Research Topics
Species | Ruiqiong RanSummaryAffiliation: University of California Country: USA Publications
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Publications
A novel 165-kDa Golgin protein induced by brain ischemia and phosphorylated by Akt protects against apoptosisRuiqiong Ran
M I N D Institute and Department of Neurology, University of California at Davis Medical Center, University of California at Davis, Sacramento, CA 95817, USA
Mol Cell Neurosci 36:392-407. 2007..These data show that Akt phosphorylation of IIGP165 protects against apoptotic cell death, and add to evidence that the Golgi apparatus also plays a role in regulating apoptosis...
Gene expression in peripheral blood differs after cardioembolic compared with large-vessel atherosclerotic stroke: biomarkers for the etiology of ischemic strokeHuichun Xu
Department of Neurology and MIND Institute, University of California at Davis, Sacramento, California 95817, USA
J Cereb Blood Flow Metab 28:1320-8. 2008..These results have wide ranging implications for similar disorders...- Gene expression in blood changes rapidly in neutrophils and monocytes after ischemic stroke in humans: a microarray studyYang Tang
MIND Institute and Department of Neurology, University of California at Davis, Sacramento, California 95817, USA
J Cereb Blood Flow Metab 26:1089-102. 2006..These data provide insights into the inflammatory responses after stroke in humans, and should be helpful in diagnosis, understanding etiology and pathogenesis, and guiding acute treatment and development of new treatments for stroke... - Hypoxia preconditioning in the brainRuiqiong Ran
Department of Neurology, M.I.N.D. Institute, University of California at Davis, Davis, CA 95817, USA
Dev Neurosci 27:87-92. 2005..This hypoxia preconditioning has potential clinical usefulness in protecting high-risk newborns or to provide protection prior to surgery... - The future of genomic profiling of neurological diseases using bloodFrank R Sharp
Department of Neurology and Medical Investigation of Neurodevelopmental Disorders Institute, University of California Davis Medical Center, Sacramento, CA 95817, USA
Arch Neurol 63:1529-36. 2006..Although all of these studies are still preliminary basic scientific endeavors, they suggest that this approach will have clinical applications to neurological diseases in humans... - Brain genomics of intracerebral hemorrhageAigang Lu
MIND Institute and Department of Neurology, University of California at Davis, Sacramento, California 95817, USA
J Cereb Blood Flow Metab 26:230-52. 2006..These genomic responses to ICH potentially provide new therapeutic targets for treatment... - Geldanamycin induces heat shock proteins in brain and protects against focal cerebral ischemiaAigang Lu
Department of Neurology, University of Cincinnati, Ohio 45267-0536, USA
J Neurochem 81:355-64. 2002..The data show that geldanamycin protects brain from focal ischemia and that this may be due, at least in part, to geldanamycin stimulation of heat shock gene transcription... - Human blood genomics: distinct profiles for gender, age and neurofibromatosis type 1Yang Tang
Department of Neurology, University of Cincinnati, Vontz Center, Room 2327, 3125 Eden Avenue, Cincinnati, OH 45267-0536, USA
Brain Res Mol Brain Res 132:155-67. 2004.... - Genomics of the periinfarction cortex after focal cerebral ischemiaAigang Lu
Department of Neurology, University of Cincinnati, Cincinnati, Ohio 45267, USA
J Cereb Blood Flow Metab 23:786-810. 2003..Genes regulated acutely after stroke may modulate cell survival and death; also, late regulated genes may be related to tissue repair and functional recovery... - Blood genomic expression profile for neuronal injuryYang Tang
Department of Neurology, Neuroscience Program, University of Cincinnati, Vontz Center for Molecular Studies Room 2327, 3125 Eden Avenue, Cincinnati, OH 45267 0536, USA
J Cereb Blood Flow Metab 23:310-9. 2003.... 
Hsp70 mutant proteins modulate additional apoptotic pathways and improve cell survivalRuiqiong Ran
Department of Neurology, Vontz Center for Molecular Studies, University of Cincinnati, Room 2327, 3125 Eden Avenue, Cincinnati, OH 45267 0536, USA
Cell Stress Chaperones 9:229-42. 2004..Hsp70 mutants represent a possible approach to antiapoptotic biotherapeutics. Similar rational designs could be used to engineer inhibitors of additional caspase family members...- Glutamate receptor blockade attenuates glucose hypermetabolism in perihematomal brain after experimental intracerebral hemorrhage in ratTimothy D Ardizzone
Department of Neurology, University of Cincinnati College of Medicine, Ohio, USA
Stroke 35:2587-91. 2004..This may provide a possible target for the treatment of intracerebral hemorrhage... - Hsp70 promotes TNF-mediated apoptosis by binding IKK gamma and impairing NF-kappa B survival signalingRuiqiong Ran
Department of Neurology, University of Cincinnati, Cincinnati, Ohio 45267, USA
Genes Dev 18:1466-81. 2004..These results provide significant novel insights into the molecular mechanism for the pro-apoptotic behavior of Hsp70 in death-receptor-mediated cell death... - Reperfusion activates metalloproteinases that contribute to neurovascular injuryAigang Lu
Department of Neurology, University of Cincinnati, Cincinnati, OH 45267 0532
Exp Neurol 210:549-59. 2008..Administering AHA 30 min before reperfusion decreased MMP-9 activation and neurovascular injury in ischemic cerebral cortex... - Hypoxic preconditioning protects against ischemic brain injuryFrank R Sharp
Department of Neurology, University of Cincinnati, Ohio 45267, USA
NeuroRx 1:26-35. 2004..Understanding the mechanisms and genes involved in hypoxic tolerance may provide new therapeutic targets to treat ischemic injury and enhance recovery...