Genomes and Genes
Nicole M Ramocki
Affiliation: University of North Carolina
- Insulin receptor substrate-1 deficiency promotes apoptosis in the putative intestinal crypt stem cell region, limits Apcmin/+ tumors, and regulates Sox9Nicole M Ramocki
Department of Cell and Molecular Physiology, University of North Carolina at Chapel Hill, North Carolina 27599 7545, USA or
Endocrinology 149:261-7. 2008....
- Haplotype insufficiency for suppressor of cytokine signaling-2 enhances intestinal growth and promotes polyp formation in growth hormone-transgenic miceCarmen Z Michaylira
Department of Cell and Molecular Physiology, University of North Carolina at Chapel Hill, 27599 7545, USA
Endocrinology 147:1632-41. 2006..Small variations in SOCS2 expression levels may significantly influence the outcome of therapeutic GH or acromegaly in intestine...
- Suppressor of cytokine signaling-2 gene disruption promotes Apc(Min/+) tumorigenesis and activator protein-1 activationVictoria A Newton
Department of Cell and Molecular Physiology, University of North Carolina, Chapel Hill, NC 27599 7545, USA
Am J Pathol 176:2320-32. 2010..Therefore, reduced expression or epigenetic silencing of SOCS2 may serve as a useful biomarker for colorectal cancer risk...
- Suppressor of cytokine signaling-2 limits intestinal growth and enterotrophic actions of IGF-I in vivoCarmen Z Michaylira
CB 7545, Dept of Cell and Molecular Physiology, Univ of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7545, USA
Am J Physiol Gastrointest Liver Physiol 291:G472-81. 2006..We conclude that SOCS2 normally limits basal and IGF-I- and EGF-induced intestinal growth in vivo and has novel inhibitory effects on the IGF-IR tyrosine kinase pathway in intestinal epithelial cells...