R Lor Randall

Summary

Affiliation: University of Utah
Country: USA

Publications

  1. ncbi Complications of cemented long-stem hip arthroplasties in metastatic bone disease
    R Lor Randall
    Huntsman Cancer Institute, Department of Orthopaedics, Salt Lake City, UT 84112, USA
    Clin Orthop Relat Res 443:287-95. 2006
  2. pmc Tumoral TP53 and/or CDKN2A alterations are not reliable prognostic biomarkers in patients with localized Ewing sarcoma: a report from the Children's Oncology Group
    Daniel M Lerman
    Department of Orthopedics, University of Utah, Salt Lake City, Utah Center for Children s Cancer Research, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah
    Pediatr Blood Cancer 62:759-65. 2015
  3. pmc Complications of cemented long-stem hip arthroplasty in metastatic bone disease revisited
    Shawn L Price
    Department of Orthopaedics Sarcoma Services, Huntsman Cancer Institute, University of Utah, 2000 Circle of Hope Drive, Salt Lake City, UT, 84112, USA
    Clin Orthop Relat Res 471:3303-7. 2013
  4. pmc Is claviculo pro humeri of value for limb salvage of pediatric proximal humerus sarcomas?
    George T Calvert
    Sarcoma Services, Center for Children s Cancer Research, Huntsman Cancer Institute, University of Utah, 2000 Circle of Hope, Suite 4260, Salt Lake City, UT, 84112 5550, USA
    Clin Orthop Relat Res 473:877-82. 2015
  5. pmc What are the 5-year survivorship outcomes of compressive endoprosthetic osseointegration fixation of the femur?
    Michael J Monument
    Sarcoma Services, Department of Orthopaedic Surgery, Huntsman Cancer Institute, University of Utah, 2000 Circle of Hope, Room 4260, Salt Lake City, UT, 84112, USA
    Clin Orthop Relat Res 473:883-90. 2015
  6. pmc Molecular inversion probe analysis detects novel copy number alterations in Ewing sarcoma
    Mona S Jahromi
    Center for Children s Cancer Research C3R, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA
    Cancer Genet 205:391-404. 2012
  7. pmc EWS/FLI-responsive GGAA microsatellites exhibit polymorphic differences between European and African populations
    Robert Beck
    Center for Children s Cancer Research, Huntsman Cancer Institute, University of Utah, Salt Lake City, USA
    Cancer Genet 205:304-12. 2012
  8. pmc miRNA signatures associate with pathogenesis and progression of osteosarcoma
    Kevin B Jones
    Department of Orthopaedics and Center for Children s Cancer Research, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah, USA
    Cancer Res 72:1865-77. 2012
  9. pmc Modeling alveolar soft part sarcomagenesis in the mouse: a role for lactate in the tumor microenvironment
    Matthew L Goodwin
    Department of Orthopaedics, University of Utah, Salt Lake City, UT 84112, USA
    Cancer Cell 26:851-62. 2014
  10. pmc Clinical and biochemical function of polymorphic NR0B1 GGAA-microsatellites in Ewing sarcoma: a report from the Children's Oncology Group
    Michael J Monument
    Sarcoma Services, Department of Orthopedic Surgery, University of Utah, Salt Lake City, Utah, United States of America Center for Children s Cancer Research, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah, United States of America
    PLoS ONE 9:e104378. 2014

Collaborators

  • Kevin B Jones
  • Stephen L Lessnick
  • Joshua D Schiffman
  • George T Calvert
  • Neyssa M Marina
  • Richard G Gorlick
  • Alana L Welm
  • Richard Smith
  • Rami I Aqeilan
  • Stefano Volinia
  • H J Siegel
  • T A Damron
  • Kristy Weber
  • Andreas Schuck
  • Patrick C Toy
  • Valerae O Lewis
  • Albert J Aboulafia
  • Javad Parvizi
  • Michael J Monument
  • David E Joyner
  • Daniel M Lerman
  • Richard B Womer
  • Julia A Bridge
  • Mark D Krailo
  • Natalie Beeler
  • Elizabeth McIlvaine
  • Laura Monovich
  • Aashi Chaturvedi
  • Holly Zhou
  • Matthew L Goodwin
  • Nicholas M Bernthal
  • David L Rothberg
  • Stephen K Aoki
  • Lynn B Jorde
  • W Scott Watkins
  • Shawn L Price
  • Robert Beck
  • Kenneth M Boucher
  • Mona S Jahromi
  • Elizabeth R Lawlor
  • Ryan B Israelsen
  • James S Meyer
  • J Sybil Biermann
  • Kenneth J Hunt
  • Mark Bernstein
  • Dali Huang
  • Xiao Qiong Liu
  • Austin J Bowles
  • Allie H Grossmann
  • Lisa Abegglen
  • Christopher C Jensen
  • Yi Chun Lin
  • Huifeng Jin
  • Kirsten M Johnson
  • Mary C Beckerle
  • Krystal Straessler
  • Kyllie Smith-Fry
  • Laura M Hoffman
  • Mario R Capecchi
  • Allie Grossmann
  • Ju Fen Zhu
  • M Aabid Farukhi
  • Chris L Peters
  • Erik N Kubiak
  • Holly Spraker-Perlman
  • Angelica R Putnam
  • Michelle Kinsey
  • David Lucas
  • Jennifer Wright
  • Colleen Druzgal
  • Dafydd Thomas
  • Andrew Rosenberg
  • Susie Crabtree
  • Benjamin E Illum
  • Helen R Nadel
  • Mark D Kailo
  • Paula J Schomberg
  • Holcombe E Grier
  • Kenneth L B Brown
  • J F Eary
  • Joel Mayerson
  • Joshua Patt
  • Richard J O'Donnell
  • Michael K Wong
  • Richard G Schmidt
  • Suzanne George
  • Sean V McGarry
  • Douglas Adkins
  • Warren Chow
  • Frank J Frassica

Detail Information

Publications30

  1. ncbi Complications of cemented long-stem hip arthroplasties in metastatic bone disease
    R Lor Randall
    Huntsman Cancer Institute, Department of Orthopaedics, Salt Lake City, UT 84112, USA
    Clin Orthop Relat Res 443:287-95. 2006
    ..Increased awareness of cement-related cardiopulmonary pathophysiology, and modifying conventional surgical techniques can minimize cement-associated complications...
  2. pmc Tumoral TP53 and/or CDKN2A alterations are not reliable prognostic biomarkers in patients with localized Ewing sarcoma: a report from the Children's Oncology Group
    Daniel M Lerman
    Department of Orthopedics, University of Utah, Salt Lake City, Utah Center for Children s Cancer Research, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah
    Pediatr Blood Cancer 62:759-65. 2015
    ..We sought to evaluate these variables in patients with localized disease treated prospectively on a single Children's Oncology Group protocol...
  3. pmc Complications of cemented long-stem hip arthroplasty in metastatic bone disease revisited
    Shawn L Price
    Department of Orthopaedics Sarcoma Services, Huntsman Cancer Institute, University of Utah, 2000 Circle of Hope Drive, Salt Lake City, UT, 84112, USA
    Clin Orthop Relat Res 471:3303-7. 2013
    ..Embolic events may precipitate cardiopulmonary complications and even death; by contrast, others have reported that the use of a cemented long-stem femoral arthroplasty in patients with metastatic bone disease is a safe procedure...
  4. pmc Is claviculo pro humeri of value for limb salvage of pediatric proximal humerus sarcomas?
    George T Calvert
    Sarcoma Services, Center for Children s Cancer Research, Huntsman Cancer Institute, University of Utah, 2000 Circle of Hope, Suite 4260, Salt Lake City, UT, 84112 5550, USA
    Clin Orthop Relat Res 473:877-82. 2015
    ..CPH represents a potential option for this complicated clinical problem in very young children, but little is known about it because the indications for its use are so uncommon...
  5. pmc What are the 5-year survivorship outcomes of compressive endoprosthetic osseointegration fixation of the femur?
    Michael J Monument
    Sarcoma Services, Department of Orthopaedic Surgery, Huntsman Cancer Institute, University of Utah, 2000 Circle of Hope, Room 4260, Salt Lake City, UT, 84112, USA
    Clin Orthop Relat Res 473:883-90. 2015
    ..Endoprosthetic reconstruction using compressive osseointegration fixation is a relatively new limb salvage technology designed to enhance osseointegration, prevent stress shielding, and provide fixation for short end-segments...
  6. pmc Molecular inversion probe analysis detects novel copy number alterations in Ewing sarcoma
    Mona S Jahromi
    Center for Children s Cancer Research C3R, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA
    Cancer Genet 205:391-404. 2012
    ..CNAs detected by microarray correlate with outcome and may be useful for risk stratification in future clinical trials...
  7. pmc EWS/FLI-responsive GGAA microsatellites exhibit polymorphic differences between European and African populations
    Robert Beck
    Center for Children s Cancer Research, Huntsman Cancer Institute, University of Utah, Salt Lake City, USA
    Cancer Genet 205:304-12. 2012
    ..These data suggest that GGAA microsatellite polymorphisms in the NR0B1 gene might influence disease susceptibility and prognosis in Ewing sarcoma in unanticipated ways...
  8. pmc miRNA signatures associate with pathogenesis and progression of osteosarcoma
    Kevin B Jones
    Department of Orthopaedics and Center for Children s Cancer Research, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah, USA
    Cancer Res 72:1865-77. 2012
    ..Thus, our findings establish a miRNA signature associated with pathogenesis of osteosarcoma as well as critical pre-treatment biomarkers of metastasis and responsiveness to therapy...
  9. pmc Modeling alveolar soft part sarcomagenesis in the mouse: a role for lactate in the tumor microenvironment
    Matthew L Goodwin
    Department of Orthopaedics, University of Utah, Salt Lake City, UT 84112, USA
    Cancer Cell 26:851-62. 2014
    ..These data demonstrate lactate's role as a driver of alveolar soft part sarcomagenesis. ..
  10. pmc Clinical and biochemical function of polymorphic NR0B1 GGAA-microsatellites in Ewing sarcoma: a report from the Children's Oncology Group
    Michael J Monument
    Sarcoma Services, Department of Orthopedic Surgery, University of Utah, Salt Lake City, Utah, United States of America Center for Children s Cancer Research, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah, United States of America
    PLoS ONE 9:e104378. 2014
    ..These microsatellites are highly polymorphic in humans, and preliminary evidence suggests EWS/FLI-mediated gene expression is highly dependent on the number of GGAA motifs within the microsatellite...
  11. doi Reducing the risk of bone cement implantation syndrome during femoral arthroplasty
    David L Rothberg
    Department of Orthopaedics, University of Utah, Salt Lake City, UT 84108, USA
    Orthopedics 36:e463-7. 2013
    ..The proposed mechanism of risk reduction is through lower intramedullary pressure with no bone-cement-implant interface pullout strength reduction. Further clinical trials are needed to prove this biomechanical effect...
  12. pmc At-risk populations for osteosarcoma: the syndromes and beyond
    George T Calvert
    Department of Orthopaedics and Huntsman Cancer Institute, The University of Utah, Salt Lake City, UT 84112, USA
    Sarcoma 2012:152382. 2012
    ..This paper reviews the genetic and clinical features of the known osteosarcoma predisposition syndromes...
  13. pmc Extra-abdominal desmoid tumors associated with familial adenomatous polyposis
    George T Calvert
    Department of Orthopaedics and Huntsman Cancer Institute, The University of Utah, Salt Lake City, UT 84112, USA
    Sarcoma 2012:726537. 2012
    ..This paper analyzes recent evidence pertaining to the epidemiology, molecular biology, histopathology, screening, and treatment of extra-abdominal desmoid tumors associated with familial adenomatous polyposis syndrome...
  14. pmc Molecular dissection of the mechanism by which EWS/FLI expression compromises actin cytoskeletal integrity and cell adhesion in Ewing sarcoma
    Aashi Chaturvedi
    Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112 Department of Oncological Sciences, University of Utah, Salt Lake City, UT 84112
    Mol Biol Cell 25:2695-709. 2014
    ..This selective advantage is paired with a tradeoff in which metastatic lung colonization is compromised. ..
  15. doi Novel applications of osseointegration in orthopedic limb salvage surgery
    Michael J Monument
    Sarcoma Services, Department of Orthopaedic Surgery, Huntsman Cancer Institute, Primary Children s Medical Center, University of Utah, 2000 Circle of Hope, Room 4260, Salt Lake City, UT 84112, USA
    Orthop Clin North Am 46:77-87. 2015
    ..This articles reviews osseointegration and emerging novel applications of this technology in limb salvage surgery and future prosthetics for amputees. ..
  16. pmc Salient features of mesenchymal stem cells-implications for Ewing sarcoma modeling
    Michael J Monument
    Sarcoma Services, Department of Orthopaedic Surgery, Huntsman Cancer Institute, University of Utah Salt Lake City, UT, USA
    Front Oncol 3:24. 2013
    ....
  17. pmc Potential for modulation of the fas apoptotic pathway by epidermal growth factor in sarcomas
    David E Joyner
    Department of Orthopaedics, Huntsman Cancer Institute, The University of Utah, Salt Lake City, UT 84112, USA
    Sarcoma 2011:847409. 2011
    ..Cells destined for elimination inhibit this prosurvival response via a presently undefined pathway. This scenario represents a novel role for EGF and CTGF as regulators of the Fas pathway in sarcomas...
  18. pmc Extremity sarcoma surgery in younger children: ten years of patients ten years and under
    Ryan B Israelsen
    Department of Orthopaedic Surgery, University of Utah, Salt Lake City, USA
    Iowa Orthop J 31:145-53. 2011
    ..Sarcoma surgery in the younger growing child presents challenges for the surgeon, patient, and parents, but is usually successful in the long-term...
  19. ncbi Her-2/neu expression in osteosarcoma increases risk of lung metastasis and can be associated with gene amplification
    Holly Zhou
    Department of Pathology, University of Utah, Salt Lake City, UT, USA
    J Pediatr Hematol Oncol 25:27-32. 2003
    ..Whether Her-2/neu expression influences outcome needs to be examined further in a prospective fashion. The hope is that Her-2/neu expression will identify patients who may benefit from the addition of directed biologic therapy...
  20. ncbi Surgical fixation of pathologic fractures: an evaluation of evolving treatment methods
    Kenneth J Hunt
    Sarcoma Service, Department of Orthopedics, Huntsman Cancer Institute, University of Utah, 2000 Circle of Hope, Suite 2100, Salt Lake City, Utah 84112, USA
    Bull Hosp Jt Dis 63:77-82. 2006
    ..02). This data, in addition to several additional advantages of indirect reduction and intramedullary fixation of pathologic fractures, supports this method of fracture care over open reduction and internal fixation in appropriate cases...
  21. ncbi Grade 1 chondrosarcoma of bone: a diagnostic and treatment dilemma
    R Lor Randall
    Department of Orthopedics, Huntsman Cancer Institute and Primary Children s Medical Center, University of Utah, Salt Lake City, UT 84112 5550, USA
    J Natl Compr Canc Netw 3:149-56. 2005
    ..We discuss the promise of emerging molecular technologies. Finally, we provide a review of the available literature on treatment outcomes, along with a discussion of our own particular preferences...
  22. pmc Fas death pathway in sarcomas correlates with epidermal growth factor transcription
    David E Joyner
    Department of Orthopaedics, Sarcoma Services, Huntsman Cancer Institute, University of Utah School of Medicine, 2000 Circle of Hope, Salt Lake City, UT 84112, USA
    Clin Orthop Relat Res 466:2092-8. 2008
    ..The results suggest ligand activity in the Fas death pathway correlates with EGF transcription in sarcomas...
  23. ncbi Sacral resection and reconstruction for tumors and tumor-like conditions
    R Lor Randall
    Sarcoma Services, Department of Orthopedics, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah, USA
    Orthopedics 28:307-13. 2005
    ..The complication rate was 33%. Tumor control was achieved in 73%. Postoperative complications occurred in 33%. Sacral resection remains a challenging operation...
  24. ncbi An approach to the management of the patient with metastatic bone disease
    Kristy L Weber
    Section of Orthopaedic Oncology, University of Texas, MD Anderson Cancer Center, Houston, Texas, USA
    Instr Course Lect 53:663-76. 2004
    ..Treatment includes stabilization with the latest prosthetic implants and new devices. Advances in the field of radiation oncology and bisphosphonate use in patients with bone metastasis are other management approaches...
  25. ncbi Transit tumor retrieval preserves RNA fidelity and obviates snap-freezing
    R Lor Randall
    Hunstman Cancer Institute SARC Lab and Primary Children s Medical Center, Syracuse, NY, USA
    Clin Orthop Relat Res 438:149-57. 2005
    ....
  26. ncbi Reconstruction of noncontained distal femoral defects with polymethylmethacrylate and crossed-screw augmentation: a biomechanical study
    Patrick C Toy
    Department of Orthopaedic Surgery, University of Tennessee Campbell Clinic, 1211 Union Avenue, Suite 510, Memphis, TN 38104, USA
    J Bone Joint Surg Am 88:171-8. 2006
    ..This biomechanical study was undertaken to determine whether augmenting the cement with crossed screws would result in a stronger reconstruction...
  27. ncbi Ewing's sarcoma family of tumors: current management
    Mark Bernstein
    Service of Hematology Oncology, Ste Justine Hospital, University of Montreal, 3175 Cote Ste Catherine Road, Montreal, Quebec, H3T 1C5, Canada
    Oncologist 11:503-19. 2006
    ..New approaches include anti-angiogenic therapy, particularly since vascular endothelial growth factor is an apparent downstream target of the ews-fli1 oncogene...
  28. doi Imaging guidelines for children with Ewing sarcoma and osteosarcoma: a report from the Children's Oncology Group Bone Tumor Committee
    James S Meyer
    Department of Radiology, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Pediatr Blood Cancer 51:163-70. 2008
    ..Recommended examinations may become required in the future. These guidelines should be considered a work in progress that will evolve with advances in imaging and childhood cancer research...
  29. ncbi Bone cancer
    J Sybil Biermann
    University of Michigan Comprehensive Cancer Center, USA
    J Natl Compr Canc Netw 5:420-37. 2007
  30. ncbi Management of lower-extremity bone metastasis
    Kristy L Weber
    Department of Orthopaedic Surgery, Johns Hopkins School of Medicine, 601 North Caroline Street, Baltimore, MD 21287, USA
    J Bone Joint Surg Am 88:11-9. 2006