Daniel Ramos

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint The Cytoplasmic Extension of the Integrin β6 Subunit Regulates Epithelial-to-Mesenchymal Transition
    Carlin Lee
    DDS, Department of Orofacial Sciences, University of California, 513 Parnassus Ave, S612, Box 0422, San Francisco, CA 94143 0422, U S A
    Anticancer Res 34:659-64. 2014
  2. ncbi request reprint Revisiting epithelial-to-mesenchymal transition through adenoid cystic carcinoma
    Amanda Siu
    Department of Orofacial Sciences, University of California at San Francisco, San Francisco, CA 94143 0422, USA
    Anticancer Res 32:3683-8. 2012
  3. ncbi request reprint Stem cell markers as predictors of oral cancer invasion
    Amanda Siu
    Department of Orofacial Sciences, University of California at San Francisco, San Francisco, CA 94143 0422, USA
    Anticancer Res 32:1163-6. 2012
  4. ncbi request reprint The role of the integrin alpha v beta6 in regulating the epithelial to mesenchymal transition in oral cancer
    Daniel M Ramos
    Department of Orofacial Sciences, University of California at San Francisco, San Francisco, CA 94143 0422, USA
    Anticancer Res 29:125-30. 2009
  5. ncbi request reprint EMMPRIN expression in oral SCC is regulated by FYN kinase
    Daniel M Ramos
    Department of Orofacial Sciences, University of California, San Francisco, CA 94143 0422, USA
    Anticancer Res 31:1205-9. 2011
  6. ncbi request reprint The expression of integrin alpha(v)beta6 promotes the epithelial cell morphology and suppresses invasive behavior in transformed oral keratinocytes
    Seiki Mogi
    Department of Orofacial Sciences, 513 Parnassus Ave, C415 Box 0422 University of California, San Francisco, San Francisco, CA 94143 2922, USA
    Anticancer Res 25:751-5. 2005
  7. ncbi request reprint Alphavbeta6-Fyn signaling promotes oral cancer progression
    Xiaowu Li
    Department of Stomatology, University of California San Francisco, San Francisco, CA 94143 0512, USA
    J Biol Chem 278:41646-53. 2003
  8. ncbi request reprint Matrix metalloproteinases and TGFbeta1 modulate oral tumor cell matrix
    Dongmin Dang
    Department of Stomatology, University of California at San Francisco, San Francisco, CA 94143 0512, USA
    Biochem Biophys Res Commun 316:937-42. 2004
  9. ncbi request reprint Expression of Fyn kinase modulates EMT in oral cancer cells
    Ben Lewin
    DDS, Department of Orofacial Sciences, University of California, 513 Parnassus Ave, S612, Box 0422, San Francisco, CA 94143 0422, USA
    Anticancer Res 30:2591-6. 2010
  10. ncbi request reprint Modulation of EGFR by oral squamous cell carcinoma cell lines
    Dongmin Dang
    University of California, San Francisco, USA
    J Calif Dent Assoc 37:869-74. 2009

Collaborators

Detail Information

Publications20

  1. ncbi request reprint The Cytoplasmic Extension of the Integrin β6 Subunit Regulates Epithelial-to-Mesenchymal Transition
    Carlin Lee
    DDS, Department of Orofacial Sciences, University of California, 513 Parnassus Ave, S612, Box 0422, San Francisco, CA 94143 0422, U S A
    Anticancer Res 34:659-64. 2014
    ..Together these results indicate that the signaling critical to epithelial-to-mesenchymal transition (EMT) is regulated by the β6 integrin cytoplasmic domain. ..
  2. ncbi request reprint Revisiting epithelial-to-mesenchymal transition through adenoid cystic carcinoma
    Amanda Siu
    Department of Orofacial Sciences, University of California at San Francisco, San Francisco, CA 94143 0422, USA
    Anticancer Res 32:3683-8. 2012
    ..The ACCh cells are highly invasive and this behavior is dependent upon the αvβ6 integrin function. Our results suggest that the transition from the cribriform to solid form may occur through EMT...
  3. ncbi request reprint Stem cell markers as predictors of oral cancer invasion
    Amanda Siu
    Department of Orofacial Sciences, University of California at San Francisco, San Francisco, CA 94143 0422, USA
    Anticancer Res 32:1163-6. 2012
    ..These results suggest that expression of specific stem cell markers in tumors may help guide a clinician's choice of treatment...
  4. ncbi request reprint The role of the integrin alpha v beta6 in regulating the epithelial to mesenchymal transition in oral cancer
    Daniel M Ramos
    Department of Orofacial Sciences, University of California at San Francisco, San Francisco, CA 94143 0422, USA
    Anticancer Res 29:125-30. 2009
    ..These results also demonstrate that the terminal 11 AA of beta6 contain information important for establishing an epithelial to mesenchymal transition...
  5. ncbi request reprint EMMPRIN expression in oral SCC is regulated by FYN kinase
    Daniel M Ramos
    Department of Orofacial Sciences, University of California, San Francisco, CA 94143 0422, USA
    Anticancer Res 31:1205-9. 2011
    ..In oral cancer, the activation of FYN occurs post β6 integrin ligand binding. That the activation of FYN drives EMMPRIN expression and several important pathways associated with invasive oral SCC is now demonstrated...
  6. ncbi request reprint The expression of integrin alpha(v)beta6 promotes the epithelial cell morphology and suppresses invasive behavior in transformed oral keratinocytes
    Seiki Mogi
    Department of Orofacial Sciences, 513 Parnassus Ave, C415 Box 0422 University of California, San Francisco, San Francisco, CA 94143 2922, USA
    Anticancer Res 25:751-5. 2005
    ..These results suggest that the expression of the alpha(v)beta6 integrin suppresses tumor formation and may promote the epithelial phenotype in 4NQO-transformed murine oral keratinocytes...
  7. ncbi request reprint Alphavbeta6-Fyn signaling promotes oral cancer progression
    Xiaowu Li
    Department of Stomatology, University of California San Francisco, San Francisco, CA 94143 0512, USA
    J Biol Chem 278:41646-53. 2003
    ..These findings indicate that integrin beta6 signaling activates Fyn and thus promotes oral cancer progression...
  8. ncbi request reprint Matrix metalloproteinases and TGFbeta1 modulate oral tumor cell matrix
    Dongmin Dang
    Department of Stomatology, University of California at San Francisco, San Francisco, CA 94143 0512, USA
    Biochem Biophys Res Commun 316:937-42. 2004
    ..These results indicate that MMP3, MMP9, and TGFbeta1 are important for the modulation, composition, and maintenance of the ECM in oral SCC...
  9. ncbi request reprint Expression of Fyn kinase modulates EMT in oral cancer cells
    Ben Lewin
    DDS, Department of Orofacial Sciences, University of California, 513 Parnassus Ave, S612, Box 0422, San Francisco, CA 94143 0422, USA
    Anticancer Res 30:2591-6. 2010
    ..Activation of Fyn promoted SCC cell migration and its suppression thwarted SCC migration toward FN. These results indicate that the activation of Fyn kinase as well as local growth factor concentration modulate EMT in oral SCC...
  10. ncbi request reprint Modulation of EGFR by oral squamous cell carcinoma cell lines
    Dongmin Dang
    University of California, San Francisco, USA
    J Calif Dent Assoc 37:869-74. 2009
    ..The authors suggest perhaps targeting both alphanubeta6 and EGFR may provide additional benefits...
  11. ncbi request reprint Specific alpha v integrin receptors modulate K1735 murine melanoma cell behavior
    Yongjian Yang
    Department of Stomatology, University of California at San Francisco, San Francisco, CA, USA
    Biochem Biophys Res Commun 308:814-9. 2003
    ....
  12. ncbi request reprint Expression of integrin beta 6 enhances invasive behavior in oral squamous cell carcinoma
    Daniel M Ramos
    Department of Stomatology, University of California at San Francisco, San Francisco, CA 94143 0512, USA
    Matrix Biol 21:297-307. 2002
    ..We suggest that the integrin alpha v beta 6 is a key component of oral SCC invasion and metastasis through modulation of MMP-3 activity...
  13. ncbi request reprint Proliferation and invasion factors in HIV-associated dysplastic and nondysplastic oral warts and in oral squamous cell carcinoma: an immunohistochemical and RT-PCR evaluation
    Joseph A Regezi
    Division of Oral Medicine, Pathology and Radiology, School of Dentistry, University of California San Francisco, USA
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 94:724-31. 2002
    ..Therefore, we evaluated lesions for expression of proteins (tenascin-C, beta6 integrin, and matrix metalloproteinase-1[MMP1]) that have been identified as important in the invasive phase of oral SCC...
  14. ncbi request reprint Tenascin and beta 6 integrin are overexpressed in floor of mouth in situ carcinomas and invasive squamous cell carcinomas
    Joseph A Regezi
    Department of Stomatology, 513 Parnassus, S 512, University of California, San Francisco, CA 94143 0424, USA
    Oral Oncol 38:332-6. 2002
    ....
  15. ncbi request reprint EMMPRIN modulates migration and deposition of TN-C in oral squamous carcinoma
    Dongmin Dang
    Department of Orofacial Sciences, University of California at San Francisco, San Francisco, CA 94143 0512, USA
    Anticancer Res 28:2049-54. 2008
    ..In the presence of the broad spectrum MMP inhibitor, GM6001, TN-C deposition by the EMMPRIN overexpressing cocultures was suppressed. Thus EMMPRIN regulates migration, MMP production by SCC cells and deposition of the TN-C matrix...
  16. ncbi request reprint Identification of {alpha}v{beta}6-positive stem cells in oral squamous cell carcinoma
    Dongmin Dang
    Department of Orofacial Sciences, University of California at San Francisco, San Francisco, CA 94143 0422, U S A
    Anticancer Res 29:2043-9. 2009
    ..The results of this study clearly demonstrated the differential distribution of pluripotent stem cells in oral SCC and that the beta6 integrin may be an important regulatory component of the pluripotent phenotype...
  17. ncbi request reprint Alphavbeta3 integrin and cofilin modulate K1735 melanoma cell invasion
    Dongmin Dang
    Department of Orofacial Sciences, University of California at San Francisco, Box 0512, San Francisco, CA 94143 0512, USA
    Exp Cell Res 312:468-77. 2006
    ..Interestingly, the invasion of M2Tbeta3 cells could be sustained by overexpression of cofilin A3. These results suggest that the integrin alphavbeta3 and cofilin together regulate K1735 melanoma cell invasion...
  18. ncbi request reprint Beta-6 Integrin, tenascin-C, and MMP-1 expression in salivary gland neoplasms
    Trent H Westernoff
    Department of Oral and Maxillofacial Surgery, 521 Parnassus Avenue, C 522, University of California, San Francisco, CA 94143 0440, United States
    Oral Oncol 41:170-4. 2005
    ..We believe that beta-6, tenascin-C, and MMP-1 proteins are part of the molecular repertoire used by salivary tumors for malignant invasion and benign tumor expansion...
  19. ncbi request reprint Tenascin-C deposition requires beta3 integrin and Src
    Yongjian Yang
    Department of Stomatology, University of California at San Francisco, San Francisco, CA, USA
    Biochem Biophys Res Commun 322:935-42. 2004
    ..The broad spectrum MMP inhibitor, GM6001, suppressed TN-C organization. These results indicate that beta3 integrin ligand binding and the activation of the Src/MAPK/MMP pathway modulate deposition of TN-C...
  20. ncbi request reprint Oral mucosal carcinogenesis in SENCAR mice
    Tae Won Kim
    Department of Stomatology, University of California San Francisco, San Francisco, CA 94143 0512, USA
    Anticancer Res 22:2733-40. 2002
    ..These results show that SENCAR mice can be used as a unique model of oral carcinogenesis with the potential for detailed molecular studies of neoplastic progression to SCC...

Research Grants10

  1. ORAL MELANOMA: ALPHA V BETA 3 EXPRESSION AND METASTASIS
    Daniel Ramos; Fiscal Year: 2000
    ..Understanding the role beta3 plays in oral melanoma invasion and metastasis may lead to novel prognostic indicators and development of new treatment strategies. ..
  2. Regulatory function of fyn in oral SCC invasion
    Daniel Ramos; Fiscal Year: 2006
    ..abstract_text> ..
  3. Regulatory function of fyn in oral SCC invasion
    Daniel Ramos; Fiscal Year: 2005
    ..abstract_text> ..
  4. ORAL MELANOMA: ALPHA V BETA 3 EXPRESSION AND METASTASIS
    Daniel Ramos; Fiscal Year: 2004
    ..Understanding the role beta3 plays in oral melanoma invasion and metastasis may lead to novel prognostic indicators and development of new treatment strategies. ..
  5. Regulatory function of fyn in oral SCC invasion
    Daniel Ramos; Fiscal Year: 2004
    ..abstract_text> ..
  6. ORAL MELANOMA: ALPHA V BETA 3 EXPRESSION AND METASTASIS
    Daniel Ramos; Fiscal Year: 2003
    ..Understanding the role beta3 plays in oral melanoma invasion and metastasis may lead to novel prognostic indicators and development of new treatment strategies. ..
  7. Regulatory function of fyn in oral SCC invasion
    Daniel Ramos; Fiscal Year: 2003
    ..abstract_text> ..
  8. ORAL MELANOMA: ALPHA V BETA 3 EXPRESSION AND METASTASIS
    Daniel Ramos; Fiscal Year: 2002
    ..Understanding the role beta3 plays in oral melanoma invasion and metastasis may lead to novel prognostic indicators and development of new treatment strategies. ..
  9. ORAL MELANOMA: ALPHA V BETA 3 EXPRESSION AND METASTASIS
    Daniel Ramos; Fiscal Year: 2001
    ..Understanding the role beta3 plays in oral melanoma invasion and metastasis may lead to novel prognostic indicators and development of new treatment strategies. ..
  10. Regulatory function of fyn in oral SCC invasion
    Daniel M Ramos; Fiscal Year: 2010
    ..abstract_text> ..