Research Topics
| Daniel RamosSummaryAffiliation: University of California Country: USA Publications
Research Grants
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Detail Information
Publications
Revisiting epithelial-to-mesenchymal transition through adenoid cystic carcinomaAmanda Siu
Department of Orofacial Sciences, University of California at San Francisco, San Francisco, CA 94143 0422, USA
Anticancer Res 32:3683-8. 2012..The ACCh cells are highly invasive and this behavior is dependent upon the αvβ6 integrin function. Our results suggest that the transition from the cribriform to solid form may occur through EMT...- Stem cell markers as predictors of oral cancer invasionAmanda Siu
Department of Orofacial Sciences, University of California at San Francisco, San Francisco, CA 94143 0422, USA
Anticancer Res 32:1163-6. 2012..These results suggest that expression of specific stem cell markers in tumors may help guide a clinician's choice of treatment... - EMMPRIN expression in oral SCC is regulated by FYN kinaseDaniel M Ramos
Department of Orofacial Sciences, University of California, San Francisco, CA 94143 0422, USA
Anticancer Res 31:1205-9. 2011..In oral cancer, the activation of FYN occurs post β6 integrin ligand binding. That the activation of FYN drives EMMPRIN expression and several important pathways associated with invasive oral SCC is now demonstrated... - The role of the integrin alpha v beta6 in regulating the epithelial to mesenchymal transition in oral cancerDaniel M Ramos
Department of Orofacial Sciences, University of California at San Francisco, San Francisco, CA 94143 0422, USA
Anticancer Res 29:125-30. 2009..These results also demonstrate that the terminal 11 AA of beta6 contain information important for establishing an epithelial to mesenchymal transition... - The expression of integrin alpha(v)beta6 promotes the epithelial cell morphology and suppresses invasive behavior in transformed oral keratinocytesSeiki Mogi
Department of Orofacial Sciences, 513 Parnassus Ave, C415 Box 0422 University of California, San Francisco, San Francisco, CA 94143-2922, USA
Anticancer Res 25:751-5. 2005..These results suggest that the expression of the alpha(v)beta6 integrin suppresses tumor formation and may promote the epithelial phenotype in 4NQO-transformed murine oral keratinocytes... - Matrix metalloproteinases and TGFbeta1 modulate oral tumor cell matrixDongmin Dang
Department of Stomatology, University of California at San Francisco, San Francisco, CA 94143 0512, USA
Biochem Biophys Res Commun 316:937-42. 2004..These results indicate that MMP3, MMP9, and TGFbeta1 are important for the modulation, composition, and maintenance of the ECM in oral SCC... - Alphavbeta6-Fyn signaling promotes oral cancer progressionXiaowu Li
Department of Stomatology, University of California San Francisco, San Francisco, CA 94143 0512, USA
J Biol Chem 278:41646-53. 2003..These findings indicate that integrin beta6 signaling activates Fyn and thus promotes oral cancer progression... - Expression of Fyn kinase modulates EMT in oral cancer cellsBen Lewin
DDS, Department of Orofacial Sciences, University of California, 513 Parnassus Ave, S612, Box 0422, San Francisco, CA 94143 0422, USA
Anticancer Res 30:2591-6. 2010..Activation of Fyn promoted SCC cell migration and its suppression thwarted SCC migration toward FN. These results indicate that the activation of Fyn kinase as well as local growth factor concentration modulate EMT in oral SCC... - Modulation of EGFR by oral squamous cell carcinoma cell linesDongmin Dang
University of California, San Francisco, USA
J Calif Dent Assoc 37:869-74. 2009..The authors suggest perhaps targeting both alphanubeta6 and EGFR may provide additional benefits... - Specific alpha v integrin receptors modulate K1735 murine melanoma cell behaviorYongjian Yang
Department of Stomatology, University of California at San Francisco, San Francisco, CA, USA
Biochem Biophys Res Commun 308:814-9. 2003.... - Tenascin and beta 6 integrin are overexpressed in floor of mouth in situ carcinomas and invasive squamous cell carcinomasJoseph A Regezi
Department of Stomatology, 513 Parnassus, S 512, University of California, San Francisco, CA 94143 0424, USA
Oral Oncol 38:332-6. 2002.... - Proliferation and invasion factors in HIV-associated dysplastic and nondysplastic oral warts and in oral squamous cell carcinoma: an immunohistochemical and RT-PCR evaluationJoseph A Regezi
Division of Oral Medicine, Pathology and Radiology, School of Dentistry, University of California San Francisco, USA
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 94:724-31. 2002..Therefore, we evaluated lesions for expression of proteins (tenascin-C, beta6 integrin, and matrix metalloproteinase-1[MMP1]) that have been identified as important in the invasive phase of oral SCC... - Expression of integrin beta 6 enhances invasive behavior in oral squamous cell carcinomaDaniel M Ramos
Department of Stomatology, University of California at San Francisco, San Francisco, CA 94143 0512, USA
Matrix Biol 21:297-307. 2002..We suggest that the integrin alpha v beta 6 is a key component of oral SCC invasion and metastasis through modulation of MMP-3 activity... - Identification of {alpha}v{beta}6-positive stem cells in oral squamous cell carcinomaDongmin Dang
Department of Orofacial Sciences, University of California at San Francisco, San Francisco, CA 94143 0422, U S A
Anticancer Res 29:2043-9. 2009..The results of this study clearly demonstrated the differential distribution of pluripotent stem cells in oral SCC and that the beta6 integrin may be an important regulatory component of the pluripotent phenotype... - EMMPRIN modulates migration and deposition of TN-C in oral squamous carcinomaDongmin Dang
Department of Orofacial Sciences, University of California at San Francisco, San Francisco, CA 94143 0512, USA
Anticancer Res 28:2049-54. 2008..In the presence of the broad spectrum MMP inhibitor, GM6001, TN-C deposition by the EMMPRIN overexpressing cocultures was suppressed. Thus EMMPRIN regulates migration, MMP production by SCC cells and deposition of the TN-C matrix... - Alphavbeta3 integrin and cofilin modulate K1735 melanoma cell invasionDongmin Dang
Department of Orofacial Sciences, University of California at San Francisco, Box 0512, San Francisco, CA 94143 0512, USA
Exp Cell Res 312:468-77. 2006..Interestingly, the invasion of M2Tbeta3 cells could be sustained by overexpression of cofilin A3. These results suggest that the integrin alphavbeta3 and cofilin together regulate K1735 melanoma cell invasion... - Beta-6 Integrin, tenascin-C, and MMP-1 expression in salivary gland neoplasmsTrent H Westernoff
Department of Oral and Maxillofacial Surgery, 521 Parnassus Avenue, C-522, University of California, San Francisco, CA 94143-0440, United States
Oral Oncol 41:170-4. 2005..We believe that beta-6, tenascin-C, and MMP-1 proteins are part of the molecular repertoire used by salivary tumors for malignant invasion and benign tumor expansion... - Tenascin-C deposition requires beta3 integrin and SrcYongjian Yang
Department of Stomatology, University of California at San Francisco, San Francisco, CA, USA
Biochem Biophys Res Commun 322:935-42. 2004..The broad spectrum MMP inhibitor, GM6001, suppressed TN-C organization. These results indicate that beta3 integrin ligand binding and the activation of the Src/MAPK/MMP pathway modulate deposition of TN-C... - Oral mucosal carcinogenesis in SENCAR miceTae-Won Kim
Department of Stomatology, University of California San Francisco, San Francisco, CA 94143-0512, USA
Anticancer Res 22:2733-40. 2002..These results show that SENCAR mice can be used as a unique model of oral carcinogenesis with the potential for detailed molecular studies of neoplastic progression to SCC...
Research Grants
- ORAL MELANOMA: ALPHA V BETA 3 EXPRESSION AND METASTASISDaniel Ramos; Fiscal Year: 2004..Understanding the role beta3 plays in oral melanoma invasion and metastasis may lead to novel prognostic indicators and development of new treatment strategies. ..
- Regulatory function of fyn in oral SCC invasionDaniel M Ramos; Fiscal Year: 2010..abstract_text> ..