusion, grading of glomerulitis is a meaningful exercise, and a quantification system based on percentage of glomerular involvement shows the most robust associations with clinical parameters and prognosis...
  31. doi request reprint Clinical significance of the distribution of C4d deposits in different anatomic compartments of the allograft kidney
    Ibrahim Batal
    Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Mod Pathol 21:1490-8. 2008
    ..Finally, C4d deposits preferentially in lesions of chronic transplant glomerulopathy and arteriolar hyalinosis...
  32. doi request reprint Re-examination of the lymphocytotoxic crossmatch in liver transplantation: can C4d stains help in monitoring?
    J Lunz
    Department of Pathology, Division of Transplantation, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Am J Transplant 12:171-82. 2012
    ..Further study in late biopsies and other tissue markers of liver AMR with simultaneous DSA measurements are needed...
  33. ncbi request reprint Arcuate and interlobular phlebitis in renal allografts
    M Torbenson
    Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD, USA
    Hum Pathol 32:1388-91. 2001
    ..However, this lesion frequently coexists with changes suggestive or diagnostic of acute cellular rejection, and intimal arteritis may be seen concurrently in up to 16% of cases...
  34. doi request reprint Banff schema for grading pancreas allograft rejection: working proposal by a multi-disciplinary international consensus panel
    C B Drachenberg
    Department of Pathology, University of Maryland School of Medicine, Baltimore, MD, USA
    Am J Transplant 8:1237-49. 2008
    ....
  35. doi request reprint Guidelines for the diagnosis of antibody-mediated rejection in pancreas allografts-updated Banff grading schema
    C B Drachenberg
    Department of Pathology, University of Maryland School of Medicine, Baltimore, MD, USA
    Am J Transplant 11:1792-802. 2011
    ..A systematized clinicopathological approach to AMR is essential for the development and assessment of much needed therapeutic interventions...
  36. pmc Kidney transplantation under minimal immunosuppression after pretransplant lymphoid depletion with Thymoglobulin or Campath
    Ron Shapiro
    Thomas E Starzl Transplantation Institute, The University of Pittsburgh Medical Center, PA 15213, USA
    J Am Coll Surg 200:505-15; quiz A59-61. 2005
    ..We have suggested that transplantation outcomes can be improved by modifying the timing and dosage of immunosuppression to facilitate natural mechanisms of alloengraftment and acquired tolerance...
  37. pmc Phylogenetic analysis of polyomavirus BK sequences
    Preety M Sharma
    Division of Transplant Pathology, E737 UPMC Montefiore Hospital, 3459 Fifth Ave, Pittsburgh, PA 15213, USA
    J Virol 80:8869-79. 2006
    ..However, within the kidney transplant population, BKV strains derived from patients with asymptomatic viruria did not show complete separation from strains associated with allograft nephropathy...
  38. doi request reprint Antihuman leukocyte antigen–specific antibody strength determined by complement-dependent or solid-phase assays can predict positive donor-specific crossmatches
    Ibrahim Batal
    Departments of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Arch Pathol Lab Med 134:1534-40. 2010
    ..The association of circulating donor-specific antibody (DSA) strength with crossmatch results is of potential interest to predict allograft outcome...
  39. doi request reprint Clinicopathologic analysis of patients with BK viruria and rejection-like graft dysfunction
    Ibrahim Batal
    Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Hum Pathol 40:1312-9. 2009
    ..08) and with significant development of viremia after antirejection treatment (5/9 [56%] versus 0/24 [0%] in patients with low VL, P < .001)...
  40. doi request reprint Neutrophilic tubulitis as a marker for urinary tract infection in renal allograft biopsies with C4d deposition
    Gaurav Gupta
    Department of Internal Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Transplantation 87:1013-8. 2009
    ..This study evaluated the incidence of UTI in biopsies with concurrent neutrophilic tubulitis and PTC C4d staining...
  41. pmc Identification of species-specific and cross-reactive epitopes in human polyomavirus capsids using monoclonal antibodies
    Parmjeet Randhawa
    Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Gen Virol 90:634-9. 2009
    ..7 and JC-7.9) and two of 13 SV40 antibodies (VP1-H2 and VP1-I2) recognized linear buried epitopes common to all three viruses and (iii) SV40 antibody VP1-E5 recognized a linear surface epitope on JCV pseudocapsids...
  42. pmc Anti-BK virus activity of nucleoside analogs
    Parmjeet Randhawa
    Division of Transplantation Pathology, Department of Pathology, University of Pittsburgh, Room Medical Center, Pittsburgh, PA 15213, USA
    Antimicrob Agents Chemother 52:1519-21. 2008
    ....
  43. pmc BK Virus replication in vitro: limited effect of drugs interfering with viral uptake and intracellular transport
    Parmjeet Randhawa
    Division of Transplantation Pathology, Department of Pathology, University of Pittsburgh, UPMC Montefiore Hospital, Pittsburgh, PA 15213, USA
    Antimicrob Agents Chemother 51:4492-4. 2007
    ..In vitro studies demonstrated slight antiviral activity for chloroquine and nystatin. A sialic acid derivative, BTB11968, was identified as a lead compound for further development...
  44. doi request reprint Monitoring of human liver and kidney allograft tolerance: a tissue/histopathology perspective
    Anthony J Demetris
    Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, PA 15213, USA
    Transpl Int 22:120-41. 2009
    ....
  45. doi request reprint The significance of renal C4d staining in patients with BK viruria, viremia, and nephropathy
    Ibrahim Batal
    Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Mod Pathol 22:1468-76. 2009
    ..A subset of biopsies with BK nephropathy shows tubular basement membrane C4d staining, which correlates with marked viral cytopathic effect...
  46. pmc Tolerogenic immunosuppression for organ transplantation
    Thomas E Starzl
    Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Lancet 361:1502-10. 2003
    ..We aimed to apply these principles in recipients of renal and extrarenal organ transplants...
  47. ncbi request reprint A schema for histologic grading of small intestine allograft acute rejection
    Tong Wu
    Department of Pathology, Thomas E Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Transplantation 75:1241-8. 2003
    ..The primary goal of this study was to develop a histologic grading system for the diagnosis of small bowel allograft acute rejection...
  48. ncbi request reprint HLA mismatching increases the risk of BK virus nephropathy in renal transplant recipients
    Yehia Awadalla
    Departments of Pathology and Biostatistics, University of Pittsburgh, Pittsburgh
    Am J Transplant 4:1691-6. 2004
    ..We propose that HLA mismatching promotes the development of BKV nephropathy through rejection-related inflammatory processes and heavy immunosuppression which cause virus reactivation and injury of the tubular epithelium...
  49. ncbi request reprint Effect of leflunomide and cidofovir on replication of BK virus in an in vitro culture system
    Noush Afarin Farasati
    Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Transplantation 79:116-8. 2005
    ..Cidofovir and Leflunomide are used empirically in the treatment of BK virus nephropathy. The aim of this study is to quantify the antiviral activity of these drugs...
  50. doi request reprint Emerging role of donor-specific anti-human leukocyte antigen antibody determination for clinical management after solid organ transplantation
    Adriana Zeevi
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Hum Immunol 70:645-50. 2009
    ..These cases exemplify the rationale for all patients to be monitored for DSA post-transplantation, with the frequency adjusted based on the individual risk for AMR...
  51. pmc Cold heparinized lactated Ringers with procaine (HeLP) preservation fluid in 266 living donor kidney transplantations
    Henkie P Tan
    the Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Transplantation 83:1134-6. 2007
    ..This study documents the effectiveness of cold HeLP as a flushing and short-term preservation fluid for living donor kidney transplantation with excellent results and significant cost benefit because of its low cost...
  52. ncbi request reprint Helicobacter pylori may play a contributory role in the pathogenesis of primary sclerosing cholangitis
    Alyssa M Krasinskas
    Department of Pathology, Division of Anatomic Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Dig Dis Sci 52:2265-70. 2007
    ....
  53. doi request reprint Renal biopsy findings predicting outcome in scleroderma renal crisis
    Ibrahim Batal
    Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Hum Pathol 40:332-40. 2009
    ..Vascular thrombosis, severe glomerular ischemic collapse, and peritubular capillary C4d deposits in scleroderma renal crisis kidney biopsies correlated with increased risk of failure to recover renal function...
  54. pmc A pilot trial of tacrolimus, sirolimus, and steroids in renal transplant recipients
    R Shapiro
    Thomas E Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Transplant Proc 34:1651-2. 2002
  55. ncbi request reprint Serum analysis after transplant nephrectomy reveals restricted antibody specificity patterns against structurally defined HLA class I mismatches
    Oyedele A Adeyi
    Division of Transplantation Pathology and CLSI Tissue Typing Laboratory, Department of Pathology, Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA, 15261 USA
    Transpl Immunol 14:53-62. 2005
    ..It provides also opportunities for determining the relative immunogenicity of mismatched triplets...
  56. pmc Genotyping schemes for polyomavirus BK, using gene-specific phylogenetic trees and single nucleotide polymorphism analysis
    Chunqing Luo
    Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Virol 83:2285-97. 2009
    ..Interstrain genetic recombination between distant loci in the VP1 and LTA areas is not a common event...
  57. pmc Validation of BKV large T-antigen ATP-binding site as a target for drug discovery
    Gang Zeng
    Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA
    Antiviral Res 81:184-7. 2009
    ..Pilot screening of 300 compounds from the Tim Tec ActiTarg K library identified a compound, STO18584, with selectivity index of 19.2...
  58. ncbi request reprint The pathobiology of polyomavirus infection in man
    Parmjeet Randhawa
    University of Pittsburgh Medical Center, Pennsylvania, USA
    Adv Exp Med Biol 577:148-59. 2006
    ..Finally, we present biochemical mechanisms that could potentially explain several key elements of tissue pathology characteristic of BKV mediated damage to human kidney...
  59. ncbi request reprint Pathogenesis and management of polyomavirus infection in transplant recipients
    Eun Jeong Kwak
    Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Clin Infect Dis 35:1081-7. 2002
    ..Clinical syndromes related to polyomavirus infection are summarized in the present review, and strategies for the management of patients who receive transplants are discussed...
  60. ncbi request reprint Retransplantation in patients with graft loss caused by polyoma virus nephropathy
    Emilio Ramos
    Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Transplantation 77:131-3. 2004
    ..The risk of recurrence does not seem to be increased in comparison with the first graft...
  61. pmc Antirejection treatment in kidney transplant patients with BK viruria
    Liise K Kayler
    Department of Pathology, the Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Transplantation 86:797-803. 2008
    ..Kidney transplant recipients with BK virus nephropathy or viremia are generally treated with reduction of immunosuppression to facilitate virus eradication...
  62. ncbi request reprint Polyomavirus allograft nephropathy: sequential assessment of histologic viral load, tubulitis, and graft function following changes in immunosuppression
    Betul Celik
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Am J Transplant 3:1378-82. 2003
    ..Lack of parallelism between viral load, tubulitis grade, and serum creatinine illustrates a complex interplay of viral and alloimmune factors leading to graft injury...
  63. pmc Kidney transplantation under a tolerogenic regimen of recipient pretreatment and low-dose postoperative immunosuppression with subsequent weaning
    Ron Shapiro
    Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Ann Surg 238:520-5; discussion 525-7. 2003
    ..The purpose of this work was to perform kidney transplantation under a regimen of immunosuppression that facilitates rather than interferes with the recently defined mechanisms of alloengraftment and acquired tolerance...
  64. ncbi request reprint Glomerular changes in BK virus nephropathy
    Betul Celik
    Department of Pathology, University of Pittsburgh School of Medicine, PA 15213, USA
    Hum Pathol 35:367-70. 2004
    ..Two biopsies showed electron-dense deposits on ultrastructural examination, but a cause and effect relationship to BK virus infection could not be established...
  65. ncbi request reprint Chronic renal failure after liver transplantation
    Parmjeet S Randhawa
    Am J Transplant 5:967-8. 2005
  66. ncbi request reprint Anti-BK virus activity of ciprofloxacin and related antibiotics
    Parmjeet S Randhawa
    Clin Infect Dis 41:1366-7; author reply 1367. 2005
  67. ncbi request reprint Occurrence of urinary tract infection in patients with renal allograft biopsies showing neutrophilic tubulitis
    Luciano Espinheira Fonseca
    Department of Anatomic Pathology and Legal Medicine, Bahia Federal Medical School, Salvador, Bahia, Brazil
    Mod Pathol 16:281-5. 2003
    ..Confirmation by urine culture is needed because biopsies with ischemic injury and acute cellular or antibody-mediated rejection can show overlapping histology...
  68. ncbi request reprint Diagnosis and treatment of BK virus-associated transplant nephropathy
    Abhay Vats
    Children s Hospital of Pittsburgh, University of Pittsburgh, Pennsylvania, USA
    Adv Exp Med Biol 577:213-27. 2006
    ..More recently several other agents have also been utilized to treat BKVAN, with variable success. This chapter summarizes the current diagnostic modalities and therapeutic options for BKVAN...
  69. ncbi request reprint Polyomavirus BK non-coding control region rearrangements in health and disease
    Preety M Sharma
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Med Virol 79:1199-207. 2007
    ..BK virus is an increasingly recognized pathogen in transplanted patients. DNA sequencing of this virus shows considerable genomic variability...
  70. doi request reprint Clinical course of kidney transplant patients with acute rejection and BK virus replication following Campath therapy
    Liise K Kayler
    Department of Pathology, the Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Clin Transplant 22:348-53. 2008
    ..Kidney transplant recipients with active BK virus (BKV) replication are generally treated with reduction in immunosuppression to allow a successful immune response against the virus...
  71. doi request reprint Acute renal allograft rejection: diagnostic significance of focal peritubular capillary C4d
    Liise K Kayler
    Department of Surgery, University of Florida Medical Center, Gainesville, FL 32610 0286, USA
    Transplantation 85:813-20. 2008
    ..Focal PTC C4d staining in acute renal allograft rejection has not been studied extensively...
  72. pmc Alemtuzumab preconditioning with tacrolimus monotherapy-the impact of serial monitoring for donor-specific antibody
    Ron Shapiro
    Department of Surgery, the Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    Transplantation 85:1125-32. 2008
    ..Antibody preconditioning with tacrolimus monotherapy has allowed many renal allograft recipients to be maintained on spaced weaning...
  73. doi request reprint Correlation of histologic findings on preimplant biopsy with kidney graft survival
    Liise K Kayler
    Department of Surgery, University of Florida Medical Center, College of Medicine, Gainesville, FL 32610 0286, USA
    Transpl Int 21:892-8. 2008
    ..0001). Donor vascular disease is an independent risk factor for suboptimal graft survival. Great caution should be exercised in the decision to transplant kidneys with moderate arterial and/or arteriolar luminal narrowing...
  74. ncbi request reprint Minimal evidence of transdifferentiation from recipient bone marrow to parenchymal cells in regenerating and long-surviving human allografts
    Tong Wu
    Division of Transplant Pathology, Thomas E Starzl Transplant Institute, University of Pittsburgh Medical Center, Pittsburgh, Pittsburgh, PA, USA
    Am J Transplant 3:1173-81. 2003
    ..Because of the extremely low frequency, interpretation was difficult. Regardless of these results, a more vigorous search for conditions that promote transdifferentiation is warranted...
  75. ncbi request reprint Cholesterol embolization in renal allografts: a clinicopathologic study of 12 cases
    Chi K Lai
    Department of Pathology and Laboratory Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Am J Surg Pathol 31:536-45. 2007
    ..Graft failure is significantly associated with donor-derived and early CE. Although its prognosis may be poor in the setting of primary nonfunction, prolonged graft survival may be seen...

Research Grants12

  1. Polyomavirus Infection after Kidney Transplantation
    Parmjeet Randhawa; Fiscal Year: 2003
    ....
  2. Polyomavirus Infection after Kidney Transplantation
    Parmjeet S Randhawa; Fiscal Year: 2010
    ..We hypothesize that anti-BKV drugs can be discovered by screening chemical libraries for compounds that can bind to two key viral proteins, namely, viral capsid protein-1 (VP-1) and large T antigen. ..
  3. Immune Response to Polyomavirus Infection
    Parmjeet Randhawa; Fiscal Year: 2009
    ..This, in turn, will help us to better predict the clinical course of the disease in individual patients, and help devise more effective forms of anti-viral therapy. ..
  4. Polyomavirus Infection after Kidney Transplantation
    Parmjeet Randhawa; Fiscal Year: 2009
    ..We hypothesize that anti-BKV drugs can be discovered by screening chemical libraries for compounds that can bind to two key viral proteins, namely, viral capsid protein-1 (VP-1) and large T antigen. ..
  5. Polyomavirus Infection after Kidney Transplantation
    Parmjeet Randhawa; Fiscal Year: 2007
    ..We hypothesize that anti-BKV drugs can be discovered by screening chemical libraries for compounds that can bind to two key viral proteins, namely, viral capsid protein-1 (VP-1) and large T antigen. ..
  6. Immune Response to Polyomavirus Infection
    Parmjeet Randhawa; Fiscal Year: 2007
    ..This, in turn, will help us to better predict the clinical course of the disease in individual patients, and help devise more effective forms of anti-viral therapy. ..
  7. Immune Response to Polyomavirus Infection
    Parmjeet Randhawa; Fiscal Year: 2006
    ..This, in turn, will help us to better predict the clinical course of the disease in individual patients, and help devise more effective forms of anti-viral therapy. ..
  8. Polyomavirus Infection after Kidney Transplantation
    Parmjeet Randhawa; Fiscal Year: 2005
    ....
  9. Polyomavirus Infection after Kidney Transplantation
    Parmjeet Randhawa; Fiscal Year: 2004
    ....
  10. Immune Response to Polyomavirus Infection
    Parmjeet S Randhawa; Fiscal Year: 2010
    ..This, in turn, will help us to better predict the clinical course of the disease in individual patients, and help devise more effective forms of anti-viral therapy. ..