Kenneth Ramos

Summary

Affiliation: University of Louisville
Country: USA

Publications

  1. pmc Albumin-like proteins are critical regulators of vascular redox signaling
    Kenneth S Ramos
    Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine, 580 South Preston Street, Louisville, KY 40202, USA
    Oxid Med Cell Longev 2013:628615. 2013
  2. pmc Computational and biological inference of gene regulatory networks of the LINE-1 retrotransposon
    Kenneth S Ramos
    Department of Biochemistry and Molecular Biology and Center for Genetics and Molecular Medicine, University of Louisville School of Medicine, Louisville, KY 40292, USA
    Genomics 90:176-85. 2007
  3. ncbi request reprint Modulation of biological regulatory networks during nephrogenesis
    Kenneth S Ramos
    Department of Biochemistry and Molecular Biology, Center for Genetics and Molecular Medicine, University of Louisville School of Medicine, Louisville, KY 40292, USA
    Drug Metab Rev 38:677-83. 2006
  4. ncbi request reprint Transcriptional profiling and functional genomics reveal a role for AHR transcription factor in nephrogenesis
    Kenneth S Ramos
    Department of Biochemistry and Molecular Biology, School of Medicine, University of Louisville Health Sciences Center, Louisville, KY 40292, USA
    Ann N Y Acad Sci 1076:728-35. 2006
  5. pmc Unraveling genetic regulatory networks of mammalian retroelements
    Kenneth S Ramos
    Department of Biochemistry and Molecular Biology and Center for Genetics and Molecular Medicine, University of Louisville School of Medicine, Louisville, Kentucky, USA
    BMC Proc 3:S3. 2009
  6. doi request reprint Genetic regulatory networks of nephrogenesis: deregulation of WT1 splicing by benzo(a)pyrene
    Kenneth S Ramos
    Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine, Delia Baxter Building, Room 227, Louisville, KY 40292, USA
    Birth Defects Res C Embryo Today 87:192-7. 2009
  7. pmc Epigenetic control of embryonic renal cell differentiation by L1 retrotransposon
    Kenneth S Ramos
    Department of Biochemistry and Molecular Biology and Center for Genetics and Molecular Medicine, School of Medicine, University of Louisville, Louisville, KY 40202, USA
    Birth Defects Res A Clin Mol Teratol 91:693-702. 2011
  8. ncbi request reprint Genetic and molecular mechanisms of chemical atherogenesis
    Kenneth S Ramos
    Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine, Louisville, KY 40292, United States
    Mutat Res 621:18-30. 2007
  9. pmc Assessment of genetic variation for the LINE-1 retrotransposon from next generation sequence data
    ERIC ROUCHKA
    Computer Engineering and Computer Science Department, Speed School of Engineering, University of Louisville, Louisville, KY 40292, USA
    BMC Bioinformatics 11:S12. 2010
  10. pmc Rpm2p, a protein subunit of mitochondrial RNase P, physically and genetically interacts with cytoplasmic processing bodies
    Vilius Stribinskis
    Department of Biochemistry and Molecular Biology and Center for Genetics and Molecular Medicine, School of Medicine, University of Louisville, Louisville, KY, USA
    Nucleic Acids Res 35:1301-11. 2007

Research Grants

Collaborators

Detail Information

Publications38

  1. pmc Albumin-like proteins are critical regulators of vascular redox signaling
    Kenneth S Ramos
    Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine, 580 South Preston Street, Louisville, KY 40202, USA
    Oxid Med Cell Longev 2013:628615. 2013
    ..Together, these results implicate albumin and albumin-like proteins as critical regulators of vascular redox signaling...
  2. pmc Computational and biological inference of gene regulatory networks of the LINE-1 retrotransposon
    Kenneth S Ramos
    Department of Biochemistry and Molecular Biology and Center for Genetics and Molecular Medicine, University of Louisville School of Medicine, Louisville, KY 40292, USA
    Genomics 90:176-85. 2007
    ..The potential impact of individual members of the network on the global dynamical behavior of LINE-1 was examined from a theoretical and empirical framework...
  3. ncbi request reprint Modulation of biological regulatory networks during nephrogenesis
    Kenneth S Ramos
    Department of Biochemistry and Molecular Biology, Center for Genetics and Molecular Medicine, University of Louisville School of Medicine, Louisville, KY 40292, USA
    Drug Metab Rev 38:677-83. 2006
    ..This work has established a role for Ahr in renal cell differentiation and kidney development and resolved putative molecular interactions between Ahr and Wt1...
  4. ncbi request reprint Transcriptional profiling and functional genomics reveal a role for AHR transcription factor in nephrogenesis
    Kenneth S Ramos
    Department of Biochemistry and Molecular Biology, School of Medicine, University of Louisville Health Sciences Center, Louisville, KY 40292, USA
    Ann N Y Acad Sci 1076:728-35. 2006
    ..A subset of the signature genes was found to be co-regulated by Ahr and Wt1 and was responsible for shifts in renal cell transdifferentiation...
  5. pmc Unraveling genetic regulatory networks of mammalian retroelements
    Kenneth S Ramos
    Department of Biochemistry and Molecular Biology and Center for Genetics and Molecular Medicine, University of Louisville School of Medicine, Louisville, Kentucky, USA
    BMC Proc 3:S3. 2009
    ..This report summarizes major findings in the laboratory defining the molecular basis of L1 retroelement activation in mammalian cells and the architecture of gene regulatory networks involved in phenotypic control...
  6. doi request reprint Genetic regulatory networks of nephrogenesis: deregulation of WT1 splicing by benzo(a)pyrene
    Kenneth S Ramos
    Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine, Delia Baxter Building, Room 227, Louisville, KY 40292, USA
    Birth Defects Res C Embryo Today 87:192-7. 2009
    ..Understanding the impact of early-life environmental exposures to chemicals that disrupt AHR signaling can help minimize negative health consequences to pregnant women and their offspring...
  7. pmc Epigenetic control of embryonic renal cell differentiation by L1 retrotransposon
    Kenneth S Ramos
    Department of Biochemistry and Molecular Biology and Center for Genetics and Molecular Medicine, School of Medicine, University of Louisville, Louisville, KY 40202, USA
    Birth Defects Res A Clin Mol Teratol 91:693-702. 2011
    ..Given that L1 is reactivated by aryl hydrocarbon receptor (AHR) ligands, we also sought to investigate the effects of benzo(a)pyrene (BaP) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the genetic network of mK4 cells...
  8. ncbi request reprint Genetic and molecular mechanisms of chemical atherogenesis
    Kenneth S Ramos
    Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine, Louisville, KY 40292, United States
    Mutat Res 621:18-30. 2007
    ..This review summarizes seminal studies over the past 20 years that shed light on critical gene-gene and gene-environment interactions mediating the atherogenic response to chemical injury...
  9. pmc Assessment of genetic variation for the LINE-1 retrotransposon from next generation sequence data
    ERIC ROUCHKA
    Computer Engineering and Computer Science Department, Speed School of Engineering, University of Louisville, Louisville, KY 40292, USA
    BMC Bioinformatics 11:S12. 2010
    ....
  10. pmc Rpm2p, a protein subunit of mitochondrial RNase P, physically and genetically interacts with cytoplasmic processing bodies
    Vilius Stribinskis
    Department of Biochemistry and Molecular Biology and Center for Genetics and Molecular Medicine, School of Medicine, University of Louisville, Louisville, KY, USA
    Nucleic Acids Res 35:1301-11. 2007
    ..The results presented here, and the transcriptional activation function demonstrated earlier, implicate Rpm2p as a coordinator of transcription and mRNA storage/decay in P bodies...
  11. ncbi request reprint Validation of a mathematical model of gene transcription in aggregated cellular systems: application to l1 retrotransposition
    Grzegorz A Rempala
    Department of Mathematics, University of Louisville, Louisville, Kentucky 40292, USA
    J Comput Biol 14:339-49. 2007
    ..The procedure compares model predicted values with the RT-PCR data for L1 by means of the standard Bayesian statistical techniques with the help of modern Markov-Chain Monte-Carlo methodology...
  12. doi request reprint Environmental risk factors of disease in the Cameron Park Colonia, a Hispanic community along the Texas-Mexico border
    Irma N Ramos
    School of Public Health and Information Sciences, University of Louisville Health Sciences Center, Louisville, KY 40292, USA
    J Immigr Minor Health 10:345-51. 2008
    ....
  13. pmc The development of abdominal aortic aneurysms in mice is enhanced by benzo(a)pyrene
    Yong Zhang
    Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine, Louisville, KY 40202, USA
    Vasc Health Risk Manag 4:1095-102. 2008
    ..We conclude that BaP aggravates AAA formation and rupture in C57/B6J mice by promoting macrophage infiltration, degeneration of elastic lamella, and loss of VSMCs in the aortic wall...
  14. ncbi request reprint A stochastic model of gene transcription: an application to L1 retrotransposition events
    Grzegorz A Rempala
    Department of Mathematics, University of Louisville, Louisville, KY 40292, USA
    J Theor Biol 242:101-16. 2006
    ..The procedure compares model predicted values with the laboratory data via the standard Bayesian techniques with the help of modern Markov-Chain Monte-Carlo methodology...
  15. ncbi request reprint Atherosclerosis and cancer: flip sides of the neoplastic response in mammalian cells?
    Kenneth S Ramos
    Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine, Louisville, KY 40292, USA
    Cardiovasc Toxicol 5:245-55. 2005
    ..Such parallels can be reconciled if atherosclerotic plaques are viewed as neoplasms of smooth muscle origin...
  16. ncbi request reprint From genomics to mechanistic insight: a global perspective on molecular deficits induced by environmental agents
    Kenneth S Ramos
    Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine, University of Louisville, Louisville, Kentucky 40202, USA
    Environ Mol Mutagen 48:395-9. 2007
    ..Molecular evidence is discussed in this review within the framework of human molecular medicine...
  17. ncbi request reprint Activation of human long interspersed nuclear element 1 retrotransposition by benzo(a)pyrene, an ubiquitous environmental carcinogen
    Vilius Stribinskis
    Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine, Louisville, Kentucky 40292, USA
    Cancer Res 66:2616-20. 2006
    ..Thus, the mutations and genomic instability observed in human populations exposed to genotoxic environmental hydrocarbons may involve epigenetic activation of mobile elements dispersed throughout the human genome...
  18. pmc Sequence analysis of RNase MRP RNA reveals its origination from eukaryotic RNase P RNA
    Yanglong Zhu
    Department of Biochemistry and Molecular Biology, and Center for Genetics and Molecular Medicine, School of Medicine, University of Louisville, Kentucky 40202, USA
    RNA 12:699-706. 2006
    ..These conserved nucleotides between the MRP and P RNAs strongly support the hypothesis that the MRP RNA is derived from the P RNA molecule in early eukaryote evolution...
  19. pmc Unraveling gene-gene interactions regulated by ligands of the aryl hydrocarbon receptor
    Charles D Johnson
    Department of Biochemistry and Molecular Biology, Center for Genetics and Molecular Medicine, University of Louisville Health Sciences Center, Louisville, KY 40292, USA
    Environ Health Perspect 112:403-12. 2004
    ..Italic)Key words:(/Italic) aryl hydrocarbon receptor, bioinformatics, gene networks, genomics. (Italic)Environ Health Perspect (/Italic)112:403-412 (2004). [Online 14 January 2004]..
  20. pmc Activation profiles of HSPA5 during the glomerular mesangial cell stress response to chemical injury
    Hadi Falahatpisheh
    Department of Biochemistry and Molecular Biology and Center for Genetics and Molecular Medicine, University of Louisville, Louisville, KY 40292, USA
    Cell Stress Chaperones 12:209-18. 2007
    ..Collectively, these findings identify HSPA5 in the stress response of rGMCs and implicate regulatory mechanisms that are distinct from those involved in TH inducibility...
  21. ncbi request reprint Context-specific regulation of LINE-1
    Ivo Teneng
    Department of Biochemistry and Molecular Biology, and Center for Genetics and Molecular Medicine, University of Louisville School of Medicine, Louisville, KY 40292, USA
    Genes Cells 12:1101-10. 2007
    ..Genetic and pharmacological experiments implicated the AHR and oxidative stress as contextual determinants of L1 inducibility by cellular stress...
  22. pmc Epigenetic control of mammalian LINE-1 retrotransposon by retinoblastoma proteins
    Diego E Montoya-Durango
    Department of Biochemistry and Molecular Biology and Center for Genetics and Molecular Medicine, University of Louisville School of Medicine Health Sciences Center, Louisville, KY 40202, USA
    Mutat Res 665:20-8. 2009
    ....
  23. ncbi request reprint Bioactivation of polycyclic aromatic hydrocarbon carcinogens within the vascular wall: implications for human atherogenesis
    Kenneth S Ramos
    Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine, Louisville, Kentucky, USA
    Drug Metab Rev 37:595-610. 2005
    ....
  24. pmc A surprisingly large RNase P RNA in Candida glabrata
    Rym Kachouri
    Department of Biochemistry and Molecular Biology, and Center for Genetics and Molecular Medicine School of Medicine, University of Louisville, 319 Abraham Flexner Way, Louisville, KY 40202, USA
    RNA 11:1064-72. 2005
    ..RNase P RNA, therefore, represents one of the most diversified noncoding RNAs in terms of size variation and structural diversity...
  25. ncbi request reprint Redox regulation of a novel L1Md-A2 retrotransposon in vascular smooth muscle cells
    Kim P Lu
    Center for Environmental and Rural Health, Texas A and M University, College Station, Texas 77843 4455, USA
    J Biol Chem 278:28201-9. 2003
    ..These elements mediated activation, with the A3 monomer playing an essential role in transactivation. This signaling pathway may contribute to gene instability during the course of atherogenesis...
  26. pmc Decoding the riddle: the dawn of RNAi for the study of gene-gene and gene-environment interactions
    Vilius Stribinskis
    Environ Health Perspect 112:A210-1. 2004
  27. ncbi request reprint Differential profiles of copper-induced ROS generation in human neuroblastoma and astrocytoma cells
    Yongchang Qian
    Department of Veterinary Integrative Biosciences, Texas A and M University, College Station, TX 77843, USA
    Brain Res Mol Brain Res 134:323-32. 2005
    ..These data suggest that neurons use the SOD-catalase system to scavenge Cu-induced ROS while glia rely on the endoplasmic reticulum stress response to compensate for the reduction of ROS scavenging capacity...
  28. ncbi request reprint The involvement of copper transporter in lead-induced oxidative stress in astroglia
    Yongchang Qian
    Department of Veterinary Integrative Biosciences, Texas A and M University, College Station, TX 77843 4458, USA
    Neurochem Res 30:429-38. 2005
    ..These findings suggest that Pb-induced oxidative stress results from the impairment of Cu metabolism by Pb targeting of Atp7a...
  29. pmc Embracing the local: enriching scientific research, education, and outreach on the Texas-Mexico border through a participatory action research partnership
    Marlynn L May
    Center for Environmental and Rural Health, Texas A and M University, College Station, Texas 77843 4455, USA
    Environ Health Perspect 111:1571-6. 2003
    ..In this article we discuss the research methodology used in the CPP, a methodology specifically chosen to address four challenges presented by colonias to conducting valid and reliable research...
  30. ncbi request reprint Polycyclic aromatic hydrocarbon-inducible DNA adducts: evidence by 32P-postlabeling and use of knockout mice for Ah receptor-independent mechanisms of metabolic activation in vivo
    Sudha R Kondraganti
    Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
    Int J Cancer 103:5-11. 2003
    ..In conclusion, these results demonstrate the existence of AHR- and CYP1A1-independent mechanisms of PAH metabolic activation in mouse liver, a phenomenon that may have important implications for PAH-mediated carcinogenesis...
  31. ncbi request reprint Ligand-activated Ahr signaling leads to disruption of nephrogenesis and altered Wilms' tumor suppressor mRNA splicing
    M Hadi Falahatpisheh
    Center for Environmental and Rural Health, Texas A and M University, College Station 77843 4455, USA
    Oncogene 22:2160-71. 2003
    ..These results indicate that ligand activation of Ahr signaling disrupts nephrogenesis in vitro, and that this response involves modulation of wt1 alternative splicing and post-transcriptional control...
  32. pmc Meeting report: hazard assessment for nanoparticles--report from an interdisciplinary workshop
    John M Balbus
    Environmental Defense, Washington, DC 20009, USA
    Environ Health Perspect 115:1654-9. 2007
    ..Finally, the group identified general policy and strategic opportunities to accelerate the development and implementation of testing protocols and ensure that the information generated is translated effectively for all stakeholders...
  33. ncbi request reprint Modulation of alpha7-integrin-mediated adhesion and expression by platelet-derived growth factor in vascular smooth muscle cells
    Jun Tzu Chao
    Division of Vascular Biology, Cardiovascular Research Institute, The Texas A and M University System Health Science Center, 336 Joe Reynolds Medical Bldg, College Station, 77843, USA
    Am J Physiol Cell Physiol 290:C972-80. 2006
    ..Together, these observations indicate that PDGF enhances alpha(7)-integrin expression in VSMC and promotes alpha(7)-integrin-mediated adhesion to laminin...
  34. ncbi request reprint Modulation of cyclin dependent kinase inhibitor proteins and ERK1/2 activity in allylamine-injured vascular smooth muscle cells
    Sarah A Jones
    Department of Medical Physiology, Texas A and M University System Health Science Center, Texas A and M University, College Station, Texas 77845 1114, USA
    J Cell Biochem 91:1248-59. 2004
    ..We conclude that substrate-dependent acquisition of proliferative phenotypes following repeated cycles of AAM injury correlates with modulation of the cyclin dependent kinase inhibitors, p27 and p21...
  35. ncbi request reprint Calmodulin involvement in stress-activated nuclear localization of albumin in JB6 epithelial cells
    Thomas J Weber
    Cell Biology Group, Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington 99352, USA
    Biochemistry 43:7443-50. 2004
    ..These results suggest that elevated calcium transients and associated increases in reactive oxygen species contribute to adaptive cellular responses through the mobilization and nuclear translocation of cellular albumin...
  36. ncbi request reprint Modulation of alpha4 integrin mRNA levels is coupled to deficits in vasomotor function in rat arterioles by allylamine
    Jessemy D Neiger
    Department of Medical Physiology and Cardiovascular Research Institute, The Texas A and M University System Health Science Center, 366 Reynolds Bldg, College Station, TX 77843 1114, USA
    Life Sci 76:1895-905. 2005
    ..These data are supported by similar decreases in alpha4integrin cell surface protein expression in cultured vascular smooth muscle cells treated either in vivo and in vitro with AAM...
  37. ncbi request reprint GRP78 compartmentalized redistribution in Pb-treated glia: role of GRP78 in lead-induced oxidative stress
    Yongchang Qian
    Department of Veterinary Integrative Biosciences, Texas A and M University, College Station, TX 77843, USA
    Neurotoxicology 26:267-75. 2005
    ..These data suggest that Pb directly targets GRP78 and induces its compartmentalized redistribution in living cells and that GRP78 plays a protective role in Pb neurotoxicity...
  38. ncbi request reprint Characterization of glomerular cell phenotypes following repeated cycles of benzo[a]pyrene injury in vitro
    Alan R Parrish
    Center for Environmental and Rural Health, Texas A and M University, College Station, TX 77843 4455, USA
    Biochem Pharmacol 64:31-9. 2002
    ..These alterations may contribute to deregulation of proliferative control following carcinogen exposure in vivo...

Research Grants20

  1. OSTEOPONTIN AND OXIDATIVE STRESS IN ATHEROGENESIS
    Kenneth Ramos; Fiscal Year: 2003
    ..These studies are important in view of the increasing scrutiny of the role of oxidative injury in the onset and progression of atherogenesis. ..
  2. 2004 Mechanisms of Toxicity Gordon Research Conference
    Kenneth Ramos; Fiscal Year: 2004
    ..Thus, the 2004 conference is poised to continue its growth as the single leading small conference in toxicology. ..
  3. MOLECULAR MECHANISMS OF CHEMICAL ATHEROGENESIS
    Kenneth Ramos; Fiscal Year: 2005
    ..These studies will enable us to define the role of ARE/EpRE binding proteins in oxidant-induced atherogenesis and identify critical transacting factors involved in the atherogenic response to environmental injury. ..
  4. Center for Environmental Genomics and Integrative Biology
    Kenneth Ramos; Fiscal Year: 2007
    ....
  5. MOLECULAR MECHANISMS OF VASCULAR TOXICITY
    Kenneth Ramos; Fiscal Year: 1999
    ..The data generated from these studies will be used to define the mechanisms of BaP atherogenicity and to better understand the role that toxic environmental chemicals play in the onset or progression of atherosclerotic vascular disease. ..
  6. Role of Retroelements in Environmental Atherogenesis
    Kenneth S Ramos; Fiscal Year: 2010
    ..Studies are proposed in this application to study the role of virus-like sequences in the onset and progression of environmentally-induced atherosclerosis in experimental systems. ..